We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
Read More
8
Cholesterol reduction in children studied
Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia.
We investigated how a special dietary supplement, which includes folate among other natural components, impacts cholesterol levels in children and adolescents with moderate to severe hypercholesterolemia. The supplement, called Armolipid, combines red yeast rice, policosanols, coenzyme Q10, astaxanthin, and folic acid.
Over the course of 16 months, we observed significant reductions in total cholesterol and some harmful types of cholesterol, including low-density lipoprotein (LDL), which is often referred to as "bad cholesterol." However, it’s important to note that despite the presence of folate in the supplement, the study did not isolate its effects from the other ingredients, making it challenging to determine folate's specific impact on high cholesterol levels.
We did not see significant changes in beneficial cholesterol levels (high-density lipoprotein or HDL), triglycerides, or other lipoproteins. For those who were using phytosterols before starting Armolipid, the supplement did provide additional benefits, particularly in reducing atherogenic lipoproteins.
Overall, while Armolipid may offer an effective and safe option for managing cholesterol in children, we should conduct further research to specifically understand the role of folate and the other ingredients separately.
Read More
Most Useful Reviews
9
Boosts energy levels
2 people found this helpful
I took this product to reduce high homocysteine and cholesterol levels as recommended by my doctor. It worked wonders—after two months, I felt more energetic and noted a decrease in homocysteine. The small capsules are easy to swallow, and I would buy this product again as it was effective for me.
Read More
9
Effective vitamin complex
1 people found this helpful
This complex worked excellently for my husband to reduce his high homocysteine levels, which increase cardiovascular risks. After using it, his levels decreased significantly, confirmed by lab results. It's unfortunate that such vitamin forms are not readily available in pharmacies, as many doctors overlook this analysis in favour of statin prescriptions.
Read More
9
Highly recommended product
1 people found this helpful
This product is fantastic for anyone with high homocysteine levels. I found it to be highly effective!
We investigated how a special dietary supplement, which includes folate among other natural components, impacts cholesterol levels in children and adolescents with moderate to severe hypercholesterolemia. The supplement, called Armolipid, combines red yeast rice, policosanols, coenzyme Q10, astaxanthin, and folic acid.
Over the course of 16 months, we observed significant reductions in total cholesterol and some harmful types of cholesterol, including low-density lipoprotein (LDL), which is often referred to as "bad cholesterol." However, it’s important to note that despite the presence of folate in the supplement, the study did not isolate its effects from the other ingredients, making it challenging to determine folate's specific impact on high cholesterol levels.
We did not see significant changes in beneficial cholesterol levels (high-density lipoprotein or HDL), triglycerides, or other lipoproteins. For those who were using phytosterols before starting Armolipid, the supplement did provide additional benefits, particularly in reducing atherogenic lipoproteins.
Overall, while Armolipid may offer an effective and safe option for managing cholesterol in children, we should conduct further research to specifically understand the role of folate and the other ingredients separately.
Read More
7
Folic acid reduces cholesterol risk
Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis.
We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.3
All Reviews
Positive Reviews
Negative Reviews
9
Boosts energy levels
2 people found this helpful
I took this product to reduce high homocysteine and cholesterol levels as recommended by my doctor. It worked wonders—after two months, I felt more energetic and noted a decrease in homocysteine. The small capsules are easy to swallow, and I would buy this product again as it was effective for me.
Read More
9
Effective vitamin complex
1 people found this helpful
This complex worked excellently for my husband to reduce his high homocysteine levels, which increase cardiovascular risks. After using it, his levels decreased significantly, confirmed by lab results. It's unfortunate that such vitamin forms are not readily available in pharmacies, as many doctors overlook this analysis in favour of statin prescriptions.
Read More
9
Highly recommended product
1 people found this helpful
This product is fantastic for anyone with high homocysteine levels. I found it to be highly effective!
Read More
9
Improved wellbeing
1 people found this helpful
I’ve taken folate from this brand before. This formulation, which includes both B12 and folate, is easily digestible. I experienced high homocysteine levels initially, but thanks to this product, my levels normalised and my wellbeing improved without any side effects. I recommend it for its value and quality.
Read More
7.5
Reduced homocysteine levels
10 people found this helpful
I ordered this drug for my elderly mother who has atherosclerosis and high cholesterol. The ultrasound showed atherosclerosis and further tests revealed high homocysteine as a contributing factor. High homocysteine levels can negatively affect vascular walls and contribute to cell death and blood clot formation. Folic acid and B12 lower homocysteine levels effectively. I found this product gentle and without side effects.
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Vitamin B refers to a group of eight essential water-soluble vitamins that play a vital role in various physiological functions in the body. These vitamins include B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate, or folic acid), and B12 (cobalamin). Each of these vitamins contributes to key processes such as energy metabolism, red blood cell formation, cognitive function, and the synthesis of DNA. Because they are water-soluble, any excess amounts are not stored in the body and can be lost through urine, making regular dietary intake important.
Foods rich in B vitamins include whole grains, meat, eggs, dairy products, legumes, seeds, nuts, and dark leafy greens. Deficiencies can lead to a host of health issues, including fatigue, anemia, cognitive decline, and skin problems. Supplements are available and can be beneficial, especially for individuals with specific dietary restrictions, such as vegetarians or those with certain medical conditions that affect nutrient absorption. Always consult a healthcare professional before starting any new supplement regimen to assess individual needs and avoid potential negative interactions.
While Vitamin B itself is not typically considered a primary treatment for high cholesterol, certain B vitamins, like Niacin (Vitamin B3), have been shown to influence cholesterol levels positively. Niacin can help increase levels of high-density lipoprotein (HDL) cholesterol, commonly referred to as "good" cholesterol, while also lowering levels of low-density lipoprotein (LDL) cholesterol, the "bad" form. Some research suggests that using Niacin in conjunction with other cholesterol-lowering medications can enhance their effectiveness. However, the use of Niacin should always be guided by a healthcare professional, as it can cause some side effects and isn't suitable for everyone.
Other B vitamins, such as B6, B12, and folic acid, play supportive roles in cardiovascular health, particularly through their involvement in reducing homocysteine levels, which, if elevated, can be a risk factor for heart disease. However, the evidence linking these specific B vitamins directly to cholesterol changes is less clear. If you are considering using B vitamins as part of your strategy to manage high cholesterol, it's essential to consult with your doctor or a nutritionist to ensure a comprehensive approach that includes a healthy diet and lifestyle changes.
Based on user reviews, many individuals taking this supplement for high cholesterol and related conditions typically report seeing notable improvements within a two to three-month timeframe. For instance, one user mentioned that after two months of consistent use, they noted a decrease in both homocysteine levels and an increase in energy, implying a positive effect on overall health markers Read Review. Similarly, another review highlighted the timeliness of results, with significant reductions in cholesterol levels being confirmed by lab tests after regular use over a period of time Read Review.
Furthermore, one user shared their experience of their levels normalizing and their wellbeing improving after a steady regimen of this supplement, suggesting effectiveness without any side effects Read Review. While the exact duration may vary from person to person, it appears that users generally have a favorable view of the supplement’s efficacy within the stated timeframes.
Based on current scientific research, there is evidence suggesting that certain supplements can support the management of high cholesterol levels. One notable study focused on a dietary supplement known as Armolipid, which includes a blend of red yeast rice, policosanols, coenzyme Q10, astaxanthin, and folic acid. Over a 16-month period, children and adolescents who used Armolipid experienced significant reductions in total cholesterol and low-density lipoprotein (LDL), often referred to as "bad cholesterol". However, it's important to note that the study did not isolate the effects of folic acid, making it unclear how much of the cholesterol-lowering effects could be attributed specifically to this component [1].
Another study examined the impact of folic acid on cholesterol and atherosclerosis risk, indicating that higher levels of folic acid are associated with better cholesterol profiles, including higher levels of high-density lipoprotein (HDL) and lower levels of LDL and triglycerides. This suggests that maintaining healthy folate levels may contribute to improved cholesterol levels and potentially reduce the risk of heart disease [2]. Overall, while there is promising evidence regarding supplements for managing cholesterol, further research is warranted to fully understand their individual effects and efficacy.
Based on user reviews, there have been several anecdotal experiences highlighting notable improvements in symptoms related to high homocysteine levels and overall wellbeing. Many users report experiencing significant reductions in their homocysteine levels after consistent use of the supplement. For example, one user noted a decrease in homocysteine and an increase in energy after two months of taking the product Read Review. Another review stated that a husband saw significant improvement in his levels as confirmed by lab tests Read Review.
Additionally, users have shared feelings of enhanced wellbeing without side effects after normalizing their levels, emphasizing the product's effectiveness and gentleness, suitable even for elderly individuals with conditions like atherosclerosis Read ReviewRead Review. Others have mentioned potential benefits for specific situations, such as addressing deficiencies crucial for pregnancy planning Read Review. While individual results can vary, these testimonials suggest a trend toward positive outcomes among users of the supplement.
