Last update
2/26/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin K₂ (as MK-7 [Menaquinone-7])
90 mcg
†
Top Medical Research Studies
9
We examined how Menaquinone-4, a form of vitamin K2, could help protect the heart during a critical event known as ischemia-reperfusion (I/R) injury, which often occurs after heart attacks. In our study, we used thirty-two rats, dividing them into three groups: a control group that experienced I/R without treatment, a group that received MK-4 before the injury, and another group that got MK-4 at the beginning of the recovery phase.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
Read More
8
We explored the effect of dietary intake of menaquinone, commonly known as vitamin K2, on heart attack risk and overall heart health. The investigation drew on data from the Rotterdam Study, tracking 4,807 individuals who did not have prior heart attacks.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
Read More
7
We examined the effectiveness of rivaroxaban compared to vitamin K antagonists (VKAs) in treating patients with left ventricular thrombus (LVT) following a heart attack. Our retrospective study involved 1,335 patients and found that rivaroxaban not only worked as effectively as VKAs but also led to quicker LVT resolution.
Although patients taking rivaroxaban experienced fewer adverse events, the difference in bleeding risks between the two treatments wasn't significant. These findings suggest that rivaroxaban may offer clinical advantages, but further research is necessary to confirm these results.
Although patients taking rivaroxaban experienced fewer adverse events, the difference in bleeding risks between the two treatments wasn't significant. These findings suggest that rivaroxaban may offer clinical advantages, but further research is necessary to confirm these results.
Read More
Most Useful Reviews
9
Essential combination
244 people found this helpful
I advise against taking vitamin D3 without MK-7 vitamin K2. D3 promotes calcium absorption in the intestines, but without K2, that calcium can calcify your arteries, leading to a heart attack. K2 helps direct calcium to the bones where it belongs, making MK-7 crucial for proper absorption.
Read More
7.5
Heart health boost
1 people found this helpful
Helps lower the risk of a heart attack and redirects excess calcium into bones instead of arteries, avoiding blockages.
Read More
7.5
Natural supplement impact
I am very satisfied with Jarrow Formulas MK-7 Vitamin K2. It supports my bone and cardiovascular health, notably reducing the risk of heart attacks. The MK-7 version is stable and easier to absorb, and I've seen positive health changes since taking it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
- All Researches
9
Coumarin indicates potential heart protection
We investigated the cardioprotective effects of a newly developed coumarin, known as 5,6-PhSHC, on heart damage caused by isoproterenol-induced myocardial infarction in rats. The study involved treating rats with 5,6-PhSHC or clopidogrel before inducing a heart attack.
Our findings showed that 5,6-PhSHC improved electrocardiogram patterns and reduced markers of heart injury. Additionally, it helped reverse tissue damage and regulated cholesterol levels. While the results are promising, more research is needed to determine its potential for human use.
Our findings showed that 5,6-PhSHC improved electrocardiogram patterns and reduced markers of heart injury. Additionally, it helped reverse tissue damage and regulated cholesterol levels. While the results are promising, more research is needed to determine its potential for human use.
Read More
9
We examined how Menaquinone-4, a form of vitamin K2, could help protect the heart during a critical event known as ischemia-reperfusion (I/R) injury, which often occurs after heart attacks. In our study, we used thirty-two rats, dividing them into three groups: a control group that experienced I/R without treatment, a group that received MK-4 before the injury, and another group that got MK-4 at the beginning of the recovery phase.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
Read More
8
Comparative effectiveness of antithrombotic therapies
We evaluated the outcomes of patients with left ventricular thrombus (LVT) after a heart attack, focusing on dual antithrombotic therapy (DAT) versus triple antithrombotic therapy (TAT).
Analyzing a decade's worth of records from our hospital, we found that those on DAT had significantly fewer major complications after one year compared to those on TAT, particularly in terms of bleeding.
With over two-thirds of complications occurring shortly after discharge, the findings suggest that DAT may be the safer option for these patients. However, a randomized study is needed for confirmation.
Analyzing a decade's worth of records from our hospital, we found that those on DAT had significantly fewer major complications after one year compared to those on TAT, particularly in terms of bleeding.
With over two-thirds of complications occurring shortly after discharge, the findings suggest that DAT may be the safer option for these patients. However, a randomized study is needed for confirmation.
Read More
8
We examined whether novel oral anticoagulants (NOACs) are more effective than vitamin K antagonists (VKAs) for treating left ventricular thrombus in heart attack patients. In our observational study of 2328 patients, we found that 4.3% had left ventricular thrombus.
Those treated with NOACs showed faster and better thrombus resolution at one year compared to the VKA group. Additionally, major bleeding events were significantly lower in the NOAC group. These findings suggest that NOACs could offer a safer and more effective option for patients post-heart attack.
Those treated with NOACs showed faster and better thrombus resolution at one year compared to the VKA group. Additionally, major bleeding events were significantly lower in the NOAC group. These findings suggest that NOACs could offer a safer and more effective option for patients post-heart attack.
Read More
8
We explored the effect of dietary intake of menaquinone, commonly known as vitamin K2, on heart attack risk and overall heart health. The investigation drew on data from the Rotterdam Study, tracking 4,807 individuals who did not have prior heart attacks.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential combination
244 people found this helpful
I advise against taking vitamin D3 without MK-7 vitamin K2. D3 promotes calcium absorption in the intestines, but without K2, that calcium can calcify your arteries, leading to a heart attack. K2 helps direct calcium to the bones where it belongs, making MK-7 crucial for proper absorption.
Read More
7.5
Heart health boost
1 people found this helpful
Helps lower the risk of a heart attack and redirects excess calcium into bones instead of arteries, avoiding blockages.
Read More
7.5
Natural supplement impact
I am very satisfied with Jarrow Formulas MK-7 Vitamin K2. It supports my bone and cardiovascular health, notably reducing the risk of heart attacks. The MK-7 version is stable and easier to absorb, and I've seen positive health changes since taking it.
Read More
7.5
Cardiovascular system health
This wonderful supplement is excellent for supporting bone and heart health. The high level of vitamin K2 (MK-7) helps regulate calcium, which is critical for maintaining the cardiovascular system and avoiding heart attacks.
Read More
7.5
Disease prevention
28 people found this helpful
This product appears innovative for preventing heart attack and heart disease. I use it every other morning with omega 3-6-9 and vitamin D. Since then, the occasional minor chest pains I've experienced over the past 20 years seem to have reduced significantly. If it indeed prevents calcium from entering arteries, it is worth exploring.
Read More
Frequently Asked Questions
7.5
Cardiovascular system health
This wonderful supplement is excellent for supporting bone and heart health. The high level of vitamin K2 (MK-7) helps regulate calcium, which is critical for maintaining the cardiovascular system and avoiding heart attacks.
8
We explored the effect of dietary intake of menaquinone, commonly known as vitamin K2, on heart attack risk and overall heart health. The investigation drew on data from the Rotterdam Study, tracking 4,807 individuals who did not have prior heart attacks.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
9
We examined how Menaquinone-4, a form of vitamin K2, could help protect the heart during a critical event known as ischemia-reperfusion (I/R) injury, which often occurs after heart attacks. In our study, we used thirty-two rats, dividing them into three groups: a control group that experienced I/R without treatment, a group that received MK-4 before the injury, and another group that got MK-4 at the beginning of the recovery phase.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
References
- Ghazouani L, Khdhiri E, Elmufti A, Zarei A, Feriani A, et al. A novel synthetised sulphonylhydrazone coumarin (E)-4-methyl-N'-(1-(3-oxo-3H-benzo[f]chromen-2- yl)ethylidene)benzenesulphonohydrazide protect against isoproterenol-induced myocardial infarction in rats by attenuating oxidative damage, biological changes and electrocardiogram. Clin Exp Pharmacol Physiol. 2022;49:1010. 10.1111/1440-1681.13690
- Park J, Jung JH, Choi EK, Lee SW, Kwon S, et al. Comparison of early clinical outcomes between dual antiplatelet therapy and triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention. PLoS One. 2022;17:e0264538. 10.1371/journal.pone.0264538
- De Luca L, Putini RL, Natale E, Terranova A, Piazza V, et al. One-year clinical outcome of patients with left ventricular thrombus after acute myocardial infarction discharged on triple or dual antithrombotic therapy. J Thromb Thrombolysis. 2022;53:410. 10.1007/s11239-021-02577-2
- Zhang Z, Si D, Zhang Q, Qu M, Yu M, et al. Rivaroxaban versus Vitamin K Antagonists (warfarin) based on the triple therapy for left ventricular thrombus after ST-Elevation myocardial infarction. Heart Vessels. 2022;37:374. 10.1007/s00380-021-01921-z
- Alcalai R, Butnaru A, Moravsky G, Yagel O, Rashad R, et al. Apixaban vs. warfarin in patients with left ventricular thrombus: a prospective multicentre randomized clinical trial‡. Eur Heart J Cardiovasc Pharmacother. 2022;8:660. 10.1093/ehjcvp/pvab057
- Wang MT, Hung CC, Lin KC, Mar GY, Kuo SH, et al. Comparison of effects of triple antithrombotic therapy and dual antiplatelet therapy on long-term outcomes of acute myocardial infarction. Heart Vessels. 2021;36:345. 10.1007/s00380-020-01708-8
- Jones DA, Wright P, Alizadeh MA, Fhadil S, Rathod KS, et al. The use of novel oral anticoagulants compared to vitamin K antagonists (warfarin) in patients with left ventricular thrombus after acute myocardial infarction. Eur Heart J Cardiovasc Pharmacother. 2021;7:398. 10.1093/ehjcvp/pvaa096
- Hassan AE, Hadhoud S, Elmahdi E, Elkattawy HA. Potential Cardioprotective Role of Menaquinone-4 Against Cardiac Ischemia-reperfusion Injury. J Cardiovasc Pharmacol. 2023;81:381. 10.1097/FJC.0000000000001413
- Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004;134:3100.
Data last updated:
