Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 9 Reviews
8.1
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Zinc (as OptiZinc® zinc monomethionine, zinc citrate)
50 mg
455%

Top Medical Research Studies

We delved into an interesting case of a 76-year-old man who developed severe esophageal ulcers, likely due to zinc deficiency following a total gastrectomy. His symptoms included sore throat, heartburn, and difficulty swallowing.

After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.
Read More
We moved forward with a double-blind, placebo-controlled study to see how zinc affects ulcers in patients with Behçet's disease. Over 12 weeks, 50 participants received either zinc gluconate or a placebo.

The results revealed that zinc significantly reduced the occurrence of genital ulcers and inflammation markers like NLRP3 and caspase-1. In fact, zinc supplementation improved clinical conditions and decreased inflammatory markers, showing promise as an additional therapy for managing Behçet's disease.
Read More
8
Zinc treatment comparable for ulcers
We explored how polaprezinc combined with a proton pump inhibitor (PPI) stacks up against rebamipide with PPI treatment for ulcers resulting from endoscopic submucosal dissection (ESD). Involving 210 patients, the study randomly assigned them to either treatment group and evaluated their ulcer healing rates after four weeks.

We found that polaprezinc's healing effectiveness was comparable to that of rebamipide, with healing rates at 90.3% and 91.4% respectively. This means that while both treatments are effective, we didn’t observe a significant advantage of one over the other in promoting ulcer healing.
Read More

Most Useful Reviews

9
Mouth ulcer prevention
13 people found this helpful
I tend to get mouth ulcers on my tongue when I run out of zinc. Taking it along with B6 helps cure them easily. It also assists in calming stomach discomfort like heartburn, which tends to linger without sufficient zinc.
Read More
9
Helps ulcers
I cannot do without this zinc as it alleviates my stomach ulcers while fulfilling my body's essential element needs.
Read More
7.5
Effective zinc supplement
263 people found this helpful
Highly dosed and well-absorbed zinc. It plays a crucial role in immune function and can prevent ulcer healing issues. My father used it to heal a leg ulcer, which had not improved with prescribed therapies. It healed quickly, and my husband took it to enhance his vision and noticed an increase in testosterone levels too.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
  • All Researches
9.5
Zinc's role in ulcer treatment
We explored the impact of zinc when incorporated into first-line treatments for Helicobacter pylori infections, particularly in patients suffering from ulcers. In a multicenter registry study involving 800 patients, we noted that the most common factors leading to treatment were dyspepsia and gastroduodenal ulcers.

The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.

We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
Read More
We investigated the effects of zinc hyaluronate (ZnHA) on ulcerative colitis (UC) using a mouse model that simulates the condition. This study aimed to explore how ZnHA could potentially alleviate the symptoms of UC, focusing on factors like inflammation and gut health.

Our experiments showed that ZnHA significantly reduced key symptoms associated with UC, such as weight loss, loose stools, and the presence of blood in stools. We also noticed notable changes at a cellular level; ZnHA helped decrease levels of inflammatory markers like tumor necrosis factor-α and interleukin-6 while boosting interleukin-10, a factor known for anti-inflammatory effects.

Additionally, our findings revealed that ZnHA positively impacted gut bacteria. It fostered the growth of beneficial bacteria that produce propionic acid, which is crucial for gut health. We also observed that ZnHA enhanced the function of proteins that maintain the intestinal barrier, such as ZO-1 and occludin.

Overall, our exploration highlights the potential of ZnHA as a supportive treatment for UC by targeting inflammation and promoting a healthy gut environment. This study provides new insights that could encourage further development of hyaluronic acid-based treatments for UC and similar conditions.
Read More
9
Zinc enhances diabetic ulcer healing
We explored how a new treatment for diabetic foot ulcers (DFUs) works, focusing on the role of zinc. This innovative formulation combines zinc with other therapeutic agents in a chitosan-based hydrogel that responds to heat. Our aim was to see if this treatment could not only fight bacteria but also help the body heal more effectively.

The combination of zinc with chlorogenic acid and indocyanine green promotes a healing environment by reducing inflammation and oxidative stress at the ulcer site. This hydrogel is designed to release its active ingredients right where they’re needed, and we found that it significantly enhances the expression of proteins important for blood vessel formation, including VEGF and CD31.