Based on user reviews, many individuals have shared positive experiences regarding the combination of this supplement with other products to manage high cholesterol and homocysteine levels. Users reported that the combination of B12 and folate within this supplement effectively improved their homocysteine levels, which they note can be crucial in cardiovascular health. One user specifically mentioned that their husband saw significant reductions in homocysteine levels, as confirmed by lab results, after taking this supplement Read Review. Furthermore, another user emphasized the supplement's effectiveness in normalizing their levels and improving overall wellbeing without any side effects, suggesting it could be a beneficial addition to a regimen aimed at managing cholesterol levels Read Review.
Users report a variety of experiences regarding the effectiveness of Vitamin B in treating high cholesterol, particularly in relation to lowering homocysteine levels. Many users noted that they took supplements containing B12 and folate (B9) to help manage their cholesterol and homocysteine levels, with several indicating that they saw significant improvements in their lab results within a couple of months of consistent use. For instance, one user mentioned their energy levels increased and their homocysteine decreased after two months (Read Review). Another reviewer highlighted that their husband's high homocysteine levels dropped significantly, confirming the efficacy of the vitamins through testing (Read Review).
As for the dosage, several users suggested that the formulations were effective at the amounts they contained; one user specifically noted that her supplement improved her homocysteine levels and felt gentle without any adverse effects (Read Review). Furthermore, another review mentioned satisfactory outcomes with their current regimen, claiming their levels had normalized and proved effective over a three-month period (Read Review). Overall, while specific dosage details weren't extensively discussed, users generally reported success with standard formulations containing B12 and folate.
9
Boosts energy levels
2 people found this helpful
I took this product to reduce high homocysteine and cholesterol levels as recommended by my doctor. It worked wonders—after two months, I felt more energetic and noted a decrease in homocysteine. The small capsules are easy to swallow, and I would buy this product again as it was effective for me.
9
Effective vitamin complex
1 people found this helpful
This complex worked excellently for my husband to reduce his high homocysteine levels, which increase cardiovascular risks. After using it, his levels decreased significantly, confirmed by lab results. It's unfortunate that such vitamin forms are not readily available in pharmacies, as many doctors overlook this analysis in favour of statin prescriptions.
9
Improved wellbeing
1 people found this helpful
I’ve taken folate from this brand before. This formulation, which includes both B12 and folate, is easily digestible. I experienced high homocysteine levels initially, but thanks to this product, my levels normalised and my wellbeing improved without any side effects. I recommend it for its value and quality.
7.5
Reduced homocysteine levels
10 people found this helpful
I ordered this drug for my elderly mother who has atherosclerosis and high cholesterol. The ultrasound showed atherosclerosis and further tests revealed high homocysteine as a contributing factor. High homocysteine levels can negatively affect vascular walls and contribute to cell death and blood clot formation. Folic acid and B12 lower homocysteine levels effectively. I found this product gentle and without side effects.
7.5
Supports pregnancy health
8 people found this helpful
This is excellent for addressing B9 and B12 deficiencies and helps lower high homocysteine levels, which are crucial, especially when planning a pregnancy. High levels can affect blood vessels and complicate conception. I had difficulty for years and nearly reached IVF, but now I’m hoping for another pregnancy with this complex. The tiny capsules are easy to take!
7.5
Quality ingredients
1 people found this helpful
I've been using this brand of folic acid with added B12 for some time. It’s a good quality product, safe ingredients, and the dosage is adequate. One bottle lasts me for three months, and I’ve seen my homocysteine levels drop below 8, which proves effective.
8
Cholesterol reduction in children studied
Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia.
We investigated how a special dietary supplement, which includes folate among other natural components, impacts cholesterol levels in children and adolescents with moderate to severe hypercholesterolemia. The supplement, called Armolipid, combines red yeast rice, policosanols, coenzyme Q10, astaxanthin, and folic acid.
Over the course of 16 months, we observed significant reductions in total cholesterol and some harmful types of cholesterol, including low-density lipoprotein (LDL), which is often referred to as "bad cholesterol." However, it’s important to note that despite the presence of folate in the supplement, the study did not isolate its effects from the other ingredients, making it challenging to determine folate's specific impact on high cholesterol levels.
We did not see significant changes in beneficial cholesterol levels (high-density lipoprotein or HDL), triglycerides, or other lipoproteins. For those who were using phytosterols before starting Armolipid, the supplement did provide additional benefits, particularly in reducing atherogenic lipoproteins.
Overall, while Armolipid may offer an effective and safe option for managing cholesterol in children, we should conduct further research to specifically understand the role of folate and the other ingredients separately.
7
Folic acid reduces cholesterol risk
Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis.
We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
References
Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. 10.3390/biom14121608
Qi J, Wu H, Chen H, Han W. Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis. Sci Rep. 2024;14:19052. 10.1038/s41598-024-69728-2