Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.8
USERS' SCORE
Good
Based on 2 Reviews
8.3
Top Medical Research Studies
9
We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
Read More
8
We examined how incorporating fly ash into magnesium phosphate repair mortar (MPM) influences its effectiveness in cold environments. Our investigation revealed that fly ash modifies the microstructure of the MPM, enhancing its performance without affecting the setting time or fluidity significantly.
We discovered that adding 10% to 15% fly ash improves the mechanical strength, adhesion, water resistance, and stability of the mortar. Notably, we found that the curing temperature plays a critical role; as the temperature rises, compressive strength increases, while properties like flexural strength decrease.
Interestingly, even when cured in icy conditions at -20°C or 0°C, MPM with fly ash retains good early strength and strong adhesion properties. This suggests magnesium phosphate repair mortar modified with fly ash is suitable for emergency repairs in cold weather, showcasing its potential for use in challenging environments.
We discovered that adding 10% to 15% fly ash improves the mechanical strength, adhesion, water resistance, and stability of the mortar. Notably, we found that the curing temperature plays a critical role; as the temperature rises, compressive strength increases, while properties like flexural strength decrease.
Interestingly, even when cured in icy conditions at -20°C or 0°C, MPM with fly ash retains good early strength and strong adhesion properties. This suggests magnesium phosphate repair mortar modified with fly ash is suitable for emergency repairs in cold weather, showcasing its potential for use in challenging environments.
Read More
9
We examined the use of copper-magnesium (CuMg) alloys, particularly focusing on those with higher magnesium content, to understand how they perform during cold metal working processes. Our testing aimed to identify the effects of magnesium on the mechanical properties and workability of these alloys, as they’re known to provide significant solid-solution hardening.
The results revealed that CuMg alloys with 2 to 4 weight percent (wt%) magnesium displayed impressive strength characteristics, outperforming commonly used materials like pure copper and aluminum. We calculated improvements in hardness and Ultimate Tensile Strength (UTS), showing increases of up to two and a half times compared to pure copper. However, we noted that while magnesium enhances strength, it also raises friction during processing, which can complicate metal forming.
We learned that increasing magnesium content could lead to brittleness when it exceeded approximately 3.6 wt%, introducing challenges for cold working. This brittleness arises from the formation of specific phases, making it challenging to use these alloys in practical applications. Our findings suggest that while magnesium can significantly boost the mechanical properties of CuMg alloys, careful consideration is needed regarding its maximum content to maintain ductility and workability.
The results revealed that CuMg alloys with 2 to 4 weight percent (wt%) magnesium displayed impressive strength characteristics, outperforming commonly used materials like pure copper and aluminum. We calculated improvements in hardness and Ultimate Tensile Strength (UTS), showing increases of up to two and a half times compared to pure copper. However, we noted that while magnesium enhances strength, it also raises friction during processing, which can complicate metal forming.
We learned that increasing magnesium content could lead to brittleness when it exceeded approximately 3.6 wt%, introducing challenges for cold working. This brittleness arises from the formation of specific phases, making it challenging to use these alloys in practical applications. Our findings suggest that while magnesium can significantly boost the mechanical properties of CuMg alloys, careful consideration is needed regarding its maximum content to maintain ductility and workability.
Read More
Most Useful Reviews
7.5
Prevents cold illness
9 people found this helpful
The only daily vitamin you need! I love these; they are easy to swallow. I take them with my biotin after breakfast without any stomach issues. I feel more energised and have been prone to illnesses like strep, the flu, or the common cold, but I've not been sick since starting them.
Read More
7.5
Muscle and immune support
2 people found this helpful
They work immediately! They are great for my muscles and immune system. I barely catch a cold now, and they are ideal to take just before a workout at the gym!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.8
- All Researches
9
We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
Read More
9
Magnesium enhances vascular preservation
We examined the effectiveness of modified Krebs-Henseleit (KH) solutions with low calcium and high magnesium levels on preserving vascular function during cold storage. Our focus was on whether adding adenosine and lidocaine could further improve the preservation of rat aortic rings after six days of cold preservation.
In our study, we found that traditional preservation solutions often fail to maintain proper vascular function after just three days of cold storage. However, when we tested a modified KH solution with lower calcium and higher magnesium, we observed significant recovery of contraction and relaxation functions in the aortic rings. This suggests that magnesium plays a vital role in preserving these functions.
Interestingly, while adding adenosine and lidocaine did not enhance contraction, it did improve the aortic rings' ability to relax in response to a chemical called acetylcholine. Furthermore, a histological examination showed that the addition of adenosine positively affected the endothelial lining and structural integrity of the vessels, highlighting its importance in cold preservation.
Overall, our findings suggest that magnesium in combination with adenosine significantly enhances the preservation of vascular structures and functionalities during extended cold storage, making it an important consideration for vascular grafts.
In our study, we found that traditional preservation solutions often fail to maintain proper vascular function after just three days of cold storage. However, when we tested a modified KH solution with lower calcium and higher magnesium, we observed significant recovery of contraction and relaxation functions in the aortic rings. This suggests that magnesium plays a vital role in preserving these functions.
Interestingly, while adding adenosine and lidocaine did not enhance contraction, it did improve the aortic rings' ability to relax in response to a chemical called acetylcholine. Furthermore, a histological examination showed that the addition of adenosine positively affected the endothelial lining and structural integrity of the vessels, highlighting its importance in cold preservation.
Overall, our findings suggest that magnesium in combination with adenosine significantly enhances the preservation of vascular structures and functionalities during extended cold storage, making it an important consideration for vascular grafts.
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9
Magnesium improves beef storage safety
We explored the effects of incorporating hydrogen-producing magnesium into minced beef meat (MBM) to see how it affects quality and safety during cold storage. The study involved vacuum packaging the MBMs and storing them at 4°C for 12 days while comparing them with other treatments, such as gassing with hydrogen or nitrogen.
What we found was quite promising. The samples with magnesium showed the lowest browning index values, which indicates less color change and better visual quality. Additionally, these samples exhibited reduced bacterial counts, including mesophilic and psychrotrophic bacteria, as well as yeast and molds. This suggests that magnesium can help in maintaining the freshness and safety of the meat.
Interestingly, the magnesium treatment also limited the formation of potentially harmful compounds, such as thiobarbituric acid reactive substances and biogenic amines, which can negatively impact meat quality. By the end of the storage period, the control samples had the highest levels of volatile compounds, hinting at spoilage, while magnesium-enhanced and vacuum-packaged samples fared better.
Overall, we observed that using hydrogen-producing magnesium while handling minced beef could be an effective way to protect important quality attributes and safety during cold storage.
What we found was quite promising. The samples with magnesium showed the lowest browning index values, which indicates less color change and better visual quality. Additionally, these samples exhibited reduced bacterial counts, including mesophilic and psychrotrophic bacteria, as well as yeast and molds. This suggests that magnesium can help in maintaining the freshness and safety of the meat.
Interestingly, the magnesium treatment also limited the formation of potentially harmful compounds, such as thiobarbituric acid reactive substances and biogenic amines, which can negatively impact meat quality. By the end of the storage period, the control samples had the highest levels of volatile compounds, hinting at spoilage, while magnesium-enhanced and vacuum-packaged samples fared better.
Overall, we observed that using hydrogen-producing magnesium while handling minced beef could be an effective way to protect important quality attributes and safety during cold storage.
Read More
9
We examined the use of copper-magnesium (CuMg) alloys, particularly focusing on those with higher magnesium content, to understand how they perform during cold metal working processes. Our testing aimed to identify the effects of magnesium on the mechanical properties and workability of these alloys, as they’re known to provide significant solid-solution hardening.
The results revealed that CuMg alloys with 2 to 4 weight percent (wt%) magnesium displayed impressive strength characteristics, outperforming commonly used materials like pure copper and aluminum. We calculated improvements in hardness and Ultimate Tensile Strength (UTS), showing increases of up to two and a half times compared to pure copper. However, we noted that while magnesium enhances strength, it also raises friction during processing, which can complicate metal forming.
We learned that increasing magnesium content could lead to brittleness when it exceeded approximately 3.6 wt%, introducing challenges for cold working. This brittleness arises from the formation of specific phases, making it challenging to use these alloys in practical applications. Our findings suggest that while magnesium can significantly boost the mechanical properties of CuMg alloys, careful consideration is needed regarding its maximum content to maintain ductility and workability.
The results revealed that CuMg alloys with 2 to 4 weight percent (wt%) magnesium displayed impressive strength characteristics, outperforming commonly used materials like pure copper and aluminum. We calculated improvements in hardness and Ultimate Tensile Strength (UTS), showing increases of up to two and a half times compared to pure copper. However, we noted that while magnesium enhances strength, it also raises friction during processing, which can complicate metal forming.
We learned that increasing magnesium content could lead to brittleness when it exceeded approximately 3.6 wt%, introducing challenges for cold working. This brittleness arises from the formation of specific phases, making it challenging to use these alloys in practical applications. Our findings suggest that while magnesium can significantly boost the mechanical properties of CuMg alloys, careful consideration is needed regarding its maximum content to maintain ductility and workability.
Read More
8
We examined how incorporating fly ash into magnesium phosphate repair mortar (MPM) influences its effectiveness in cold environments. Our investigation revealed that fly ash modifies the microstructure of the MPM, enhancing its performance without affecting the setting time or fluidity significantly.
We discovered that adding 10% to 15% fly ash improves the mechanical strength, adhesion, water resistance, and stability of the mortar. Notably, we found that the curing temperature plays a critical role; as the temperature rises, compressive strength increases, while properties like flexural strength decrease.
Interestingly, even when cured in icy conditions at -20°C or 0°C, MPM with fly ash retains good early strength and strong adhesion properties. This suggests magnesium phosphate repair mortar modified with fly ash is suitable for emergency repairs in cold weather, showcasing its potential for use in challenging environments.
We discovered that adding 10% to 15% fly ash improves the mechanical strength, adhesion, water resistance, and stability of the mortar. Notably, we found that the curing temperature plays a critical role; as the temperature rises, compressive strength increases, while properties like flexural strength decrease.
Interestingly, even when cured in icy conditions at -20°C or 0°C, MPM with fly ash retains good early strength and strong adhesion properties. This suggests magnesium phosphate repair mortar modified with fly ash is suitable for emergency repairs in cold weather, showcasing its potential for use in challenging environments.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Prevents cold illness
9 people found this helpful
The only daily vitamin you need! I love these; they are easy to swallow. I take them with my biotin after breakfast without any stomach issues. I feel more energised and have been prone to illnesses like strep, the flu, or the common cold, but I've not been sick since starting them.
Read More
7.5
Muscle and immune support
2 people found this helpful
They work immediately! They are great for my muscles and immune system. I barely catch a cold now, and they are ideal to take just before a workout at the gym!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Fenzl A, Kulterer OC, Spirk K, Mitulović G, Marculescu R, et al. Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis. Mol Metab. 2020;42:101088. doi:10.1016/j.molmet.2020.101088
- Arsyad A, Lembang GKR, Linda SL, Djabir YY, Dobson GP. Low Calcium-High Magnesium Krebs-Henseleit Solution Combined with Adenosine and Lidocaine Improved Rat Aortic Function and Structure Following Cold Preservation. Medicina (Kaunas). 2024;60. doi:10.3390/medicina60081284
- Liu J, Zhang J, Li A, Xia X, Chen J. Effect of fly ash and curing temperature on the properties of magnesium phosphate repair mortar. Sci Rep. 2024;14:15512. doi:10.1038/s41598-024-66581-1
- Çelebi Y, Kavrut E, Bulut M, Çetintaş Y, Tekin A, et al. Incorporation of hydrogen-producing magnesium into minced beef meat protects the quality attributes and safety of the product during cold storage. Food Chem. 2024;448:139185. doi:10.1016/j.foodchem.2024.139185
- Strzępek P, Zasadzińska M. Prospective cold metal working and analysis of deformation susceptibility of CuMg alloys with high magnesium content. Sci Rep. 2024;14:6447. doi:10.1038/s41598-024-57083-1
