5/15/2025
Last update
5/15/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Good
Based on 20 Reviews
8.8
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
Top Medical Research Studies
8
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Read More
8
Vitamin B12 reduces cardiovascular risks
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
7
Folate may slow atherosclerosis progression
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Read More
Most Useful Reviews
10
Essential vitamins
90 people found this helpful
Perfectly! Superfood! Gold! Bioactive folate and vitamin B12 are vital for the body and can prevent cardiovascular disease. A deficiency causes serious ailments, while these vitamins make treatment feasible. This product, made of bioactive components, aids in their absorption. Keep an eye on your vitamin levels for optimal health!
Read More
9
Women’s health support
50 people found this helpful
EXCELLENT RESULT! If you consume little greens, this supplement is essential. Folic acid is crucial for women, aiding cardiovascular health and overall organ function. Vitamin B12 combats fatigue and irritability. They work best together, and I highly recommend buying this product! Thank you!
Read More
7.5
Supports postpartum recovery
15 people found this helpful
Good folic acid with vitamin B12! After giving birth, I experienced health issues including fatigue and depression. I realised folic acid is essential for women's health, promoting cardiovascular health and uplifting mood. Taking these vitamins regularly has calmed me, improved my hair and skin, and enhanced my sleep.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
- All Researches
8
We explored the connection between serum folate levels and stroke risk by examining a diverse group of 4,903 individuals from a Chinese community. Over a follow-up period of about 9.3 years, we recorded a total of 407 strokes, with the majority being ischemic strokes.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Read More
8
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Read More
8
Vitamin B12 reduces cardiovascular risks
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
7
Folate may slow atherosclerosis progression
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Read More
7
We explored the relationship between hypertension and global DNA methylation levels in a group of 2,300 individuals aged 30 to 75 from rural Punjab, India. Our research particularly aimed to see how folate, along with other vitamins and biochemical markers, affects blood pressure and cardiovascular health.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Essential vitamins
90 people found this helpful
Perfectly! Superfood! Gold! Bioactive folate and vitamin B12 are vital for the body and can prevent cardiovascular disease. A deficiency causes serious ailments, while these vitamins make treatment feasible. This product, made of bioactive components, aids in their absorption. Keep an eye on your vitamin levels for optimal health!
Read More
9
Women’s health support
50 people found this helpful
EXCELLENT RESULT! If you consume little greens, this supplement is essential. Folic acid is crucial for women, aiding cardiovascular health and overall organ function. Vitamin B12 combats fatigue and irritability. They work best together, and I highly recommend buying this product! Thank you!
Read More
7.5
Supports postpartum recovery
15 people found this helpful
Good folic acid with vitamin B12! After giving birth, I experienced health issues including fatigue and depression. I realised folic acid is essential for women's health, promoting cardiovascular health and uplifting mood. Taking these vitamins regularly has calmed me, improved my hair and skin, and enhanced my sleep.
Read More
9
Anemia and depression
11 people found this helpful
Recommended for cardiovascular disease and depression, this formula with vitamins B12 and B9 revitalises the body. These vitamins are crucial for blood health and neural function. This product helps manage sleep and boosts immunity. It can even act as an antidepressant by increasing happiness hormones.
Read More
8.5
Prevention of anemia
8 people found this helpful
Life Extension is excellent! I’ve tried multiple products, and this one effectively combats folate deficiency, which is vital for cardiovascular health, especially during pregnancy. Paired with vitamin B12, it helps prevent anemia and even blood cancer. I recommend prophylactic use for continued health.
Read More
Frequently Asked Questions
9
Dizziness relief
1 people found this helpful
I have Ménière's disease, causing occasional dizziness. My doctor advised taking folic acid with B12, and since starting this supplement, I have not experienced dizziness. I'm pleased with my progress and will continue repurchasing.
6
Trustworthy supplement
1 people found this helpful
Life Extension produces reliable products with a proven track record. This supplement contains bioactive folate and B12, aiding in cardiovascular disease prevention, energy levels, and overall well-being. Though changes are subtle, my health remains stable, making this complex a trustworthy addition to my diet.
9
Cardiovascular marker control
4 people found this helpful
Fine! I gave this to my 72-year-old mother to normalise homocysteine related to cardiovascular disease. The product helped lower her levels considerably. It's proven effective and the high-quality ingredients make a visible difference. If my review is helpful, please like it.
7.5
Supports postpartum recovery
15 people found this helpful
Good folic acid with vitamin B12! After giving birth, I experienced health issues including fatigue and depression. I realised folic acid is essential for women's health, promoting cardiovascular health and uplifting mood. Taking these vitamins regularly has calmed me, improved my hair and skin, and enhanced my sleep.
9
Women’s health support
50 people found this helpful
EXCELLENT RESULT! If you consume little greens, this supplement is essential. Folic acid is crucial for women, aiding cardiovascular health and overall organ function. Vitamin B12 combats fatigue and irritability. They work best together, and I highly recommend buying this product! Thank you!
9
Homocysteine reduction
1 people found this helpful
An excellent complex! I gave it to my husband to lower his homocysteine levels, linked to increased risk of cardiovascular disease. The bioactive forms of folic acid and B12 worked effectively, confirmed by lab results. Such vitamin forms are hard to find in pharmacies.
9
Essential nutrients
This supplement effectively supports cardiovascular health through bioactive folate and vitamin B12, contributing to nerve growth and energy production. It is beneficial for maintaining blood cell production and overall well-being.
7.5
Supports women's health
If you don't consume enough greens, this supplement is beneficial. The active forms of folate restore cardiovascular health and support overall bodily functions. Combined with vitamin B12, it effectively combats mood issues, fatigue, and irritability.
7.5
Heart health benefits
1 people found this helpful
Folate, along with B6 and B12, creates a coenzyme that reduces homocysteine levels, which negatively impacts cardiovascular disease.
8.5
Prevention of anemia
8 people found this helpful
Life Extension is excellent! I’ve tried multiple products, and this one effectively combats folate deficiency, which is vital for cardiovascular health, especially during pregnancy. Paired with vitamin B12, it helps prevent anemia and even blood cancer. I recommend prophylactic use for continued health.
9
Active folate forms
1 people found this helpful
I really like Life Extension; these vitamins are excellent, especially when considering pregnancy. The active forms of folate are crucial since many people cannot assimilate folic acid, leading to cardiovascular disease risks. Long-term intake requires balancing with vitamin B12 to avoid deficiencies. It’s essential to be aware of one's genetics and choose suitable forms like methylfolate. If that's not relevant, regular folic acid should not exceed 400-600 mg. Knowledge is key; stay healthy!
8
We explored the connection between serum folate levels and stroke risk by examining a diverse group of 4,903 individuals from a Chinese community. Over a follow-up period of about 9.3 years, we recorded a total of 407 strokes, with the majority being ischemic strokes.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
7
Folate may slow atherosclerosis progression
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
8
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
7
We explored the relationship between hypertension and global DNA methylation levels in a group of 2,300 individuals aged 30 to 75 from rural Punjab, India. Our research particularly aimed to see how folate, along with other vitamins and biochemical markers, affects blood pressure and cardiovascular health.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
References
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. 10.3390/nu17010159
- Palchetti CZ, Gonçalves NG, Suemoto CK, Santos IS, Lotufo PA, et al. Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification. Clin Nutr ESPEN. 2025;65:144. 10.1016/j.clnesp.2024.11.034
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. 10.1055/s-0044-1788280
- Kaushik A, Bhattacharjee D, Chaudhary V, Dahal S, Devi NK, et al. Hypertension and global DNA methylation: a population-based study in rural, Punjab, India. Sci Rep. 2024;14:25826. 10.1038/s41598-024-77437-z
- Siddiqi SM, Liu L, Du Y, Song Y, Chen P, et al. Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension. J Nutr. 2024. 10.1016/j.tjnut.2024.09.003
- Liang X, Huang D, Bi Y, He Y, Mao T, et al. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study. J Hum Hypertens. 2024;38:844. 10.1038/s41371-024-00955-w
