We investigated how selenium supplementation affects cholesterol levels and the associated molecular changes. Using Sprague-Dawley male rats, we fed them diets supplemented with selenium alongside high cholesterol for three months.
The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.
Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.
Read More
9
Potential atheroprotective effects of T3
Atheroprotective effects of pure tocotrienol supplementation in the treatment of rabbits with experimentally induced early and established atherosclerosis.
We aimed to explore how pure tocotrienol (T3), a form of vitamin E, might help in fighting atherosclerosis, a condition often linked to high cholesterol. In our study, 30 rabbits were fed high-cholesterol diets and then divided into groups receiving different doses of T3 or a control without T3.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
Read More
9
Selenium nanoparticles show limited effectiveness
Selenium nanoparticles inhibit the formation of atherosclerosis in apolipoprotein E deficient mice by alleviating hyperlipidemia and oxidative stress.
We investigated whether selenium nanoparticles (SeNPs) could combat atherosclerosis related to high cholesterol. In our study involving apolipoprotein E deficient mice on a high-fat diet, both BSA- and chitosan-coated SeNPs showed promise in reducing atherosclerotic lesions over 12 weeks.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
Read More
Most Useful Reviews
7.5
Reduced hair loss
10 people found this helpful
The ingredients are balanced, the quantity is appropriate, and the packaging is good. This product helped me avoid thyroid medication. Although the taste and smell are not pleasant, I've experienced no symptoms and repeat my order, having found hair loss reduced simply by using this effective formula, albeit at an expensive price.
Read More
9
Selenium deficiency corrected
7 people found this helpful
Two years ago, I found I was selenium deficient. Selenium is a super antioxidant that aids thyroid hormone production, crucial for maintenance of function. I found this selenium supplement with 200 micrograms, taking one capsule daily. After two years, my selenium levels are now normal, which brings me great happiness. I highly recommend this high-quality selenium.
Read More
9
Improved thyroid function
4 people found this helpful
I recommend this high-quality complex. Selenium is crucial for the thyroid gland, activating thyroxine. It also improves iodine absorption and protects the thyroid from free radical damage, combating hypothyroidism. With vitamin E, the absorption is significantly enhanced. I once reduced my dose of euthyrox from 100 to 50, which shows its effectiveness. The capsules are easily swallowed, and the results have been significant for me.
We investigated whether selenium nanoparticles (SeNPs) could combat atherosclerosis related to high cholesterol. In our study involving apolipoprotein E deficient mice on a high-fat diet, both BSA- and chitosan-coated SeNPs showed promise in reducing atherosclerotic lesions over 12 weeks.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
Read More
9
Selenium nanoparticles reduce cholesterol
Selenium nanoparticles alleviate hyperlipidemia and vascular injury in ApoE-deficient mice by regulating cholesterol metabolism and reducing oxidative stress.
We explored the effects of selenium nanoparticles on high cholesterol by studying ApoE-deficient mice on a high-fat diet. Over eight weeks, we noted that selenium nanoparticles significantly reduced total cholesterol and triglycerides while boosting beneficial HDL levels.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
Read More
9
Selenium may help cholesterol levels
Hypercholesterolemia and LDL receptor mRNA expression: modulation by selenium supplementation.
We investigated the effects of selenium supplementation on LDL receptor activity and mRNA expression in male rats with high cholesterol. The study involved feeding the rats diets with varying selenium levels along with a high-cholesterol diet over three months.
Our results showed that while high cholesterol reduced both LDL receptor activity and mRNA expression, selenium at 1 ppm effectively improved these measures. This suggests that selenium may play a positive role in managing cholesterol levels and supporting lipid metabolism.
Read More
9
Selenium supports cholesterol management
Modulation of hypercholesterolemia-induced alterations in apolipoprotein B and HMG-CoA reductase expression by selenium supplementation.
We investigated how selenium supplementation affects cholesterol levels and the associated molecular changes. Using Sprague-Dawley male rats, we fed them diets supplemented with selenium alongside high cholesterol for three months.
The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.
Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.
Read More
9
Selenium reduces cholesterol in rats
[Effect of selenium on serum, hepatic and lipoprotein lipids concentration in rats fed on a high-cholesterol diet].
We explored how selenium affects lipid levels in rats consuming a high-cholesterol diet over ten weeks. By comparing selenium-treated groups with control rats, we found that selenium effectively reduced triglycerides, total cholesterol, and low-density lipoprotein cholesterol.
Additionally, it inhibited liver fat accumulation. These findings suggest that selenium could play a beneficial, recuperative role against high cholesterol. However, it's important to note that this research is based on animal studies, so human applicability requires further investigation.
The ingredients are balanced, the quantity is appropriate, and the packaging is good. This product helped me avoid thyroid medication. Although the taste and smell are not pleasant, I've experienced no symptoms and repeat my order, having found hair loss reduced simply by using this effective formula, albeit at an expensive price.
Read More
9
Selenium deficiency corrected
7 people found this helpful
Two years ago, I found I was selenium deficient. Selenium is a super antioxidant that aids thyroid hormone production, crucial for maintenance of function. I found this selenium supplement with 200 micrograms, taking one capsule daily. After two years, my selenium levels are now normal, which brings me great happiness. I highly recommend this high-quality selenium.
Read More
9
Improved thyroid function
4 people found this helpful
I recommend this high-quality complex. Selenium is crucial for the thyroid gland, activating thyroxine. It also improves iodine absorption and protects the thyroid from free radical damage, combating hypothyroidism. With vitamin E, the absorption is significantly enhanced. I once reduced my dose of euthyrox from 100 to 50, which shows its effectiveness. The capsules are easily swallowed, and the results have been significant for me.
Read More
8
Normalised cholesterol levels
3 people found this helpful
Selenium is best absorbed with vitamin E, thus purchasing both together is recommended. It is essential for treating conditions like arrhythmia, coronary heart disease, hypertension, and atherosclerosis, and helps normalise fat metabolism and blood cholesterol levels. It protects blood vessels and heart muscle while reducing hypertension risk. An excellent supplement with a superb composition!
Read More
7.5
Mitigated deficiency
1 people found this helpful
I am a fan of Life Extension supplements. Selenium is essential for me to mitigate the deficiency due to hypothyroidism. The composition of this supplement is impressive, made with high-quality, Non-GMO ingredients. The pill size is perfect, reducing the need to buy this supplement monthly. The contribution of selenium significantly improves my symptoms.
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Selenium is a powerful and widely used open-source tool designed for automating web applications for testing purposes. It enables developers and testers to write code in various programming languages such as Java, Python, C#, and Ruby to simulate user interactions with a web browser. Selenium's flexibility allows users to create complex test scenarios that mimic real-world user behaviors, making it an essential tool for ensuring web application functionality and performance.
In addition to its core functionalities, Selenium consists of several components, including Selenium WebDriver for automating browsers, Selenium Grid for running tests across multiple machines and environments in parallel, and Selenium IDE for record-and-playback test creation. Its compatibility with multiple browser types—such as Chrome, Firefox, Safari, and Edge—makes it a versatile choice for automated testing, catering to a wide range of projects and team needs. For anyone involved in web development or quality assurance, understanding and utilizing Selenium can significantly improve testing efficiency and reliability.
Based on user reviews, the time it generally takes to see results from a selenium supplement for high cholesterol can vary significantly. Many users report improvements in their health indicators after one to two months of consistent use. For example, one reviewer noted that after two months of taking a substantial selenium dosage, their antibody levels decreased, showing that the supplement was effective Read Review. Another user mentioned their thyroid-stimulating hormone (TSH) levels dropped significantly after using the supplement, indicating a notable impact Read Review.
However, it is essential to recognize that individual experiences may vary, and some users might take longer to notice significant changes, particularly if they are addressing specific deficiencies or health conditions. One reviewer indicated a gradual improvement in their metabolism and TSH levels, hinting at a multi-month timeline for others Read Review. Therefore, while many users see results within a few weeks to months, it's advisable to monitor your own health closely and consult with a healthcare professional for personalized guidance.
The scientific research surrounding supplements for managing high cholesterol presents mixed findings. Notably, a study on a novel selenoglycoside compound, GlcSeCys, indicated promising results, showing significant reductions in fat accumulation and improvements in blood sugar levels among mice on a high-cholesterol diet. This suggests potential benefits for metabolic disorders linked to high cholesterol, although more research is needed to fully validate efficacy in humans [1]. Similarly, selenium nanoparticles demonstrated a reduction in atherosclerotic lesions and improvements in cholesterol levels among animal models [2], but the effects vary based on the form of selenium used and how it interacts with cholesterol metabolism [4].
Additionally, Brazil nut flour has been linked to significant reductions in cholesterol levels in patients already on lipid-lowering medication, indicating its potential as a supportive dietary supplement for cholesterol management [5]. However, while these results are promising, they often arise from animal studies or specific subject populations, meaning human applicability remains unclear. Therefore, while certain supplements show potential based on existing scientific research, further investigations are essential to confirm their practical benefits in cholesterol management among broader human populations.
Based on user reviews, many individuals have reported significant improvements in their symptoms after using a selenium supplement. For instance, one reviewer with thyroid issues stated that the supplement helped them avoid medication while also reducing hair loss, showcasing its effectiveness in managing symptoms related to thyroid health Read Review. Another user shared their satisfaction as their selenium levels normalized after two years of consistent use, leading to a notable enhancement in their overall well-being Read Review. Additionally, users have mentioned reductions in thyroid-stimulating hormone (TSH) levels and antibody counts, with some stating they were able to decrease their medication dosage as a result Read ReviewRead Review.
Furthermore, several users found the supplement beneficial for issues like hot flashes during menopause, leading to complete symptom relief Read Review. Reviewers frequently noted enhancements in their energy levels and metabolism, indicating that selenium may play a crucial role in promoting overall health and vitality Read Review. However, it is essential to remember that individual results can vary widely based on personal health conditions and the duration of use. Therefore, those interested in trying selenium should consult with a healthcare provider for personalized recommendations.
Based on user reviews, many individuals have successfully combined selenium supplements with other vitamins, particularly vitamin E, to enhance their effectiveness in managing high cholesterol and thyroid health. Multiple reviewers indicated that vitamin E plays a crucial role in improving the absorption of selenium, resulting in better overall outcomes. For instance, one user noted that selenium is best absorbed with vitamin E and emphasized its importance in managing conditions like hypertension and atherosclerosis, thereby helping to normalize blood cholesterol levels Read Review. Another reviewer stated that combining selenium with vitamin E contributed to significant improvements in their symptoms and even allowed them to reduce thyroid medication dosages Read Review.
Additionally, users highlighted the complementary effects of these supplements on overall health. A review mentioned that incorporating vitamin E helped lower LDL (bad) cholesterol and gathered positive effects in combination with selenium Read Review. This synthesis suggests that combining these supplements can be beneficial in addressing high cholesterol and promoting heart health, showcasing the potential for an effective regimen when used together Read Review. However, as with any supplementation, users have advised consulting with healthcare providers to tailor decisions to individual health conditions.
Users have shared various insights regarding the appropriate dosage of selenium for managing high cholesterol levels. A common dosage mentioned across reviews is around 200 micrograms per day, which users found beneficial for improving their overall health, including cholesterol levels. For instance, one user highlighted that their endocrinologist recommended a substantial selenium dose to address high antibody levels, indicating that higher doses may be necessary for specific medical conditions, although caution is advised against indiscriminate use Read Review. Another user reported a positive experience with a daily intake of selenium, leading to improved thyroid marker levels and contributing positively to their health trajectory Read Review.
7.5
Medical necessity recommended
1 people found this helpful
Due to high antibody levels, my endocrinologist recommended a substantial selenium dosage. After two months of regular usage, my antibody levels indeed decreased. I advise against indiscriminate consumption; it's best for those with legitimate medical needs, while lower dosages are suitable for prevention. Avoid taking it continuously beyond three months; breaks are necessary.
7.5
Improved thyroid levels
2 people found this helpful
I purchased this product as my thyroid levels were slightly elevated. Previously, my TSH was around 7-8, but it has since dropped to 3-4. I trust the quality of Life Extension, and this product also contains vitamin E in an easy-to-swallow size.
7.5
Boosts metabolism
7 people found this helpful
We all require this mineral. Great product! Selenium is essential for thyroid function. I've noticed my metabolism increasing while TSH levels have decreased. I highly recommend it.
7.5
Reduced hair loss
10 people found this helpful
The ingredients are balanced, the quantity is appropriate, and the packaging is good. This product helped me avoid thyroid medication. Although the taste and smell are not pleasant, I've experienced no symptoms and repeat my order, having found hair loss reduced simply by using this effective formula, albeit at an expensive price.
9
Selenium deficiency corrected
7 people found this helpful
Two years ago, I found I was selenium deficient. Selenium is a super antioxidant that aids thyroid hormone production, crucial for maintenance of function. I found this selenium supplement with 200 micrograms, taking one capsule daily. After two years, my selenium levels are now normal, which brings me great happiness. I highly recommend this high-quality selenium.
9
Eliminated hot flashes
195 people found this helpful
I bought selenium from iHerb on my friend's recommendation, as I heard that centenarians have high levels of healthy minerals, including selenium. This Selenium Super Complex contains three forms of selenium plus vitamin E for good health. I found it beneficial, particularly as menopause brought hot flashes. After using this complex, symptoms like hot flashes and weakness vanished. I realised this complex aids the body in combatting oxidative damage. You only need to take it once a day, with 100 capsules in a jar lasting three months.
8
Normalised cholesterol levels
3 people found this helpful
Selenium is best absorbed with vitamin E, thus purchasing both together is recommended. It is essential for treating conditions like arrhythmia, coronary heart disease, hypertension, and atherosclerosis, and helps normalise fat metabolism and blood cholesterol levels. It protects blood vessels and heart muscle while reducing hypertension risk. An excellent supplement with a superb composition!
9
Improved thyroid function
4 people found this helpful
I recommend this high-quality complex. Selenium is crucial for the thyroid gland, activating thyroxine. It also improves iodine absorption and protects the thyroid from free radical damage, combating hypothyroidism. With vitamin E, the absorption is significantly enhanced. I once reduced my dose of euthyrox from 100 to 50, which shows its effectiveness. The capsules are easily swallowed, and the results have been significant for me.
6
Cholesterol reduction
1 people found this helpful
I take vitamin E to help reduce my bad cholesterol, as it is known to prevent arteriosclerosis and blood clots. It effectively lowers LDL (bad) cholesterol and maintains healthy cell membranes.
7.5
Helps manage antibodies
3 people found this helpful
I occasionally take selenium as my antibodies are high, and it helps reduce them. This time, I combined it with vitamin E, which I appreciated for its antioxidant properties, and I found a great price for this double-strength product.
8
GlcSeCys reduces obesity, cholesterol
A novel selenoglycoside compound GlcSeCys alleviates diets-induced obesity and metabolic dysfunctions with the modulation of Galectin-1 and selenoproteins.
We explored the effects of a novel selenoglycoside compound, GlcSeCys, on obesity and high cholesterol in mice fed a high-fat, high-cholesterol diet. This compound demonstrated significant benefits, including reduced fat accumulation and improved blood sugar levels.
We observed that GlcSeCys works by inhibiting fat production in the liver and reducing inflammation, while also supporting healthy fat tissue function. This study highlights GlcSeCys as a potential new approach for treating obesity and metabolic disorders linked to high cholesterol.
9
Selenium nanoparticles show limited effectiveness
Selenium nanoparticles inhibit the formation of atherosclerosis in apolipoprotein E deficient mice by alleviating hyperlipidemia and oxidative stress.
We investigated whether selenium nanoparticles (SeNPs) could combat atherosclerosis related to high cholesterol. In our study involving apolipoprotein E deficient mice on a high-fat diet, both BSA- and chitosan-coated SeNPs showed promise in reducing atherosclerotic lesions over 12 weeks.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
9
Selenium nanoparticles reduce cholesterol
Selenium nanoparticles alleviate hyperlipidemia and vascular injury in ApoE-deficient mice by regulating cholesterol metabolism and reducing oxidative stress.
We explored the effects of selenium nanoparticles on high cholesterol by studying ApoE-deficient mice on a high-fat diet. Over eight weeks, we noted that selenium nanoparticles significantly reduced total cholesterol and triglycerides while boosting beneficial HDL levels.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
8
Brazil nuts reduce cholesterol levels
Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients--a randomized controlled trial.
We explored the effects of incorporating Brazil nut flour into the diets of dyslipidemic and hypertensive patients. In a randomized, double-blind study, 77 patients already taking lipid-lowering medications were given either Brazil nut flour or a placebo over 90 days.
Those consuming the Brazil nut flour showed significant reductions in total cholesterol and non-HDL cholesterol levels, suggesting a positive impact on cholesterol management. However, there were no notable differences in blood pressure or overall serum lipids between the two groups.
While the Brazil nuts appear beneficial, more research is needed to fully understand these effects.
References
Zhang R, Xie X, Liu J, Pan R, Huang Y, et al. A novel selenoglycoside compound GlcSeCys alleviates diets-induced obesity and metabolic dysfunctions with the modulation of Galectin-1 and selenoproteins. Life Sci. 2024;359:123259. doi:10.1016/j.lfs.2024.123259
Xiao S, Mao L, Xiao J, Wu Y, Liu H. Selenium nanoparticles inhibit the formation of atherosclerosis in apolipoprotein E deficient mice by alleviating hyperlipidemia and oxidative stress. Eur J Pharmacol. 2021;902:174120. doi:10.1016/j.ejphar.2021.174120
Fang H, He X, Wu Y, Chen S, Zhang M, et al. Association Between Selenium Level in Blood and Glycolipid Metabolism in Residents of Enshi Prefecture, China. Biol Trace Elem Res. 2021;199:2456. doi:10.1007/s12011-020-02372-9
Guo L, Xiao J, Liu H, Liu H. Selenium nanoparticles alleviate hyperlipidemia and vascular injury in ApoE-deficient mice by regulating cholesterol metabolism and reducing oxidative stress. Metallomics. 2020;12:204. doi:10.1039/c9mt00215d
Carvalho RF, Huguenin GV, Luiz RR, Moreira AS, Oliveira GM, et al. Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients--a randomized controlled trial. Nutr J. 2015;14:59. doi:10.1186/s12937-015-0036-x
Harisa GI, Abo-Salem OM, El-sayed el-SM, Shazly G. Effects of nutritional and excessive levels of selenium on red blood cells of rats fed a high cholesterol diet. Biol Trace Elem Res. 2013;152:41. doi:10.1007/s12011-012-9588-1
Kaur H, Bansal MP. Studies on scavenger receptors under experimental hypercholesterolemia: modulation on selenium supplementation. Biol Trace Elem Res. 2011;143:310. doi:10.1007/s12011-010-8833-8
Poirier J, Cockell KA, Ratnayake WM, Scoggan KA, Hidiroglou N, et al. Antioxidant Supplements Improve Profiles of Hepatic Oxysterols and Plasma Lipids in Butter-fed Hamsters. Nutr Metab Insights. 2010;3:1. doi:10.4137/NMI.S3911
Kaur HD, Bansal MP. Studies on HDL associated enzymes under experimental hypercholesterolemia: possible modulation on selenium supplementation. Lipids Health Dis. 2009;8:55. doi:10.1186/1476-511X-8-55
Agbor GA, Vinson JA, Patel S, Patel K, Scarpati J, et al. Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model. J Agric Food Chem. 2007;55:8731.
Dhingra S, Bansal MP. Hypercholesterolemia and LDL receptor mRNA expression: modulation by selenium supplementation. Biometals. 2006;19:493.
Dhingra S, Bansal MP. Modulation of hypercholesterolemia-induced alterations in apolipoprotein B and HMG-CoA reductase expression by selenium supplementation. Chem Biol Interact. 2006;161:49.
Dhingra S, Bansal MP. Hypercholesterolemia and apolipoprotein B expression: regulation by selenium status. Lipids Health Dis. 2005;4:28.
Leborgne L, Pakala R, Dilcher C, Hellinga D, Seabron R, et al. Effect of antioxidants on atherosclerotic plaque formation in balloon-denuded and irradiated hypercholesterolemic rabbits. J Cardiovasc Pharmacol. 2005;46:540.
Sato J, O'Brien T, Katusic ZS, Fu A, Nygren J, et al. Dietary antioxidants preserve endothelium dependent vasorelaxation in overfed rats. Atherosclerosis. 2002;161:327.
Iizuka Y, Sakurai E, Tanaka Y. [Effect of selenium on serum, hepatic and lipoprotein lipids concentration in rats fed on a high-cholesterol diet]. Yakugaku Zasshi. 2001;121:93.
Sozen E, Demirel-Yalciner T, Koroglu MK, Elmas MA, Ercan F, et al. High cholesterol diet activates ER stress mediated apoptosis in testes tissue: Role of α-tocopherol. IUBMB Life. 2022;74:85. doi:10.1002/iub.2535
Sun T, Zhang B, Ru QJ, Chen XM, Lv BD. Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) restoring the balance of intestinal flora in rats. Pharm Biol. 2021;59:723. doi:10.1080/13880209.2021.1916542
Demirel-Yalciner T, Sozen E, Ozaltin E, Sahin A, Ozer NK. alpha-Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis. Biofactors. 2021;47:403. doi:10.1002/biof.1700
Bozaykut P, Ekren R, Sezerman OU, Gladyshev VN, Ozer NK. High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. Biofactors. 2020;46:653. doi:10.1002/biof.1635
Sarkisova EA, Chumak AA, Ovsyannikova LM, Alekhina LM, Nosach OV, et al. THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON-ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION. Probl Radiac Med Radiobiol. 2018;23:452. doi:10.33145/2304-8336-2018-23-452-461
Sozen E, Yazgan B, Sahin A, Ince U, Ozer NK. High Cholesterol Diet-Induced Changes in Oxysterol and Scavenger Receptor Levels in Heart Tissue. Oxid Med Cell Longev. 2018;2018:8520746. doi:10.1155/2018/8520746
Farràs M, Fernández-Castillejo S, Rubió L, Arranz S, Catalán Ú, et al. Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial. J Nutr Biochem. 2018;51:99. doi:10.1016/j.jnutbio.2017.09.010
Libinaki R, Vinh A, Tesanovic-Klajic S, Widdop R, Gaspari T. The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice. Clin Exp Pharmacol Physiol. 2017;44 Suppl 1:107. doi:10.1111/1440-1681.12821
Rahman TA, Hassim NF, Zulkafli N, Muid S, Kornain NK, et al. Atheroprotective effects of pure tocotrienol supplementation in the treatment of rabbits with experimentally induced early and established atherosclerosis. Food Nutr Res. 2016;60:31525. doi:10.3402/fnr.v60.31525
Bumrungpert A, Pavadhgul P, Kalpravidh RW. Camellia Oil-Enriched Diet Attenuates Oxidative Stress and Inflammatory Markers in Hypercholesterolemic Subjects. J Med Food. 2016;19:895. doi:10.1089/jmf.2016.3659
Apostolidou C, Adamopoulos K, Lymperaki E, Iliadis S, Papapreponis P, et al. Cardiovascular risk and benefits from antioxidant dietary intervention with red wine in asymptomatic hypercholesterolemics. Clin Nutr ESPEN. 2015;10:e224. doi:10.1016/j.clnesp.2015.08.001
Katsarou AI, Kaliora AC, Chiou A, Kalogeropoulos N, Papalois A, et al. Amelioration of oxidative and inflammatory status in hearts of cholesterol-fed rats supplemented with oils or oil-products with extra virgin olive oil components. Eur J Nutr. 2016;55:1283. doi:10.1007/s00394-015-0947-5
Schuchardt JP, Heine S, Hahn A. A combination of palm oil tocotrienols and citrus peel polymethoxylated flavones does not influence elevated LDL cholesterol and high-sensitivity C-reactive protein levels. Eur J Clin Nutr. 2015;69:1209. doi:10.1038/ejcn.2015.44
Busso D, Mascareño L, Salas F, Berkowitz L, Santander N, et al. Early onset intrauterine growth restriction in a mouse model of gestational hypercholesterolemia and atherosclerosis. Biomed Res Int. 2014;2014:280497. doi:10.1155/2014/280497
Bento AP, Cominetti C, Simões Filho A, Naves MM. Baru almond improves lipid profile in mildly hypercholesterolemic subjects: a randomized, controlled, crossover study. Nutr Metab Cardiovasc Dis. 2014;24:1330. doi:10.1016/j.numecd.2014.07.002
Hobbs T, Caso R, McMahon D, Nymark M. A novel, multi-ingredient supplement to manage elevated blood lipids in patients with no evidence of cardiovascular disease: a pilot study. Altern Ther Health Med. 2014;20:18.