Overview
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.7
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
1000 mg
1111%
Bio-Quercetin® Proprietary Blend[providing 35% quercetin (5 mg) [from Japanese sophora concentrate (flower bud)],30% galactomannans (4 mg) [from fenugreek (seed)]
15 mg
**
Top Medical Research Studies
9
We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
Read More
8
We explored a unique case of a 14-year-old boy with autism who presented with deep vein thrombosis (DVT) due to large bilateral subperiosteal hematomas caused by vitamin C deficiency, known as scurvy. This rare situation is noteworthy as scurvy is typically associated with other symptoms, but here it led to an unusual complication of DVT.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
Read More
8
We explored how vitamin C influences blood clotting in response to inflammation, specifically focusing on how it affects certain proteins involved in this process. In our study, we tested vitamin C at clinically relevant doses within human monocyte-derived macrophages. This investigation involved examining its effects on tissue factor (TF) and Factor VII Activating Protease (FSAP), two key proteins that play a role in triggering blood clotting after exposure to lipopolysaccharide (LPS), which is often associated with infection and inflammation.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
Read More
Most Useful Reviews
9
Enhanced blood flow
4 people found this helpful
An excellent supplement for immunity in COVID-19, quercetin can effectively prevent blood clots, reduces inflammation, and stops viruses from entering cells. I take it daily with iron, and if I feel weak or have a headache, I increase my dosage to two tablets, after which I feel much better.
Read More
9
Prevents blood clots
3 people found this helpful
Quercetin, the king of flavonoids, alongside vitamin C alleviates allergies and prevents blood clots. After meals, I take a quality supplement and bile salts with enzymes, which have improved my health significantly. My headaches have ceased, my breathing is clearer, and I've even lost weight.
Read More
6
Prevents virus entry
3 people found this helpful
Recent studies indicate that quercetin reduces inflammation and prevents blood clots by blocking the virus from entering cells. It enhances immune response, supports lymphocyte activity, and protects tissues from oxidative stress. Its critical role in treating coronavirus is promising.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.7
- All Researches
9
In our investigation, we looked at how vitamin C, in combination with a fibrin clot, influences the healing of Achilles tendon injuries in rats. We used 52 adult Wistar-Albino rats and divided them into four distinct groups to assess various treatments.
The results showed that vitamin C, when paired with fibrin clot, significantly improved tendon healing. Not only did it enhance the mechanical strength of the tendon, but it also led to better histological and biochemical outcomes, suggesting a more robust healing process. We noted increased levels of important growth factors in the groups treated with fibrin clot and vitamin C.
Importantly, the findings indicated that vitamin C plays a beneficial role in recovery, especially when combined with other treatment strategies. While further research may be necessary to fully understand its isolated effects, the data suggests that vitamin C is a valuable component in the healing bundle for Achilles tendon injuries.
The results showed that vitamin C, when paired with fibrin clot, significantly improved tendon healing. Not only did it enhance the mechanical strength of the tendon, but it also led to better histological and biochemical outcomes, suggesting a more robust healing process. We noted increased levels of important growth factors in the groups treated with fibrin clot and vitamin C.
Importantly, the findings indicated that vitamin C plays a beneficial role in recovery, especially when combined with other treatment strategies. While further research may be necessary to fully understand its isolated effects, the data suggests that vitamin C is a valuable component in the healing bundle for Achilles tendon injuries.
Read More
9
We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
Read More
8
We explored a unique case of a 14-year-old boy with autism who presented with deep vein thrombosis (DVT) due to large bilateral subperiosteal hematomas caused by vitamin C deficiency, known as scurvy. This rare situation is noteworthy as scurvy is typically associated with other symptoms, but here it led to an unusual complication of DVT.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
Read More
8
We explored how vitamin C influences blood clotting in response to inflammation, specifically focusing on how it affects certain proteins involved in this process. In our study, we tested vitamin C at clinically relevant doses within human monocyte-derived macrophages. This investigation involved examining its effects on tissue factor (TF) and Factor VII Activating Protease (FSAP), two key proteins that play a role in triggering blood clotting after exposure to lipopolysaccharide (LPS), which is often associated with infection and inflammation.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
Read More
4
We explored the use of ascorbic acid, commonly known as vitamin C, as an additional treatment option for patients critically ill with COVID-19. This study was conducted across two large hospitals in Saudi Arabia and involved a thorough look at the outcomes for these patients, especially concerning blood clotting and overall health.
