Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.4
Top Medical Research Studies
8
Zinc may alleviate anxiety symptoms
We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.
What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.
In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.
What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.
In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.
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8
We explored how vitamin A, more specifically its active form retinoic acid (RA), impacts anxiety levels. In this study, researchers discovered that a specific protein, cellular RA binding protein 1 (Crabp1), plays a crucial role in regulating responses to stress. Mice lacking Crabp1 showed significantly lower levels of anxiety and less stress-induced hormone release, indicating that Crabp1 dampens the body's stress response.
By examining the interactions between Crabp1 and another protein called FKBP5, we observed that reducing Crabp1 levels led to decreased FKBP5 expression. This is important because lower FKBP5 levels lessened feedback inhibition in the hypothalamic-pituitary-adrenal (HPA) axis, which in turn helped reduce anxiety-like behaviors. It was noted that stress and RA can actually increase Crabp1 levels, which may heighten FKBP5 expression and possibly raise the risk of anxiety disorders.
Essentially, this study sheds light on the complex relationship between vitamin A, Crabp1, and anxiety, suggesting that while Crabp1 modulates stress responses beneficially, an overabundance can potentially increase anxiety risks.
By examining the interactions between Crabp1 and another protein called FKBP5, we observed that reducing Crabp1 levels led to decreased FKBP5 expression. This is important because lower FKBP5 levels lessened feedback inhibition in the hypothalamic-pituitary-adrenal (HPA) axis, which in turn helped reduce anxiety-like behaviors. It was noted that stress and RA can actually increase Crabp1 levels, which may heighten FKBP5 expression and possibly raise the risk of anxiety disorders.
Essentially, this study sheds light on the complex relationship between vitamin A, Crabp1, and anxiety, suggesting that while Crabp1 modulates stress responses beneficially, an overabundance can potentially increase anxiety risks.
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7
Zinc alleviates acrylamide-induced anxiety
We explored the effects of zinc treatment on anxiety caused by exposure to acrylamide, a harmful chemical found in some foods that can lead to cognitive decline and emotional distress. In our study, twenty male Wistar rats were divided into four groups; one group received water, while the other groups were given a daily oral dose of acrylamide.
Among those exposed to acrylamide, some were treated with low and high doses of zinc for eight weeks. We observed that zinc significantly improved anxiety-like behavior in the treated groups. This suggests that zinc acts not only as a protector against cognitive impairment but also helps in alleviating anxiety symptoms associated with acrylamide exposure.
Furthermore, zinc demonstrated antioxidant and anti-inflammatory effects, which could contribute to its ability to improve mood and mental function. Overall, zinc emerged as a promising contender in mitigating anxiety and cognitive challenges posed by acrylamide, leading to better mental clarity and emotional well-being.
Among those exposed to acrylamide, some were treated with low and high doses of zinc for eight weeks. We observed that zinc significantly improved anxiety-like behavior in the treated groups. This suggests that zinc acts not only as a protector against cognitive impairment but also helps in alleviating anxiety symptoms associated with acrylamide exposure.
Furthermore, zinc demonstrated antioxidant and anti-inflammatory effects, which could contribute to its ability to improve mood and mental function. Overall, zinc emerged as a promising contender in mitigating anxiety and cognitive challenges posed by acrylamide, leading to better mental clarity and emotional well-being.
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Most Useful Reviews
7.5
Improved mood swings
7 people found this helpful
My son suffered from anxiety and had poor nutrition. I started him on this supplement and vitamin D out of concern. After two months, his mood swings improved, and his appetite returned. He agreed to take these vitamins due to their texture, and I’m very pleased with the results.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
- All Researches
9
We aimed to understand how zinc chloride may help reduce anxiety, particularly when combined with diazepam. In our study, we organized Wistar albino rats into five groups, with each group receiving different combinations of zinc chloride and diazepam. The dosages included two different levels of diazepam (1 and 2 mg/kg) paired with a consistent dose of zinc chloride (10 mg/kg).
To assess the anxiety levels of the rats, we employed four established models: the Elevated Plus Maze, the hole board, the light and dark box, and the mirror chamber. Our observations indicated that when combined, zinc chloride and diazepam produced more potent anxiolytic effects compared to when either treatment was used alone. This suggests a possible synergistic effect that could enhance anxiety relief.
Overall, we found that zinc chloride, especially when combined with diazepam, can significantly improve anxiety outcomes in these animal models. This research opens the door to further studies on zinc's role in anxiety management and its potential as a supplementary treatment option alongside traditional medications.
To assess the anxiety levels of the rats, we employed four established models: the Elevated Plus Maze, the hole board, the light and dark box, and the mirror chamber. Our observations indicated that when combined, zinc chloride and diazepam produced more potent anxiolytic effects compared to when either treatment was used alone. This suggests a possible synergistic effect that could enhance anxiety relief.
Overall, we found that zinc chloride, especially when combined with diazepam, can significantly improve anxiety outcomes in these animal models. This research opens the door to further studies on zinc's role in anxiety management and its potential as a supplementary treatment option alongside traditional medications.
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9
Zinc reduces anxiety in treatment
In a recent study, we investigated how zinc supplementation could impact anxiety levels among patients undergoing methadone maintenance treatment for opioid use disorder. The research involved a randomized controlled trial with 68 participants. We divided them into two groups: one received zinc supplements along with their usual methadone treatment, while the other group only received methadone.
Our findings revealed some encouraging results regarding anxiety reduction. Specifically, we noted a significant decrease in anxiety levels among those who took zinc, with a marked difference when compared to the control group. This was assessed using the Depression, Anxiety, and Stress Scale 21 (DASS-21), where we observed a notable reduction in anxiety scores following the treatment period.
Overall, it appears that zinc supplementation may contribute positively to reducing anxiety in this particular patient demographic. However, since zinc was combined with methadone treatment, it's essential we approach these findings with caution and encourage further research to clarify the role of zinc supplementation alone.
Our findings revealed some encouraging results regarding anxiety reduction. Specifically, we noted a significant decrease in anxiety levels among those who took zinc, with a marked difference when compared to the control group. This was assessed using the Depression, Anxiety, and Stress Scale 21 (DASS-21), where we observed a notable reduction in anxiety scores following the treatment period.
Overall, it appears that zinc supplementation may contribute positively to reducing anxiety in this particular patient demographic. However, since zinc was combined with methadone treatment, it's essential we approach these findings with caution and encourage further research to clarify the role of zinc supplementation alone.
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8
This study explored the effects of anxiety treatments, specifically focusing on the role of vitamin A. We discovered that while vitamin A was mentioned among other potential therapies, its isolated effect on anxiety was not clearly defined. Out of several treatments tested on stressed adolescent rodents, vitamin A showed promise but was grouped with other interventions, limiting our ability to pinpoint its direct impact.
Interestingly, prior findings suggest that a healthy diet rich in omega-3 fatty acids and vitamin A, along with antidepressants and other treatments, could prevent or reverse the negative consequences of stress. However, the current data doesn't provide strong evidence that vitamin A alone can effectively reduce anxiety or improve cognitive functions related to stress exposure.
Overall, the relationship between vitamin A and anxiety needs further exploration. We remain hopeful that future studies will clarify its specific benefits and allow us to better understand how dietary factors can influence mental health during critical developmental periods.
Interestingly, prior findings suggest that a healthy diet rich in omega-3 fatty acids and vitamin A, along with antidepressants and other treatments, could prevent or reverse the negative consequences of stress. However, the current data doesn't provide strong evidence that vitamin A alone can effectively reduce anxiety or improve cognitive functions related to stress exposure.
Overall, the relationship between vitamin A and anxiety needs further exploration. We remain hopeful that future studies will clarify its specific benefits and allow us to better understand how dietary factors can influence mental health during critical developmental periods.
Read More
8
We explored how vitamin A, more specifically its active form retinoic acid (RA), impacts anxiety levels. In this study, researchers discovered that a specific protein, cellular RA binding protein 1 (Crabp1), plays a crucial role in regulating responses to stress. Mice lacking Crabp1 showed significantly lower levels of anxiety and less stress-induced hormone release, indicating that Crabp1 dampens the body's stress response.
By examining the interactions between Crabp1 and another protein called FKBP5, we observed that reducing Crabp1 levels led to decreased FKBP5 expression. This is important because lower FKBP5 levels lessened feedback inhibition in the hypothalamic-pituitary-adrenal (HPA) axis, which in turn helped reduce anxiety-like behaviors. It was noted that stress and RA can actually increase Crabp1 levels, which may heighten FKBP5 expression and possibly raise the risk of anxiety disorders.
Essentially, this study sheds light on the complex relationship between vitamin A, Crabp1, and anxiety, suggesting that while Crabp1 modulates stress responses beneficially, an overabundance can potentially increase anxiety risks.
By examining the interactions between Crabp1 and another protein called FKBP5, we observed that reducing Crabp1 levels led to decreased FKBP5 expression. This is important because lower FKBP5 levels lessened feedback inhibition in the hypothalamic-pituitary-adrenal (HPA) axis, which in turn helped reduce anxiety-like behaviors. It was noted that stress and RA can actually increase Crabp1 levels, which may heighten FKBP5 expression and possibly raise the risk of anxiety disorders.
Essentially, this study sheds light on the complex relationship between vitamin A, Crabp1, and anxiety, suggesting that while Crabp1 modulates stress responses beneficially, an overabundance can potentially increase anxiety risks.
Read More
8
We explored the effects of retinoic acid (RA), a form of vitamin A, on anxiety-like behaviors in zebrafish. Our study aimed to understand how RA could help alleviate the anxiety induced by exposure to benzo[a]pyrene (B[a]P), a common environmental contaminant known to cause oxidative stress and neurotoxicity.
Through careful observation, we found that B[a]P exposure did indeed lead to increased anxiety-like behaviors in zebrafish. However, co-supplementing with RA appeared to reduce these anxiety responses. We noticed that the antioxidant activities were also positively influenced by RA, suggesting that it plays a protective role against the neurotoxic effects of B[a]P.
Yet, it's important to note that excessive or insufficient levels of RA could also induce oxidative stress, highlighting the delicate balance needed for this vitamin to be effective. Our study indicated that a careful administration of RA could provide therapeutic benefits, particularly in mitigating the neurotoxic effects caused by environmental contaminants like B[a]P.
In summary, we found that while RA can help counteract anxiety-like behaviors associated with B[a]P toxicity in zebrafish, caution is necessary regarding its concentration. The findings shed light on the potential of RA as an essential nutrient for maintaining mental health, particularly in polluted environments.
Through careful observation, we found that B[a]P exposure did indeed lead to increased anxiety-like behaviors in zebrafish. However, co-supplementing with RA appeared to reduce these anxiety responses. We noticed that the antioxidant activities were also positively influenced by RA, suggesting that it plays a protective role against the neurotoxic effects of B[a]P.
Yet, it's important to note that excessive or insufficient levels of RA could also induce oxidative stress, highlighting the delicate balance needed for this vitamin to be effective. Our study indicated that a careful administration of RA could provide therapeutic benefits, particularly in mitigating the neurotoxic effects caused by environmental contaminants like B[a]P.
In summary, we found that while RA can help counteract anxiety-like behaviors associated with B[a]P toxicity in zebrafish, caution is necessary regarding its concentration. The findings shed light on the potential of RA as an essential nutrient for maintaining mental health, particularly in polluted environments.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved mood swings
7 people found this helpful
My son suffered from anxiety and had poor nutrition. I started him on this supplement and vitamin D out of concern. After two months, his mood swings improved, and his appetite returned. He agreed to take these vitamins due to their texture, and I’m very pleased with the results.
Read More
Frequently Asked Questions
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References
- Borsini A, Giacobbe J, Mandal G, Boldrini M. Acute and long-term effects of adolescence stress exposure on rodent adult hippocampal neurogenesis, cognition, and behaviour. Mol Psychiatry. 2023;28:4124. doi:10.1038/s41380-023-02229-2
- Lin YL, Wei CW, Lerdall TA, Nhieu J, Wei LN. Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression. Int J Mol Sci. 2021;22. doi:10.3390/ijms222212240
- Qin XY, Fang H, Shan QH, Qi CC, Zhou JN. All-trans Retinoic Acid-induced Abnormal Hippocampal Expression of Synaptic Genes and is Correlated with Anxiety or Depression-Like Behavior in Mice. Int J Mol Sci. 2020;21. doi:10.3390/ijms21082677
- Mohanty R, Das SK, Patri M. Modulation of Benzo[a]Pyrene Induced Anxiolytic-Like Behavior by Retinoic Acid in Zebrafish: Involvement of Oxidative Stress and Antioxidant Defense System. Neurotox Res. 2017;31:493. doi:10.1007/s12640-016-9694-5
- Schnorr CE, Bittencourt Lda S, Petiz LL, Gelain DP, Zeidán-Chuliá F, et al. Chronic retinyl palmitate supplementation to middle-aged Wistar rats disrupts the brain redox homeostasis and induces changes in emotional behavior. Mol Nutr Food Res. 2015;59:979. doi:10.1002/mnfr.201400637
- Tomášová L, Hvizdošová N, Boleková A, Smajda B, Kluchová D. Vitamin A and amygdala: functional and morphological consequences. Neurol Sci. 2014;35:1585. doi:10.1007/s10072-014-1802-9
- Bonhomme D, Minni AM, Alfos S, Roux P, Richard E, et al. Vitamin A status regulates glucocorticoid availability in Wistar rats: consequences on cognitive functions and hippocampal neurogenesis?. Front Behav Neurosci. 2014;8:20. doi:10.3389/fnbeh.2014.00020
- Ajibare AJ, Akintoye OO, Oriowo OA, Asuku AO, Oriyomi IA, et al. Zinc Ameliorates Acrylamide-Induced Cognitive Impairment in Male Wistar Rats: Modulation of Oxidative Stress, Neuro-inflammation, and Neurotrophic Pathways. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04490-0
- Apryatin S, Lopachev A, Zhukov I, Efimova E, Apryatina V. BEHAVIORAL AND NEUROCHEMICAL CHANGES DURING INTRANASAL ADMINISTRATION OF ALPHA-GLUTAMYL-TRYPTOPHAN AND CHELATE COMPLEX OF ZINC ARGINYL-GLYCINATE ON MONOAMINE SYSTEMS DYSFUNCTIONS KNOCK-OUT MODELS. Georgian Med News. 2024.
- Naik VV, Desai VH, Noronha S. Synergistic anxiolytic efficacy exploring the combined effects of diazepam and zinc chloride in wistar albino rats. Drug Res (Stuttg). 2024;74:220. doi:10.1055/a-2308-9192
- Tomas-Sanchez C, Blanco-Alvarez VM, Gonzalez-Barrios JA, Martinez-Fong D, Soto-Rodriguez G, et al. Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack. Heliyon. 2024;10:e30017. doi:10.1016/j.heliyon.2024.e30017
- Sameei P, Fatehfar S, Abdollahzadeh N, Chodari L, Saboory E, et al. The effects of forced exercise and zinc supplementation during pregnancy on prenatally stress-induced behavioral and neurobiological consequences in adolescent female rat offspring. Dev Psychobiol. 2023;65:e22411. doi:10.1002/dev.22411
- Azargoonjahromi A. A systematic review of the association between zinc and anxiety. Nutr Rev. 2024;82:612. doi:10.1093/nutrit/nuad076
- Hamdi E, Muñiz-Gonzalez AB, Hidouri S, Bermejo AM, Sakly M, et al. Prevention of neurotoxicity and cognitive impairment induced by zinc nanoparticles by oral administration of saffron extract. J Anim Physiol Anim Nutr (Berl). 2023;107:1473. doi:10.1111/jpn.13848
- Amini Z, HeidariFarsani E. Investigating the effect of zinc supplementation on probability of relapse and mental health in patients with opioid use disorder undergoing methadone maintenance treatment. Subst Abuse Treat Prev Policy. 2023;18:1. doi:10.1186/s13011-023-00514-5
