Last update
3/31/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.3
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.6
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
9
We investigated how selenium supplementation affects cholesterol levels and the associated molecular changes. Using Sprague-Dawley male rats, we fed them diets supplemented with selenium alongside high cholesterol for three months.
The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.
Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.
The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.
Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.
Read More
9
Potential atheroprotective effects of T3
We aimed to explore how pure tocotrienol (T3), a form of vitamin E, might help in fighting atherosclerosis, a condition often linked to high cholesterol. In our study, 30 rabbits were fed high-cholesterol diets and then divided into groups receiving different doses of T3 or a control without T3.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
Read More
9
Selenium nanoparticles show limited effectiveness
We investigated whether selenium nanoparticles (SeNPs) could combat atherosclerosis related to high cholesterol. In our study involving apolipoprotein E deficient mice on a high-fat diet, both BSA- and chitosan-coated SeNPs showed promise in reducing atherosclerotic lesions over 12 weeks.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
Read More
Most Useful Reviews
9
Selenium deficiency corrected
7 people found this helpful
Two years ago, I found I was selenium deficient. Selenium is a super antioxidant that aids thyroid hormone production, crucial for maintenance of function. I found this selenium supplement with 200 micrograms, taking one capsule daily. After two years, my selenium levels are now normal, which brings me great happiness. I highly recommend this high-quality selenium.
Read More
9
Improved thyroid function
4 people found this helpful
I recommend this high-quality complex. Selenium is crucial for the thyroid gland, activating thyroxine. It also improves iodine absorption and protects the thyroid from free radical damage, combating hypothyroidism. With vitamin E, the absorption is significantly enhanced. I once reduced my dose of euthyrox from 100 to 50, which shows its effectiveness. The capsules are easily swallowed, and the results have been significant for me.
Read More
7.5
Improved indicators
217 people found this helpful
An excellent complex of high-quality yeast-free selenium - I take courses as prescribed by an endocrinologist. After taking, the indicators improve, which means the drug really works!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.3
- All Researches
9
Selenium nanoparticles show limited effectiveness
We investigated whether selenium nanoparticles (SeNPs) could combat atherosclerosis related to high cholesterol. In our study involving apolipoprotein E deficient mice on a high-fat diet, both BSA- and chitosan-coated SeNPs showed promise in reducing atherosclerotic lesions over 12 weeks.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
Read More
9
We explored the effects of selenium nanoparticles on high cholesterol by studying ApoE-deficient mice on a high-fat diet. Over eight weeks, we noted that selenium nanoparticles significantly reduced total cholesterol and triglycerides while boosting beneficial HDL levels.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
Read More
9
Selenium may help cholesterol levels
We investigated the effects of selenium supplementation on LDL receptor activity and mRNA expression in male rats with high cholesterol. The study involved feeding the rats diets with varying selenium levels along with a high-cholesterol diet over three months.
Our results showed that while high cholesterol reduced both LDL receptor activity and mRNA expression, selenium at 1 ppm effectively improved these measures. This suggests that selenium may play a positive role in managing cholesterol levels and supporting lipid metabolism.
Our results showed that while high cholesterol reduced both LDL receptor activity and mRNA expression, selenium at 1 ppm effectively improved these measures. This suggests that selenium may play a positive role in managing cholesterol levels and supporting lipid metabolism.
Read More
9
We investigated how selenium supplementation affects cholesterol levels and the associated molecular changes. Using Sprague-Dawley male rats, we fed them diets supplemented with selenium alongside high cholesterol for three months.
The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.
Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.
The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.
Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.
Read More
9
We explored how selenium affects lipid levels in rats consuming a high-cholesterol diet over ten weeks. By comparing selenium-treated groups with control rats, we found that selenium effectively reduced triglycerides, total cholesterol, and low-density lipoprotein cholesterol.
Additionally, it inhibited liver fat accumulation. These findings suggest that selenium could play a beneficial, recuperative role against high cholesterol. However, it's important to note that this research is based on animal studies, so human applicability requires further investigation.
Additionally, it inhibited liver fat accumulation. These findings suggest that selenium could play a beneficial, recuperative role against high cholesterol. However, it's important to note that this research is based on animal studies, so human applicability requires further investigation.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Selenium deficiency corrected
7 people found this helpful
Two years ago, I found I was selenium deficient. Selenium is a super antioxidant that aids thyroid hormone production, crucial for maintenance of function. I found this selenium supplement with 200 micrograms, taking one capsule daily. After two years, my selenium levels are now normal, which brings me great happiness. I highly recommend this high-quality selenium.
