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SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Excellent
Based on 20 Reviews
9.1
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
Top Medical Research Studies
8
Folate's potential in heart health
Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Relevant to cardiovascular health
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Read More
8
Vitamin B12 reduces cardiovascular risks
Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension.
Moderate relevance to findings
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
7
Folate may slow atherosclerosis progression
Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification.
Relevant but limited findings
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Read More
Most Useful Reviews
10
Essential vitamins
Perfectly! Superfood! Gold! Bioactive folate and vitamin B12 are vital for the body and can prevent cardiovascular disease. A deficiency causes serious ailments, while these vitamins make treatment feasible. This product, made of bioactive components, aids in their absorption. Keep an eye on your vitamin levels for optimal health!
Read More
9.5
Women’s health support
EXCELLENT RESULT! If you consume little greens, this supplement is essential. Folic acid is crucial for women, aiding cardiovascular health and overall organ function. Vitamin B12 combats fatigue and irritability. They work best together, and I highly recommend buying this product! Thank you!
Read More
8.8
Supports postpartum recovery
Good folic acid with vitamin B12! After giving birth, I experienced health issues including fatigue and depression. I realised folic acid is essential for women's health, promoting cardiovascular health and uplifting mood. Taking these vitamins regularly has calmed me, improved my hair and skin, and enhanced my sleep.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
8
Folate lowers stroke risk
Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses.
Moderate relevance to cardiovascular disease.
We explored the connection between serum folate levels and stroke risk by examining a diverse group of 4,903 individuals from a Chinese community. Over a follow-up period of about 9.3 years, we recorded a total of 407 strokes, with the majority being ischemic strokes.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Read More
8
Folate's potential in heart health
Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Relevant to cardiovascular health
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Read More
8
Vitamin B12 reduces cardiovascular risks
Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension.
Moderate relevance to findings
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
7
Folate may slow atherosclerosis progression
Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification.
Relevant but limited findings
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Read More
7
Folate's role in hypertension examined
Hypertension and global DNA methylation: a population-based study in rural, Punjab, India.
Highlights folate and hypertension link
We explored the relationship between hypertension and global DNA methylation levels in a group of 2,300 individuals aged 30 to 75 from rural Punjab, India. Our research particularly aimed to see how folate, along with other vitamins and biochemical markers, affects blood pressure and cardiovascular health.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 20 Reviews
9.1
10
Essential vitamins
Perfectly! Superfood! Gold! Bioactive folate and vitamin B12 are vital for the body and can prevent cardiovascular disease. A deficiency causes serious ailments, while these vitamins make treatment feasible. This product, made of bioactive components, aids in their absorption. Keep an eye on your vitamin levels for optimal health!
Read More
9.5
Women’s health support
EXCELLENT RESULT! If you consume little greens, this supplement is essential. Folic acid is crucial for women, aiding cardiovascular health and overall organ function. Vitamin B12 combats fatigue and irritability. They work best together, and I highly recommend buying this product! Thank you!
Read More
9.5
Anemia and depression
Recommended for cardiovascular disease and depression, this formula with vitamins B12 and B9 revitalises the body. These vitamins are crucial for blood health and neural function. This product helps manage sleep and boosts immunity. It can even act as an antidepressant by increasing happiness hormones.
Read More
9.5
Cardiovascular marker control
Fine! I gave this to my 72-year-old mother to normalise homocysteine related to cardiovascular disease. The product helped lower her levels considerably. It's proven effective and the high-quality ingredients make a visible difference. If my review is helpful, please like it.
9.5
Immune system boost
A very effective supplement that enhances the immune system and supports cardiovascular health. The combination of folate and vitamin B12 is excellent for developing nerve cells. I am very pleased with the results and highly recommend it!
