5/13/2025
Last update
5/13/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 8 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Zinc (as OptiZinc® zinc monomethionine, zinc citrate)
50 mg
455%
Top Medical Research Studies
9
We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Read More
8
We explored the relationship between atrial natriuretic peptide (ANP) and zinc, particularly how they work together to protect the heart during reperfusion after ischemia. The study involved comparing various experimental rats and mice, as well as assessing plasma samples from patients experiencing heart-related conditions.
Our findings highlighted that ANP significantly boosts zinc levels during the crucial period of reperfusion. This increase in zinc appears to protect heart cells from damage by helping to maintain mitochondrial health, effectively reducing the size of heart tissue injuries. We observed that when ANP was administered alone, it improved heart function, but combining it with a substance that removes zinc led to poorer outcomes.
We also noted that ANP works through a specific signaling pathway (the PI3K pathway) to decrease levels of a zinc transporter, ZnT8, which is upregulated during reperfusion injury. Interestingly, both ANP and zinc had a role in regulating important proteins linked to heart health. Overall, our research suggests that managing zinc levels through ANP treatment can help shield the heart from the harsh effects of ischemia/reperfusion injury.
Our findings highlighted that ANP significantly boosts zinc levels during the crucial period of reperfusion. This increase in zinc appears to protect heart cells from damage by helping to maintain mitochondrial health, effectively reducing the size of heart tissue injuries. We observed that when ANP was administered alone, it improved heart function, but combining it with a substance that removes zinc led to poorer outcomes.
We also noted that ANP works through a specific signaling pathway (the PI3K pathway) to decrease levels of a zinc transporter, ZnT8, which is upregulated during reperfusion injury. Interestingly, both ANP and zinc had a role in regulating important proteins linked to heart health. Overall, our research suggests that managing zinc levels through ANP treatment can help shield the heart from the harsh effects of ischemia/reperfusion injury.
Read More
8
We investigated how zinc levels may influence sleep duration in patients with cardiovascular diseases (CVDs). Our study included 150 participants from the Ravansar Non-Communicable Disease Cohort Study, where we measured serum concentrations of zinc and other elements, including essential minerals and toxic metals.
A significant finding was that we observed a strong correlation between higher zinc concentrations and optimal sleep duration. Specifically, the data indicated that as zinc levels increased, the likelihood of achieving an appropriate sleep duration of 7 to 8 hours also increased.
However, when we looked deeper into the data, we did not find significant differences in the serum concentrations of both essential and toxic elements across different sleep duration categories. This suggests that while zinc may play a role in regulating sleep duration, it does not entirely account for sleep issues among CVD patients.
Ultimately, our results encourage further exploration of zinc's impact, particularly as it relates to sleep quality and overall health in individuals with cardiovascular conditions.
A significant finding was that we observed a strong correlation between higher zinc concentrations and optimal sleep duration. Specifically, the data indicated that as zinc levels increased, the likelihood of achieving an appropriate sleep duration of 7 to 8 hours also increased.
However, when we looked deeper into the data, we did not find significant differences in the serum concentrations of both essential and toxic elements across different sleep duration categories. This suggests that while zinc may play a role in regulating sleep duration, it does not entirely account for sleep issues among CVD patients.
Ultimately, our results encourage further exploration of zinc's impact, particularly as it relates to sleep quality and overall health in individuals with cardiovascular conditions.
Read More
Most Useful Reviews
9
Improved healing
263 people found this helpful
Highly dosed and well-absorbed zinc is essential for proper immune function and brain development. A deficiency can lead to cognitive impairment and mental disorders. Zinc is also crucial for maintaining taste, vision, and testosterone production in men. My family used zinc monomethionine for deficiency; it aided my father's ulcer healing and improved my husband's vision and testosterone levels. Be cautious, though, as excessive zinc can interfere with copper absorption.
