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SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.1
USERS' SCORE
Good
Based on 10 Reviews
8.7
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
Top Medical Research Studies
8
Iodine seeds improve localization outcomes
Breast cancer localization by iodine seed 125I vs. wire- -guided localization - retrospective case-control study.
Highly relevant investigation of iodine use.
In a recent study, we explored the effectiveness of two different localization techniques for non-palpable breast tumors: iodine seed (125I) localization and the traditional wire-guided method. This retrospective case-control study involved 62 patients, with an equal split between the two methods, aiming to determine which technique results in better patient outcomes.
Our findings highlighted that using iodine seeds led to a significantly smaller amount of tissue being removed during surgery, with an average volume of 46.2 cm³ compared to 83.7 cm³ for the wire-guided method. Additionally, we noted that the iodine seed method had a tendency to achieve clear margins (R0 resection) more often, though this did not reach statistically significant levels.
Importantly, in the subgroup using iodine seeds, none of the patients required re-resections due to inadequate margins, while 19.4% of those using wire guidance had to undergo further surgery for the same reason. Overall, the results suggest that iodine seeds may offer advantages in breast cancer localization, potentially leading to less tissue removal and better surgical outcomes.
Our findings highlighted that using iodine seeds led to a significantly smaller amount of tissue being removed during surgery, with an average volume of 46.2 cm³ compared to 83.7 cm³ for the wire-guided method. Additionally, we noted that the iodine seed method had a tendency to achieve clear margins (R0 resection) more often, though this did not reach statistically significant levels.
Importantly, in the subgroup using iodine seeds, none of the patients required re-resections due to inadequate margins, while 19.4% of those using wire guidance had to undergo further surgery for the same reason. Overall, the results suggest that iodine seeds may offer advantages in breast cancer localization, potentially leading to less tissue removal and better surgical outcomes.
Read More
9.5
Iodine enhances sonodynamic therapy
Sonodynamic Therapy for HER2+ Breast Cancer with Iodinated Heptamethine Cyanine-Trastuzumab Conjugate.
Significant but complex findings
We set out to explore the effectiveness of iodine treatment in breast cancer, specifically through a unique approach called sonodynamic therapy (SDT). This involved using a specialized conjugate that combines a cyanine dye with the antibody trastuzumab, targeting HER2+ breast cancer cells in a mouse model.
Our findings demonstrated that a single dose of iodinated heptamethine cyanine, followed by sonication, led to significant tumor growth suppression. In fact, it achieved a remarkable 3.5-fold reduction in tumor volume within 45 days and was found to be significantly more effective than the non-iodinated version of the treatment.
Additionally, the iodinated variant outperformed traditional photodynamic therapy, highlighting the potential of utilizing iodine in combination with SDT. This treatment option showed no detectable toxicity to surrounding healthy tissues, making it a promising candidate for targeted cancer treatment. Overall, our study indicates that iodine plays a crucial role in enhancing the effectiveness of sonodynamic therapy for breast cancer treatment, paving the way for future research in this area.
Our findings demonstrated that a single dose of iodinated heptamethine cyanine, followed by sonication, led to significant tumor growth suppression. In fact, it achieved a remarkable 3.5-fold reduction in tumor volume within 45 days and was found to be significantly more effective than the non-iodinated version of the treatment.
Additionally, the iodinated variant outperformed traditional photodynamic therapy, highlighting the potential of utilizing iodine in combination with SDT. This treatment option showed no detectable toxicity to surrounding healthy tissues, making it a promising candidate for targeted cancer treatment. Overall, our study indicates that iodine plays a crucial role in enhancing the effectiveness of sonodynamic therapy for breast cancer treatment, paving the way for future research in this area.
Read More
7
Alpha-mangostin may target ERα
Investigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ERα) in Breast Cancer: In Silico Design, Synthesis, and Biological Evaluation.
Focuses on iodine treatment
We investigated the potential of iodine-125 (I)-labeled alpha-mangostin (AM) to target breast cancer by binding to estrogen receptor alpha (ERα). Using MCF-7 cell lines, we conducted in vitro experiments to assess how effectively [I]I-AM could latch onto ERα. Additionally, we injected [I]I-AM into nude mice with MCF-7 tumors to study its behavior in a living system.
Our findings were intriguing. The uptake of [I]I-AM in MCF-7 cells was inhibited by both AM and tamoxifen, indicating that some uptake does indeed involve ERα. In the biodistribution studies, [I]I-AM showed an ability to accumulate in tumor tissues, which is promising for targeting breast cancer. However, we also observed that deiodination of [I]I-AM occurred, limiting the amount of iodine-125 reaching the cancer cells.
Overall, these results suggest that AM could serve as a foundation for developing new radiopharmaceuticals aimed at targeting ERα in breast cancer treatments. Nonetheless, further research is essential to tackle the issue of deiodination in vivo to enhance its effectiveness in clinical settings.
Our findings were intriguing. The uptake of [I]I-AM in MCF-7 cells was inhibited by both AM and tamoxifen, indicating that some uptake does indeed involve ERα. In the biodistribution studies, [I]I-AM showed an ability to accumulate in tumor tissues, which is promising for targeting breast cancer. However, we also observed that deiodination of [I]I-AM occurred, limiting the amount of iodine-125 reaching the cancer cells.
Overall, these results suggest that AM could serve as a foundation for developing new radiopharmaceuticals aimed at targeting ERα in breast cancer treatments. Nonetheless, further research is essential to tackle the issue of deiodination in vivo to enhance its effectiveness in clinical settings.
Read More
Most Useful Reviews
9.5
Breast pain relief
After taking this with NOW's evening primrose oil, my breast pain disappeared completely. It's as if I never had the pain, and I had forgotten it was ever a symptom.
Read More
8.3
Helped breast condition
This iodine supplement has helped significantly with my fibrocystic breasts. I ordered it years ago and experienced a great improvement. It has no taste and I find it very good quality.
Read More
8.8
Clarified brain fog
I have hypothyroidism and understand brain fog well. This iodine is the only one that has provided noticeable results; neither kelp nor iodoral clarified my thinking as this has. It also alleviated my fibrocystic breast disease symptoms; the cysts became smaller.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.1
9.5
Iodine enhances sonodynamic therapy
Sonodynamic Therapy for HER2+ Breast Cancer with Iodinated Heptamethine Cyanine-Trastuzumab Conjugate.
Significant but complex findings
We set out to explore the effectiveness of iodine treatment in breast cancer, specifically through a unique approach called sonodynamic therapy (SDT). This involved using a specialized conjugate that combines a cyanine dye with the antibody trastuzumab, targeting HER2+ breast cancer cells in a mouse model.
Our findings demonstrated that a single dose of iodinated heptamethine cyanine, followed by sonication, led to significant tumor growth suppression. In fact, it achieved a remarkable 3.5-fold reduction in tumor volume within 45 days and was found to be significantly more effective than the non-iodinated version of the treatment.
Additionally, the iodinated variant outperformed traditional photodynamic therapy, highlighting the potential of utilizing iodine in combination with SDT. This treatment option showed no detectable toxicity to surrounding healthy tissues, making it a promising candidate for targeted cancer treatment. Overall, our study indicates that iodine plays a crucial role in enhancing the effectiveness of sonodynamic therapy for breast cancer treatment, paving the way for future research in this area.
Our findings demonstrated that a single dose of iodinated heptamethine cyanine, followed by sonication, led to significant tumor growth suppression. In fact, it achieved a remarkable 3.5-fold reduction in tumor volume within 45 days and was found to be significantly more effective than the non-iodinated version of the treatment.
Additionally, the iodinated variant outperformed traditional photodynamic therapy, highlighting the potential of utilizing iodine in combination with SDT. This treatment option showed no detectable toxicity to surrounding healthy tissues, making it a promising candidate for targeted cancer treatment. Overall, our study indicates that iodine plays a crucial role in enhancing the effectiveness of sonodynamic therapy for breast cancer treatment, paving the way for future research in this area.
Read More
8
Potential radiosensitizer for breast cancer
Iodinated Copper-Cysteamine Nanoparticles as Radiosensitizers for Tumor Radiotherapy.
Combination treatment evaluated
We aimed to explore the potential of iodinated copper-cysteamine (Cu-Cy-I) nanoparticles as a treatment option for breast cancer when combined with X-ray radiotherapy. Our study involved synthesizing these nanoparticles and evaluating their effects on tumor cells by examining both in vitro and in vivo studies.
During our experiments, we observed that the presence of Cu-Cy-I nanoparticles significantly increased the levels of reactive oxygen species (ROS) in the breast cancer cells upon X-ray irradiation. This combination led to greater DNA damage and a more effective killing of 4T1 tumor cells compared to X-ray treatment alone.
In live mouse models with 4T1 tumors, we found that the combination therapy—using both intratumoral injections of Cu-Cy-I nanoparticles alongside X-ray radiotherapy—intensified the tumor cell death and extended the survival of the mice. While we found these nanoparticles promising as radiosensitizers, the study did not specifically verify the effectiveness of iodine treatment at low doses alone in improving breast cancer outcomes.
During our experiments, we observed that the presence of Cu-Cy-I nanoparticles significantly increased the levels of reactive oxygen species (ROS) in the breast cancer cells upon X-ray irradiation. This combination led to greater DNA damage and a more effective killing of 4T1 tumor cells compared to X-ray treatment alone.
In live mouse models with 4T1 tumors, we found that the combination therapy—using both intratumoral injections of Cu-Cy-I nanoparticles alongside X-ray radiotherapy—intensified the tumor cell death and extended the survival of the mice. While we found these nanoparticles promising as radiosensitizers, the study did not specifically verify the effectiveness of iodine treatment at low doses alone in improving breast cancer outcomes.