Read More
9
Improved thyroid function
4 people found this helpful
I recommend this high-quality complex. Selenium is crucial for the thyroid gland, activating thyroxine. It also improves iodine absorption and protects the thyroid from free radical damage, combating hypothyroidism. With vitamin E, the absorption is significantly enhanced. I once reduced my dose of euthyrox from 100 to 50, which shows its effectiveness. The capsules are easily swallowed, and the results have been significant for me.
Read More
7.5
Improved indicators
217 people found this helpful
An excellent complex of high-quality yeast-free selenium - I take courses as prescribed by an endocrinologist. After taking, the indicators improve, which means the drug really works!
Read More
7.5
Improved well-being
21 people found this helpful
My endocrinologist prescribed selenium, stating everyone should take it several times a year. Since taking it, my hair stopped falling out and my general well-being improved. I wish everyone health and happiness! I gave one star, as I’ve noticed high-rated products increase in price. Please give my review a like!
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6
Skin feels rejuvenated
8 people found this helpful
Veggie capsule Vitamin E is a fat-soluble vitamin with strong antioxidant effects. It prevents lipid oxidation, arteriosclerosis, and blood clots, while reducing LDL (bad) cholesterol and maintaining healthy cell membranes. Dubbed the "vitamin of rejuvenation", it helps prevent age-related diseases. As I turned 50, I started taking this supplement, opting for a vegetable capsule due to my concerns about additives. Gradually, I’ve noticed my skin feeling younger.
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Frequently Asked Questions
7.5
Medical necessity recommended
1 people found this helpful
Due to high antibody levels, my endocrinologist recommended a substantial selenium dosage. After two months of regular usage, my antibody levels indeed decreased. I advise against indiscriminate consumption; it's best for those with legitimate medical needs, while lower dosages are suitable for prevention. Avoid taking it continuously beyond three months; breaks are necessary.
7.5
Improved thyroid levels
2 people found this helpful
I purchased this product as my thyroid levels were slightly elevated. Previously, my TSH was around 7-8, but it has since dropped to 3-4. I trust the quality of Life Extension, and this product also contains vitamin E in an easy-to-swallow size.
7.5
Boosts metabolism
7 people found this helpful
We all require this mineral. Great product! Selenium is essential for thyroid function. I've noticed my metabolism increasing while TSH levels have decreased. I highly recommend it.
9
Selenium deficiency corrected
7 people found this helpful
Two years ago, I found I was selenium deficient. Selenium is a super antioxidant that aids thyroid hormone production, crucial for maintenance of function. I found this selenium supplement with 200 micrograms, taking one capsule daily. After two years, my selenium levels are now normal, which brings me great happiness. I highly recommend this high-quality selenium.
9
Improved thyroid function
4 people found this helpful
I recommend this high-quality complex. Selenium is crucial for the thyroid gland, activating thyroxine. It also improves iodine absorption and protects the thyroid from free radical damage, combating hypothyroidism. With vitamin E, the absorption is significantly enhanced. I once reduced my dose of euthyrox from 100 to 50, which shows its effectiveness. The capsules are easily swallowed, and the results have been significant for me.
6
Cholesterol reduction
1 people found this helpful
I take vitamin E to help reduce my bad cholesterol, as it is known to prevent arteriosclerosis and blood clots. It effectively lowers LDL (bad) cholesterol and maintains healthy cell membranes.
7.5
Helps manage antibodies
3 people found this helpful
I occasionally take selenium as my antibodies are high, and it helps reduce them. This time, I combined it with vitamin E, which I appreciated for its antioxidant properties, and I found a great price for this double-strength product.
8
We explored the effects of a novel selenoglycoside compound, GlcSeCys, on obesity and high cholesterol in mice fed a high-fat, high-cholesterol diet. This compound demonstrated significant benefits, including reduced fat accumulation and improved blood sugar levels.
We observed that GlcSeCys works by inhibiting fat production in the liver and reducing inflammation, while also supporting healthy fat tissue function. This study highlights GlcSeCys as a potential new approach for treating obesity and metabolic disorders linked to high cholesterol.
We observed that GlcSeCys works by inhibiting fat production in the liver and reducing inflammation, while also supporting healthy fat tissue function. This study highlights GlcSeCys as a potential new approach for treating obesity and metabolic disorders linked to high cholesterol.
