We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Read More
7
Vitamin D3 reduces allergy cytokines
Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis.
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Read More
7
Vitamin D3 may reduce eczema risk
Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Read More
Most Useful Reviews
9
No allergy-inducing
1 people found this helpful
Good vitamins! I ordered them based on recommendations and reviews. The packaging is convenient, making it easy to squeeze out the right amount of drops. The main point is that it does not contain anything that may cause allergies.
Read More
10
No side effects
Everything is superb! I did not experience any allergies or other reactions. Regarding the dispenser—carefully read the product description! With proper use, everything drips fine. It is a little expensive, of course, but enough for a short time.
Read More
10
Effective switch
Excellent vitamin D, one of the best formulas for newborns. After using regular water bottles that caused an allergy, we switched to these, and now there are no allergies. This is one of my favourite companies; I also take other products from them.
Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy.
We investigated the effects of combining vitamin D3 with fluticasone propionate inhalation aerosol in children with bronchial asthma. Our study involved 110 patients who were divided into two groups: one receiving only the inhalation treatment and the other receiving both the inhalation treatment and vitamin D3. By comparing these groups, we aimed to understand how vitamin D3 could potentially enhance immune function and improve symptoms related to asthma.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
Read More
8
Vitamin D3 impacts allergy severity
Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis.
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Read More
7
Vitamin D3 reduces allergy cytokines
Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis.
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Read More
7
Vitamin D3 may reduce eczema risk
Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Read More
7
Vitamin D's role in allergies
Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study.
We conducted a study focusing on the intriguing relationship between vitamin D3 levels and allergies, specifically in patients with chronic and allergic sinusitis. Our research involved 90 subjects divided into three groups: healthy controls, chronic sinusitis patients, and those suffering from allergic sinusitis.
Throughout the study, we measured serum levels of vitamin D3 and immunoglobulin E (IgE) using an ELISA method. The results revealed that a significant portion of our participants—60%—had insufficient vitamin D, with those afflicted by allergic sinusitis showing even higher deficiencies.
Interestingly, we observed that female participants were more likely to experience vitamin D deficiency. Additionally, cravings for higher levels of IgE protein were primarily noted in the allergic sinusitis group, further linking low vitamin D levels with allergy severity.
Our findings suggest that vitamin D deficiency may play a role in increasing susceptibility to allergic sinusitis, presenting a case for considering vitamin D supplementation as a potential adjunctive therapy for these patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 34 Reviews
8.4
All Reviews
Positive Reviews
Negative Reviews
9
No allergy-inducing
1 people found this helpful
Good vitamins! I ordered them based on recommendations and reviews. The packaging is convenient, making it easy to squeeze out the right amount of drops. The main point is that it does not contain anything that may cause allergies.
Read More
10
No side effects
Everything is superb! I did not experience any allergies or other reactions. Regarding the dispenser—carefully read the product description! With proper use, everything drips fine. It is a little expensive, of course, but enough for a short time.
Read More
10
Effective switch
Excellent vitamin D, one of the best formulas for newborns. After using regular water bottles that caused an allergy, we switched to these, and now there are no allergies. This is one of my favourite companies; I also take other products from them.
Read More
9
No allergic reactions
Excellent! This is my find for a child with a predisposition to allergies. The allergist advised against giving the vitamin in coconut oil, which I had originally. This preparation is based on organic sunflower seeds. There is no allergic reaction.
Read More
9
Well tolerated
Vitamin D3: The baby responds well to this vitamin; the ingredients do not cause allergies or gas. The taste is neutral and oily. We began using it at one month, and it has continued.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Children's Vitamin D is a dietary supplement specifically formulated to support the health and development of children. Vitamin D is crucial for maintaining healthy bones and teeth, and it plays an essential role in the functioning of the immune system. Young children, especially those who may have limited sun exposure or dietary intake of vitamin D, are often recommended to take these supplements to ensure they receive adequate levels for optimal growth and development.
Typically, children's vitamin D supplements come in various forms such as chewable tablets, gummies, or liquid drops, making them more palatable for younger audiences. The most common form is vitamin D3 (cholecalciferol), which is considered more effective in raising vitamin D levels in the body than D2 (ergocalciferol). It's essential for parents to consult with a pediatrician before starting any supplement to determine the right dosage based on individual health needs and lifestyle factors. Proper intake of vitamin D not only supports bone health but also has been linked to other health benefits, such as improved mood and immune response, making it a valuable addition to children's wellness routines.
Based on user reviews, many individuals report experiencing positive results shortly after starting the supplement. While specific timelines for allergy relief are not consistently mentioned, the general sentiment suggests a quick response. For instance, several users noted that they did not face any allergic reactions right from the first dose or initial use, and many felt reassured by the absence of side effects. This includes feedback from parents who specifically stated their children showed no allergies after starting the supplement, with statements like "The child drinks it and there are no allergies!" [Read Review] and "It did not cause allergies in the child." [Read Review].
However, it's essential to note that experiences can vary among individuals, and while many report alleviation or prevention of allergy symptoms soon after use, others may take longer to see similar outcomes. Consequently, while you may expect to see results quickly, it’s advisable to monitor your response over a period and consult with a healthcare professional for personalized advice.
Recent studies indicate that vitamin D3 may offer some benefits for managing allergies, particularly regarding its influence on immune responses. For example, a study showed that calcitriol, the active form of vitamin D3, significantly reduced the production of key cytokines associated with allergic reactions, namely IL-4 and IL-13. This suggests that vitamin D3 could help modulate immune cell behavior related to allergies, providing a basis for further research into its therapeutic potential in allergy management [2].
Moreover, other research has linked low vitamin D3 levels with increased severity of allergic conditions like allergic rhinitis and sinusitis, demonstrating a notable inverse relationship between vitamin D3 levels and immunoglobulin E (IgE)—a marker commonly associated with allergic responses [4]. However, while these findings point to potential associations between vitamin D3 and alleviation of allergy symptoms, the exact mechanisms and efficacy of vitamin D3 as a standalone treatment for allergies require more extensive investigation to establish clearer guidelines [1]. Overall, while vitamin D3 shows promise, it should be approached as a complementary approach rather than a primary solution for allergies.
Users of this vitamin D supplement have reported a consistent improvement in symptoms, particularly in relation to allergic reactions. Many reviewers highlight that neither they nor their children experienced any allergies after starting the product. For example, one user emphasized, "It does not cause allergies," while another shared their relief stating, "The child drinks it and there are no allergies!" [Read Review]. This trend is reinforced across multiple reviews where users confidently recommend the product based on their experiences of safety and efficacy regarding allergies—evident in statements like, "Excellent! The composition is good, and the child has no allergies" [Read Review].
Moreover, several parents noted a noticeable absence of symptoms like gas and discomfort often associated with other supplements, making them feel more secure in administering this product to their infants. A user remarked that their baby "responds well to this vitamin; the ingredients do not cause allergies or gas" [Read Review]. Overall, the comments indicate that many have found success in using this vitamin D supplement, particularly for children with a predisposition to allergies. However, as always, individual experiences may vary, and it’s prudent for users to monitor their own or their child's responses when introducing any new supplement.
Based on user reviews, many individuals have found that this vitamin D supplement can be effectively combined with other dietary supplements without triggering allergic reactions. Users reported that after switching to this product, they experienced no allergy symptoms, even when introduced alongside other vitamins. For example, one parent noted a successful transition from regular water bottles that caused allergies to this vitamin D, stating, "After using regular water bottles that caused an allergy, we switched to these, and now there are no allergies" Read Review. Furthermore, a user shared their positive experience of having a child with a predisposition to allergies who shows no adverse reactions after mixing the supplement with milk, expressing satisfaction with, "We drip into the mixture for the baby; there are no allergies" Read Review.
Overall, users highlight the safety and compatibility of this supplement with other products in managing allergies, emphasizing the clean composition that avoids common allergens. One parent specifically noted, "It does not cause allergies," underscoring the consistent feedback on the product's effectiveness in preventing allergic reactions when combined with various foods or supplements Read Review. While individual experiences may differ, the general consensus suggests that users are pleased with the seamless integration of this vitamin in their child's dietary routine, reporting no adverse effects.
Based on user reviews, many parents reported success with administering Children's Vitamin D for allergy prevention, noting that the product's formula seemed to be well-tolerated by their children. The optimal dosing mentioned by users often ranged from one to two drops daily. For instance, one review indicated that a user gave 2 drops as prescribed by their doctor without any allergic reactions (Read Review), while another mentioned giving 1 drop daily in the morning as a good practice to avoid potential disruptions to sleep (Read Review).
Parents appreciated the ingredient composition, which was claimed to be free from common allergens. Several reviews highlighted that switching to this particular Vitamin D product relieved their children's allergy symptoms when compared to alternatives, such as those in coconut oil (Read Review). Most users expressed satisfaction with the ease of use and convenience of the drops, making it simpler to administer vitamins without adverse reactions (Read Review). Overall, the feedback suggests that the right dosage of Children's Vitamin D, when properly administered, can be effective in managing allergies in children.
9
Child drinks
The child drinks it and there are no allergies!
9
No allergies
Excellent! Everyone liked it. It did not cause allergies in the child.
9
Good composition
Excellent! The composition is good, and the child has no allergies. I give 2 drops as prescribed by the doctor.
9
Well tolerated
Vitamin D3: The baby responds well to this vitamin; the ingredients do not cause allergies or gas. The taste is neutral and oily. We began using it at one month, and it has continued.
10
Effective switch
Excellent vitamin D, one of the best formulas for newborns. After using regular water bottles that caused an allergy, we switched to these, and now there are no allergies. This is one of my favourite companies; I also take other products from them.
9
No allergies
Excellent! We drip into the mixture for the baby; there are no allergies.
9
Convenient to take
Perfectly formulated! One of the best D3 for babies; it does not cause allergies and is convenient to take.
9
No sleep issues
Excellent vitamin D; we use 2 drops from birth. It is organic and does not cause allergies. It's better to administer it in the morning, as taking it in the evening might disrupt the child's sleep.
9
No allergic reactions
Excellent! This is my find for a child with a predisposition to allergies. The allergist advised against giving the vitamin in coconut oil, which I had originally. This preparation is based on organic sunflower seeds. There is no allergic reaction.
9
No allergies
This product is great for babies! I purchased it for my newborn, and there were no allergies. It’s easy to dose, and since I only need to give 1-3 drops a day, a small volume lasts a long time.
7
Vitamin D3 reduces allergy cytokines
Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis.
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
8
Vitamin D3 impacts allergy severity
Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis.
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
8
Vitamin D3 may support asthma treatment
Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy.
We investigated the effects of combining vitamin D3 with fluticasone propionate inhalation aerosol in children with bronchial asthma. Our study involved 110 patients who were divided into two groups: one receiving only the inhalation treatment and the other receiving both the inhalation treatment and vitamin D3. By comparing these groups, we aimed to understand how vitamin D3 could potentially enhance immune function and improve symptoms related to asthma.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
References
Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
Biswas B, Chattopadhyay S, Hazra S, Goswami R. Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis. J Immunol. 2024;213:831. 10.4049/jimmunol.2400078
Zeng R, Lodge CJ, Koplin JJ, Lopez DJ, Erbas B, et al. Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age. Nutrients. 2024;16. 10.3390/nu16091303
Al-Allaff RGM, Bakr Al-Sawaf TM. Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis. Pak J Biol Sci. 2024;27:27. 10.3923/pjbs.2024.27.34
Bagheri P, Nouri M, Eskandarzadeh H, Darvishi M. Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study. Recent Adv Inflamm Allergy Drug Discov. 2024;18:108. 10.2174/0127722708281623240116100806