Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.7
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.9
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
9
We set out to explore the effects of selenium-containing compounds on breast cancer cells, particularly focusing on their potential as treatments. Our research involved testing several novel selenoesters on two breast cancer cell lines, MCF-7 and MDA-MB-231, to understand how these compounds can impact cell growth and survival.
What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.
The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.
In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.
What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.
The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.
In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.
9
Anticancer effects of selenium compounds
We focused on exploring the effectiveness of organoselenocyanates—specifically derivatives of selenium—on triple-negative breast cancer cells. By designing two series of these compounds incorporating unique chemical structures, we aimed to see how they could impact cancer cell growth and behavior.
Through a careful multi-step synthesis process, we successfully created these selenium compounds and put them to the test against cancer cells. After evaluating their anti-proliferative effects, we discovered that one particular compound, known as 15 a, stood out for its promising results. This compound not only hindered cancer cell migration but also triggered significant changes in the cell cycle, causing cells to halt in the G1 phase and promoting early apoptosis, or programmed cell death.
We further investigated how this compound affected the redox balance within the breast cancer cells. Our findings revealed that 15 a demonstrated antioxidant properties by reducing levels of reactive oxygen species (ROS) and increasing the expression of a protective enzyme called TrxR1. On a molecular level, it also activated pathways related to cell signaling that suppressed cancer cell proliferation by manipulating important proteins such as p-ERK, p-Akt, and c-Myc.
These encouraging results highlight the potential of selenium-based treatments as new therapeutic options for battling triple-negative breast cancer. We believe our insights could pave the way for future developments in cancer therapies.
Through a careful multi-step synthesis process, we successfully created these selenium compounds and put them to the test against cancer cells. After evaluating their anti-proliferative effects, we discovered that one particular compound, known as 15 a, stood out for its promising results. This compound not only hindered cancer cell migration but also triggered significant changes in the cell cycle, causing cells to halt in the G1 phase and promoting early apoptosis, or programmed cell death.
We further investigated how this compound affected the redox balance within the breast cancer cells. Our findings revealed that 15 a demonstrated antioxidant properties by reducing levels of reactive oxygen species (ROS) and increasing the expression of a protective enzyme called TrxR1. On a molecular level, it also activated pathways related to cell signaling that suppressed cancer cell proliferation by manipulating important proteins such as p-ERK, p-Akt, and c-Myc.
These encouraging results highlight the potential of selenium-based treatments as new therapeutic options for battling triple-negative breast cancer. We believe our insights could pave the way for future developments in cancer therapies.
9
We investigated the effects of selenium nanoparticles (SeNPs) produced by marine yeast on breast cancer cells, specifically the MCF-7 cell line. Through a detailed process of isolating and identifying the potent yeast strains, we found optimal conditions for generating SeNPs, including specific temperature and pH levels. This biosynthesized form of selenium was then characterized using various techniques for its size and shape.
When we examined the impact of these nanoparticles on MCF-7 cells, the results were promising. SeNPs displayed significant anti-cancer properties, yielding lower concentrations needed to inhibit cell growth compared to other cancer types like colon and liver cells. In fact, the concentration required to inhibit the growth of MCF-7 cells was as low as 19.59 µg/ml, while it was higher for other cancer cells. Importantly, there were no adverse effects seen on normal human skin fibroblast (HSF) cells, indicating a level of selectivity that could be beneficial in treatment.
Our findings highlighted that treatment with SeNPs led to a halt in cell cycle progression at the G2/M phase and promoted programmed cell death, or apoptosis, in the MCF-7 cells. We also observed increased oxidative stress levels and a decline in the activity of antioxidant enzymes, which suggests a mechanism through which selenium may exert its effects. In conclusion, the biosynthesized selenium nanoparticles from yeast offer promising insights into potential therapies for breast cancer.
When we examined the impact of these nanoparticles on MCF-7 cells, the results were promising. SeNPs displayed significant anti-cancer properties, yielding lower concentrations needed to inhibit cell growth compared to other cancer types like colon and liver cells. In fact, the concentration required to inhibit the growth of MCF-7 cells was as low as 19.59 µg/ml, while it was higher for other cancer cells. Importantly, there were no adverse effects seen on normal human skin fibroblast (HSF) cells, indicating a level of selectivity that could be beneficial in treatment.
Our findings highlighted that treatment with SeNPs led to a halt in cell cycle progression at the G2/M phase and promoted programmed cell death, or apoptosis, in the MCF-7 cells. We also observed increased oxidative stress levels and a decline in the activity of antioxidant enzymes, which suggests a mechanism through which selenium may exert its effects. In conclusion, the biosynthesized selenium nanoparticles from yeast offer promising insights into potential therapies for breast cancer.
Most Useful Reviews
9
Effective skin remedy
14 people found this helpful
This brand and dosage are fantastic! After a period of late nights and sleep deprivation, I had a flare-up of skin issues. Upon taking a blend of vitamins and this selenium supplement, I noticed significant improvement. The swollen, itchy skin reduced drastically within two days. It's far more effective than Western antiviral medicines! Now, it's a staple in my home for daily intake. If you have hepatitis B, I recommend combining selenium with natural vitamin E and silymarin to protect your liver and lower the risk of liver cancer.
9
Disease prevention
2 people found this helpful
As we age, physical health becomes a priority. Selenium is renowned as the "king of anti-cancer" and is vital for life's activities. It synthesises various selenoenzymes and proteins with diverse biological functions. Adequate selenium supplementation is significant for maintaining health and preventing diseases. Studies indicate that areas with high selenium levels have lower cancer incidences. A decade-long study showed selenium supplementation can reduce cancer occurrence by one-third and halved mortality rates.
9
Treats breast cancer
Everyone liked it! We use it alongside cruciferous plants for breast cancer treatment. The quality and dosage suit us well, and there are no side effects. 
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.7
- All Researches
9
Anticancer effects of selenium compounds
We focused on exploring the effectiveness of organoselenocyanates—specifically derivatives of selenium—on triple-negative breast cancer cells. By designing two series of these compounds incorporating unique chemical structures, we aimed to see how they could impact cancer cell growth and behavior.
Through a careful multi-step synthesis process, we successfully created these selenium compounds and put them to the test against cancer cells. After evaluating their anti-proliferative effects, we discovered that one particular compound, known as 15 a, stood out for its promising results. This compound not only hindered cancer cell migration but also triggered significant changes in the cell cycle, causing cells to halt in the G1 phase and promoting early apoptosis, or programmed cell death.
We further investigated how this compound affected the redox balance within the breast cancer cells. Our findings revealed that 15 a demonstrated antioxidant properties by reducing levels of reactive oxygen species (ROS) and increasing the expression of a protective enzyme called TrxR1. On a molecular level, it also activated pathways related to cell signaling that suppressed cancer cell proliferation by manipulating important proteins such as p-ERK, p-Akt, and c-Myc.
These encouraging results highlight the potential of selenium-based treatments as new therapeutic options for battling triple-negative breast cancer. We believe our insights could pave the way for future developments in cancer therapies.
Through a careful multi-step synthesis process, we successfully created these selenium compounds and put them to the test against cancer cells. After evaluating their anti-proliferative effects, we discovered that one particular compound, known as 15 a, stood out for its promising results. This compound not only hindered cancer cell migration but also triggered significant changes in the cell cycle, causing cells to halt in the G1 phase and promoting early apoptosis, or programmed cell death.
We further investigated how this compound affected the redox balance within the breast cancer cells. Our findings revealed that 15 a demonstrated antioxidant properties by reducing levels of reactive oxygen species (ROS) and increasing the expression of a protective enzyme called TrxR1. On a molecular level, it also activated pathways related to cell signaling that suppressed cancer cell proliferation by manipulating important proteins such as p-ERK, p-Akt, and c-Myc.
These encouraging results highlight the potential of selenium-based treatments as new therapeutic options for battling triple-negative breast cancer. We believe our insights could pave the way for future developments in cancer therapies.
9
We investigated the effects of selenium nanoparticles (SeNPs) produced by marine yeast on breast cancer cells, specifically the MCF-7 cell line. Through a detailed process of isolating and identifying the potent yeast strains, we found optimal conditions for generating SeNPs, including specific temperature and pH levels. This biosynthesized form of selenium was then characterized using various techniques for its size and shape.
When we examined the impact of these nanoparticles on MCF-7 cells, the results were promising. SeNPs displayed significant anti-cancer properties, yielding lower concentrations needed to inhibit cell growth compared to other cancer types like colon and liver cells. In fact, the concentration required to inhibit the growth of MCF-7 cells was as low as 19.59 µg/ml, while it was higher for other cancer cells. Importantly, there were no adverse effects seen on normal human skin fibroblast (HSF) cells, indicating a level of selectivity that could be beneficial in treatment.
Our findings highlighted that treatment with SeNPs led to a halt in cell cycle progression at the G2/M phase and promoted programmed cell death, or apoptosis, in the MCF-7 cells. We also observed increased oxidative stress levels and a decline in the activity of antioxidant enzymes, which suggests a mechanism through which selenium may exert its effects. In conclusion, the biosynthesized selenium nanoparticles from yeast offer promising insights into potential therapies for breast cancer.
When we examined the impact of these nanoparticles on MCF-7 cells, the results were promising. SeNPs displayed significant anti-cancer properties, yielding lower concentrations needed to inhibit cell growth compared to other cancer types like colon and liver cells. In fact, the concentration required to inhibit the growth of MCF-7 cells was as low as 19.59 µg/ml, while it was higher for other cancer cells. Importantly, there were no adverse effects seen on normal human skin fibroblast (HSF) cells, indicating a level of selectivity that could be beneficial in treatment.
Our findings highlighted that treatment with SeNPs led to a halt in cell cycle progression at the G2/M phase and promoted programmed cell death, or apoptosis, in the MCF-7 cells. We also observed increased oxidative stress levels and a decline in the activity of antioxidant enzymes, which suggests a mechanism through which selenium may exert its effects. In conclusion, the biosynthesized selenium nanoparticles from yeast offer promising insights into potential therapies for breast cancer.
9
Selenium compounds may combat resistance
We focused on how selenium compounds could help fight breast cancer, particularly when it comes to overcoming multidrug resistance, a major hurdle in effective treatment. Our research specifically assessed two novel selenoesters, EDAG-1 and EDAG-8, for their potential to inhibit resistance proteins in breast cancer cells.
Through various analyses, we discovered that these compounds, especially EDAG-8, effectively blocked the action of important efflux pumps known as BCRP, MDR1, and MRP1. This action makes cancer cells more susceptible to treatment, giving us a hopeful avenue for developing better therapies. Notably, the testing showed that EDAG-8 outperformed traditional reference compounds, indicating its promising role in treatment strategies.
Our in silico studies further supported these findings, highlighting that EDAG-8's unique structure and lower binding energy to these proteins enhances its anticancer activity. This reveals a compelling potential for selenium-based treatments in the battle against breast cancer, positioning EDAG-8 as an exciting candidate for future drug development.
Through various analyses, we discovered that these compounds, especially EDAG-8, effectively blocked the action of important efflux pumps known as BCRP, MDR1, and MRP1. This action makes cancer cells more susceptible to treatment, giving us a hopeful avenue for developing better therapies. Notably, the testing showed that EDAG-8 outperformed traditional reference compounds, indicating its promising role in treatment strategies.
Our in silico studies further supported these findings, highlighting that EDAG-8's unique structure and lower binding energy to these proteins enhances its anticancer activity. This reveals a compelling potential for selenium-based treatments in the battle against breast cancer, positioning EDAG-8 as an exciting candidate for future drug development.
9
We explored the potential of selenium nanoparticles (SeNPs) in treating breast cancer, especially their effects in combination with a KRAS nanovaccine. Our study utilized various stabilizing agents to develop stable SeNPs, with a focus on bovine serum albumin (BSA). The BSA-stabilized SeNPs were particularly noteworthy, showing remarkable stability under different conditions while remaining effective in targeting cancer cells.
When we tested these nanoparticles, we found that they exhibited enhanced toxicity against cancer cell lines, while not harming normal human cells. This selectivity is promising for cancer treatments. Moreover, we observed significant synergy when we combined BSA-SeNPs with the nanovaccine, leading to substantial reductions in tumor size in a mouse model of breast cancer.
