Can Metagenics Vitamin D3 Help with Migraine?

Reviewed By

🩺 Dr. Talia Klein

Overview

SCIENTIFIC SCORE

Possibly Effective

Based on 29 Researches

7.3

USERS' SCORE

Good

Based on 2 Reviews

8.6

Top Medical Research Studies

Vitamin D helps reduce migraines

Hu C, Fan Y, Wu S, Zou Y, Qu X. Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021;50:784. doi:10.1016/j.ajem.2021.07.062

We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.

Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.

However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.

Vitamin D reduces migraine symptoms

Zhang YF, Xu ZQ, Zhou HJ, Liu YZ, Jiang XJ. The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies. Clin Neuropharmacol. 2021;44:5. doi:10.1097/WNF.0000000000000419

We explored how vitamin D may impact migraines through a systematic review and meta-analysis of randomized controlled trials.

Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.

This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.

Vitamin D linked to lower migraines

Niu PP, Wang X, Xu YM. Higher Circulating Vitamin D Levels Are Associated With Decreased Migraine Risk: A Mendelian Randomization Study. Front Nutr. 2022;9:907789. doi:10.3389/fnut.2022.907789

We investigated how vitamin D levels in the body are related to the risk of experiencing migraines. Using a method called Mendelian randomization, we carefully examined data from a large group of over 400,000 individuals to identify genetic factors linked to vitamin D levels. We found a total of 184 genetic instruments to analyze the potential relationship.

The findings were intriguing: as vitamin D levels increase, the risk of migraines appears to decrease. This association was confirmed through multiple datasets, showing that higher vitamin D is associated with a reduced likelihood of having migraines. The results were consistent not just for general migraine types but also for specific subtypes, such as migraines with and without aura.

Interestingly, while we checked for potential mediators like serum calcium, the contribution of calcium to this relationship was minimal. Our research suggests that low vitamin D levels could be a concern for migraine sufferers, and it highlighted the need for further well-designed studies. We recommend that future research explore the effects of vitamin D supplementation, especially for those who may be deficient in this important nutrient.

Most Useful Reviews

Chronic migraines resolved

28 people found this helpful

Great product! I would recommend it to everyone. I've struggled with sinus issues for years, but since starting this, I haven't had any symptoms! For the first time in years, I also used to experience chronic migraines, and they have completely gone away. After researching this, I realised I had many symptoms of low vitamin D3. I thought, what do I have to lose? I'm ordering my second bottle and am certain I will continue taking it indefinitely!

Improved condition noted

5 people found this helpful

I adore Metagenics, but it needs higher MK7 content. My Integrative Health physician recommended this brand for my thin 15-year-old son. We take the PhytoMulti and D3/K2 combination, and the quality has been superb. My son's health has considerably improved, and he hasn't experienced a migraine since starting this vitamin. His eczema has cleared up entirely. These vitamins come packaged in brown glass—no plastic. I love them and believe they are worth the price.

Medical Researches

SCIENTIFIC SCORE

Possibly Effective

Based on 29 Researches

7.3

9.5

Effective migraine prevention strategy

Buettner C, Nir RR, Bertisch SM, Bernstein C, Schain A, et al. Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial. Ann Neurol. 2015;78:970. doi:10.1002/ana.24534

We conducted a thorough investigation into the effectiveness of simvastatin paired with vitamin D3 for preventing migraines in adults with episodic migraine. Our study was a well-structured randomized, double-blind, placebo-controlled trial involving 57 participants over a span of 24 weeks.

Participants were divided into two groups: one receiving simvastatin and vitamin D3, while the other received placebos. Throughout the trial, we observed that those taking the combination of simvastatin and vitamin D3 experienced a significant reduction in the number of migraine days when compared to those on placebos. Specifically, during the first 12 weeks, participants on the active regimen reported a decrease of 8.0 migraine days, whereas those on placebos noted an increase of 1.0 migraine days.

By the end of the 24-week period, an impressive 29% of participants taking the medication reported a 50% or more reduction in their migraine days. In contrast, only 3% of those taking the placebo experienced similar relief. Interestingly, we found that the occurrence of adverse events was similar in both groups, indicating that the combination therapy was generally well-tolerated.

Our findings showcase the potential benefits of using simvastatin alongside vitamin D3 as an effective strategy for managing migraines, while also addressing some underlying health risks associated with migraines, such as vascular issues.

Vitamin D may alleviate migraines

Ioannidou E, Tsakiris C, Goulis DG, Christoforidis A, Zafeiriou D. The association of serum vitamin D concentrations in paediatric migraine. Eur J Paediatr Neurol. 2023;47:60. doi:10.1016/j.ejpn.2023.09.007

We aimed to understand how vitamin D impacts migraine headaches in children. Through a thorough review of existing literature, we explored the significant association between serum vitamin D levels and the frequency and duration of migraine episodes in the pediatric population.

Our findings suggest that children with migraines might benefit from vitamin D supplementation. By potentially reducing the number and intensity of migraine episodes, vitamin D could improve the overall quality of life for these young patients.

It's important to note that this connection primarily focuses on children, as most studies have looked at adults. With vitamin D deficiency being a growing public health concern, our research highlights how addressing this deficiency may serve as a helpful strategy in managing pediatric migraines.

Pediatric migraines and vitamin D

Kotb Elmala M, Suliman HA, Al-Shokary AH, Ibrahim AO, Kamal NM, et al. The Impact of Vitamin D Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis. J Child Neurol. 2022;37:833. doi:10.1177/08830738221092882

We conducted a study to investigate whether adding vitamin D supplements to topiramate therapy would improve migraine outcomes in children aged 5 to 14. In our double-blinded clinical trial, we randomly assigned participants to receive either topiramate with a daily 5000-IU vitamin D supplement or topiramate with a placebo for four months. By evaluating changes in headache frequency, severity, disability, and overall response to treatment, we aimed to see if vitamin D could provide additional benefits.

Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.

Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.

Vitamin D helps reduce migraines

Hu C, Fan Y, Wu S, Zou Y, Qu X. Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021;50:784. doi:10.1016/j.ajem.2021.07.062

Vitamin D reduces migraine symptoms

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