9
Selenium nanoparticles show limited effectiveness
We investigated whether selenium nanoparticles (SeNPs) could combat atherosclerosis related to high cholesterol. In our study involving apolipoprotein E deficient mice on a high-fat diet, both BSA- and chitosan-coated SeNPs showed promise in reducing atherosclerotic lesions over 12 weeks.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
9
We explored the effects of selenium nanoparticles on high cholesterol by studying ApoE-deficient mice on a high-fat diet. Over eight weeks, we noted that selenium nanoparticles significantly reduced total cholesterol and triglycerides while boosting beneficial HDL levels.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
8
We explored the effects of incorporating Brazil nut flour into the diets of dyslipidemic and hypertensive patients. In a randomized, double-blind study, 77 patients already taking lipid-lowering medications were given either Brazil nut flour or a placebo over 90 days.
Those consuming the Brazil nut flour showed significant reductions in total cholesterol and non-HDL cholesterol levels, suggesting a positive impact on cholesterol management. However, there were no notable differences in blood pressure or overall serum lipids between the two groups.
While the Brazil nuts appear beneficial, more research is needed to fully understand these effects.
Those consuming the Brazil nut flour showed significant reductions in total cholesterol and non-HDL cholesterol levels, suggesting a positive impact on cholesterol management. However, there were no notable differences in blood pressure or overall serum lipids between the two groups.
While the Brazil nuts appear beneficial, more research is needed to fully understand these effects.
References
- Zhang R, Xie X, Liu J, Pan R, Huang Y, et al. A novel selenoglycoside compound GlcSeCys alleviates diets-induced obesity and metabolic dysfunctions with the modulation of Galectin-1 and selenoproteins. Life Sci. 2024;359:123259. 10.1016/j.lfs.2024.123259
- Xiao S, Mao L, Xiao J, Wu Y, Liu H. Selenium nanoparticles inhibit the formation of atherosclerosis in apolipoprotein E deficient mice by alleviating hyperlipidemia and oxidative stress. Eur J Pharmacol. 2021;902:174120. 10.1016/j.ejphar.2021.174120
- Fang H, He X, Wu Y, Chen S, Zhang M, et al. Association Between Selenium Level in Blood and Glycolipid Metabolism in Residents of Enshi Prefecture, China. Biol Trace Elem Res. 2021;199:2456. 10.1007/s12011-020-02372-9
- Guo L, Xiao J, Liu H, Liu H. Selenium nanoparticles alleviate hyperlipidemia and vascular injury in ApoE-deficient mice by regulating cholesterol metabolism and reducing oxidative stress. Metallomics. 2020;12:204. 10.1039/c9mt00215d
- Carvalho RF, Huguenin GV, Luiz RR, Moreira AS, Oliveira GM, et al. Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients--a randomized controlled trial. Nutr J. 2015;14:59. 10.1186/s12937-015-0036-x
- Harisa GI, Abo-Salem OM, El-sayed el-SM, Shazly G. Effects of nutritional and excessive levels of selenium on red blood cells of rats fed a high cholesterol diet. Biol Trace Elem Res. 2013;152:41. 10.1007/s12011-012-9588-1
- Kaur H, Bansal MP. Studies on scavenger receptors under experimental hypercholesterolemia: modulation on selenium supplementation. Biol Trace Elem Res. 2011;143:310. 10.1007/s12011-010-8833-8
- Poirier J, Cockell KA, Ratnayake WM, Scoggan KA, Hidiroglou N, et al. Antioxidant Supplements Improve Profiles of Hepatic Oxysterols and Plasma Lipids in Butter-fed Hamsters. Nutr Metab Insights. 2010;3:1. 10.4137/NMI.S3911
- Kaur HD, Bansal MP. Studies on HDL associated enzymes under experimental hypercholesterolemia: possible modulation on selenium supplementation. Lipids Health Dis. 2009;8:55. 10.1186/1476-511X-8-55
- Agbor GA, Vinson JA, Patel S, Patel K, Scarpati J, et al. Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model. J Agric Food Chem. 2007;55:8731. PubMed
- Dhingra S, Bansal MP. Hypercholesterolemia and LDL receptor mRNA expression: modulation by selenium supplementation. Biometals. 2006;19:493. PubMed
- Dhingra S, Bansal MP. Modulation of hypercholesterolemia-induced alterations in apolipoprotein B and HMG-CoA reductase expression by selenium supplementation. Chem Biol Interact. 2006;161:49. PubMed
