Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8

Top Medical Research Studies

9
Nicomide shows notable acne improvement
We conducted a study to evaluate how effective Nicomide, which includes folic acid, is for treating acne and rosacea. Over eight weeks, 198 patients tracked their progress. Remarkably, 79% reported noticeable improvements after just four weeks, with many seeing over 50% reduction in lesions.

What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
Read More
We explored the effectiveness of biotin as a treatment for acne, focusing on its potential benefits for those experiencing skin issues linked to biotin deficiency. Biotin is a vitamin that, when levels are low, can contribute to hair loss and skin disorders like seborrheic dermatitis.

In our overview, we noted that while biotin may help improve hair loss, its impact on acne treatment shows promise primarily when combined with other therapies, particularly topical retinoids. These treatments address not just acne but also flaking and irritation commonly associated with skin conditions.

Overall, we found that biotin's role in managing acne is intriguing, especially given its excellent tolerability and safety, even at high doses. However, we emphasize that biotin should be taken under medical supervision following a proper diagnosis.
Read More
9
Tracnil™ shows efficacy for acne
We evaluated the effectiveness of Tracnil™, a blend of myo-inositol, folic acid, and vitamin D3, in treating acne among 33 overweight women with normal hormone levels. This single-arm study monitored acne severity, hirsutism, and menstrual irregularities over eight weeks.

Results revealed significant reductions in acne lesions and improvements in hirsutism and menstrual cycles, all with minimal side effects. Although the subjects had normal hormone levels, Tracnil™ seemed to enhance receptor sensitivity to sex hormones, positioning it as a promising first-line treatment for acne linked to PCOS.
Read More

Most Useful Reviews

7.5
Reduced cystic acne
4 people found this helpful
Great for Hair. I initially took a different gummy vitamin for hair loss but got the Olly vitamin as a substitute. I feel converted as my hair has never been healthier; it’s growing and shining as it should. I’ve noticed less intense cystic acne while taking these, making the experience positive for me.
Read More
6
Effective multivitamin
13 people found this helpful
Works as it should! I took the entire 90 count bottle, and nothing odd happened. I was hesitant to try these vitamins due to concerns about breakouts, but they didn’t worsen my acne. I didn’t experience hair loss, and I feel more energetic. While some complain about the taste, I find them acceptable because they are vitamins, not sweets. They work well for me as a daily multivitamin.
Read More
2
Breakout concerns
5 people found this helpful
I've been taking these vitamins for about a month, and I've noticed a couple of things. I can’t be sure if the vitamins are the cause, but I had no menstrual cramps this month. That’s remarkable since I usually suffer terribly. However, I also experienced a sudden outbreak of deep pimples on my face and back, which is unusual. As I researched, I found this is a common side effect of multivitamins, so I suspect they are to blame. I have stopped taking them to see if my acne clears up.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
  • All Researches
9
Tracnil™ shows efficacy for acne
We evaluated the effectiveness of Tracnil™, a blend of myo-inositol, folic acid, and vitamin D3, in treating acne among 33 overweight women with normal hormone levels. This single-arm study monitored acne severity, hirsutism, and menstrual irregularities over eight weeks.

Results revealed significant reductions in acne lesions and improvements in hirsutism and menstrual cycles, all with minimal side effects. Although the subjects had normal hormone levels, Tracnil™ seemed to enhance receptor sensitivity to sex hormones, positioning it as a promising first-line treatment for acne linked to PCOS.
Read More
We examined the impact of adding a new dietary supplement, NicAzel, to existing acne treatments in 235 patients with inflammatory acne vulgaris over an 8-week period.

The study showed promising results, with 88% of participants reporting a reduction in inflammatory lesions after using NicAzel. Moreover, 81% felt their complexion improved significantly, and many rated this supplement as effective as previous antibiotic treatments.

However, it's essential to note that while these findings are encouraging, further studies are needed to fully understand its long-term efficacy and safety.
Read More
9
Nicomide shows notable acne improvement
We conducted a study to evaluate how effective Nicomide, which includes folic acid, is for treating acne and rosacea. Over eight weeks, 198 patients tracked their progress. Remarkably, 79% reported noticeable improvements after just four weeks, with many seeing over 50% reduction in lesions.

What’s interesting is that adding oral antibiotics didn’t enhance the results compared to using Nicomide alone. This suggests that Nicomide could be a valuable alternative to antibiotics for those struggling with these skin conditions.
Read More
We explored the potential of combining an oral biotin supplement with a topical gel in addressing mild to moderate acne. Our research focused on understanding whether this innovative treatment approach could provide better results than traditional therapies, which often come with side effects.

In our study, we treated participants with a specially formulated supplement containing biotin and three strains of lactic ferments, alongside a topical gel that included azelaic acid, hydroxypinacolone retinoate, and α-hydroxy acids. After 60 days of treatment, we observed notable improvements among the patients.

While we did not solely evaluate the isolated effects of biotin, our findings indicate that combining it with topical treatments may hold promise for managing acne symptoms. However, we must acknowledge that more focused research is necessary to pinpoint the direct impact of biotin itself on acne specifically.
Read More
8
Biotin aids isotretinoin effects
We evaluated the effects of biotin on acne treatment by studying two groups of patients undergoing isotretinoin therapy. Our research involved 60 participants, with each group consisting of 30 individuals. Both groups received isotretinoin, but only one group incorporated a daily biotin supplement.

Throughout the study, we measured changes in skin and hair using various methods, including a digital dermoscope and a specialized device assessing skin hydration and sebum levels. We found that the group taking biotin experienced significant improvements: the rate of hair in the anagen (growth) phase increased, while hair in the telogen (resting) phase decreased. Meanwhile, those who just took isotretinoin alone faced a notable drop in skin hydration.

The results suggest that adding biotin can effectively help maintain skin health and reduce some common side effects associated with isotretinoin. This indicates that biotin may have a protective role against the adverse effects typically seen in patients undergoing acne treatments.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Reduced cystic acne
4 people found this helpful
Great for Hair. I initially took a different gummy vitamin for hair loss but got the Olly vitamin as a substitute. I feel converted as my hair has never been healthier; it’s growing and shining as it should. I’ve noticed less intense cystic acne while taking these, making the experience positive for me.
Read More
6
Effective multivitamin
13 people found this helpful
Works as it should! I took the entire 90 count bottle, and nothing odd happened. I was hesitant to try these vitamins due to concerns about breakouts, but they didn’t worsen my acne. I didn’t experience hair loss, and I feel more energetic. While some complain about the taste, I find them acceptable because they are vitamins, not sweets. They work well for me as a daily multivitamin.
Read More
2
Breakout concerns
5 people found this helpful
I've been taking these vitamins for about a month, and I've noticed a couple of things. I can’t be sure if the vitamins are the cause, but I had no menstrual cramps this month. That’s remarkable since I usually suffer terribly. However, I also experienced a sudden outbreak of deep pimples on my face and back, which is unusual. As I researched, I found this is a common side effect of multivitamins, so I suspect they are to blame. I have stopped taking them to see if my acne clears up.
Read More

Frequently Asked Questions

No FAQs are available for this product and symptom.

References

  1. Ramanan EA, Ravi S, Anbu KRR, Michael M. Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study. Dermatol Res Pract. 2020;2020:7019126. doi:10.1155/2020/7019126
  2. Advani K, Batra M, Tajpuriya S, Gupta R, Saraswat A, et al. Efficacy of combination therapy of inositols, antioxidants and vitamins in obese and non-obese women with polycystic ovary syndrome: an observational study. J Obstet Gynaecol. 2020;40:96. doi:10.1080/01443615.2019.1604644
  3. Ghiasi M, Mortazavi H, Jafari M. Efficacy of Folic Acid and Vitamin B Replacement Therapies in the Reduction of Adverse Effects of Isotretinoin: A Randomized Controlled Trial. Skinmed. 2018;16:239.
  4. Tolino E, Skroza N, Mambrin A, Bernardini N, Zuber S, et al. Novel combination for the treatment of acne differentiated based on gender: a new step towards personalized treatment. G Ital Dermatol Venereol. 2018;153:866. doi:10.23736/S0392-0488.18.05710-3
  5. Shalita AR, Falcon R, Olansky A, Iannotta P, Akhavan A, et al. Inflammatory acne management with a novel prescription dietary supplement. J Drugs Dermatol. 2012;11:1428.
  6. Niren NM, Torok HM. The Nicomide Improvement in Clinical Outcomes Study (NICOS): results of an 8-week trial. Cutis. 2006;77:17.
  7. Marasca C, Ruggiero A, Cacciapuoti S, Fabbrocini G, Annunziata MC. Probiotic supplement combined with topical therapy in the treatment of mild to moderate acne: results from an Italian single centre interventional study. Ital J Dermatol Venerol. 2022;157:510. doi:10.23736/S2784-8671.22.07361-3
  8. Aksac SE, Bilgili SG, Yavuz GO, Yavuz IH, Aksac M, et al. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters. Int J Dermatol. 2021;60:980. doi:10.1111/ijd.15485
  9. Piraccini BM, Berardesca E, Fabbrocini G, Micali G, Tosti A. Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea. G Ital Dermatol Venereol. 2019;154:557. doi:10.23736/S0392-0488.19.06434-4
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