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Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.
We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.
In the study, thirty-three participants, averaging 56 years and deficient in vitamin D, were evaluated before and after receiving cholecalciferol supplements. Initially, we examined both their calcium excretion and urine supersaturation levels, which help indicate the risk of stone formation.
Following the supplementation, we observed several significant changes. Notably, the serum levels of vitamin D increased, and more participants became hypercalciuric, meaning they were excreting higher levels of calcium in their urine. This was concerning as increased urine supersaturation with calcium could elevate the risk of kidney stones.
Despite the rise in vitamin D levels, we didn’t see any major changes in overall calcium levels in the blood, suggesting that the body was managing these variations. However, for those undergoing this treatment, there remains a cautionary note about the potential for increased stone formation due to higher calcium excretion.
To see if supplementing vitamin D3 would provide benefits, we gave 37 of these vitamin D-deficient patients a weekly dose of 20,000 IU for four months. While we noted that this supplementation raised serum vitamin D levels and reduced parathyroid hormone concentrations, the increase in urinary calcium excretion after treatment did not reach statistical significance.
Interestingly, 22 patients had higher calcium levels in their urine, but others experienced a decrease or no change. What’s crucial here is that six patients who were initially normal concerning calcium levels ended up developing hypercalciuria after treatment. This means we should carefully monitor patients who receive vitamin D3 to ensure that they do not experience unexpected increases in calcium excretion that could raise the risk of kidney stones.
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To see if supplementing vitamin D3 would provide benefits, we gave 37 of these vitamin D-deficient patients a weekly dose of 20,000 IU for four months. While we noted that this supplementation raised serum vitamin D levels and reduced parathyroid hormone concentrations, the increase in urinary calcium excretion after treatment did not reach statistical significance.
Interestingly, 22 patients had higher calcium levels in their urine, but others experienced a decrease or no change. What’s crucial here is that six patients who were initially normal concerning calcium levels ended up developing hypercalciuria after treatment. This means we should carefully monitor patients who receive vitamin D3 to ensure that they do not experience unexpected increases in calcium excretion that could raise the risk of kidney stones.
Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.
We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.
In the study, thirty-three participants, averaging 56 years and deficient in vitamin D, were evaluated before and after receiving cholecalciferol supplements. Initially, we examined both their calcium excretion and urine supersaturation levels, which help indicate the risk of stone formation.
Following the supplementation, we observed several significant changes. Notably, the serum levels of vitamin D increased, and more participants became hypercalciuric, meaning they were excreting higher levels of calcium in their urine. This was concerning as increased urine supersaturation with calcium could elevate the risk of kidney stones.
Despite the rise in vitamin D levels, we didn’t see any major changes in overall calcium levels in the blood, suggesting that the body was managing these variations. However, for those undergoing this treatment, there remains a cautionary note about the potential for increased stone formation due to higher calcium excretion.
After the supplementation, we observed some notable changes. While serum calcium and phosphate levels remained stable, the level of vitamin D3 in the blood saw a significant increase. This led to more kidney stone formers experiencing higher urinary calcium levels. Notably, the percentage of participants with hypercalciuria grew from 18.2% to 39.4%. We also noted an increase in urine supersaturation for brushite, hinting at a potential risk for stone formation.
Overall, our findings suggest that while vitamin D3 supplementation can elevate vitamin D levels, it may also increase urinary calcium and the risk of recurrences for kidney stones. Consequently, careful monitoring of urinary metabolic profiles for patients receiving vitamin D may be necessary to tailor preventive strategies effectively.
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Frequently Asked Questions
Kidney stones are hard deposits made of minerals and salts that form inside your kidneys. While they can vary in size from tiny particles to large stones, they all begin as crystallized substances that develop when urine contains more crystal-forming substances than the fluid in your urine can dilute. When the crystals stick together, they can form stones, which may cause severe pain, especially when they pass through the urinary tract. Common types of kidney stones include calcium stones, struvite stones, uric acid stones, and cystine stones.
The symptoms of kidney stones can include sharp pain in the side and back, pain during urination, pink or red urine, and frequent urination. Various factors can increase the risk of developing kidney stones, including dehydration, certain dietary choices, and genetic predisposition. Preventing kidney stones often involves drinking plenty of water, avoiding excessive salt and animal protein, and ensuring a balanced intake of calcium. For those who suffer from kidney stones, a medical evaluation may be necessary to determine the best management and preventive strategies.
Vitamin D3 K2 is a supplement that combines two vital nutrients: vitamin D3 (cholecalciferol) and vitamin K2 (menaquinone). Vitamin D3 is crucial for maintaining healthy bones and immune function, as it helps the body absorb calcium, which is essential for bone strength. It can be obtained through sunlight exposure, certain foods, and supplements. On the other hand, vitamin K2 plays a significant role in directing calcium to the bones and teeth while preventing it from depositing in the arteries and soft tissues, thus promoting cardiovascular health and overall well-being.
The synergy between vitamin D3 and K2 is particularly important because they work together to ensure that calcium is utilized effectively in the body. While vitamin D3 boosts calcium absorption, vitamin K2 ensures that this calcium is deposited properly in the bones rather than accumulating in the arteries. This combination is believed to support bone density, cardiovascular health, and overall vitality. Many health professionals recommend considering a D3 and K2 supplement, especially for individuals who may be at risk of deficiency or those who live in areas with limited sunlight exposure. Always consult a healthcare provider before starting any new supplement regimen.
Based on user reviews, the timeframe for seeing results from vitamin D and K2 supplementation in relation to kidney stones varies. Some users have noted improvements relatively quickly, specifically mentioning that their kidney conditions have shown positive changes after starting the vitamins (see (Read Review)). However, the general consensus does not specify an exact duration for noticeable effects, indicating that experiences may differ depending on individual health conditions and underlying causes of kidney stones, such as vitamin D deficiency or high uric acid levels (refer to (Read Review)).
In general, users suggest that these combinations can help in preventing future stone formation and promoting kidney health, but specific timelines remain anecdotal. Thus, while some individuals may report metrics of improvement shortly after starting the supplement regimen, others may not see significant results for a longer period. As always, it is advisable to consult with a healthcare provider for personalized timelines and recommendations.
The current scientific evidence raises concerns about the relationship between vitamin D3 supplementation and kidney stones. Several studies, including those identified by research IDs [1], [2], and [3], highlight that, while vitamin D3 can enhance serum vitamin D levels, it may also result in increased urinary calcium excretion. In particular, the risk of developing kidney stones seems to be heightened for individuals who become hypercalciuric following supplementation. This shift in urinary calcium levels could lead to a greater likelihood of stone formation, particularly in patients with a history of kidney stones.
Moreover, the findings that show no significant benefits in preventing kidney stone formation purely from vitamin D3 supplementation [1] suggest that those considering this supplement—especially individuals prone to stones—should proceed with caution. The presence of variations in calcium excretion levels and the potential development of hypercalciuria in some patients after treatment [4] indicate the need for tailored monitoring and management strategies when using vitamin D3. In summary, while vitamin D is crucial for many bodily functions, its role in kidney stone prevention remains unclear, necessitating further exploration and caution.
Users have reported various improvements in symptoms related to kidney health after incorporating vitamin D and K2 supplements into their routines. For instance, one user noted a significant enhancement in their condition after following their doctor's recommendation, stating that the vitamins were effective and helped with small kidney stone formation ((Read Review)). Additionally, others have emphasized the importance of vitamin K in conjunction with vitamin D, highlighting how vitamin K2 helps direct calcium to necessary locations and prevents it from settling in the kidneys, which some users have also linked to a reduction in symptoms and concerns regarding kidney stones ((Read Review)).
Moreover, one individual shared they chose this supplement to avoid vitamin D3 accumulation in the kidneys, suggesting a preventive approach without side effects ((Read Review)). Overall, while many users reflect positively on the potential benefits for kidney health, individual experiences may vary, and it's prudent to consult health professionals for tailored advice and to assess personal health needs.
Based on user reviews, there seems to be a consensus that combining vitamin D with vitamin K2 may be beneficial for managing kidney stones and promoting overall kidney health. Many users reported their healthcare providers recommending this combination specifically to mitigate risks associated with kidney stones. For example, one user noted significant improvements after using vitamin D with vitamin K2, which their doctor suggested as a measure against the formation of small kidney stones ((Read Review)). Additionally, another reviewer emphasized the preventive role of vitamin K2 in directing calcium away from the kidneys, further supporting the idea that this combination can play a critical role in stone prevention ((Read Review)).
