Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.5
Top Medical Research Studies
9
We aimed to understand how retinoic acid (RA), a derivative of vitamin A, impacts hair loss, particularly in individuals suffering from androgenetic alopecia (AGA). By examining hair follicles from both the occipital and frontal areas of the scalp, we were able to conduct RNA sequencing to observe patterns relevant to HFSC (hair follicle stem cell) health.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
9
We explored how zinc acetate hydrate impacts hair loss for patients experiencing symptoms after COVID-19. In our analysis, we looked at 120 symptomatic outpatients over 12 weeks, observing their recovery patterns and any improvements in their symptoms. The focus was on various lingering effects, including fatigue and hair loss, particularly how zinc could potentially alleviate these issues.
Our findings highlighted significant improvements in hair loss for those treated with zinc acetate hydrate at multiple checkpoints (4, 8, and 12 weeks) compared to those who did not receive this treatment. The results were statistically significant and suggested that zinc could be a useful option for those struggling with hair loss post-COVID-19.
Additionally, we noted improvements in fatigue among those receiving zinc, although this was not as pronounced at all time intervals. As a whole, our study emphasized zinc's beneficial effects, particularly for hair loss, providing promising insights for anyone dealing with these challenging post-viral symptoms.
Our findings highlighted significant improvements in hair loss for those treated with zinc acetate hydrate at multiple checkpoints (4, 8, and 12 weeks) compared to those who did not receive this treatment. The results were statistically significant and suggested that zinc could be a useful option for those struggling with hair loss post-COVID-19.
Additionally, we noted improvements in fatigue among those receiving zinc, although this was not as pronounced at all time intervals. As a whole, our study emphasized zinc's beneficial effects, particularly for hair loss, providing promising insights for anyone dealing with these challenging post-viral symptoms.
8
We assessed the impact of a topical solution featuring essential oils, polyunsaturated fatty acids, and Vitamin E on rabbits facing skin diseases. The study included thirty New Zealand rabbits divided into two groups: one treated with the natural formula and a control group.
Over the treatment period, we observed notable improvements in hair shine, hydration, and a reduction in flaking, bad odor, and hair loss in the treatment group. In contrast, the control group showed no such benefits. Overall, this suggests that Vitamin E combined with other natural ingredients can enhance skin and hair health in rabbits.
Over the treatment period, we observed notable improvements in hair shine, hydration, and a reduction in flaking, bad odor, and hair loss in the treatment group. In contrast, the control group showed no such benefits. Overall, this suggests that Vitamin E combined with other natural ingredients can enhance skin and hair health in rabbits.
Most Useful Reviews
9
Stops hair loss
3 people found this helpful
I stopped losing my hair! After noticing hair loss while showering, I began taking these multi-vitamins. Since starting, there has been a significant reduction in hair loss. I will continue to use this for that reason alone.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.8
- All Researches
9
We aimed to understand how retinoic acid (RA), a derivative of vitamin A, impacts hair loss, particularly in individuals suffering from androgenetic alopecia (AGA). By examining hair follicles from both the occipital and frontal areas of the scalp, we were able to conduct RNA sequencing to observe patterns relevant to HFSC (hair follicle stem cell) health.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
In our experiments, we utilized a mouse model to see how administering RA affects hair growth during the telogen phase, a resting period for hair follicles. We then subjected miniaturized hair follicles to RA treatment in controlled organ cultures to assess hair shaft elongation and the activity of HFSCs.
The results revealed that RA signaling appeared to be diminished during AGA, leading to dysfunction in HFSCs. When we treated hair follicles with RA, we observed a notable recovery in hair regeneration. This treatment seemed to promote hair growth by activating HFSCs through Wnt/β-catenin signaling pathways, facilitating their transition from a quiescent to an active state.
Additionally, a clinical part of the study confirmed that RA may hold promise as an early intervention tactic in AGA, reinforcing its role in reviving hair follicle activity. Overall, our findings suggested that vitamin A can be a game-changer in addressing hair loss by effectively reactivating stem cells in hair follicles.
9
We designed a microneedle patch that contains zinc and curcumin, aiming to assess how these ingredients work together to promote hair growth. In our study, we utilized two different animal models to examine the effectiveness of this patch. One model represented androgenic alopecia (AGA), and the other focused on wound healing.
By delivering bioactive zinc particles directly into the skin, we explored how this method could enhance hair regrowth. Our findings showed that the zinc-curcumin combination significantly improved the viability of certain skin cells and countered the negative effects of common hair loss factors, like excess reactive oxygen species and dihydrotestosterone.
Most strikingly, the treatment not only encouraged hair regrowth in the AGA model but also facilitated wound healing. We noted an increase in hair follicles and better cell proliferation, which points to zinc's potential role in supporting both hair health and skin recovery. Overall, our research suggests a promising direction in the use of zinc for addressing hair loss and skin healing more effectively than traditional methods alone.
By delivering bioactive zinc particles directly into the skin, we explored how this method could enhance hair regrowth. Our findings showed that the zinc-curcumin combination significantly improved the viability of certain skin cells and countered the negative effects of common hair loss factors, like excess reactive oxygen species and dihydrotestosterone.
Most strikingly, the treatment not only encouraged hair regrowth in the AGA model but also facilitated wound healing. We noted an increase in hair follicles and better cell proliferation, which points to zinc's potential role in supporting both hair health and skin recovery. Overall, our research suggests a promising direction in the use of zinc for addressing hair loss and skin healing more effectively than traditional methods alone.
9
We explored how zinc acetate hydrate impacts hair loss for patients experiencing symptoms after COVID-19. In our analysis, we looked at 120 symptomatic outpatients over 12 weeks, observing their recovery patterns and any improvements in their symptoms. The focus was on various lingering effects, including fatigue and hair loss, particularly how zinc could potentially alleviate these issues.
Our findings highlighted significant improvements in hair loss for those treated with zinc acetate hydrate at multiple checkpoints (4, 8, and 12 weeks) compared to those who did not receive this treatment. The results were statistically significant and suggested that zinc could be a useful option for those struggling with hair loss post-COVID-19.
Additionally, we noted improvements in fatigue among those receiving zinc, although this was not as pronounced at all time intervals. As a whole, our study emphasized zinc's beneficial effects, particularly for hair loss, providing promising insights for anyone dealing with these challenging post-viral symptoms.
Our findings highlighted significant improvements in hair loss for those treated with zinc acetate hydrate at multiple checkpoints (4, 8, and 12 weeks) compared to those who did not receive this treatment. The results were statistically significant and suggested that zinc could be a useful option for those struggling with hair loss post-COVID-19.
Additionally, we noted improvements in fatigue among those receiving zinc, although this was not as pronounced at all time intervals. As a whole, our study emphasized zinc's beneficial effects, particularly for hair loss, providing promising insights for anyone dealing with these challenging post-viral symptoms.
8
We assessed the impact of a topical solution featuring essential oils, polyunsaturated fatty acids, and Vitamin E on rabbits facing skin diseases. The study included thirty New Zealand rabbits divided into two groups: one treated with the natural formula and a control group.
Over the treatment period, we observed notable improvements in hair shine, hydration, and a reduction in flaking, bad odor, and hair loss in the treatment group. In contrast, the control group showed no such benefits. Overall, this suggests that Vitamin E combined with other natural ingredients can enhance skin and hair health in rabbits.
Over the treatment period, we observed notable improvements in hair shine, hydration, and a reduction in flaking, bad odor, and hair loss in the treatment group. In contrast, the control group showed no such benefits. Overall, this suggests that Vitamin E combined with other natural ingredients can enhance skin and hair health in rabbits.
8
We investigated the effects of nut oil from Prunus mira on hair growth, inspired by traditional Tibetan uses. Using KM and C57BL/6 mice models, we tested different doses and observed an increase in hair follicles and dermal thickness after treatment.
Our findings indicate that specific compounds, including Vitamin E, may boost hair growth by activating the Wnt/β-catenin signaling pathway. While the study shows promise for using this oil in hair restoration, further research is needed to fully understand its effectiveness and application in humans.
Our findings indicate that specific compounds, including Vitamin E, may boost hair growth by activating the Wnt/β-catenin signaling pathway. While the study shows promise for using this oil in hair restoration, further research is needed to fully understand its effectiveness and application in humans.
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Stops hair loss
3 people found this helpful
I stopped losing my hair! After noticing hair loss while showering, I began taking these multi-vitamins. Since starting, there has been a significant reduction in hair loss. I will continue to use this for that reason alone.
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Wen L, Fan Z, Huang W, Miao Y, Zhang J, et al. Retinoic acid drives hair follicle stem cell activation via Wnt/β-catenin signalling in androgenetic alopecia. J Eur Acad Dermatol Venereol. 2025;39:189. doi:10.1111/jdv.20000
- Waisburd GS, Cordero AM, Núñez CR, Contreras LM, Cárdenas RH, et al. Topical effect of a specific spot-on treatment made of natural ingredients in rabbits () with skin problems: A pilot study. Vet World. 2020;13:1760. doi:10.14202/vetworld.2020.1760-1763
- Zhou Y, Tang G, Li X, Sun W, Liang Y, et al. Study on the chemical constituents of nut oil from Prunus mira Koehne and the mechanism of promoting hair growth. J Ethnopharmacol. 2020;258:112831. doi:10.1016/j.jep.2020.112831
- Beoy LA, Woei WJ, Hay YK. Effects of tocotrienol supplementation on hair growth in human volunteers. Trop Life Sci Res. 2010;21:91.
- Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. doi:10.1111/jocd.16740
- Mahmoud H, Saifdeen PM, Al-Timimi D, Saeed SA. Zinc Status in Kurdish Adults With Hair Loss. Cureus. 2024;16:e67264. doi:10.7759/cureus.67264
- Zufishan S, Haque Z, Nazar S, Afaq E, Aamir E, et al. Role of zinc in chronic telogen effluvium in serum and hair of patients with alopecia. J Pak Med Assoc. 2024;74:S47. doi:10.47391/JPMA-DUHS-S10
- Lalosevic J, Gajic-Veljic M, Lalosevic Misovic J, Nikolic M. Serum Zinc Concentration in Patients with Alopecia Areata. Acta Derm Venereol. 2023;103:adv13358. doi:10.2340/actadv.v103.13358
- Yang Y, Wang P, Gong Y, Yu Z, Gan Y, et al. Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth. Theranostics. 2023;13:3675. doi:10.7150/thno.84118
- Starace M, Cedirian S, Bruni F, Alessandrini AM, Quadrelli F, et al. Clinical study on the efficacy and tolerability of an oral supplement based on arginine, l-cystine, zinc and B6 vitamin (Cystiphane®) in patients with telogen effluvium. Ital J Dermatol Venerol. 2023;158:255. doi:10.23736/S2784-8671.23.07576-X
- Matsuoka N, Mizutani T, Kawakami K. Symptom Profile of Patients With Post-COVID-19 Conditions and Influencing Factors for Recovery. J Clin Med Res. 2023;15:116. doi:10.14740/jocmr4855