After evaluating 739 patients, 296 were matched for a fair comparison. Notably, the findings suggest that while there was no significant reduction in mortality rates for those receiving vitamin C compared to those who did not, the use of vitamin C was linked to a lower occurrence of thrombosis—an abnormal blood clotting condition. The incidence of thrombosis in the vitamin C group was 6.1%, compared to 13% in the non-vitamin C group, indicating a possible protective effect against blood clots.
Ultimately, while the addition of vitamin C did not show a direct mortality benefit, it may offer some hope for reducing blood clot complications in these severely affected patients. However, further research will be necessary to validate these findings and clarify the role of vitamin C in treatment protocols for COVID-19.
After evaluating 739 patients, 296 were matched for a fair comparison. Notably, the findings suggest that while there was no significant reduction in mortality rates for those receiving vitamin C compared to those who did not, the use of vitamin C was linked to a lower occurrence of thrombosis—an abnormal blood clotting condition. The incidence of thrombosis in the vitamin C group was 6.1%, compared to 13% in the non-vitamin C group, indicating a possible protective effect against blood clots.
Ultimately, while the addition of vitamin C did not show a direct mortality benefit, it may offer some hope for reducing blood clot complications in these severely affected patients. However, further research will be necessary to validate these findings and clarify the role of vitamin C in treatment protocols for COVID-19.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhanced blood flow
4 people found this helpful
An excellent supplement for immunity in COVID-19, quercetin can effectively prevent blood clots, reduces inflammation, and stops viruses from entering cells. I take it daily with iron, and if I feel weak or have a headache, I increase my dosage to two tablets, after which I feel much better.
Read More
9
Prevents blood clots
3 people found this helpful
Quercetin, the king of flavonoids, alongside vitamin C alleviates allergies and prevents blood clots. After meals, I take a quality supplement and bile salts with enzymes, which have improved my health significantly. My headaches have ceased, my breathing is clearer, and I've even lost weight.
Read More
6
Prevents virus entry
3 people found this helpful
Recent studies indicate that quercetin reduces inflammation and prevents blood clots by blocking the virus from entering cells. It enhances immune response, supports lymphocyte activity, and protects tissues from oxidative stress. Its critical role in treating coronavirus is promising.
Read More
6
Improves blood flow
1 people found this helpful
I purchased this for vaccine detox to improve blood flow and prevent blood clots, with promising expectations.
Read More
9
Minimises bruising
1 people found this helpful
It helps prevent bruising when combined with blood clot supplements, which I appreciate.
Read More
Frequently Asked Questions
9
Enhanced blood flow
4 people found this helpful
An excellent supplement for immunity in COVID-19, quercetin can effectively prevent blood clots, reduces inflammation, and stops viruses from entering cells. I take it daily with iron, and if I feel weak or have a headache, I increase my dosage to two tablets, after which I feel much better.
9
Prevents blood clots
3 people found this helpful
Quercetin, the king of flavonoids, alongside vitamin C alleviates allergies and prevents blood clots. After meals, I take a quality supplement and bile salts with enzymes, which have improved my health significantly. My headaches have ceased, my breathing is clearer, and I've even lost weight.
0
Caused stomach issues
Unfortunately, this product didn't work for me. It caused stomach bloating and gas, and my blood pressure increased. I wouldn't recommend it as it created more troubles.
7.5
Supports blood fluidity
1 people found this helpful
I bought this product for a neighbour with high blood pressure. It's beneficial for blood fluidity and cardiovascular health, thanks to its inclusion of vitamin C that supports overall cellular function. We hope to see results with the sufficient number of capsules.
9
Minimises bruising
1 people found this helpful
It helps prevent bruising when combined with blood clot supplements, which I appreciate.
6
Improves blood flow
1 people found this helpful
I purchased this for vaccine detox to improve blood flow and prevent blood clots, with promising expectations.
4
We explored the use of ascorbic acid, commonly known as vitamin C, as an additional treatment option for patients critically ill with COVID-19. This study was conducted across two large hospitals in Saudi Arabia and involved a thorough look at the outcomes for these patients, especially concerning blood clotting and overall health.
After evaluating 739 patients, 296 were matched for a fair comparison. Notably, the findings suggest that while there was no significant reduction in mortality rates for those receiving vitamin C compared to those who did not, the use of vitamin C was linked to a lower occurrence of thrombosis—an abnormal blood clotting condition. The incidence of thrombosis in the vitamin C group was 6.1%, compared to 13% in the non-vitamin C group, indicating a possible protective effect against blood clots.
Ultimately, while the addition of vitamin C did not show a direct mortality benefit, it may offer some hope for reducing blood clot complications in these severely affected patients. However, further research will be necessary to validate these findings and clarify the role of vitamin C in treatment protocols for COVID-19.
After evaluating 739 patients, 296 were matched for a fair comparison. Notably, the findings suggest that while there was no significant reduction in mortality rates for those receiving vitamin C compared to those who did not, the use of vitamin C was linked to a lower occurrence of thrombosis—an abnormal blood clotting condition. The incidence of thrombosis in the vitamin C group was 6.1%, compared to 13% in the non-vitamin C group, indicating a possible protective effect against blood clots.
Ultimately, while the addition of vitamin C did not show a direct mortality benefit, it may offer some hope for reducing blood clot complications in these severely affected patients. However, further research will be necessary to validate these findings and clarify the role of vitamin C in treatment protocols for COVID-19.
9
We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
2
We examined the impact of high doses of vitamin C on blood clotting, particularly focusing on its effect on red blood cells (RBCs). Through our research, we discovered that vitamin C, when injected intravenously in doses of 0.5 to 5 mM, can increase the tendency of RBCs to become procoagulant. This increase was linked to a process where a molecule called phosphatidylserine is exposed on the outer membrane of these cells, which can lead to blood clot formation.
The molecular changes in RBCs were attributed to oxidative stress induced by high vitamin C levels, disrupting important calcium and thiol balance in the cells. Furthermore, our findings showed that administering vitamin C at 0.5 to 1.0 g/kg in rats resulted in a significant increase in thrombosis events. More importantly, RBCs from cancer patients displayed an increased sensitivity to these prothrombotic effects compared to healthy individuals.
Given these observations, it’s crucial to approach high-dose vitamin C therapy with caution, particularly in patients already at a higher risk for blood clotting. While vitamin C is often thought to have health benefits, our study reveals a potential risk that must not be overlooked.
The molecular changes in RBCs were attributed to oxidative stress induced by high vitamin C levels, disrupting important calcium and thiol balance in the cells. Furthermore, our findings showed that administering vitamin C at 0.5 to 1.0 g/kg in rats resulted in a significant increase in thrombosis events. More importantly, RBCs from cancer patients displayed an increased sensitivity to these prothrombotic effects compared to healthy individuals.
Given these observations, it’s crucial to approach high-dose vitamin C therapy with caution, particularly in patients already at a higher risk for blood clotting. While vitamin C is often thought to have health benefits, our study reveals a potential risk that must not be overlooked.
8
We explored how vitamin C influences blood clotting in response to inflammation, specifically focusing on how it affects certain proteins involved in this process. In our study, we tested vitamin C at clinically relevant doses within human monocyte-derived macrophages. This investigation involved examining its effects on tissue factor (TF) and Factor VII Activating Protease (FSAP), two key proteins that play a role in triggering blood clotting after exposure to lipopolysaccharide (LPS), which is often associated with infection and inflammation.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
References
- de Boer HC, Sawhney JS. Pediatric scurvy case report: a novel presentation with deep vein thrombosis secondary to large bilateral spontaneous iliac subperiosteal hematomas. BMC Pediatr. 2024;24:126. doi:10.1186/s12887-024-04579-4
- Al Sulaiman K, Aljuhani O, Saleh KB, Badreldin HA, Al Harthi A, et al. Ascorbic acid as an adjunctive therapy in critically ill patients with COVID-19: a propensity score matched study. Sci Rep. 2021;11:17648. doi:10.1038/s41598-021-96703-y
- Çelik M, Bayrak A, Duramaz A, Başaran SH, Kızılkaya C, et al. The effect of fibrin clot and C vitamin on the surgical treatment of Achilles tendon injury in the rat model✰. Foot Ankle Surg. 2021;27:681. doi:10.1016/j.fas.2020.09.006
- Kwon JH, Kim D, Cho H, Shin BS. Ascorbic acid improves thrombotic function of platelets during living donor liver transplantation by modulating the function of the E3 ubiquitin ligases c-Cbl and Cbl-b. J Int Med Res. 2019;47:1856. doi:10.1177/0300060518817408
- Parahuleva MS, Jung J, Burgazli M, Erdogan A, Parviz B, et al. Vitamin C suppresses lipopolysaccharide-induced procoagulant response of human monocyte-derived macrophages. Eur Rev Med Pharmacol Sci. 2016;20:2174.
- Kim K, Bae ON, Koh SH, Kang S, Lim KM, et al. High-Dose Vitamin C Injection to Cancer Patients May Promote Thrombosis Through Procoagulant Activation of Erythrocytes. Toxicol Sci. 2015;147:350. doi:10.1093/toxsci/kfv133