Read More
9
Strengthens immunity
1 people found this helpful
Life Extension’s zinc is tested for quality. It not only strengthens immunity but also aids in antioxidant production and stimulates enzymes essential for various bodily functions. It supports cardiovascular health and maintains vision in the elderly.
Read More
7.5
Supports recovery
173 people found this helpful
Zinc is vital in combating coronavirus by aiding resistance and fostering quicker recovery from the illness.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
- All Researches
9
We focused our research on how zinc oxide nanoparticles (ZnONPs) might help reduce heart damage caused by cisplatin, a well-known chemotherapy drug. In this study, we used rats divided into different groups, some receiving varying doses of ZnONPs and others serving as control groups.
Our findings indicated that as the dosage of ZnONPs increased up to 50 mg/kg, there was a marked improvement in cardiovascular markers. We observed reduced levels of oxidative stress, inflammation, and cell damage in the heart tissues of those treated with ZnONPs. More specifically, measures related to heart tissue health and serum biomarkers showed that rats receiving higher doses exhibited recovery similar to that of healthy rats.
Overall, we concluded that ZnONPs serve as a protective agent against cisplatin-induced cardiotoxicity, showcasing their potential in improving heart health during cancer treatment.
Our findings indicated that as the dosage of ZnONPs increased up to 50 mg/kg, there was a marked improvement in cardiovascular markers. We observed reduced levels of oxidative stress, inflammation, and cell damage in the heart tissues of those treated with ZnONPs. More specifically, measures related to heart tissue health and serum biomarkers showed that rats receiving higher doses exhibited recovery similar to that of healthy rats.
Overall, we concluded that ZnONPs serve as a protective agent against cisplatin-induced cardiotoxicity, showcasing their potential in improving heart health during cancer treatment.
Read More
9
We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Read More
8
We explored the relationship between atrial natriuretic peptide (ANP) and zinc, particularly how they work together to protect the heart during reperfusion after ischemia. The study involved comparing various experimental rats and mice, as well as assessing plasma samples from patients experiencing heart-related conditions.
Our findings highlighted that ANP significantly boosts zinc levels during the crucial period of reperfusion. This increase in zinc appears to protect heart cells from damage by helping to maintain mitochondrial health, effectively reducing the size of heart tissue injuries. We observed that when ANP was administered alone, it improved heart function, but combining it with a substance that removes zinc led to poorer outcomes.
We also noted that ANP works through a specific signaling pathway (the PI3K pathway) to decrease levels of a zinc transporter, ZnT8, which is upregulated during reperfusion injury. Interestingly, both ANP and zinc had a role in regulating important proteins linked to heart health. Overall, our research suggests that managing zinc levels through ANP treatment can help shield the heart from the harsh effects of ischemia/reperfusion injury.
Our findings highlighted that ANP significantly boosts zinc levels during the crucial period of reperfusion. This increase in zinc appears to protect heart cells from damage by helping to maintain mitochondrial health, effectively reducing the size of heart tissue injuries. We observed that when ANP was administered alone, it improved heart function, but combining it with a substance that removes zinc led to poorer outcomes.
We also noted that ANP works through a specific signaling pathway (the PI3K pathway) to decrease levels of a zinc transporter, ZnT8, which is upregulated during reperfusion injury. Interestingly, both ANP and zinc had a role in regulating important proteins linked to heart health. Overall, our research suggests that managing zinc levels through ANP treatment can help shield the heart from the harsh effects of ischemia/reperfusion injury.
Read More
8
We investigated how zinc levels may influence sleep duration in patients with cardiovascular diseases (CVDs). Our study included 150 participants from the Ravansar Non-Communicable Disease Cohort Study, where we measured serum concentrations of zinc and other elements, including essential minerals and toxic metals.
A significant finding was that we observed a strong correlation between higher zinc concentrations and optimal sleep duration. Specifically, the data indicated that as zinc levels increased, the likelihood of achieving an appropriate sleep duration of 7 to 8 hours also increased.