Overall, our findings suggest that selenium nanoparticles, especially when paired with immunotherapy approaches like the nanovaccine, could be a valuable strategy inbreast cancer treatment. This innovative combination offers exciting possibilities for improving cancer immunotherapy outcomes.
When we tested these nanoparticles, we found that they exhibited enhanced toxicity against cancer cell lines, while not harming normal human cells. This selectivity is promising for cancer treatments. Moreover, we observed significant synergy when we combined BSA-SeNPs with the nanovaccine, leading to substantial reductions in tumor size in a mouse model of breast cancer.
Overall, our findings suggest that selenium nanoparticles, especially when paired with immunotherapy approaches like the nanovaccine, could be a valuable strategy inbreast cancer treatment. This innovative combination offers exciting possibilities for improving cancer immunotherapy outcomes.
9
We set out to explore the effects of selenium-containing compounds on breast cancer cells, particularly focusing on their potential as treatments. Our research involved testing several novel selenoesters on two breast cancer cell lines, MCF-7 and MDA-MB-231, to understand how these compounds can impact cell growth and survival.
What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.
The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.
In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.
What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.
The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.
In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.
User Reviews
USERS' SCORE
Moderately Good
Based on 19 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective skin remedy
14 people found this helpful
This brand and dosage are fantastic! After a period of late nights and sleep deprivation, I had a flare-up of skin issues. Upon taking a blend of vitamins and this selenium supplement, I noticed significant improvement. The swollen, itchy skin reduced drastically within two days. It's far more effective than Western antiviral medicines! Now, it's a staple in my home for daily intake. If you have hepatitis B, I recommend combining selenium with natural vitamin E and silymarin to protect your liver and lower the risk of liver cancer.
9
Disease prevention
2 people found this helpful
As we age, physical health becomes a priority. Selenium is renowned as the "king of anti-cancer" and is vital for life's activities. It synthesises various selenoenzymes and proteins with diverse biological functions. Adequate selenium supplementation is significant for maintaining health and preventing diseases. Studies indicate that areas with high selenium levels have lower cancer incidences. A decade-long study showed selenium supplementation can reduce cancer occurrence by one-third and halved mortality rates.
9
Treats breast cancer
Everyone liked it! We use it alongside cruciferous plants for breast cancer treatment. The quality and dosage suit us well, and there are no side effects.
7.5
Reduces cancer risk
7 people found this helpful
I take iron, copper, and selenium together, splitting the dosage. Selenium is crucial for combating extreme free radical exposure. Adequate intake is associated with lower cancer risks, including colon and breast cancer, alongside heart disease reduction. Selenium helps eliminate toxic heavy metals like mercury from the body and maintains healthy glutathione levels—our master antioxidant—along with promoting cell division and thyroid health.
7.5
Anti-cancer benefits
1 people found this helpful
I buy this selenium for the second time. It’s great because it contains multiple forms, including selenocysteine, which I need. The effect isn't immediately visible, but I've been taking it regularly since having ovarian cancer. Selenium is reputed to offer anti-cancer properties. Wishing you all good health – we only have one body in this life!
Frequently Asked Questions
9
Effective skin remedy
14 people found this helpful
This brand and dosage are fantastic! After a period of late nights and sleep deprivation, I had a flare-up of skin issues. Upon taking a blend of vitamins and this selenium supplement, I noticed significant improvement. The swollen, itchy skin reduced drastically within two days. It's far more effective than Western antiviral medicines! Now, it's a staple in my home for daily intake. If you have hepatitis B, I recommend combining selenium with natural vitamin E and silymarin to protect your liver and lower the risk of liver cancer.
7.5
Post-cancer health
3 people found this helpful
An excellent supplement! It took me time to find the right selenium. After taking a Selenium complex for 18-20 months as a post-cancer patient, I find it greatly beneficial to my health.
7.5
Anti-cancer benefits
1 people found this helpful
I buy this selenium for the second time. It’s great because it contains multiple forms, including selenocysteine, which I need. The effect isn't immediately visible, but I've been taking it regularly since having ovarian cancer. Selenium is reputed to offer anti-cancer properties. Wishing you all good health – we only have one body in this life!
