Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8.4
Top Medical Research Studies
8
High-dose vitamin D reduces anxiety
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Read More
8
We examined if there is a connection between vitamin D levels and anxiety among US adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2012. The study included over 12,000 participants and employed sophisticated statistical methods to determine the relationship between serum vitamin D and anxiety.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Read More
8
Vitamin D mitigates anxiety symptoms
We explored the impact of changing levels of a specific enzyme, CYP11A1, in the placenta and how it might influence anxiety and social behavior in offspring. Using a unique mouse model, we found that higher levels of this enzyme are associated with behaviors similar to those seen in autism spectrum disorders (ASD), such as reduced social interaction and increased anxiety.
Interestingly, we observed that these anxiety-related behaviors improved significantly after administering vitamin D3. Behavioral tests, including open field and elevated plus maze assessments, showed that the mice exhibited less anxiety when given this supplement.
Additionally, our study highlighted that vitamin D3 could help correct some of the hormonal imbalances linked to CYP11A1 overexpression. Higher progesterone levels and increased inflammation were noted in the affected mice, and these issues seemed to reverse with vitamin D3 treatment.
This research underscores not only the potential role of vitamin D in managing anxiety but also suggests that examining CYP11A1 levels could be important for understanding and perhaps preventing some neurodevelopmental disorders. Overall, it appears vitamin D3 may serve as a useful tool in mitigating anxiety linked to hormonal changes during development.
Interestingly, we observed that these anxiety-related behaviors improved significantly after administering vitamin D3. Behavioral tests, including open field and elevated plus maze assessments, showed that the mice exhibited less anxiety when given this supplement.
Additionally, our study highlighted that vitamin D3 could help correct some of the hormonal imbalances linked to CYP11A1 overexpression. Higher progesterone levels and increased inflammation were noted in the affected mice, and these issues seemed to reverse with vitamin D3 treatment.
This research underscores not only the potential role of vitamin D in managing anxiety but also suggests that examining CYP11A1 levels could be important for understanding and perhaps preventing some neurodevelopmental disorders. Overall, it appears vitamin D3 may serve as a useful tool in mitigating anxiety linked to hormonal changes during development.
Read More
Most Useful Reviews
7.5
Improved mood swings
7 people found this helpful
My son experienced anxiety and did not eat well. After introducing this supplement and vitamin D, his mood swings improved, and his appetite got better after a couple of months. He liked these vitamins, and I’m very pleased overall.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
- All Researches
8
High-dose vitamin D reduces anxiety
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Read More
8
Vitamin D mitigates anxiety symptoms
We explored the impact of changing levels of a specific enzyme, CYP11A1, in the placenta and how it might influence anxiety and social behavior in offspring. Using a unique mouse model, we found that higher levels of this enzyme are associated with behaviors similar to those seen in autism spectrum disorders (ASD), such as reduced social interaction and increased anxiety.
Interestingly, we observed that these anxiety-related behaviors improved significantly after administering vitamin D3. Behavioral tests, including open field and elevated plus maze assessments, showed that the mice exhibited less anxiety when given this supplement.
Additionally, our study highlighted that vitamin D3 could help correct some of the hormonal imbalances linked to CYP11A1 overexpression. Higher progesterone levels and increased inflammation were noted in the affected mice, and these issues seemed to reverse with vitamin D3 treatment.
This research underscores not only the potential role of vitamin D in managing anxiety but also suggests that examining CYP11A1 levels could be important for understanding and perhaps preventing some neurodevelopmental disorders. Overall, it appears vitamin D3 may serve as a useful tool in mitigating anxiety linked to hormonal changes during development.
Interestingly, we observed that these anxiety-related behaviors improved significantly after administering vitamin D3. Behavioral tests, including open field and elevated plus maze assessments, showed that the mice exhibited less anxiety when given this supplement.
Additionally, our study highlighted that vitamin D3 could help correct some of the hormonal imbalances linked to CYP11A1 overexpression. Higher progesterone levels and increased inflammation were noted in the affected mice, and these issues seemed to reverse with vitamin D3 treatment.
This research underscores not only the potential role of vitamin D in managing anxiety but also suggests that examining CYP11A1 levels could be important for understanding and perhaps preventing some neurodevelopmental disorders. Overall, it appears vitamin D3 may serve as a useful tool in mitigating anxiety linked to hormonal changes during development.
Read More
8
We examined if there is a connection between vitamin D levels and anxiety among US adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2012. The study included over 12,000 participants and employed sophisticated statistical methods to determine the relationship between serum vitamin D and anxiety.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Read More
8
We evaluated the effectiveness of a treatment combining probiotics and vitamin D on patients suffering from irritable bowel syndrome, particularly focusing on those who experience anxiety. The study involved adult participants diagnosed with diarrhea-predominant IBS or mixed bowel movements, who took a daily sachet containing specific probiotic strains and vitamin D for 42 days.
At the end of the treatment period, we saw that a significant percentage of patients reported relief from their symptoms. Specifically, many in the study reported a marked decrease in the severity of their IBS symptoms, which was linked to improved quality of life and reductions in both anxiety and depression scores.
However, while vitamin D was part of the treatment regimen, it was used alongside probiotics, making it challenging to pinpoint the individual effect of vitamin D alone on anxiety. Still, the findings suggest that the combination might beneficially impact gut-related anxiety among IBS patients.
At the end of the treatment period, we saw that a significant percentage of patients reported relief from their symptoms. Specifically, many in the study reported a marked decrease in the severity of their IBS symptoms, which was linked to improved quality of life and reductions in both anxiety and depression scores.
However, while vitamin D was part of the treatment regimen, it was used alongside probiotics, making it challenging to pinpoint the individual effect of vitamin D alone on anxiety. Still, the findings suggest that the combination might beneficially impact gut-related anxiety among IBS patients.
Read More
8
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.
This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved mood swings
7 people found this helpful
My son experienced anxiety and did not eat well. After introducing this supplement and vitamin D, his mood swings improved, and his appetite got better after a couple of months. He liked these vitamins, and I’m very pleased overall.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Charoenporn V, Tungsukruthai P, Teacharushatakit P, Hanvivattanakul S, Sriyakul K, et al. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial. Psychiatry Clin Neurosci. 2024;78:595. doi:10.1111/pcn.13716
- Yin H, Zhang J, Chen Y, Guo J, Li Q, et al. Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention. Brain Behav Immun. 2024;121:13. doi:10.1016/j.bbi.2024.07.012
- Domacassé D, de Rooij SR, Vrijkotte T, de Jonge A, Henrichs J. Associations Between Early-Pregnancy Vitamin D Status and Postpartum Depressive and Anxiety Symptoms. Psychosom Med. 2024;86:648. doi:10.1097/PSY.0000000000001328
- Wen Z, Bai L, Wu S, Chen J, Jama HA, et al. Association of serum vitamin D with anxiety in US adults: a cross-sectional study. Front Nutr. 2024;11:1371170. doi:10.3389/fnut.2024.1371170
- Zhao W, Zhu DM, Shen Y, Zhang Y, Chen T, et al. The protective effect of vitamin D supplementation as adjunctive therapy to antidepressants on brain structural and functional connectivity of patients with major depressive disorder: a randomized controlled trial. Psychol Med. 2024;54:2403. doi:10.1017/S0033291724000539
- Jouët P, Altman C, Bruley DES Varannes S, Juhel C, Henri F. Probiotics plus vitamin D in irritable bowel syndrome: a prospective multicentric non-interventional study. Minerva Gastroenterol (Torino). 2024;70:332. doi:10.23736/S2724-5985.24.03581-2
- Renteria KM, Constantine E, Teoh CM, Cooper A, Lozano N, et al. Combination of vitamin D and fructooligosaccharides upregulates colonic vitamin D receptor in C57BL/6J mice and affects anxiety-related behavior in a sex-specific manner. Nutr Res. 2024;125:16. doi:10.1016/j.nutres.2024.02.003
- Gammoh O, Ibrahim A, Yehya A, Alqudah A, Qnais E, et al. Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide. Int J Mol Sci. 2024;25. doi:10.3390/ijms25041960
- Nunes EJ, Kimble V, Rajadhyaksha AM, Addy NA. L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats. Neuroscience. 2025;568:314. doi:10.1016/j.neuroscience.2025.01.003
