Last update
3/31/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Moderately Good
Based on 23 Reviews
7.9
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
8
We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.
Read More
8
We explored how sweet corn cob polysaccharide selenium nanoparticles (U-SCPSeNPs) might help alleviate symptoms of chronic fatigue syndrome (CFS). In this study, we used mouse models to test the effects of these nanoparticles, which were created using an ultrasound-assisted method.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
Read More
7
CoQ10 and selenium may benefit ME/CFS
We explored whether combining Coenzyme Q10 and selenium could improve outcomes for individuals with chronic fatigue syndrome (ME/CFS). In this study, 27 patients took an oral supplement for 8 weeks. While we noted improvements in overall fatigue severity and quality of life, sleep disturbances did not show any significant change. Additionally, we found increased antioxidant capacity and decreased inflammatory markers, indicating potential benefits. However, other key biomarkers did not show significant changes. Overall, this suggests that long-term supplementation might help some symptoms in ME/CFS.
Read More
Most Useful Reviews
10
Strengthened immunity
I've been taking the super complex of selenium with vitamin E for a month, and the results are impressive! I've noticed improved skin condition, increased energy, and disappearance of fatigue, along with a stronger immune system.
Read More
9
Increased energy levels
I liked the complex; I felt more lively, energetic, and active. My Chronic Fatigue Syndrome symptoms eased, and my facial skin became fresher.
Read More
9
Impressive results
This is my first dietary supplement, and I chose this brand based on reviews, which I do not regret. After a long search, I found selenium with vitamin E. I lost some weight, and my fatigue eased; I feel lighter and more cheerful. In three months, I did not catch a cold, a notable change from being ill monthly, even in summer. With natural ingredients, the results speak for themselves, alleviating all symptoms that had bothered me. I took it once a day after breakfast without noticing any taste. I recommend it to anyone suffering from Chronic Fatigue Syndrome and apathy.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
We explored how sweet corn cob polysaccharide selenium nanoparticles (U-SCPSeNPs) might help alleviate symptoms of chronic fatigue syndrome (CFS). In this study, we used mouse models to test the effects of these nanoparticles, which were created using an ultrasound-assisted method.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
Read More
8
We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.
Read More
7
CoQ10 and selenium may benefit ME/CFS
We explored whether combining Coenzyme Q10 and selenium could improve outcomes for individuals with chronic fatigue syndrome (ME/CFS). In this study, 27 patients took an oral supplement for 8 weeks. While we noted improvements in overall fatigue severity and quality of life, sleep disturbances did not show any significant change. Additionally, we found increased antioxidant capacity and decreased inflammatory markers, indicating potential benefits. However, other key biomarkers did not show significant changes. Overall, this suggests that long-term supplementation might help some symptoms in ME/CFS.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 23 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
Strengthened immunity
I've been taking the super complex of selenium with vitamin E for a month, and the results are impressive! I've noticed improved skin condition, increased energy, and disappearance of fatigue, along with a stronger immune system.
Read More
9
Increased energy levels
I liked the complex; I felt more lively, energetic, and active. My Chronic Fatigue Syndrome symptoms eased, and my facial skin became fresher.
Read More
9
Impressive results
This is my first dietary supplement, and I chose this brand based on reviews, which I do not regret. After a long search, I found selenium with vitamin E. I lost some weight, and my fatigue eased; I feel lighter and more cheerful. In three months, I did not catch a cold, a notable change from being ill monthly, even in summer. With natural ingredients, the results speak for themselves, alleviating all symptoms that had bothered me. I took it once a day after breakfast without noticing any taste. I recommend it to anyone suffering from Chronic Fatigue Syndrome and apathy.
Read More
9
Helpful supplement
Great selenium with vitamin E in a good dosage. It helps with chronic fatigue and thyroid issues. The capsules are small and easy to swallow, although there is a distinct smell typical of selenium supplements.
Read More
7.5
Supports overall health
This is where the selenium and vitamin E supercomplex really comes in. Selenium is an essential trace mineral that aids various biological processes. It helps combat atherosclerosis, has an anti-cancer effect, provides antioxidant support, alleviates Chronic Fatigue Syndrome, and eases asthma symptoms. Selenium enhances heart and brain health and is crucial for boosting immune response. The manufacturer presents this supplement as a tool for good health and longevity. I'm hoping that's how it works.
Read More
Frequently Asked Questions
10
Strengthened immunity
I've been taking the super complex of selenium with vitamin E for a month, and the results are impressive! I've noticed improved skin condition, increased energy, and disappearance of fatigue, along with a stronger immune system.
7.5
Reduced fatigue
This is excellent; I take it alongside iodine for better absorption. After starting, I experienced a noticeable increase in cheerfulness and no longer feel fatigue as before.
8
We explored how sweet corn cob polysaccharide selenium nanoparticles (U-SCPSeNPs) might help alleviate symptoms of chronic fatigue syndrome (CFS). In this study, we used mouse models to test the effects of these nanoparticles, which were created using an ultrasound-assisted method.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
7
CoQ10 and selenium may benefit ME/CFS
We explored whether combining Coenzyme Q10 and selenium could improve outcomes for individuals with chronic fatigue syndrome (ME/CFS). In this study, 27 patients took an oral supplement for 8 weeks. While we noted improvements in overall fatigue severity and quality of life, sleep disturbances did not show any significant change. Additionally, we found increased antioxidant capacity and decreased inflammatory markers, indicating potential benefits. However, other key biomarkers did not show significant changes. Overall, this suggests that long-term supplementation might help some symptoms in ME/CFS.
8
We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.
References
- Wang J, Wang X, Xiu W, Li C, Yu S, et al. Ultrasound-assisted preparation of sweet corn cob polysaccharide selenium nanoparticles alleviates symptoms of chronic fatigue syndrome. Food Funct. 2025;16:133. 10.1039/d4fo04195j
- Castro-Marrero J, Domingo JC, Cordobilla B, Ferrer R, Giralt M, et al. Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?. Antioxid Redox Signal. 2022;36:729. 10.1089/ars.2022.0018
- Shao C, Song J, Zhao S, Jiang H, Wang B, et al. Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Green Tea on Chronic Fatigue Syndrome. Polymers (Basel). 2018;10. 10.3390/polym10111269
Data last updated:
