Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 12 Reviews
8.2
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
9
We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
Read More
9
We examined how selenium supplementation affects patients with autoimmune thyroid disease (AITD) by reviewing 17 randomized controlled trials involving nearly 2,000 participants.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
Read More
8
We searched extensive studies to evaluate selenium supplementation's impact on Hashimoto thyroiditis (HT). Our analysis of 35 trials revealed that selenium can significantly lower TSH and thyroid antibodies in those not undergoing thyroid hormone replacement therapy. Despite these positive effects, there were no noticeable changes in thyroid hormone levels or other immune markers. Importantly, selenium was deemed safe, with no increased side effects compared to control groups. Overall, while selenium shows promise in managing certain aspects of HT, its effects on hormone production remain limited.
Read More
Most Useful Reviews
7.5
Reduced antibodies
27 people found this helpful
Great selenium supplement! I use this because I have Hashimoto's thyroiditis, and selenium aids in reducing thyroid antibodies. This supplement contains three forms of selenium, ensuring its effectiveness. It also includes vitamin E, enhancing selenium absorption, and the price on iHerb is fantastic!
Read More
9
Essential supplement
2 people found this helpful
Excellent brand! This selenium is an essential supplement for managing Hashimoto's disease.
Read More
9
Proven benefits
2 people found this helpful
You really need this for thyroid health. I was diagnosed with Hashimoto's but refused prescribed drugs and began taking vitamins A, E, zinc, and THIS SELENIUM! It is vital for my thyroid health. My blood tests prove it; results are much better after six months.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
- All Researches
9
We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
Read More
9
We examined how selenium supplementation affects patients with autoimmune thyroid disease (AITD) by reviewing 17 randomized controlled trials involving nearly 2,000 participants.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
The results revealed promising benefits; selenium significantly reduced levels of free triiodothyronine (FT3), free thyroxine (FT4), and anti-thyroid peroxidase antibodies (TPOAb).
However, thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibody (TGAb) levels showed no significant changes. Overall, these findings indicate that selenium plays a crucial role in managing AITD.
Read More
8
We searched extensive studies to evaluate selenium supplementation's impact on Hashimoto thyroiditis (HT). Our analysis of 35 trials revealed that selenium can significantly lower TSH and thyroid antibodies in those not undergoing thyroid hormone replacement therapy. Despite these positive effects, there were no noticeable changes in thyroid hormone levels or other immune markers. Importantly, selenium was deemed safe, with no increased side effects compared to control groups. Overall, while selenium shows promise in managing certain aspects of HT, its effects on hormone production remain limited.
Read More
8
We explored the potential benefits of selenium supplementation for patients with Hashimoto thyroiditis (HT). In our systematic review of seven controlled trials with 342 participants, we found that while there was no notable change in thyroid peroxidase antibodies (TPOAb) levels after three months, there was a significant reduction in TPOAb and thyroglobulin antibodies (TgAb) levels after six months of treatment.
Although these findings indicate positive effects of selenium, further research is necessary to assess overall health quality and disease progression in HT patients.
Although these findings indicate positive effects of selenium, further research is necessary to assess overall health quality and disease progression in HT patients.
Read More
8
Selenium intake may reduce HT risk
We examined how dietary selenium influences Hashimoto's thyroiditis (HT) using data from the National Health and Nutrition Examination Survey, involving over 8,700 participants. The findings suggest that higher selenium intake is linked to a lower risk of developing HT.
We also noted a negative correlation between selenium and thyroid peroxidase antibodies, indicating that selenium might help manage this autoimmune condition effectively. This suggests that incorporating selenium into our diet could serve as a beneficial, affordable strategy for preventing and treating HT.
We also noted a negative correlation between selenium and thyroid peroxidase antibodies, indicating that selenium might help manage this autoimmune condition effectively. This suggests that incorporating selenium into our diet could serve as a beneficial, affordable strategy for preventing and treating HT.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced antibodies
27 people found this helpful
Great selenium supplement! I use this because I have Hashimoto's thyroiditis, and selenium aids in reducing thyroid antibodies. This supplement contains three forms of selenium, ensuring its effectiveness. It also includes vitamin E, enhancing selenium absorption, and the price on iHerb is fantastic!
Read More
9
Essential supplement
2 people found this helpful
Excellent brand! This selenium is an essential supplement for managing Hashimoto's disease.
Read More
9
Proven benefits
2 people found this helpful
You really need this for thyroid health. I was diagnosed with Hashimoto's but refused prescribed drugs and began taking vitamins A, E, zinc, and THIS SELENIUM! It is vital for my thyroid health. My blood tests prove it; results are much better after six months.
