Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
USERS' SCORE
Moderately Good
Based on 32 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Biotin
10,000 mcg
33,333%
Calcium (as Dibasic Calcium Phosphate)
66 mg
5%
Top Medical Research Studies
9.5
We explored the effects of biotin therapy on a neonate suffering from a rare metabolic disorder known as holocarboxylase synthetase deficiency. After initiating a biotin mega-dose regimen, we observed impressive results, with the baby showing notable clinical improvement just one day later.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
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9.5
Biotin treatment showed significant effect
We examined a patient diagnosed with holocarboxylase synthetase (HCS) deficiency, who presented with a notable rash and other severe symptoms. This condition disrupts biotin's incorporation into enzymes, leading to serious health challenges.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
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8
Biotin treatment mitigates rash symptoms
This study looked at children with partial biotinidase deficiency to understand its effects and inheritance. While many were healthy at diagnosis, we found that one child developed skin rash, hair loss, and muscle weakness—symptoms that improved following biotin treatment.
Notably, other family members also displayed partial deficiency without symptoms, but one adult had minor issues that were alleviated with biotin. Overall, while most individuals are symptom-free at birth, this research suggests that biotin therapy could be beneficial for preventing future complications.
Notably, other family members also displayed partial deficiency without symptoms, but one adult had minor issues that were alleviated with biotin. Overall, while most individuals are symptom-free at birth, this research suggests that biotin therapy could be beneficial for preventing future complications.
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Most Useful Reviews
9
No rashes experienced
45 people found this helpful
I take this biotin in courses, and the effect was immediate; my hair became more manageable and my skin smooth without rashes. I highly recommend buying it! If you appreciate this review, please support it with a like!
Read More
9
Rashes prevented
22 people found this helpful
There was an immediate effect! I've suffered from atopy and skin rashes due to sweating, but since I started taking biotin, I've not experienced any itchy skin problems. Normally, I take one tablet at night, but if I feel the rash coming back, I double the dose. I recommend this supplement; many friends have also noticed the positive effects!
Read More
9
Improved skin condition
7 people found this helpful
Due to COVID-19, my family faced hair loss issues. Biotin significantly improved my sister's facial skin, eliminating rashes, and her hair looks great despite styling. My mother's hair loss has also drastically reduced with biotin, and it has improved almost back to normal after suffering a lot from coronavirus.
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Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
- All Researches
9.5
We explored the effects of biotin therapy on a neonate suffering from a rare metabolic disorder known as holocarboxylase synthetase deficiency. After initiating a biotin mega-dose regimen, we observed impressive results, with the baby showing notable clinical improvement just one day later.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Read More
9.5
We reviewed the clinical and biochemical characteristics of 28 Chinese patients with holocarboxylase synthetase (HLCS) deficiency. Through this retrospective analysis, we observed that most patients exhibited symptoms like rash, seizures, and vomiting. However, after timely biotin supplementation, almost all showed remarkable improvement in their symptoms and overall health.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
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9.5
We explored a fascinating case involving a 6-year-old Vietnamese boy diagnosed with holocarboxylase synthetase deficiency, which is linked to biotin metabolism issues. The boy had a significant skin rash and metabolic acidosis, raising suspicion of multiple carboxylase deficiency. After confirming the diagnosis through urine and genetic tests, he began treatment with biotin.
Remarkably, he experienced a dramatic improvement in his condition within just days of starting the treatment. This strongly suggests that biotin can effectively address symptoms related to this deficiency, including skin rashes.
Remarkably, he experienced a dramatic improvement in his condition within just days of starting the treatment. This strongly suggests that biotin can effectively address symptoms related to this deficiency, including skin rashes.
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9.5
We explored a case involving a 2-month-old boy who presented with severe symptoms, including seizures and rash, and was quickly suspected of having biotinidase deficiency. After starting him on biotin supplements, we observed remarkable improvement within just 48 hours. His skin conditions, including perioral and perianal rashes, as well as overall health, significantly improved after regular biotin intake. At 10 months, the child is thriving and seizure-free, showcasing how effective timely biotin treatment can be in alleviating symptoms and resolving rash in such cases.
Read More
9.5
Biotin treatment showed significant effect
We examined a patient diagnosed with holocarboxylase synthetase (HCS) deficiency, who presented with a notable rash and other severe symptoms. This condition disrupts biotin's incorporation into enzymes, leading to serious health challenges.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 32 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
No rashes experienced
45 people found this helpful
I take this biotin in courses, and the effect was immediate; my hair became more manageable and my skin smooth without rashes. I highly recommend buying it! If you appreciate this review, please support it with a like!
Read More
9
Rashes prevented
22 people found this helpful
There was an immediate effect! I've suffered from atopy and skin rashes due to sweating, but since I started taking biotin, I've not experienced any itchy skin problems. Normally, I take one tablet at night, but if I feel the rash coming back, I double the dose. I recommend this supplement; many friends have also noticed the positive effects!
Read More
9
Improved skin condition
7 people found this helpful
Due to COVID-19, my family faced hair loss issues. Biotin significantly improved my sister's facial skin, eliminating rashes, and her hair looks great despite styling. My mother's hair loss has also drastically reduced with biotin, and it has improved almost back to normal after suffering a lot from coronavirus.
Read More
9
Joint cracks vanished
6 people found this helpful
I struggled with symptoms like cracked hands and rashes on my fingers due to atopic dermatitis. After a month of biotin therapy, my rough hands started to feel better, and my skin issues, including eczema in summer, have not returned. I will keep using biotin to enhance my overall condition.
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6
No rashes experienced
4 people found this helpful
Works! Hair loss ceased on the fifth day of biotin intake! I do not understand how this is possible, but it is a fact. I have an autoimmune condition (focal baldness), and the battle to retain my hair is ongoing; now IT is my salvation! I have no rashes on my face in the form of small spots, I feel fine, and I am unsure how biotin will affect my nails after just five days. However, it is evident that it has quickly become my favourite!
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Frequently Asked Questions
9
Significant rash reduction
1 people found this helpful
I liked the biotin as it provided a greater effect on my skin than I anticipated. The rash noticeably decreased by 90%. While my nails did become stronger, they resisted any coatings. This is a high-strength dosage, more suitable for therapeutic effects. I saw results within a week, and after 2 weeks, it's best to reduce to a lower dose every 3 days to maintain results.
7.5
Less hair loss
2 people found this helpful
I noticed the result after 2 weeks and was amazed. I originally bought this supplement to prevent hair loss, and it did help—my hair has started to fall out less. My nails also grew quickly and are now strong without creases. Additionally, I observed fewer rashes on my skin.
9
Joint cracks vanished
6 people found this helpful
I struggled with symptoms like cracked hands and rashes on my fingers due to atopic dermatitis. After a month of biotin therapy, my rough hands started to feel better, and my skin issues, including eczema in summer, have not returned. I will keep using biotin to enhance my overall condition.
9
No rashes experienced
45 people found this helpful
I take this biotin in courses, and the effect was immediate; my hair became more manageable and my skin smooth without rashes. I highly recommend buying it! If you appreciate this review, please support it with a like!
9
Rashes prevented
22 people found this helpful
There was an immediate effect! I've suffered from atopy and skin rashes due to sweating, but since I started taking biotin, I've not experienced any itchy skin problems. Normally, I take one tablet at night, but if I feel the rash coming back, I double the dose. I recommend this supplement; many friends have also noticed the positive effects!
0
Repeated rashes
This biotin caused skin rashes; I stopped taking it several times but returned to it each time. However, the rashes consistently recurred.
7.5
Rashes significantly reduced
This biotin (Vitamin B7) is of excellent quality, halting hair loss effectively, with a suitable dosage of 10,000 per tablet. It truly works, along with reducing rashes on my skin, and it accelerates hair growth. When combined with vitamin D3, omega, and collagen, the effects are super.
9
Rashes subsided
During my entire use of biotin, I experienced no gastrointestinal discomfort or allergic reactions. I've read online that it should be taken at night for better absorption, and I did so. After realising that higher doses could cause rashes, I began to halve the pills, extending the course, which resulted in everything returning to normal. I noticed my hair stopped falling out significantly.
2
Rash and itching experienced
1 people found this helpful
This is the first biotin that didn't suit me. We thought that a higher dosage would be better, but it resulted in too much vitamin content, leading to reactions starting with a rash and itchiness of my skin. A lower dosage is required.
2
Stopped usage due to rash
After a few days, my skin began to itch, so I refrained from taking it again. I developed a rash; falling asleep became difficult. It may be due to the high dosage. Once I stopped, the itching ceased, so I won't be consuming it any longer.
We evaluated two premature twin infants who experienced serious health issues due to riboflavin and biotin deficiencies. They presented with skin rash and other severe complications while receiving prolonged parenteral nutrition.
After starting biotin and riboflavin supplementation, the surviving twin showed significant improvement within a few days. Remarkably, the rash and other clinical signs improved, allowing him to be discharged in stable condition.
This case highlights the positive impact of biotin on rash resolution in the context of vitamin deficiencies.
After starting biotin and riboflavin supplementation, the surviving twin showed significant improvement within a few days. Remarkably, the rash and other clinical signs improved, allowing him to be discharged in stable condition.
This case highlights the positive impact of biotin on rash resolution in the context of vitamin deficiencies.
9.5
We explored a case involving a 2-month-old boy who presented with severe symptoms, including seizures and rash, and was quickly suspected of having biotinidase deficiency. After starting him on biotin supplements, we observed remarkable improvement within just 48 hours. His skin conditions, including perioral and perianal rashes, as well as overall health, significantly improved after regular biotin intake. At 10 months, the child is thriving and seizure-free, showcasing how effective timely biotin treatment can be in alleviating symptoms and resolving rash in such cases.
9
We examined a rare case of a 3-year-old boy who faced severe respiratory distress and a persistent rash due to biotinidase deficiency. Initially, the symptoms were typical but progressed to include restlessness and mental decline over two years. After a detailed examination, we diagnosed him with this uncommon condition and began treatment with supplemental biotin. Remarkably, he responded well to the treatment, highlighting biotin's role in addressing the rash and other symptoms associated with this metabolic disorder.
7
Biotin supplementation improves rash symptoms
We explored how valproic acid (VPA), a common treatment for seizures, influences biotin levels and skin rashes in children. In our study with 75 young patients, we discovered that VPA can lower biotinidase activity, leading to dermatological issues like rashes and hair loss.
Interestingly, when we supplemented these patients with biotin, we observed improvements in their skin lesions. This indicates that while VPA may cause side effects related to biotin deficiency, biotin treatment can help manage these reactions effectively.
Interestingly, when we supplemented these patients with biotin, we observed improvements in their skin lesions. This indicates that while VPA may cause side effects related to biotin deficiency, biotin treatment can help manage these reactions effectively.
8
Biotin shows variable rash improvement
We investigated the effects of biotin therapy on patients suffering from a rare condition affecting holocarboxylase formation. Among the five patients, four showed a significant improvement in their rashes with doses ranging from 10 to 20 mg daily.
However, one patient required a much higher dose of 100 mg daily for her skin rash to improve. While biotin was effective in alleviating some symptoms, it did not completely resolve all clinical issues for everyone involved in the study. We concluded that biotin can help with rashes in certain cases, but the benefits vary greatly among individuals.
However, one patient required a much higher dose of 100 mg daily for her skin rash to improve. While biotin was effective in alleviating some symptoms, it did not completely resolve all clinical issues for everyone involved in the study. We concluded that biotin can help with rashes in certain cases, but the benefits vary greatly among individuals.
9.5
We explored the effects of biotin treatment on a young boy diagnosed with biotinidase deficiency, which presented with neurological issues and a skin rash. Upon administration of 20 mg of biotin daily, we observed a significant and rapid improvement in both his clinical condition and biochemical markers, leading to the cessation of antiseizure medications. Importantly, despite the presence of a rash, biotin showed clear efficacy in improving the patient's overall health without developmental delays by 18 months.