- Dhingra S, Bansal MP. Hypercholesterolemia and apolipoprotein B expression: regulation by selenium status. Lipids Health Dis. 2005;4:28. PubMed
- Leborgne L, Pakala R, Dilcher C, Hellinga D, Seabron R, et al. Effect of antioxidants on atherosclerotic plaque formation in balloon-denuded and irradiated hypercholesterolemic rabbits. J Cardiovasc Pharmacol. 2005;46:540. PubMed
- Sato J, O'Brien T, Katusic ZS, Fu A, Nygren J, et al. Dietary antioxidants preserve endothelium dependent vasorelaxation in overfed rats. Atherosclerosis. 2002;161:327. PubMed
- Iizuka Y, Sakurai E, Tanaka Y. [Effect of selenium on serum, hepatic and lipoprotein lipids concentration in rats fed on a high-cholesterol diet]. Yakugaku Zasshi. 2001;121:93. PubMed
- Sozen E, Demirel-Yalciner T, Koroglu MK, Elmas MA, Ercan F, et al. High cholesterol diet activates ER stress mediated apoptosis in testes tissue: Role of α-tocopherol. IUBMB Life. 2022;74:85. 10.1002/iub.2535
- Sun T, Zhang B, Ru QJ, Chen XM, Lv BD. Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) restoring the balance of intestinal flora in rats. Pharm Biol. 2021;59:723. 10.1080/13880209.2021.1916542
- Demirel-Yalciner T, Sozen E, Ozaltin E, Sahin A, Ozer NK. alpha-Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis. Biofactors. 2021;47:403. 10.1002/biof.1700
- Bozaykut P, Ekren R, Sezerman OU, Gladyshev VN, Ozer NK. High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. Biofactors. 2020;46:653. 10.1002/biof.1635
- Sarkisova EA, Chumak AA, Ovsyannikova LM, Alekhina LM, Nosach OV, et al. THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON-ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION. Probl Radiac Med Radiobiol. 2018;23:452. 10.33145/2304-8336-2018-23-452-461
- Sozen E, Yazgan B, Sahin A, Ince U, Ozer NK. High Cholesterol Diet-Induced Changes in Oxysterol and Scavenger Receptor Levels in Heart Tissue. Oxid Med Cell Longev. 2018;2018:8520746. 10.1155/2018/8520746
- Farràs M, Fernández-Castillejo S, Rubió L, Arranz S, Catalán Ú, et al. Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial. J Nutr Biochem. 2018;51:99. 10.1016/j.jnutbio.2017.09.010
- Libinaki R, Vinh A, Tesanovic-Klajic S, Widdop R, Gaspari T. The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice. Clin Exp Pharmacol Physiol. 2017;44 Suppl 1:107. 10.1111/1440-1681.12821
- Rahman TA, Hassim NF, Zulkafli N, Muid S, Kornain NK, et al. Atheroprotective effects of pure tocotrienol supplementation in the treatment of rabbits with experimentally induced early and established atherosclerosis. Food Nutr Res. 2016;60:31525. 10.3402/fnr.v60.31525
- Bumrungpert A, Pavadhgul P, Kalpravidh RW. Camellia Oil-Enriched Diet Attenuates Oxidative Stress and Inflammatory Markers in Hypercholesterolemic Subjects. J Med Food. 2016;19:895. 10.1089/jmf.2016.3659
- Apostolidou C, Adamopoulos K, Lymperaki E, Iliadis S, Papapreponis P, et al. Cardiovascular risk and benefits from antioxidant dietary intervention with red wine in asymptomatic hypercholesterolemics. Clin Nutr ESPEN. 2015;10:e224. 10.1016/j.clnesp.2015.08.001
- Katsarou AI, Kaliora AC, Chiou A, Kalogeropoulos N, Papalois A, et al. Amelioration of oxidative and inflammatory status in hearts of cholesterol-fed rats supplemented with oils or oil-products with extra virgin olive oil components. Eur J Nutr. 2016;55:1283. 10.1007/s00394-015-0947-5
- Schuchardt JP, Heine S, Hahn A. A combination of palm oil tocotrienols and citrus peel polymethoxylated flavones does not influence elevated LDL cholesterol and high-sensitivity C-reactive protein levels. Eur J Clin Nutr. 2015;69:1209. 10.1038/ejcn.2015.44
- Busso D, Mascareño L, Salas F, Berkowitz L, Santander N, et al. Early onset intrauterine growth restriction in a mouse model of gestational hypercholesterolemia and atherosclerosis. Biomed Res Int. 2014;2014:280497. 10.1155/2014/280497
- Bento AP, Cominetti C, Simões Filho A, Naves MM. Baru almond improves lipid profile in mildly hypercholesterolemic subjects: a randomized, controlled, crossover study. Nutr Metab Cardiovasc Dis. 2014;24:1330. 10.1016/j.numecd.2014.07.002
- Hobbs T, Caso R, McMahon D, Nymark M. A novel, multi-ingredient supplement to manage elevated blood lipids in patients with no evidence of cardiovascular disease: a pilot study. Altern Ther Health Med. 2014;20:18. PubMed
Data last updated:
