Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
Top Medical Research Studies
9
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
Read More
9
We explored the effects of vitamin B12 treatment on a patient experiencing severe back pain, along with other symptoms associated with subacute combined degeneration (SCD) from prolonged vitamin B12 deficiency. This case involved a 49-year-old man who faced a year of worsening weakness, pain, and gait abnormalities.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Read More
7
Methylcobalamin shows pain relief potential
We explored the potential effects of methylcobalamin, an activated form of vitamin B12, in alleviating back pain. In recent studies, this vitamin has shown promise in treating various pain conditions, including diabetic neuropathy and low back pain.
Our observations highlighted that methylcobalamin may contribute to pain relief by enhancing nerve regeneration and improving nerve conduction. Additionally, it appears to decrease ectopic discharges in sensory neurons, which could be linked to pain sensitivity.
While the findings suggest that methylcobalamin may be effective in reducing back pain, we noted that it is not clear whether the vitamin was studied as a standalone treatment. This aspect slightly limits our understanding of its true efficacy. Overall, the potential analgesic properties of methylcobalamin present an interesting area for further research and consideration in pain management strategies.
Our observations highlighted that methylcobalamin may contribute to pain relief by enhancing nerve regeneration and improving nerve conduction. Additionally, it appears to decrease ectopic discharges in sensory neurons, which could be linked to pain sensitivity.
While the findings suggest that methylcobalamin may be effective in reducing back pain, we noted that it is not clear whether the vitamin was studied as a standalone treatment. This aspect slightly limits our understanding of its true efficacy. Overall, the potential analgesic properties of methylcobalamin present an interesting area for further research and consideration in pain management strategies.
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Most Useful Reviews
9
Eliminated nerve pain
1 people found this helpful
I found this B12 neuronutrient to be a great help in relieving my back pain caused by previous herpes zoster. Since switching, the pain has completely disappeared!
Read More
9
Back pain relief
1 people found this helpful
After suffering frequent headaches, the doctor recommended B vitamins. Since taking this supplement, my back pain has dissipated.
Read More
9
Good for back pain
1 people found this helpful
My mother had foot pain, but after using this B12, her back pain has gone. It's also beneficial for eye health and fatigue, with safe ingredients and simple packaging.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.4
- All Researches
9.5
We investigated the impact of a treatment combining mannitol and vitamin B on piriformis syndrome (PS), which is characterized by sciatic nerve entrapment. In a study involving 22 patients, participants received a five-day intravenous infusion of mannitol alongside a six-week regimen of vitamin B, including B1, B2, and B12.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Read More
9
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
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9
We explored the effects of combining dexamethasone with vitamin B12 during epidural injections in patients undergoing a specific type of spinal surgery, known as percutaneous endoscopic interlaminar discectomy (PEID). This study aimed to determine whether this combination could alleviate low back and leg pain that often lingers after the surgery. Patients were randomly assigned to two groups: one received only the surgery (the single surgery group), while the other received the surgery along with the combined treatment of medication.
We found that patients who received the combination of dexamethasone and vitamin B12 experienced a notable reduction in early postoperative pain, which we measured using various scoring systems. Additionally, the injections appeared to decrease the levels of certain inflammatory factors in the body, suggesting a potential biological mechanism behind the relief they experienced. Early recovery metrics, like hospital stay duration and overall satisfaction, were also improved in those receiving the combined treatment.
Therefore, the results encourage considering the use of vitamin B12 along with dexamethasone for patients recovering from disc surgery, as it seems to enhance their recovery experience effectively.
We found that patients who received the combination of dexamethasone and vitamin B12 experienced a notable reduction in early postoperative pain, which we measured using various scoring systems. Additionally, the injections appeared to decrease the levels of certain inflammatory factors in the body, suggesting a potential biological mechanism behind the relief they experienced. Early recovery metrics, like hospital stay duration and overall satisfaction, were also improved in those receiving the combined treatment.
Therefore, the results encourage considering the use of vitamin B12 along with dexamethasone for patients recovering from disc surgery, as it seems to enhance their recovery experience effectively.
Read More
9
We explored the effects of vitamin B12 treatment on a patient experiencing severe back pain, along with other symptoms associated with subacute combined degeneration (SCD) from prolonged vitamin B12 deficiency. This case involved a 49-year-old man who faced a year of worsening weakness, pain, and gait abnormalities.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Read More
9
Gelatin sponge aids postoperative recovery
We conducted a study to understand if a "cocktail treatment," which includes a gelatin sponge soaked in ropivacaine, dexamethasone, and vitamin B12, could improve recovery after a procedure known as percutaneous endoscopic lumbar discectomy (PELD). This treatment aimed to address not just the mechanical issues of a herniated disc but also the inflammatory responses that often lead to prolonged pain.
Our research involved 100 patients who underwent PELD for single-level lumbar disc herniation. Half of them received the cocktail treatment, while the other half were given a gelatin sponge without any medication as a control group. We evaluated the outcomes based on pain relief and functional recovery, using tools like the Visual Analog Scale (VAS) for assessing back and leg pain and the Oswestry Disability Index (ODI) for measuring disability.
The inclusion of vitamin B12 in the cocktail treatment seems to promote earlier pain relief and functional recovery after surgery. However, because this treatment was mixed with other medications, it’s hard to isolate the specific effect of vitamin B12 on its own. While we saw positive results in terms of overall recovery, we can't definitively claim that vitamin B12 alone contributed significantly to alleviating back pain.
Our research involved 100 patients who underwent PELD for single-level lumbar disc herniation. Half of them received the cocktail treatment, while the other half were given a gelatin sponge without any medication as a control group. We evaluated the outcomes based on pain relief and functional recovery, using tools like the Visual Analog Scale (VAS) for assessing back and leg pain and the Oswestry Disability Index (ODI) for measuring disability.
The inclusion of vitamin B12 in the cocktail treatment seems to promote earlier pain relief and functional recovery after surgery. However, because this treatment was mixed with other medications, it’s hard to isolate the specific effect of vitamin B12 on its own. While we saw positive results in terms of overall recovery, we can't definitively claim that vitamin B12 alone contributed significantly to alleviating back pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eliminated nerve pain
1 people found this helpful
I found this B12 neuronutrient to be a great help in relieving my back pain caused by previous herpes zoster. Since switching, the pain has completely disappeared!
Read More
9
Back pain relief
1 people found this helpful
After suffering frequent headaches, the doctor recommended B vitamins. Since taking this supplement, my back pain has dissipated.
Read More
9
Good for back pain
1 people found this helpful
My mother had foot pain, but after using this B12, her back pain has gone. It's also beneficial for eye health and fatigue, with safe ingredients and simple packaging.
Read More
9
Ovarian pain relief
I'm following the doctor's prescription for this supplement, and I feel much better; the back pain is gone as well!
Read More
7.5
Increased energy
I’ve noticed better energy levels and less back pain since taking this supplement for my hip osteoarthritis. The capsules are also conveniently small.
Read More
Frequently Asked Questions
9
Eliminated nerve pain
1 people found this helpful
I found this B12 neuronutrient to be a great help in relieving my back pain caused by previous herpes zoster. Since switching, the pain has completely disappeared!
9
Back pain relief
1 people found this helpful
After suffering frequent headaches, the doctor recommended B vitamins. Since taking this supplement, my back pain has dissipated.
9
Ovarian pain relief
I'm following the doctor's prescription for this supplement, and I feel much better; the back pain is gone as well!
9
Good for back pain
1 people found this helpful
My mother had foot pain, but after using this B12, her back pain has gone. It's also beneficial for eye health and fatigue, with safe ingredients and simple packaging.
7.5
Increased energy
I’ve noticed better energy levels and less back pain since taking this supplement for my hip osteoarthritis. The capsules are also conveniently small.
8
We conducted a double-blinded, randomized controlled trial to assess how effective intramuscular methylcobalamin (a form of vitamin B12) is for treating chronic nonspecific low back pain. In this study, 60 patients were divided into two groups: one received the vitamin B12 injections while the other received a placebo saline solution.
After two months of treatment, we saw significant improvements in patients taking methylcobalamin. Notably, scores on both the Oswestry Disability Index and the Visual Analogue Scale reflected less pain and better disability levels compared to those who received the placebo. Most participants only reported mild side effects like injection-site pain or minor bruising, which suggests that the treatment is safe as well.
Overall, our findings indicate that intramuscular methylcobalamin can be an effective and safe approach to managing nonspecific low back pain, either alone or alongside other treatments. This could be promising news for those suffering from this common ailment.
After two months of treatment, we saw significant improvements in patients taking methylcobalamin. Notably, scores on both the Oswestry Disability Index and the Visual Analogue Scale reflected less pain and better disability levels compared to those who received the placebo. Most participants only reported mild side effects like injection-site pain or minor bruising, which suggests that the treatment is safe as well.
Overall, our findings indicate that intramuscular methylcobalamin can be an effective and safe approach to managing nonspecific low back pain, either alone or alongside other treatments. This could be promising news for those suffering from this common ailment.
8
In our investigation of back pain treatment, we conducted a comprehensive study comparing the effectiveness of diclofenac alone to a combination of diclofenac and B vitamins, including B12, in patients experiencing acute pain in the lumbar region. This randomized double-blind study involved 418 participants across multiple centers, all of whom took the medications over a two-week period.
The results showed that a significant number of patients found relief with the combination treatment. Specifically, 53 out of 184 patients using the vitamin B combination were able to stop treatment due to sufficient pain relief, compared to 48 out of 192 patients on diclofenac alone. Furthermore, the use of a pain questionnaire indicated that those receiving the B-vitamin boost experienced greater reductions in pain intensity, especially among patients who had severe pain to start with.
Importantly, the study revealed no significant differences in side effects between the two treatment groups, which is reassuring. Therefore, it appears that combining diclofenac with B vitamins, including B12, can enhance pain relief for individuals suffering from painful vertebral syndromes, making it a valuable option in pain management strategies.
The results showed that a significant number of patients found relief with the combination treatment. Specifically, 53 out of 184 patients using the vitamin B combination were able to stop treatment due to sufficient pain relief, compared to 48 out of 192 patients on diclofenac alone. Furthermore, the use of a pain questionnaire indicated that those receiving the B-vitamin boost experienced greater reductions in pain intensity, especially among patients who had severe pain to start with.
Importantly, the study revealed no significant differences in side effects between the two treatment groups, which is reassuring. Therefore, it appears that combining diclofenac with B vitamins, including B12, can enhance pain relief for individuals suffering from painful vertebral syndromes, making it a valuable option in pain management strategies.
8
We conducted a thorough evaluation of how a combination of nucleotides—including uridine and cytidine—alongside B vitamins, including vitamin B12, influences the treatment of low back pain. In a carefully designed randomized, double-blind, controlled trial with 634 participants, we compared two groups: one receiving the nucleotide and B vitamin blend, and the other receiving standard B vitamins alone.
Our results showed that both groups experienced improvements in pain relief, measured using the visual analog scale (VAS) for pain at 30 and 60 days. However, at the first checkpoint (day 30), the group receiving nucleotides and B vitamins demonstrated significantly greater pain reduction. By day 60, the benefits seemed to level out, with both groups showing similar pain relief.
Importantly, treatment with the nucleotide and B vitamin combination was associated with fewer adverse events compared to the B vitamins alone, and no participants in that group had to discontinue treatment due to side effects. While the study highlighted the potential for improved outcomes using nucleotides, the isolated effect of vitamin B12 on back pain remains unclear and needs further exploration.
Our results showed that both groups experienced improvements in pain relief, measured using the visual analog scale (VAS) for pain at 30 and 60 days. However, at the first checkpoint (day 30), the group receiving nucleotides and B vitamins demonstrated significantly greater pain reduction. By day 60, the benefits seemed to level out, with both groups showing similar pain relief.
Importantly, treatment with the nucleotide and B vitamin combination was associated with fewer adverse events compared to the B vitamins alone, and no participants in that group had to discontinue treatment due to side effects. While the study highlighted the potential for improved outcomes using nucleotides, the isolated effect of vitamin B12 on back pain remains unclear and needs further exploration.
References
- Chen H, Yan L, Wang J, Sun Y, Li X, et al. Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway. Eur J Pharmacol. 2017;796:131. 10.1016/j.ejphar.2016.12.032
- He C, Li J, Hu W, Xiao B, Fan T, et al. Effects of dexamethasone combined with vitamin B12 on percutaneous endoscopic interlaminar discectomy early outcomes: a randomized controlled trial. J Orthop Surg Res. 2024;19:733. 10.1186/s13018-024-05210-z
- Demko AW, Rustom DH. Progressive Decrease in Function and Ambulation Potential: A Case of Subacute Combined Degeneration. Cureus. 2024;16:e64027. 10.7759/cureus.64027
- Li QD, Yang JS, Gong HL, Wei JM, Wang XF, et al. Can Additional Facet Joint Block Improve the Clinical Outcome of Kyphoplasty for Acute Osteoporotic Vertebral Compression Fractures?. Pain Physician. 2021;24:283.
- Mibielli MAN, Nunes CP, Goldberg H, Buchman L, Oliveira L, et al. Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study. J Pain Res. 2020;13:2531. 10.2147/JPR.S277024
- Yang JS, Liu KX, Chu L, Chan YK, Fan H, et al. Cocktail Treatment with a Gelatin Sponge Impregnated with Ropivacaine, Dexamethasone, and Vitamin B12 Promotes Early Postoperative Recovery after Percutaneous Endoscopic Lumbar Discectomy: A Retrospective, Case-Controlled Study. Pain Physician. 2020;23:E211.
- Buesing S, Costa M, Schilling JM, Moeller-Bertram T. Vitamin B12 as a Treatment for Pain. Pain Physician. 2019;22:E45.
- Huang ZF, Lin BQ, Torsha TT, Dilshad S, Yang DS, et al. Effect of Mannitol plus Vitamins B in the management of patients with piriformis syndrome. J Back Musculoskelet Rehabil. 2019;32:329. 10.3233/BMR-170983
- Zhang M, Han W, Hu S, Xu H. Methylcobalamin: a potential vitamin of pain killer. Neural Plast. 2013;2013:424651. 10.1155/2013/424651
- Chiu CK, Low TH, Tey YS, Singh VA, Shong HK. The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain: a randomised controlled trial. Singapore Med J. 2011;52:868.
- Mibielli MA, Nunes CP, Cohen JC, Scussel AB, Higashi R, et al. Treatment of acute, non-traumatic pain using a combination of diclofenac-cholestyramine, uridine triphosphate, cytidine monophosphate, and hydroxycobalamin. Proc West Pharmacol Soc. 2010;53:5.
- Mibielli MA, Geller M, Cohen JC, Goldberg SG, Cohen MT, et al. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study. Curr Med Res Opin. 2009;25:2589. 10.3111/13696990903246911
- Jurna I. [Analgesic and analgesia-potentiating action of B vitamins]. Schmerz. 1998;12:136.
- Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.
- Brüggemann G, Koehler CO, Koch EM. [Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study]. Klin Wochenschr. 1990;68:116.
- Kuhlwein A, Meyer HJ, Koehler CO. [Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes]. Klin Wochenschr. 1990;68:107.
- Vetter G, Brüggemann G, Lettko M, Schwieger G, Asbach H, et al. [Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes]. Z Rheumatol. 1988;47:351.