In our experiments, both in the lab and in real-life conditions, this zinc-enriched hydrogel showed promising results. It effectively inhibited the growth of the common bacteria Staphylococcus aureus after applying laser treatment and helped wounds remodel within 14 days.

This study suggests that incorporating zinc into wound care strategies could significantly improve treatment outcomes for patients suffering from DFUs. Overall, our findings open up new avenues for managing this challenging health issue.
Read More
9
New treatment reduces digital dermatitis
We embarked on an investigation to understand whether a new hoof care product featuring iron, zinc, and aluminum can effectively reduce and prevent digital dermatitis (DD) in dairy cows. In a controlled trial involving over 130 dairy cows, we treated one hind foot of each cow twice a week with this product while leaving the other foot untreated for comparison.

The results were revealing! Our analysis indicated that the use of the hoof care product significantly reduced the severity of DD compared to the untreated group. In fact, cows treated with the product had a much lower chance of developing lesions. The outcome showed that in the control group, the odds of having a lesion were four times higher than in the treated group, and the likelihood of experiencing an active lesion versus an inactive one was even more pronounced.

Interestingly, we also observed positive outcomes in heifers, with only one developing an active lesion in the treated group, showcasing the potential for this product to help manage and prevent DD even before these young cows enter the herd. The study indicates that the combination of ingredients in this hoof care product could be a promising alternative to traditional, harsher treatments.

While zinc is included as one of the components in the product, it's essential to note that we can't isolate its effect on ulcers from the other ingredients. Therefore, we can't definitively conclude zinc's sole effectiveness when it comes to DD treatment, but the overall findings are encouraging for improving hoof health in dairy cows.
Read More
9
Zinc and Polaprezinc's synergistic effects
We explored the potential impact of Polaprezinc, a drug commonly used for gastric ulcers, on neuroinflammation, a key factor in neurodegenerative diseases. By using LPS-induced BV-2 microglia, we observed that Polaprezinc significantly reduced the production of harmful compounds like nitric oxide and reactive oxygen species. Additionally, it inhibited the expression of inflammatory markers, suggesting its anti-inflammatory properties may extend beyond ulcer treatment.

Interestingly, we also examined how the combination of Polaprezinc with Aspergillusidone G could enhance these effects. When we treated the microglia with both substances, the results were promising. The duo improved the inhibition of nitric oxide generation from about 30% to an impressive 80%. This indicates a possible synergistic anti-inflammatory effect that could offer new approaches in managing neuroinflammatory conditions.

Overall, our findings shed light on the importance of zinc's role in the therapeutic effects of Polaprezinc, especially when paired with other compounds like Aspergillusidone G. This combination opens up exciting avenues for research into treatments for neurodegenerative diseases, highlighting the crucial connection between inflammation and zinc in the context of ulcer management.
Read More

User Reviews

USERS' SCORE
Good
Based on 9 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Mouth ulcer prevention
13 people found this helpful
I tend to get mouth ulcers on my tongue when I run out of zinc. Taking it along with B6 helps cure them easily. It also assists in calming stomach discomfort like heartburn, which tends to linger without sufficient zinc.
Read More
9
Helps ulcers
I cannot do without this zinc as it alleviates my stomach ulcers while fulfilling my body's essential element needs.
Read More
7.5
Effective zinc supplement
263 people found this helpful
Highly dosed and well-absorbed zinc. It plays a crucial role in immune function and can prevent ulcer healing issues. My father used it to heal a leg ulcer, which had not improved with prescribed therapies. It healed quickly, and my husband took it to enhance his vision and noticed an increase in testosterone levels too.
Read More
7.5
Regenerative power
10 people found this helpful
The dosage is manageable, and I've noticed it prevents mouth ulcers during stressful times. Consistent use seems to enhance my skin's healing abilities, so I plan to continue taking it alongside other supplements.
Read More
7.5
No more issues
3 people found this helpful
Highly recommend. I have ulcers and take one capsule with dinner; I've had no gastro issues since. When my Amazon order is a few pounds short of free shipping, I simply add this. It's a great price and works out perfectly. I'm very happy with the price and quality.
Read More

Frequently Asked Questions

9
Persistent ulcers gone
1 people found this helpful
I struggled with intermittent mouth ulcers that were quite painful. However, after taking one to two zinc tablets daily, they are nearly gone and heal quickly when they do occur.
7.5
Regenerative power
10 people found this helpful
The dosage is manageable, and I've noticed it prevents mouth ulcers during stressful times. Consistent use seems to enhance my skin's healing abilities, so I plan to continue taking it alongside other supplements.
7.5
Effective zinc supplement
263 people found this helpful
Highly dosed and well-absorbed zinc. It plays a crucial role in immune function and can prevent ulcer healing issues. My father used it to heal a leg ulcer, which had not improved with prescribed therapies. It healed quickly, and my husband took it to enhance his vision and noticed an increase in testosterone levels too.
9
Helps ulcers
I cannot do without this zinc as it alleviates my stomach ulcers while fulfilling my body's essential element needs.
7.5
Essential for healing
Zinc is vital for the body’s functions and immunity. A deficiency can heighten the risk of infections, ulcers, and skin injuries. It aids in wound healing and reduces inflammation effectively.
7.5
Irritation noted
2 people found this helpful
Taking this on an empty stomach can irritate, so I suggest taking it after meals. Zinc's effects are impressive; it has even reduced swelling from mouth issues, helping me avoid ulcers. I also noticed it may deter hair loss.
9
Mouth ulcer prevention
13 people found this helpful
I tend to get mouth ulcers on my tongue when I run out of zinc. Taking it along with B6 helps cure them easily. It also assists in calming stomach discomfort like heartburn, which tends to linger without sufficient zinc.
We investigated the effects of zinc hyaluronate (ZnHA) on ulcerative colitis (UC) using a mouse model that simulates the condition. This study aimed to explore how ZnHA could potentially alleviate the symptoms of UC, focusing on factors like inflammation and gut health.

Our experiments showed that ZnHA significantly reduced key symptoms associated with UC, such as weight loss, loose stools, and the presence of blood in stools. We also noticed notable changes at a cellular level; ZnHA helped decrease levels of inflammatory markers like tumor necrosis factor-α and interleukin-6 while boosting interleukin-10, a factor known for anti-inflammatory effects.

Additionally, our findings revealed that ZnHA positively impacted gut bacteria. It fostered the growth of beneficial bacteria that produce propionic acid, which is crucial for gut health. We also observed that ZnHA enhanced the function of proteins that maintain the intestinal barrier, such as ZO-1 and occludin.

Overall, our exploration highlights the potential of ZnHA as a supportive treatment for UC by targeting inflammation and promoting a healthy gut environment. This study provides new insights that could encourage further development of hyaluronic acid-based treatments for UC and similar conditions.
7
Zinc shows promise for ulcers
We explored how zinc-enriched multivitamins could help patients suffering from recurrent aphthous stomatitis, a condition marked by painful mouth ulcers. Our study focused on those who had not yet tried any treatments and aimed to find a safer alternative to traditional medications. Over a decade, we gathered data from 201 patients who took a daily zinc supplement called ZnVita for at least a month.

After analyzing the results, we found that 58.7% of patients experienced some level of relief from their symptoms. Notably, those who had symptoms related to Behçet's disease were less likely to benefit from the zinc treatment. We were pleased to see that the treatment was generally well-tolerated, with only a small percentage reporting mild digestive issues.

Overall, our findings suggest that zinc supplementation could provide valuable relief for a significant number of patients dealing with these painful ulcers, particularly for those without concurrent Behçet's disease symptoms. This could lead to a reduced reliance on more invasive treatments in the future.
9.5
Zinc's role in ulcer treatment
We explored the impact of zinc when incorporated into first-line treatments for Helicobacter pylori infections, particularly in patients suffering from ulcers. In a multicenter registry study involving 800 patients, we noted that the most common factors leading to treatment were dyspepsia and gastroduodenal ulcers.

The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.

We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
We set out to explore how zinc, when included in oral nutritional formulas, impacts the healing of chronic ulcers. Our investigation looked at various research involving a total of 741 patients with different types of wounds, which primarily included pressure injuries and diabetic foot ulcers.

Among the studies we examined, some suggested that a hypercaloric and hyperproteic formula enriched with zinc, along with important vitamins A, C, and E, could promote wound healing effectively. Specifically, four studies indicated that these enriched formulas led to a noticeable reduction in wound area, showcasing an increase in healing rates.

