Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.4
USERS' SCORE
Good
Based on 2 Reviews
8.7
Top Medical Research Studies
9.5
Potassium channels induce migraines
We explored the question of whether levcromakalim, a potassium channel opener, can induce migraine attacks in individuals already treated with erenumab, a CGRP receptor antibody. In a double-blind, placebo-controlled study, participants received injections of both levcromakalim and placebo to compare their effects on migraine frequency.
Our findings revealed that levcromakalim led to significantly more migraine attacks within 12 hours compared to placebo, with 88% of participants experiencing attacks after the potassium infusion. This suggests that potassium channels can trigger migraines independently of CGRP activation.
Our findings revealed that levcromakalim led to significantly more migraine attacks within 12 hours compared to placebo, with 88% of participants experiencing attacks after the potassium infusion. This suggests that potassium channels can trigger migraines independently of CGRP activation.
Read More
8
We conducted a thorough investigation into whether levcromakalim, a potassium channel opener, can trigger migraine-like headaches in individuals suffering from persistent post-traumatic headaches.
In our randomized, double-blind study with a placebo group, we found that 57% of participants experienced such headaches after receiving levcromakalim, compared to only 14% after the placebo.
This suggests that potassium channels may play a significant role in the nature of these headaches and indicates that K channel blockers could be a promising area for future treatments.
In our randomized, double-blind study with a placebo group, we found that 57% of participants experienced such headaches after receiving levcromakalim, compared to only 14% after the placebo.
This suggests that potassium channels may play a significant role in the nature of these headaches and indicates that K channel blockers could be a promising area for future treatments.
Read More
7
We investigated whether the drug MaxiPost, which opens large conductance calcium-activated potassium channels, can trigger migraine-like headaches in adults with persistent post-traumatic headache (PPTH) after mild brain injuries.
In a randomized double-blind trial, participants received either MaxiPost or a placebo, with sessions spaced a week apart to prevent bias.
Our findings suggest that activating these potassium channels can indeed induce migraine-like symptoms, paving the way for potential new treatments. However, further research is needed for solid conclusions about using BK channel blockers for PPTH.
In a randomized double-blind trial, participants received either MaxiPost or a placebo, with sessions spaced a week apart to prevent bias.
Our findings suggest that activating these potassium channels can indeed induce migraine-like symptoms, paving the way for potential new treatments. However, further research is needed for solid conclusions about using BK channel blockers for PPTH.
Read More
Most Useful Reviews
10
No migraines enjoyed
44 people found this helpful
Best Travel Med ever, for me. These are simply the best! I easily overheat, which often sidelines me for a day or two. Heat and fatigue trigger my migraines. During a recent holiday in Egypt, I took a pack of these daily at breakfast and an extra pack whenever I felt hot. I managed the entire trip without a migraine or overheating, even in the Sahara! Others became dehydrated and felt ill, but they felt better within 30 minutes of taking these. I now never travel without them.
Read More
9
Highly effective
6 people found this helpful
These tablets are essential in my medicine cabinet! I received them in a wedding welcome bag a year ago, and they changed my life. I experience severe headaches and migraines if dehydrated, but these tablets make rehydration incredibly simple. I take them at the onset of a headache or after a busy day when my water intake has been lacking. They are perfect following a night of festivities.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.4
- All Researches
9.5
Potassium channels induce migraines
We explored the question of whether levcromakalim, a potassium channel opener, can induce migraine attacks in individuals already treated with erenumab, a CGRP receptor antibody. In a double-blind, placebo-controlled study, participants received injections of both levcromakalim and placebo to compare their effects on migraine frequency.
Our findings revealed that levcromakalim led to significantly more migraine attacks within 12 hours compared to placebo, with 88% of participants experiencing attacks after the potassium infusion. This suggests that potassium channels can trigger migraines independently of CGRP activation.
Our findings revealed that levcromakalim led to significantly more migraine attacks within 12 hours compared to placebo, with 88% of participants experiencing attacks after the potassium infusion. This suggests that potassium channels can trigger migraines independently of CGRP activation.
Read More
9
Exploring TRESK's impact on migraine
We examined how TRESK potassium channels could play a role in managing migraine pain. Using both in-vivo and ex-vivo rat models, we tested different activation methods and found that cloxyquin, a TRESK activator, significantly reduced pain and the associated chemical markers linked to migraines.
Although combining it with sumatriptan showed promising results in lab settings, this didn't translate to the animal models. Our findings suggest that targeting TRESK channels might be a viable method for alleviating migraine symptoms.
Although combining it with sumatriptan showed promising results in lab settings, this didn't translate to the animal models. Our findings suggest that targeting TRESK channels might be a viable method for alleviating migraine symptoms.
Read More
8
We conducted a thorough investigation into whether levcromakalim, a potassium channel opener, can trigger migraine-like headaches in individuals suffering from persistent post-traumatic headaches.
In our randomized, double-blind study with a placebo group, we found that 57% of participants experienced such headaches after receiving levcromakalim, compared to only 14% after the placebo.
This suggests that potassium channels may play a significant role in the nature of these headaches and indicates that K channel blockers could be a promising area for future treatments.
In our randomized, double-blind study with a placebo group, we found that 57% of participants experienced such headaches after receiving levcromakalim, compared to only 14% after the placebo.
This suggests that potassium channels may play a significant role in the nature of these headaches and indicates that K channel blockers could be a promising area for future treatments.
Read More
7
We investigated whether the drug MaxiPost, which opens large conductance calcium-activated potassium channels, can trigger migraine-like headaches in adults with persistent post-traumatic headache (PPTH) after mild brain injuries.
In a randomized double-blind trial, participants received either MaxiPost or a placebo, with sessions spaced a week apart to prevent bias.
Our findings suggest that activating these potassium channels can indeed induce migraine-like symptoms, paving the way for potential new treatments. However, further research is needed for solid conclusions about using BK channel blockers for PPTH.
In a randomized double-blind trial, participants received either MaxiPost or a placebo, with sessions spaced a week apart to prevent bias.
Our findings suggest that activating these potassium channels can indeed induce migraine-like symptoms, paving the way for potential new treatments. However, further research is needed for solid conclusions about using BK channel blockers for PPTH.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
No migraines enjoyed
44 people found this helpful
Best Travel Med ever, for me. These are simply the best! I easily overheat, which often sidelines me for a day or two. Heat and fatigue trigger my migraines. During a recent holiday in Egypt, I took a pack of these daily at breakfast and an extra pack whenever I felt hot. I managed the entire trip without a migraine or overheating, even in the Sahara! Others became dehydrated and felt ill, but they felt better within 30 minutes of taking these. I now never travel without them.
Read More
9
Highly effective
6 people found this helpful
These tablets are essential in my medicine cabinet! I received them in a wedding welcome bag a year ago, and they changed my life. I experience severe headaches and migraines if dehydrated, but these tablets make rehydration incredibly simple. I take them at the onset of a headache or after a busy day when my water intake has been lacking. They are perfect following a night of festivities.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Torun IE, Kilinc YB, Kilinc E, Töre F. TRESK channel activation ameliorates migraine-like pain via modulation of CGRP release from the trigeminovascular system and meningeal mast cells in experimental migraine models. Life Sci. 2024;357:123091. doi:10.1016/j.lfs.2024.123091
- Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Melchior AG, et al. Hypersensitivity to BK channel opening in persistent post-traumatic headache. J Headache Pain. 2024;25:102. doi:10.1186/s10194-024-01808-0
- Raffaelli B, Do TP, Chaudhry BA, Amin FM, Ashina H, et al. Activation of ATP-sensitive potassium channels triggers migraine attacks independent of calcitonin gene-related peptide receptors: a randomized placebo-controlled trial. Cephalalgia. 2024;44:3331024231222916. doi:10.1177/03331024231222916
- Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Burstein R, et al. Hypersensitivity to opening of ATP-sensitive potassium channels in post-traumatic headache. Cephalalgia. 2023;43:3331024231210930. doi:10.1177/03331024231210930