Read More
8
Improved lab results
2 people found this helpful
I have been taking this selenium for a few months, and my lab results have improved significantly. Having Hashimoto's, I find it very beneficial.
Read More
7.5
Superior to nuts
2 people found this helpful
This selenium supplement is more effective than Brazil nuts for managing Hashimoto's thyroiditis.
Read More
Frequently Asked Questions
7.5
Significant improvement
Hashimoto, buy this selenium supplement, gluten-free; take one tablet a day for three months, and my index has dropped significantly. It is safe and effective.
9
Proven benefits
2 people found this helpful
You really need this for thyroid health. I was diagnosed with Hashimoto's but refused prescribed drugs and began taking vitamins A, E, zinc, and THIS SELENIUM! It is vital for my thyroid health. My blood tests prove it; results are much better after six months.
10
Normal thyroid levels
1 people found this helpful
The best form of selenium on the market! After just four months of trying this product, I eliminated my Hashimoto thyroid condition! The proof: my annual thyroid tests have remained at normal levels for the past three years. Furthermore, following my success, my doctor now recommends this product to her patients...
8
Improved lab results
2 people found this helpful
I have been taking this selenium for a few months, and my lab results have improved significantly. Having Hashimoto's, I find it very beneficial.
7.5
Reduced antibodies noted
5 people found this helpful
I think it works! I purchase this supplement due to elevated antibodies in my thyroid. I read about Hashimoto's and how selenium is beneficial. After a year of consistent use, my antibodies reduced by about 50%, and I am continuing.
7.5
Lowered antibodies
Good. The package arrived properly and on time. My doctor prescribed the capsules for Hashimoto's issues. By taking selenium with other vitamins, I've managed to lower my antibody levels, all supervised by my doctor.
9
Essential supplement
An essential supplement for AIT / Hashimoto's. It provides an optimal dosage of selenium plus vitamin E. I take it on an empty stomach and separately from other supplements.
9
We examined the impact of selenium supplements on thyroid autoantibody levels in patients with Hashimoto's thyroiditis.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
In our analysis, selenium showed significant effectiveness in lowering both thyroid peroxidase and thyroglobulin autoantibodies compared to placebo.
However, other supplements like Vitamin D and Myo-inositol, including their combinations, did not demonstrate similar benefits over six months.
This suggests that including selenium might be a valuable addition to traditional treatments for individuals managing Hashimoto's.
8
We searched extensive studies to evaluate selenium supplementation's impact on Hashimoto thyroiditis (HT). Our analysis of 35 trials revealed that selenium can significantly lower TSH and thyroid antibodies in those not undergoing thyroid hormone replacement therapy. Despite these positive effects, there were no noticeable changes in thyroid hormone levels or other immune markers. Importantly, selenium was deemed safe, with no increased side effects compared to control groups. Overall, while selenium shows promise in managing certain aspects of HT, its effects on hormone production remain limited.
4
We explored the effects of selenium supplementation on patients with chronic autoimmune thyroiditis (also known as Hashimoto's disease). We reviewed 23 studies that compared selenium use alongside standard treatment versus a placebo. While selenium appeared to reduce autoantibody levels, it did not significantly impact thyroid-stimulating hormone levels.
Ultimately, despite some positive findings, the overall evidence does not support the routine use of selenium in managing Hashimoto's disease, particularly given the potential for adverse effects.
Ultimately, despite some positive findings, the overall evidence does not support the routine use of selenium in managing Hashimoto's disease, particularly given the potential for adverse effects.
7
We examined the impact of selenium supplementation on autoimmune thyroiditis (AIT) by assessing data from various databases. Although findings indicated a potential reduction in thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (Tg-Ab) at three and six months for those not treated with levothyroxine (LT4), the certainty of this evidence remains low.
In contrast, the effects on those treated with LT4 were mixed, with some antibody levels showing improvement. However, the overall conclusion suggests that while selenium might offer some benefits, the evidence isn’t strong enough to make definitive claims.
In contrast, the effects on those treated with LT4 were mixed, with some antibody levels showing improvement. However, the overall conclusion suggests that while selenium might offer some benefits, the evidence isn’t strong enough to make definitive claims.
7
Selenium shows potential in Hashimoto's
We explored the impact of selenium supplementation on women who had just been diagnosed with Hashimoto's thyroiditis in an area known for low selenium levels. For six months, participants received 100 µg/day of sodium selenite.