However, it's worth noting that two studies reported no significant differences in healing rates when zinc was incorporated into the treatment. Additionally, other approaches featuring combinations like arginine and glutamine did not show significant improvements over the control groups, further complicating the picture.

This indicates that while zinc might play a beneficial role, the evidence isn't uniformly strong regarding its isolated effect on ulcer healing. Overall, we found that a desirable formula for promoting healing seems to focus on high calories, protein content, and antioxidants, which may include zinc as part of a larger cocktail of nutrients.

References

  1. Zhang L, Fu X, Li J, Xiao W, Xiong X, et al. Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice. J Microbiol Biotechnol. 2025;35:e2408050. 10.4014/jmb.2408.08050
  2. Seo HR, Chung KB, Kim DY. The Possible Impact of Zinc-Enriched Multivitamins on Treatment-Naïve Recurrent Aphthous Stomatitis Patients. J Clin Med. 2025;14. 10.3390/jcm14010260
  3. Wu Z, Wu W, Zhang C, Zhang W, Li Y, et al. Enhanced diabetic foot ulcer treatment with a chitosan-based thermosensitive hydrogel loaded self-assembled multi-functional nanoparticles for antibacterial and angiogenic effects. Carbohydr Polym. 2025;347:122740. 10.1016/j.carbpol.2024.122740
  4. Grimm K, Fiedler A, Kröger C. Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds. J Dairy Sci. 2025;108:1869. 10.3168/jds.2024-25134
  5. Laudanno O, Ahumaran G, Thome M, Adami P, Ustares F, et al. [Argentinean registry on the management of Helicobacter pylori infection: effectiveness and safety of first line treatment]. Medicina (B Aires). 2024;84:884.
  6. Huang Y, Shang S, Du H. Causal association of micronutrients and supplements with pressure ulcer: A Mendelian randomization study. Skin Res Technol. 2024;30:e13904. 10.1111/srt.13904
  7. Ban F, Zhou L, Yang Z, Liu Y, Zhang Y. Aspergillusidone G Potentiates the Anti-Inflammatory Effects of Polaprezinc in LPS-Induced BV2 Microglia: A Bioinformatics and Experimental Study. Mar Drugs. 2024;22. 10.3390/md22070324
  8. Govindarasu M, Vaiyapuri M, Kim JC. Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model. Bioprocess Biosyst Eng. 2024;47:1393. 10.1007/s00449-024-03047-8
  9. Zheng M, Xie C, Ye D, Chen Y, Wang Z, et al. Qingzhuan dark tea polysaccharides-zinc alleviates dextran sodium sulfate-induced ulcerative colitis. J Sci Food Agric. 2024;104:7617. 10.1002/jsfa.13597
  10. Santo ACSDE, Sugizaki CSA, de Morais Junior AC, Costa NA, Bachion MM, et al. Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. Nutrition. 2024;124:112449. 10.1016/j.nut.2024.112449
  11. Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. 10.1016/j.nut.2023.111999
  12. Faghfouri AH, Baradaran B, Khabbazi A, Abdoli Shadbad M, Papi S, et al. Regulation of NLRP3 inflammasome by zinc supplementation in Behçet's disease patients: A double-blind, randomized placebo-controlled clinical trial. Int Immunopharmacol. 2022;109:108825. 10.1016/j.intimp.2022.108825
  13. Jung DH, Park JC, Lee YC, Lee SK, Shin SK, et al. Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers. J Clin Gastroenterol. 2021;55:233. 10.1097/MCG.0000000000001357
  14. Scheid PL, Lâm TT, Sinsch U, Balczun C. Vermamoeba vermiformis as etiological agent of a painful ulcer close to the eye. Parasitol Res. 2019;118:1999. 10.1007/s00436-019-06312-y
  15. Ficarra G, Cicchi P, Amorosi A, Piluso S. Oral Crohn's disease and pyostomatitis vegetans. An unusual association. Oral Surg Oral Med Oral Pathol. 1993;75:220.
  16. Cho CH, Ogle CW, Dai S. Effects of zinc chloride on gastric secretion and ulcer formation in pylorus-occluded rats. Eur J Pharmacol. 1976;38:337.
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