Read More
8
Iodine seeds improve localization outcomes
Breast cancer localization by iodine seed 125I vs. wire- -guided localization - retrospective case-control study.
Highly relevant investigation of iodine use.
In a recent study, we explored the effectiveness of two different localization techniques for non-palpable breast tumors: iodine seed (125I) localization and the traditional wire-guided method. This retrospective case-control study involved 62 patients, with an equal split between the two methods, aiming to determine which technique results in better patient outcomes.
Our findings highlighted that using iodine seeds led to a significantly smaller amount of tissue being removed during surgery, with an average volume of 46.2 cm³ compared to 83.7 cm³ for the wire-guided method. Additionally, we noted that the iodine seed method had a tendency to achieve clear margins (R0 resection) more often, though this did not reach statistically significant levels.
Importantly, in the subgroup using iodine seeds, none of the patients required re-resections due to inadequate margins, while 19.4% of those using wire guidance had to undergo further surgery for the same reason. Overall, the results suggest that iodine seeds may offer advantages in breast cancer localization, potentially leading to less tissue removal and better surgical outcomes.
Our findings highlighted that using iodine seeds led to a significantly smaller amount of tissue being removed during surgery, with an average volume of 46.2 cm³ compared to 83.7 cm³ for the wire-guided method. Additionally, we noted that the iodine seed method had a tendency to achieve clear margins (R0 resection) more often, though this did not reach statistically significant levels.
Importantly, in the subgroup using iodine seeds, none of the patients required re-resections due to inadequate margins, while 19.4% of those using wire guidance had to undergo further surgery for the same reason. Overall, the results suggest that iodine seeds may offer advantages in breast cancer localization, potentially leading to less tissue removal and better surgical outcomes.
Read More
7
Alpha-mangostin may target ERα
Investigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ERα) in Breast Cancer: In Silico Design, Synthesis, and Biological Evaluation.
Focuses on iodine treatment
We investigated the potential of iodine-125 (I)-labeled alpha-mangostin (AM) to target breast cancer by binding to estrogen receptor alpha (ERα). Using MCF-7 cell lines, we conducted in vitro experiments to assess how effectively [I]I-AM could latch onto ERα. Additionally, we injected [I]I-AM into nude mice with MCF-7 tumors to study its behavior in a living system.
Our findings were intriguing. The uptake of [I]I-AM in MCF-7 cells was inhibited by both AM and tamoxifen, indicating that some uptake does indeed involve ERα. In the biodistribution studies, [I]I-AM showed an ability to accumulate in tumor tissues, which is promising for targeting breast cancer. However, we also observed that deiodination of [I]I-AM occurred, limiting the amount of iodine-125 reaching the cancer cells.
Overall, these results suggest that AM could serve as a foundation for developing new radiopharmaceuticals aimed at targeting ERα in breast cancer treatments. Nonetheless, further research is essential to tackle the issue of deiodination in vivo to enhance its effectiveness in clinical settings.
Our findings were intriguing. The uptake of [I]I-AM in MCF-7 cells was inhibited by both AM and tamoxifen, indicating that some uptake does indeed involve ERα. In the biodistribution studies, [I]I-AM showed an ability to accumulate in tumor tissues, which is promising for targeting breast cancer. However, we also observed that deiodination of [I]I-AM occurred, limiting the amount of iodine-125 reaching the cancer cells.
Overall, these results suggest that AM could serve as a foundation for developing new radiopharmaceuticals aimed at targeting ERα in breast cancer treatments. Nonetheless, further research is essential to tackle the issue of deiodination in vivo to enhance its effectiveness in clinical settings.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.7
9.5
Fights breast cancer
If you're feeling low, consider adding iodine and vitamin D3; they can energise your thyroid. Iodine is vital in combating potential breast cancer, especially if you're genetically predisposed. LifeExtension is a trusted brand among health professionals.
9.5
Breast pain relief
After taking this with NOW's evening primrose oil, my breast pain disappeared completely. It's as if I never had the pain, and I had forgotten it was ever a symptom.
8.8
Clarified brain fog
I have hypothyroidism and understand brain fog well. This iodine is the only one that has provided noticeable results; neither kelp nor iodoral clarified my thinking as this has. It also alleviated my fibrocystic breast disease symptoms; the cysts became smaller.
8.8
Remarkable improvement
I had very sore fibrocystic breasts, but after taking 2000mcg of iodine daily and quitting coffee, I’m now 95% better. My doctor dismissed the pain as non-cancerous, but my own research helped me find relief.
8.8
Softened fibroids
I'm taking this for breast fibroids and believe in the power of natural healing. After my first bottle, my breasts felt softer, and I couldn't feel the fibroids. I restarted after a break, hoping to replicate the initial success.