References
- Zou H, Yang L, Zhang R, Qin Y. Case report: A case of holocarboxylase synthetase deficiency with respiratory tract as the initial symptom. Front Genet. 2024;15:1439343. doi:10.3389/fgene.2024.1439343
- Kim SW, Lee HJ, Choi N, Kim EK, Ko JM. Dramatic Clinical Improvement With Biotin Mega-Dose Therapy in a Neonate With Holocarboxylase Synthetase Deficiency. Mol Genet Genomic Med. 2024;12:e70002. doi:10.1002/mgg3.70002
- Adie MA, Martes Gomez M, Yom J, Durand M, Wertheimer F, et al. Twin Premature Infants With Riboflavin and Biotin Deficiency Presenting With Refractory Lactic Acidosis, Rash, and Multiorgan Failure During Prolonged Parenteral Nutrition. J Investig Med High Impact Case Rep. 2023;11:23247096231168111. doi:10.1177/23247096231168111
- Ling S, Qiu W, Zhang H, Liang L, Lu D, et al. Clinical, biochemical, and genetic analysis of 28 Chinese patients with holocarboxylase synthetase deficiency. Orphanet J Rare Dis. 2023;18:48. doi:10.1186/s13023-023-02656-y
- Shoaib M, Faraz A, Ahmed SA, Jamil M, Aijaz Z. Diagnostic Dilemma Of Biotinidase Deficiency: Case Of A Child From Pakistan. J Ayub Med Coll Abbottabad. 2016;28:821.
- Ogawa Y, Kiba T, Nakano K, Fujiwara K, Taniguchi H, et al. [Prospective study of biotin treatment in patients with erythema due to gefitinib or erlotinib]. Gan To Kagaku Ryoho. 2014;41:517.
- Hui J, Law E, Chung C, Fung S, Yuen P, et al. The first reported HLCS gene mutation causing holocarboxylase synthetase deficiency in a Vietnamese patient. World J Pediatr. 2012;8:278. doi:10.1007/s12519-011-0301-9
- Rajendiran A, Sampath S. Biotinidase deficiency--clinching the diagnosis rapidly can make all the difference!. BMJ Case Rep. 2011;2011. doi:10.1136/bcr.07.2011.4494
- Chou IC, Wang CS, Lin WD, Lin HC, Tsai CH, et al. Holocarboxylase synthetase deficiency: report of one case. Acta Paediatr Taiwan. 2006;47:309.
- Kimura M, Fukui T, Tagami Y, Fujiwaki T, Yokoyama M, et al. Normalization of low biotinidase activity in a child with biotin deficiency after biotin supplementation. J Inherit Metab Dis. 2003;26:715.
- Schulpis KH, Karikas GA, Tjamouranis J, Regoutas S, Tsakiris S. Low serum biotinidase activity in children with valproic acid monotherapy. Epilepsia. 2001;42:1359.
- Gulati S, Passi GR, Kumar A, Kabra M, Kalra V, et al. Biotinidase deficiency--a treatable entity. Indian J Pediatr. 2000;67:464.
- Suormala T, Fowler B, Duran M, Burtscher A, Fuchshuber A, et al. Five patients with a biotin-responsive defect in holocarboxylase formation: evaluation of responsiveness to biotin therapy in vivo and comparative biochemical studies in vitro. Pediatr Res. 1997;41:666.
- Livne M, Gibson KM, Amir N, Eshel G, Elpeleg ON. Holocarboxylase synthetase deficiency: a treatable metabolic disorder masquerading as cerebral palsy. J Child Neurol. 1994;9:170.
- Héron B, Gautier A, Dulac O, Ponsot G. [Biotinidase deficiency. Progressive encephalopathy curable with biotin]. Arch Fr Pediatr. 1993;50:875.
- McVoy JR, Levy HL, Lawler M, Schmidt MA, Ebers DD, et al. Partial biotinidase deficiency: clinical and biochemical features. J Pediatr. 1990;116:78.
