Last update
9/28/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 20 Reviews
8.2
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Zinc (as OptiZinc® zinc monomethionine, zinc citrate)
50 mg
455%
Top Medical Research Studies
7
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Read More
9
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
8
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
Read More
Most Useful Reviews
9
Boosted energy levels
90 people found this helpful
I've battled chronic fatigue syndrome for a long time, searching for a suitable vitamin without side effects. This supplement has given me a surge of energy and significantly improved my condition. I recommend it to anyone looking for relief.
Read More
9
Covid recovery
1 people found this helpful
I've added zinc to my routine during the pandemic alongside D3. I'm over 50 and find it energising and crucial against chronic fatigue syndrome. My recovery from Covid was smooth, and I wholeheartedly recommend it. Wishing everyone good health!
Read More
9
Increased vitality
Zinc excels in boosting vitality and alleviating chronic fatigue syndrome symptoms. It rejuvenates the body, supports the immune system, and improves overall strength. Since starting zinc, I feel energetic, sleep better, and my hair looks healthy again.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
- All Researches
9
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
We investigated the impact of a 3-month supplementation with a special synbiotic mixture on adults suffering from post-COVID-19 chronic fatigue syndrome (ME/CFS). This study was thoughtfully designed as a placebo-controlled, double-blind trial involving 26 participants. The intention was to see how this synbiotic, which notably contains zinc among other components, would influence patients' overall experiences, exercise tolerance, and metabolism in tissues affected by fatigue.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
Read More
8
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
Read More
8
Beta-glucan improves cognitive fatigue
We conducted a study to explore the potential benefits of beta-glucan supplementation in individuals suffering from chronic fatigue syndrome (ME/CFS). Over 36 weeks, we engaged 65 patients in a randomized, double-blind trial where they received either a daily combination of beta-glucan, vitamin D3, vitamin B6, and zinc, or a placebo that contained only microcrystalline cellulose. This approach allowed us to assess the overall impact of this nutritional supplement on fatigue, sleep quality, anxiety, and cognitive performance.
Our findings were particularly encouraging regarding cognitive fatigue; those who received the beta-glucan supplementation showed a significant improvement in cognitive fatigue symptoms over the study period. While zinc was included in the supplement mix, it makes it challenging to pinpoint its isolated contribution to the benefits observed. Therefore, we caution that any conclusions about zinc’s effects on chronic fatigue syndrome should be drawn with care.
This research provides valuable insights into how yeast-derived beta-glucan might serve as a helpful supplement for patients facing cognitive challenges associated with ME/CFS. Moving forward, further investigations are needed to confirm these outcomes and to better understand the immunometabolic mechanisms at play.
Our findings were particularly encouraging regarding cognitive fatigue; those who received the beta-glucan supplementation showed a significant improvement in cognitive fatigue symptoms over the study period. While zinc was included in the supplement mix, it makes it challenging to pinpoint its isolated contribution to the benefits observed. Therefore, we caution that any conclusions about zinc’s effects on chronic fatigue syndrome should be drawn with care.
This research provides valuable insights into how yeast-derived beta-glucan might serve as a helpful supplement for patients facing cognitive challenges associated with ME/CFS. Moving forward, further investigations are needed to confirm these outcomes and to better understand the immunometabolic mechanisms at play.
Read More
8
Zinc's limited role in fatigue relief
We conducted a study to explore how oral supplementation of melatonin combined with zinc affects fatigue in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The trial lasted 16 weeks, involved 50 participants, and was designed as a randomized, double-blind, placebo-controlled study. Patients were divided to receive either melatonin with zinc or a placebo daily.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Boosted energy levels
90 people found this helpful
I've battled chronic fatigue syndrome for a long time, searching for a suitable vitamin without side effects. This supplement has given me a surge of energy and significantly improved my condition. I recommend it to anyone looking for relief.
Read More
9
Covid recovery
1 people found this helpful
I've added zinc to my routine during the pandemic alongside D3. I'm over 50 and find it energising and crucial against chronic fatigue syndrome. My recovery from Covid was smooth, and I wholeheartedly recommend it. Wishing everyone good health!
Read More
9
Increased vitality
Zinc excels in boosting vitality and alleviating chronic fatigue syndrome symptoms. It rejuvenates the body, supports the immune system, and improves overall strength. Since starting zinc, I feel energetic, sleep better, and my hair looks healthy again.
Read More
9
Mood enhancement
After a blood test revealed zinc deficiency leading to chronic fatigue syndrome, I've felt lighter and more energetic since beginning daily supplements, especially in winter.
Read More
7.5
Zinc deficiency symptoms
122 people found this helpful
The importance of zinc for women cannot be overstated. Symptoms like constant fatigue, irritability, and poor eyesight signify its deficiency. My hair fell out and became brittle as well. Hormonal balance is vital, especially with age—it influences appearance. Ladies, strive to be beautiful. If this has helped you, please give a thumbs up.
Read More
Frequently Asked Questions
9
Improved mood and energy
34 people found this helpful
I've been taking this excellent zinc supplement for a month. I find it easier to wake up, my chronic fatigue syndrome has improved, and my mood is better. It helps with memory and rejuvenates my skin. I've noticed positive effects on my nails and hair too.
7.5
Less fatigue
3 people found this helpful
I started taking this zinc supplement to combat chronic fatigue syndrome. After six months, I feel more energetic and less fatigued. My hair has improved too. The taste and smell didn't bother me.
9
Mood enhancement
After a blood test revealed zinc deficiency leading to chronic fatigue syndrome, I've felt lighter and more energetic since beginning daily supplements, especially in winter.
9
Boosted energy levels
90 people found this helpful
I've battled chronic fatigue syndrome for a long time, searching for a suitable vitamin without side effects. This supplement has given me a surge of energy and significantly improved my condition. I recommend it to anyone looking for relief.
9
Covid recovery
1 people found this helpful
I've added zinc to my routine during the pandemic alongside D3. I'm over 50 and find it energising and crucial against chronic fatigue syndrome. My recovery from Covid was smooth, and I wholeheartedly recommend it. Wishing everyone good health!
9
Increased vitality
Zinc excels in boosting vitality and alleviating chronic fatigue syndrome symptoms. It rejuvenates the body, supports the immune system, and improves overall strength. Since starting zinc, I feel energetic, sleep better, and my hair looks healthy again.
9
Reduced inflammation
Since starting zinc, my chronic inflammation has resolved, and I feel much happier. It has made a significant positive impact on my health.
7.5
Immunity boost
18 people found this helpful
For over a year, I've relied on this potent zinc type. It helps with fatigue and has strengthened my immune system, particularly during illness. I've recommended it to my family and believe it's beneficial; just consult a doctor first.
7.5
Clearer skin
20 people found this helpful
I take zinc for skin health and to strengthen my immune system. One tablet daily with a meal has revitalised my body, reduced my fatigue and improved my skin clarity. I absolutely adore this brand.
9
Effective remedy
1 people found this helpful
For two years, I've consistently taken zinc citrate, renowned for its high digestibility and pleasant taste. It alleviated symptoms like irritability and chronic fatigue syndrome, along with improving my skin and hair. I feel fantastic now, and it truly works!
7
We conducted a study to explore how zinc, along with other natural substances, impacts chronic fatigue syndrome (CFS). Over a period of 10 to 14 months, we analyzed the levels of specific antibodies in the blood of 41 CFS patients before and after they took a combination of natural anti-inflammatory and antioxidant substances, including zinc, while following a leaky gut diet.
Our findings indicate that zinc may help normalize immune responses related to gut health in CFS patients. Specifically, we saw that as the levels of antibodies related to translocated lipopolysaccharides (LPS) from harmful bacteria normalized, many patients reported clinical improvements. This suggests that gut health is an important factor in managing CFS and that treatments like zinc may play a supportive role.
However, it's important to note that the direct effects of zinc alone cannot be clearly separated from those of other substances taken in the study. The combined approach points to a potential pathway in CFS treatment that emphasizes the role of a healthy gut and could open doors for new drug development targeting gut-related inflammation in CFS patients.
Our findings indicate that zinc may help normalize immune responses related to gut health in CFS patients. Specifically, we saw that as the levels of antibodies related to translocated lipopolysaccharides (LPS) from harmful bacteria normalized, many patients reported clinical improvements. This suggests that gut health is an important factor in managing CFS and that treatments like zinc may play a supportive role.
However, it's important to note that the direct effects of zinc alone cannot be clearly separated from those of other substances taken in the study. The combined approach points to a potential pathway in CFS treatment that emphasizes the role of a healthy gut and could open doors for new drug development targeting gut-related inflammation in CFS patients.
8
Zinc's limited role in fatigue relief
We conducted a study to explore how oral supplementation of melatonin combined with zinc affects fatigue in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The trial lasted 16 weeks, involved 50 participants, and was designed as a randomized, double-blind, placebo-controlled study. Patients were divided to receive either melatonin with zinc or a placebo daily.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
We investigated the impact of a 3-month supplementation with a special synbiotic mixture on adults suffering from post-COVID-19 chronic fatigue syndrome (ME/CFS). This study was thoughtfully designed as a placebo-controlled, double-blind trial involving 26 participants. The intention was to see how this synbiotic, which notably contains zinc among other components, would influence patients' overall experiences, exercise tolerance, and metabolism in tissues affected by fatigue.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
References
- Ranisavljev M, Stajer V, Todorovic N, Ostojic J, Cvejic JH, et al. The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial. Eur J Nutr. 2024;64:28. 10.1007/s00394-024-03546-0
- Noce A, Marrone G, Di Lauro M, Vita C, Montalto G, et al. Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients. Pharmaceuticals (Basel). 2024;17. 10.3390/ph17040463
- Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, et al. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. 10.3390/nu15214504
- Imai K, Yamano T, Nishi S, Nishi R, Nishi T, et al. Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment. Viruses. 2022;14. 10.3390/v14050907
- Castro-Marrero J, Zaragozá MC, López-Vílchez I, Galmés JL, Cordobilla B, et al. Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Antioxidants (Basel). 2021;10. 10.3390/antiox10071010
- Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008;29:902.
- Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.