After the treatment, we noted increased selenium levels in their serum, indicating successful supplementation. Although this may help protect against overt hypothyroidism, it didn't significantly affect other health parameters, like antioxidant status.
After the treatment, we noted increased selenium levels in their serum, indicating successful supplementation. Although this may help protect against overt hypothyroidism, it didn't significantly affect other health parameters, like antioxidant status.
8
We explored the impacts of selenium supplementation on patients with Hashimoto's thyroiditis, a common autoimmune condition. After studying 100 participants over six months, we found that those who received 200 micrograms of selenium yeast showed an improvement in their selenium levels.
Most importantly, we observed a significant reduction in thyroid antibodies, TGAb and TPOAb, suggesting that selenium may help manage this condition by lowering these autoantibodies. While selenium deficiency was common initially, supplementation appears beneficial in these patients.
Most importantly, we observed a significant reduction in thyroid antibodies, TGAb and TPOAb, suggesting that selenium may help manage this condition by lowering these autoantibodies. While selenium deficiency was common initially, supplementation appears beneficial in these patients.
References
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878
- Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34:295. doi:10.1089/thy.2023.0556
- Wang W, Jiang QL, Xu Q, Zeng Y, Jiang R, et al. Selenium regulates T cell differentiation in experimental autoimmune thyroiditis in mice. Int Immunopharmacol. 2023;124:110993. doi:10.1016/j.intimp.2023.110993
- Wang YS, Liang SS, Ren JJ, Wang ZY, Deng XX, et al. The Effects of Selenium Supplementation in the Treatment of Autoimmune Thyroiditis: An Overview of Systematic Reviews. Nutrients. 2023;15. doi:10.3390/nu15143194
- Kong XQ, Qiu GY, Yang ZB, Tan ZX, Quan XQ. Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e33791. doi:10.1097/MD.0000000000033791
- Zheng G, Cai Y, Guo Y, Song F, Hu Y, et al. The association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National Health and Nutrition Examination Survey (NHANES), 2007-2012. J Endocrinol Invest. 2023;46:1385. doi:10.1007/s40618-022-01987-0
- Kryczyk-Kozioł J, Prochownik E, Błażewska-Gruszczyk A, Słowiaczek M, Sun Q, et al. Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto's Thyroiditis. Nutrients. 2022;14. doi:10.3390/nu14142869
- Wu Q, Wang Y, Chen P, Wei J, Lv H, et al. Increased Incidence of Hashimoto Thyroiditis in Selenium Deficiency: A Prospective 6-Year Cohort Study. J Clin Endocrinol Metab. 2022;107:e3603. doi:10.1210/clinem/dgac410
- Minnetti M, Sada V, Feola T, Giannetta E, Pozza C, et al. Selenium Supplementation in Pregnant Women with Autoimmune Thyroiditis: A Practical Approach. Nutrients. 2022;14. doi:10.3390/nu14112234
- Wang LF, Sun RX, Li CF, Wang XH. The effects of selenium supplementation on antibody titres in patients with Hashimoto's thyroiditis. Endokrynol Pol. 2021;72:666. doi:10.5603/EP.a2021.0074
- Kryczyk-Kozioł J, Zagrodzki P, Prochownik E, Błażewska-Gruszczyk A, Słowiaczek M, et al. Positive effects of selenium supplementation in women with newly diagnosed Hashimoto's thyroiditis in an area with low selenium status. Int J Clin Pract. 2021;75:e14484. doi:10.1111/ijcp.14484
- Filipowicz D, Majewska K, Kalantarova A, Szczepanek-Parulska E, Ruchała M. The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge. Endokrynol Pol. 2021;72:153. doi:10.5603/EP.a2021.0017
- Zuo Y, Li Y, Gu X, Lei Z. The correlation between selenium levels and autoimmune thyroid disease: a systematic review and meta-analysis. Ann Palliat Med. 2021;10:4398. doi:10.21037/apm-21-449
- Qiu Y, Xing Z, Xiang Q, Yang Q, Zhu J, et al. Insufficient evidence to support the clinical efficacy of selenium supplementation for patients with chronic autoimmune thyroiditis. Endocrine. 2021;73:384. doi:10.1007/s12020-021-02642-z
- Hu Y, Feng W, Chen H, Shi H, Jiang L, et al. Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized-controlled trial. Clin Transl Sci. 2021;14:1390. doi:10.1111/cts.12993
- Pace C, Tumino D, Russo M, Le Moli R, Naselli A, et al. Role of selenium and myo-inositol supplementation on autoimmune thyroiditis progression. Endocr J. 2020;67:1093. doi:10.1507/endocrj.EJ20-0062