7.5
Immunity support
1 people found this helpful
This product has been part of my regimen for several years, as it has proven to help enhance immunity against various cancers. I feel very healthy and will continue taking it. The pill is easy to swallow and reasonably priced on iHerb. I also combine it with beta glucan for added immunity enhancement. Thank you, LE, and iHerb – great quality at a great price!
7.5
Reduces cancer risk
7 people found this helpful
I take iron, copper, and selenium together, splitting the dosage. Selenium is crucial for combating extreme free radical exposure. Adequate intake is associated with lower cancer risks, including colon and breast cancer, alongside heart disease reduction. Selenium helps eliminate toxic heavy metals like mercury from the body and maintains healthy glutathione levels—our master antioxidant—along with promoting cell division and thyroid health.
9
Treats breast cancer
Everyone liked it! We use it alongside cruciferous plants for breast cancer treatment. The quality and dosage suit us well, and there are no side effects.
7.5
Fights cancer
1 people found this helpful
The mixture is fantastic! Selenium is known for combatting cancer formation, and its combination with vitamin E has improved my regimen, allowing me to take just one capsule instead of two. 
6
Reduces recurrence
I bought this after reading reviews about its effectiveness for dry skin, wrinkles, and cancer recurrence. I also take vitamins C, D, NAC, biotin, and iron. The capsules are small and easy to swallow, and the scent isn't bothersome.
7.5
Combats cancer deficiency
7 people found this helpful
Studies indicate that many cancer patients suffer from selenium deficiency, which is not absorbed without vitamin E. It's wonderful that these two vital elements are combined. Vitamin E should be taken with healthy fats, proteins, and fibre at breakfast. Please like if you find this information helpful!
7.5
Anticancer benefits
The Super Selenium Complex with vitamin E is a natural supplement that offers antioxidant protection against cardiovascular diseases and possesses oncoprotective properties. It's vital for proper growth, sexual function, and enhancing immunity. Selenium plays a significant role as a strong antioxidant, combating tumour development and aging while aiding in the production of red blood cells. Taking one capsule daily with meals is advisable.
7.5
Fights cancer
4 people found this helpful
Selenium is an essential mineral for the thyroid gland and combats cancer. It contains vitamin E, which is beneficial. For dosage, take one pill each night, an hour or half an hour before bed.
8
Selenium nanoparticles show promise
We assessed the effectiveness of selenium nanoparticles (SeNPs) derived from the plant Indigofera aspalathoides for treating breast cancer. Through innovative green synthesis methods utilizing the plant's extract, we created nanoparticles that were carefully characterized to confirm their stability and size. This is an important step since the size and structure of nanoparticles can greatly influence their effectiveness in medical applications.
We found that these SeNPs displayed notable antioxidant properties, which can be crucial in combating oxidative stress associated with cancer. In our experiments, the SeNPs achieved high levels of DPPH and hydroxyl radical scavenging, significantly surpassing the antioxidant activity of the extract on its own.
Notably, when we tested the cytotoxic effects on the MCF-7 breast cancer cell line, we observed promising results. The nanoparticles exhibited a protective effect on HepG2 liver cells, promoting cell viability at certain concentrations. While moderate doses of the SeNPs showed excellent results, higher doses did present some cytotoxicity.
Overall, our findings highlight the potential of I. aspalathoides-derived SeNPs as a promising avenue in nanomedicine for addressing not just oxidative stress, but also for supporting liver health as it relates to breast cancer treatment.
We found that these SeNPs displayed notable antioxidant properties, which can be crucial in combating oxidative stress associated with cancer. In our experiments, the SeNPs achieved high levels of DPPH and hydroxyl radical scavenging, significantly surpassing the antioxidant activity of the extract on its own.
Notably, when we tested the cytotoxic effects on the MCF-7 breast cancer cell line, we observed promising results. The nanoparticles exhibited a protective effect on HepG2 liver cells, promoting cell viability at certain concentrations. While moderate doses of the SeNPs showed excellent results, higher doses did present some cytotoxicity.
Overall, our findings highlight the potential of I. aspalathoides-derived SeNPs as a promising avenue in nanomedicine for addressing not just oxidative stress, but also for supporting liver health as it relates to breast cancer treatment.
7
Our investigation focused on the effects of selenium nanoparticles (SeNPs) derived from the microalga Spirulina platensis and their potential impact on breast cancer. We observed that these nanoparticles are not only small and stable but also exhibit important bioactive properties.
In particular, we assessed how SeNPs influenced breast adenocarcinoma cells (MCF-7) and found that they significantly reduced cell viability by approximately 17.6% at a concentration of 100 µg/ml. This suggests that selenium, in this nanoparticle form, may contribute to inhibiting the growth of cancer cells.
Beyond their impact on breast cancer, our findings also highlighted the broader biomedical potential of SeNPs, including antioxidant and anti-inflammatory effects. Overall, the study opens up exciting avenues for utilizing selenium in cancer treatment, though further research is needed to fully understand its clinical applications.
In particular, we assessed how SeNPs influenced breast adenocarcinoma cells (MCF-7) and found that they significantly reduced cell viability by approximately 17.6% at a concentration of 100 µg/ml. This suggests that selenium, in this nanoparticle form, may contribute to inhibiting the growth of cancer cells.
Beyond their impact on breast cancer, our findings also highlighted the broader biomedical potential of SeNPs, including antioxidant and anti-inflammatory effects. Overall, the study opens up exciting avenues for utilizing selenium in cancer treatment, though further research is needed to fully understand its clinical applications.
4
We investigated the impact of selenium on breast cancer treatment, especially in combination with other agents like Genistein. While selenium is often highlighted for its potential health benefits, the findings indicate that its effects on breast cancer aren't as strong or straightforward as one might hope.
Although we looked at different studies, the overall evidence suggests that selenium did not significantly improve breast cancer outcomes on its own. Instead, its role appears to be more about enhancing the effectiveness of other treatments rather than being a standalone solution.
This complexity makes it challenging to determine selenium's isolated effect on breast cancer progression. Therefore, while it’s considered in combination therapies, it’s clear that additional research is needed to fully understand its potential.
Ultimately, our exploration of selenium shows promise in conjunction with other treatments but highlights the need for further investigation to clarify its role in breast cancer management.
Although we looked at different studies, the overall evidence suggests that selenium did not significantly improve breast cancer outcomes on its own. Instead, its role appears to be more about enhancing the effectiveness of other treatments rather than being a standalone solution.
This complexity makes it challenging to determine selenium's isolated effect on breast cancer progression. Therefore, while it’s considered in combination therapies, it’s clear that additional research is needed to fully understand its potential.
Ultimately, our exploration of selenium shows promise in conjunction with other treatments but highlights the need for further investigation to clarify its role in breast cancer management.
References
- Raman S, Kasirajan S, Chinnapandi B, Karthikeyan K, Pandian A, et al. Luminescent Biogenic Selenium Nanoparticles From Indigofera aspalathoides Vahl ex DC: A Novel Hepatoprotective Strategy for Enhancing Live Health. Luminescence. 2025;40:e70101. doi:10.1002/bio.70101
- Yassein AS, Elamary RB, Alwaleed EA. Biogenesis, characterization, and applications of Spirulina selenium nanoparticles. Microb Cell Fact. 2025;24:39. doi:10.1186/s12934-025-02656-6
- Guo K, Yang X, Wang J, Chang W, Liu S, et al. Synthesis and Bioactivity of Selenium Nanoparticles From Tussilago farfara L. Polysaccharides: Antioxidant Properties and MCF-7 Cell Inhibition. Chem Biodivers. 2025. doi:10.1002/cbdv.202402677
- Zhang Q, Ali T, Ponnamperumage TNF, Lin Z, Setu NI, et al. A Photoinducible DNA Cross-Linking Agent with Potent Cytotoxicity and Selectivity Toward Triple-Negative Breast Cancer Cell Line. Chem Res Toxicol. 2025;38:216. doi:10.1021/acs.chemrestox.4c00499
- Sidira D, Siafaka A, Chrysikos D, Papadopoulos G, Stratopoulos E, et al. Selenium and Triple Negative Breast Cancer. Acta Med Acad. 2024;53:155. doi:10.5644/ama2006-124.450
- Zhang W, Wang Y, Gu M, Mao Z, Guan Y, et al. Manganese nanosheets loaded with selenium and gemcitabine activate the tumor microenvironment to enhance anti-tumor immunity. J Colloid Interface Sci. 2025;682:556. doi:10.1016/j.jcis.2024.11.224
- Pal N, Banerjee K, Sarkar S, Mandal TK, Bhabak KP. Synthesis of Thiazolidinedione- and Triazole-Linked Organoselenocyanates and Evaluation of Anticancer Activities Against Breast Cancer with Mechanistic Investigations. Chemistry. 2025;31:e202403026. doi:10.1002/chem.202403026
- Ali BA, Allam RM, Hasanin MS, Hassabo AA. Biosynthesis of selenium nanoparticles as a potential therapeutic agent in breast cancer: G2/M arrest and apoptosis induction. Toxicol Rep. 2024;13:101792. doi:10.1016/j.toxrep.2024.101792
- Qaed E, Liu W, Almoiliqy M, Mohamed R, Tang Z. Unleashing the potential of Genistein and its derivatives as effective therapeutic agents for breast cancer treatment. Naunyn Schmiedebergs Arch Pharmacol. 2024. doi:10.1007/s00210-024-03579-6
- Adibifar A, Salimi M, Rostamkhani N, Karami Z, Agh-Atabay AH, et al. Folic acid-conjugated bovine serum albumin-coated selenium-ZIF-8 core/shell nanoparticles for dual target-specific drug delivery in breast cancer. Drug Deliv Transl Res. 2024. doi:10.1007/s13346-024-01714-7
- Radomska D, Czarnomysy R, Marciniec K, Nowakowska J, Domínguez-Álvarez E, et al. Short Communication: Novel Di- and Triselenoesters as Effective Therapeutic Agents Inhibiting Multidrug Resistance Proteins in Breast Cancer Cells. Int J Mol Sci. 2024;25. doi:10.3390/ijms25179732
- Xu M, Gao X, Yue L, Li J, Feng X, et al. Sensitivity of triple negative breast cancer cells to ATM-dependent ferroptosis induced by sodium selenite. Exp Cell Res. 2024;442:114222. doi:10.1016/j.yexcr.2024.114222
- Ferro C, Matos AI, Serpico L, Fontana F, Chiaro J, et al. Selenium Nanoparticles Synergize with a KRAS Nanovaccine against Breast Cancer. Adv Healthc Mater. 2025;14:e2401523. doi:10.1002/adhm.202401523
- Li Y, Liu M, Kong B, Zhang G, Zhang Q. The role of selenium intervention in gut microbiota homeostasis and gene function in mice with breast cancer on a high-fat diet. Front Microbiol. 2024;15:1439652. doi:10.3389/fmicb.2024.1439652
- Radomska D, Czarnomysy R, Szymanowska A, Radomski D, Chalecka M, et al. Di- and Triselenoesters-Promising Drug Candidates for the Future Therapy of Triple-Negative Breast Cancer. Int J Mol Sci. 2024;25. doi:10.3390/ijms25147764
- Saad S, Abdelghany AM, Abou-ElWafa GS, Aldesuquy HS, Eltanahy E. Bioactivity of selenium nanoparticles biosynthesized by crude phycocyanin extract of Leptolyngbya sp. SSI24 cultivated on recycled filter cake wastes from sugar-industry. Microb Cell Fact. 2024;23:211. doi:10.1186/s12934-024-02482-2
- Wang Y, Du Z, Du H, Zhao J, Duan Y, et al. Associations between dietary intake of zinc and selenium and breast cancer: findings from a NHANES cross-sectional study. Chin Clin Oncol. 2025;14:2. doi:10.21037/cco-24-83
- Szwiec M, Tomiczek-Szwiec J, Marciniak W, Derkacz R, Huzarski T, et al. The Effect of Blood Selenium Level on the pCR Rate in Breast Cancer Patient Receiving Neoadjuvant Chemotherapy. Cancers (Basel). 2025;17. doi:10.3390/cancers17050839