Users have also mentioned the importance of cautious supplementation, advising against taking vitamin D without vitamin K due to potential harm to the kidneys, such as renal artery calcification ((Read Review)). Another review suggested that the product helps in preventing vitamin D3 from accumulating in the kidneys, thereby avoiding additional complications related to kidney stones ((Read Review)). Overall, while many users report positive outcomes, combining these supplements should ideally be discussed with a healthcare professional to address individual health needs.
Based on user reviews, many individuals report using Vitamin D3 paired with K2 as a beneficial approach for managing kidney stone formation. One user indicated that their doctor specifically prescribed this combination due to the development of small kidney stones, and they noted noticeable improvement in their condition while taking these vitamins (Read Review). It seems that users appreciate the preventive nature of the dosage they are taking, as a few reviews highlight the importance of Vitamin K in conjunction with Vitamin D to mitigate potential risks to kidney health, especially in avoiding calcium deposits in the kidneys (Read Review).
Additionally, there’s a consensus that this combination can not only support kidney function but also address broader health concerns such as arterial calcification and vitamin deficiencies (Read Review). Users emphasized that the right dosing of these vitamins is critical, pointing out how K2 plays a role in directing calcium to the right locations, preventing its harmful accumulation within the kidneys (Read Review). Thus, for those considering Vitamin D3 and K2 for kidney stone treatment or prevention, ensuring a proper dosage is vital for achieving favorable outcomes.
Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.
We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.
In the study, thirty-three participants, averaging 56 years and deficient in vitamin D, were evaluated before and after receiving cholecalciferol supplements. Initially, we examined both their calcium excretion and urine supersaturation levels, which help indicate the risk of stone formation.
Following the supplementation, we observed several significant changes. Notably, the serum levels of vitamin D increased, and more participants became hypercalciuric, meaning they were excreting higher levels of calcium in their urine. This was concerning as increased urine supersaturation with calcium could elevate the risk of kidney stones.
Despite the rise in vitamin D levels, we didn’t see any major changes in overall calcium levels in the blood, suggesting that the body was managing these variations. However, for those undergoing this treatment, there remains a cautionary note about the potential for increased stone formation due to higher calcium excretion.
After the supplementation, we observed some notable changes. While serum calcium and phosphate levels remained stable, the level of vitamin D3 in the blood saw a significant increase. This led to more kidney stone formers experiencing higher urinary calcium levels. Notably, the percentage of participants with hypercalciuria grew from 18.2% to 39.4%. We also noted an increase in urine supersaturation for brushite, hinting at a potential risk for stone formation.
Overall, our findings suggest that while vitamin D3 supplementation can elevate vitamin D levels, it may also increase urinary calcium and the risk of recurrences for kidney stones. Consequently, careful monitoring of urinary metabolic profiles for patients receiving vitamin D may be necessary to tailor preventive strategies effectively.
To see if supplementing vitamin D3 would provide benefits, we gave 37 of these vitamin D-deficient patients a weekly dose of 20,000 IU for four months. While we noted that this supplementation raised serum vitamin D levels and reduced parathyroid hormone concentrations, the increase in urinary calcium excretion after treatment did not reach statistical significance.
Interestingly, 22 patients had higher calcium levels in their urine, but others experienced a decrease or no change. What’s crucial here is that six patients who were initially normal concerning calcium levels ended up developing hypercalciuria after treatment. This means we should carefully monitor patients who receive vitamin D3 to ensure that they do not experience unexpected increases in calcium excretion that could raise the risk of kidney stones.
References
- Sardari Masihi L, Borumandnia N, Taheri M, Basiri A, Imani H, et al. Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial. Eur J Med Res. 2023;28:246. doi:10.1186/s40001-023-01226-z
- Vitale C, Marangella M, Bermond F, Fabbrini L, Tricerri A. Metabolic effects of cholecalciferol supplementation in patients with calcium nephrolithiasis and vitamin D deficiency. World J Urol. 2021;39:597. doi:10.1007/s00345-020-03222-y
- Vitale C, Tricerri A, Bermond F, Fabbrini L, Guiotto C, et al. [Metabolic effects of Cholecalciferol supplementation in kidney stone formers with vitamin D deficiency]. G Ital Nefrol. 2018;35.
- Johri N, Jaeger P, Ferraro PM, Shavit L, Nair D, et al. Vitamin D deficiency is prevalent among idiopathic stone formers, but does correction pose any risk?. Urolithiasis. 2017;45:535. doi:10.1007/s00240-016-0954-x