However, when we looked deeper into the data, we did not find significant differences in the serum concentrations of both essential and toxic elements across different sleep duration categories. This suggests that while zinc may play a role in regulating sleep duration, it does not entirely account for sleep issues among CVD patients.
Ultimately, our results encourage further exploration of zinc's impact, particularly as it relates to sleep quality and overall health in individuals with cardiovascular conditions.
A significant finding was that we observed a strong correlation between higher zinc concentrations and optimal sleep duration. Specifically, the data indicated that as zinc levels increased, the likelihood of achieving an appropriate sleep duration of 7 to 8 hours also increased.
However, when we looked deeper into the data, we did not find significant differences in the serum concentrations of both essential and toxic elements across different sleep duration categories. This suggests that while zinc may play a role in regulating sleep duration, it does not entirely account for sleep issues among CVD patients.
Ultimately, our results encourage further exploration of zinc's impact, particularly as it relates to sleep quality and overall health in individuals with cardiovascular conditions.
Read More
7
We explored the relationship between dietary zinc intake and the risk of atherosclerotic cardiovascular disease (ASCVD) in patients with diabetes mellitus (DM). Utilizing data from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018, we calculated the 10-year ASCVD risk according to established clinical guidelines. Our analysis focused on dietary zinc intake based on food recall data from the participants.
The findings suggest that sufficient dietary zinc intake could positively influence cardiovascular health in diabetes patients. This is particularly important, as diabetes is closely linked with increased oxidative stress and inflammation, two factors that contribute to the development of heart disease. While we see an association between zinc and improved heart health, it's essential to note that further research is needed. Large-scale, well-designed prospective studies should aim to clarify the specific role of zinc in this context.
Overall, our results underscore the potential benefits of zinc for cardiovascular health, particularly in individuals managing diabetes. As we delve deeper into these associations, we aim to provide clearer guidance on how dietary choices can impact health outcomes for those living with diabetes.
The findings suggest that sufficient dietary zinc intake could positively influence cardiovascular health in diabetes patients. This is particularly important, as diabetes is closely linked with increased oxidative stress and inflammation, two factors that contribute to the development of heart disease. While we see an association between zinc and improved heart health, it's essential to note that further research is needed. Large-scale, well-designed prospective studies should aim to clarify the specific role of zinc in this context.
Overall, our results underscore the potential benefits of zinc for cardiovascular health, particularly in individuals managing diabetes. As we delve deeper into these associations, we aim to provide clearer guidance on how dietary choices can impact health outcomes for those living with diabetes.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved healing
263 people found this helpful
Highly dosed and well-absorbed zinc is essential for proper immune function and brain development. A deficiency can lead to cognitive impairment and mental disorders. Zinc is also crucial for maintaining taste, vision, and testosterone production in men. My family used zinc monomethionine for deficiency; it aided my father's ulcer healing and improved my husband's vision and testosterone levels. Be cautious, though, as excessive zinc can interfere with copper absorption.
Read More
9
Strengthens immunity
1 people found this helpful
Life Extension’s zinc is tested for quality. It not only strengthens immunity but also aids in antioxidant production and stimulates enzymes essential for various bodily functions. It supports cardiovascular health and maintains vision in the elderly.
Read More
7.5
Supports recovery
173 people found this helpful
Zinc is vital in combating coronavirus by aiding resistance and fostering quicker recovery from the illness.
Read More
7.5
Must-have supplement
28 people found this helpful
I bought this 50mg zinc for my brother. It's an excellent antioxidant and vital for cardiovascular health. This key mineral is integral for supporting hormone function.
Read More
7.5
Boosts immunity
1 people found this helpful
High-efficiency zinc bolsters the immune system, provides strong antioxidants, and supports cardiovascular health, preventing heart disease. It's especially beneficial for those lacking beef in their diet.
Read More
Frequently Asked Questions
9
Improved healing
263 people found this helpful
Highly dosed and well-absorbed zinc is essential for proper immune function and brain development. A deficiency can lead to cognitive impairment and mental disorders. Zinc is also crucial for maintaining taste, vision, and testosterone production in men. My family used zinc monomethionine for deficiency; it aided my father's ulcer healing and improved my husband's vision and testosterone levels. Be cautious, though, as excessive zinc can interfere with copper absorption.
7.5
Supports recovery
173 people found this helpful
Zinc is vital in combating coronavirus by aiding resistance and fostering quicker recovery from the illness.
7.5
Boosts immunity
1 people found this helpful
High-efficiency zinc bolsters the immune system, provides strong antioxidants, and supports cardiovascular health, preventing heart disease. It's especially beneficial for those lacking beef in their diet.
7.5
Must-have supplement
28 people found this helpful
I bought this 50mg zinc for my brother. It's an excellent antioxidant and vital for cardiovascular health. This key mineral is integral for supporting hormone function.
7.5
Maintains vision
1 people found this helpful
Zinc supports the immune system and cardiovascular health. Deficiency, particularly in the elderly, can weaken immune function. Supplements can help maintain a healthy immune response and reduce inflammation, which is crucial for preventing cardiovascular disease.
7.5
Daily dosage
1 people found this helpful
This zinc is bioavailable and well-absorbed, essential for immunity, especially during the autumn-winter months. I take one capsule daily, which has improved my health. It's vital for men, particularly in times of malaise or inflammation, but should be taken separately from copper.
7
We explored the relationship between dietary zinc intake and the risk of atherosclerotic cardiovascular disease (ASCVD) in patients with diabetes mellitus (DM). Utilizing data from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018, we calculated the 10-year ASCVD risk according to established clinical guidelines. Our analysis focused on dietary zinc intake based on food recall data from the participants.
The findings suggest that sufficient dietary zinc intake could positively influence cardiovascular health in diabetes patients. This is particularly important, as diabetes is closely linked with increased oxidative stress and inflammation, two factors that contribute to the development of heart disease. While we see an association between zinc and improved heart health, it's essential to note that further research is needed. Large-scale, well-designed prospective studies should aim to clarify the specific role of zinc in this context.
Overall, our results underscore the potential benefits of zinc for cardiovascular health, particularly in individuals managing diabetes. As we delve deeper into these associations, we aim to provide clearer guidance on how dietary choices can impact health outcomes for those living with diabetes.
The findings suggest that sufficient dietary zinc intake could positively influence cardiovascular health in diabetes patients. This is particularly important, as diabetes is closely linked with increased oxidative stress and inflammation, two factors that contribute to the development of heart disease. While we see an association between zinc and improved heart health, it's essential to note that further research is needed. Large-scale, well-designed prospective studies should aim to clarify the specific role of zinc in this context.
Overall, our results underscore the potential benefits of zinc for cardiovascular health, particularly in individuals managing diabetes. As we delve deeper into these associations, we aim to provide clearer guidance on how dietary choices can impact health outcomes for those living with diabetes.
8
We explored the relationship between atrial natriuretic peptide (ANP) and zinc, particularly how they work together to protect the heart during reperfusion after ischemia. The study involved comparing various experimental rats and mice, as well as assessing plasma samples from patients experiencing heart-related conditions.
Our findings highlighted that ANP significantly boosts zinc levels during the crucial period of reperfusion. This increase in zinc appears to protect heart cells from damage by helping to maintain mitochondrial health, effectively reducing the size of heart tissue injuries. We observed that when ANP was administered alone, it improved heart function, but combining it with a substance that removes zinc led to poorer outcomes.
We also noted that ANP works through a specific signaling pathway (the PI3K pathway) to decrease levels of a zinc transporter, ZnT8, which is upregulated during reperfusion injury. Interestingly, both ANP and zinc had a role in regulating important proteins linked to heart health. Overall, our research suggests that managing zinc levels through ANP treatment can help shield the heart from the harsh effects of ischemia/reperfusion injury.
Our findings highlighted that ANP significantly boosts zinc levels during the crucial period of reperfusion. This increase in zinc appears to protect heart cells from damage by helping to maintain mitochondrial health, effectively reducing the size of heart tissue injuries. We observed that when ANP was administered alone, it improved heart function, but combining it with a substance that removes zinc led to poorer outcomes.
We also noted that ANP works through a specific signaling pathway (the PI3K pathway) to decrease levels of a zinc transporter, ZnT8, which is upregulated during reperfusion injury. Interestingly, both ANP and zinc had a role in regulating important proteins linked to heart health. Overall, our research suggests that managing zinc levels through ANP treatment can help shield the heart from the harsh effects of ischemia/reperfusion injury.
9
We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
7
Zinc's role in cardiovascular health
We explored how zinc deficiency relates to cardiovascular disease among obese adults in Serbia. By conducting a case-control study with 31 obese participants and 31 control subjects, we set out to understand how zinc affects body weight, lipid levels, and inflammation.
Our findings revealed that obese individuals had significantly lower serum zinc levels compared to those who weren't obese. We observed notable negative correlations between zinc levels and various health metrics, including body weight, body fat percentage, and triglycerides.
On the flip side, higher zinc levels correlated positively with beneficial high-density lipoproteins. Interestingly, we noted that the atherosclerotic index was significantly linked to zinc, suggesting that zinc status could play a role in assessing cardiovascular risk in obese individuals.
While this study spotlights zinc's intriguing relationship with cardiovascular risk factors, it does not specifically evaluate the benefits of zinc treatment on cardiovascular outcomes.
Our findings revealed that obese individuals had significantly lower serum zinc levels compared to those who weren't obese. We observed notable negative correlations between zinc levels and various health metrics, including body weight, body fat percentage, and triglycerides.
On the flip side, higher zinc levels correlated positively with beneficial high-density lipoproteins. Interestingly, we noted that the atherosclerotic index was significantly linked to zinc, suggesting that zinc status could play a role in assessing cardiovascular risk in obese individuals.
While this study spotlights zinc's intriguing relationship with cardiovascular risk factors, it does not specifically evaluate the benefits of zinc treatment on cardiovascular outcomes.
References
- Lyu X, Chen L, Wang W. Dietary zinc intake and 10-year atherosclerotic cardiovascular disease risk in diabetes mellitus patients: evidence from NHANES database. Thromb J. 2025;23:18. 10.1186/s12959-025-00693-0
- Ma YT, Laga T, Zhong CN, Zhuang BQ, Quan HL, et al. ANP Increases Zn Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts. Curr Med Sci. 2025;45:35. 10.1007/s11596-025-00019-1
- Al-Lbban AM. Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats. Braz J Biol. 2025;84:e287764. 10.1590/1519-6984.287764
- Soskic S, Gluvic Z, Obradovic M, Ilincic B, Cabarkapa V, et al. A pilot study on the relationship between zinc deficiency and anthropometric and metabolic parameters in obese adults in Serbia. Scand J Clin Lab Invest. 2025;85:51. 10.1080/00365513.2025.2460034
- Zhang H, Zhou W, Wang X, Men H, Wang J, et al. Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling. Int J Biol Sci. 2025;21:1032. 10.7150/ijbs.105513
- Guo J, Ma T, Wang B, Xing B, Huang L, et al. Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation. Cell Signal. 2025;127:111629. 10.1016/j.cellsig.2025.111629
- Azadi NA, Nakhaee S, Hassan NE, Mansouri B, Ariyaee M. Role of toxic and essential elements in sleep duration of patients with cardiovascular diseases. Sci Rep. 2025;15:2392. 10.1038/s41598-025-86873-4
