' 
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.6
USERS' SCORE
Moderately Good
Based on 57 Reviews
7.3
Supplement Facts
Serving Size: 2 Gummies
Amount Per Serving
%DV
Calories
20
Total Carbohydrate
4 g
1%*
Total Sugars
3 g
**
Includes 3 g Added Sugars
6%*
Sodium
5 mg
<1%
Melatonin
10 mg
**
Top Medical Research Studies
9.5
Melatonin improves sleep apnea outcomes
Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
Relevant and promising findings
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
Read More
7
Agomelatine shows promise for OSA
Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.
Moderate relevance to sleep therapies.
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
Read More
7
Melatonin's role in sleep apnea
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
Significance of melatonin in OSA
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
Read More
Most Useful Reviews
9.5
Sound sleep achieved
I bought this for my son, who faced a sleep disorder causing him to reverse day and night; now, I use it myself. Consuming it guarantees a restful night’s sleep yet seems to wear off after about 6 hours. A dose taken 6 hours before waking makes a significant difference. The taste is delightful; even one drop is effective.
Read More
9.5
Fast asleep experience
This is fantastic! Taking it half an hour before bed means I fall asleep almost instantly. Everyone in my family has started taking it since my husband suffers from insomnia. It greatly assists him, allowing him to fall asleep quickly and combat his sleep apnea effectively.
Read More
8.8
No more tiredness
This product proves to be very effective; I take it 15 minutes before bed. It makes me feel very sleepy, ensuring a comfortable, prolonged slumber. I wake up refreshed without feeling tired, and I appreciate that it doesn't create an addiction. I enjoy the taste and quality; it has become a staple for addressing my sleep apnea.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.6
- All Researches
9.5
Melatonin improves sleep apnea outcomes
Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
Relevant and promising findings
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
Read More
7
Melatonin's role in sleep apnea
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
Significance of melatonin in OSA
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
Read More
7
Agomelatine shows promise for OSA
Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.
Moderate relevance to sleep therapies.
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
Read More
7
REM Sleep Behavior Disorder Overview
REM sleep behavior disorder as a complex condition with heterogeneous underlying disorders: clinical management and prognostic implications [Commentary].
Highly relevant clinical insights
We explored REM sleep behavior disorder (RBD) as a complex condition that can be linked to a variety of underlying disorders. Through a literature review and insights from foundational texts, we recognized that RBD may emerge at any age and can initially appear as an isolated issue or be associated with other significant conditions like Parkinson’s and narcolepsy.
Our findings highlighted that effective management often includes melatonin or clonazepam as treatment options. Furthermore, ongoing research into the connections between RBD and other sleep disorders, such as obstructive sleep apnea, remains vital for enhancing diagnostics and treatment strategies.
Our findings highlighted that effective management often includes melatonin or clonazepam as treatment options. Furthermore, ongoing research into the connections between RBD and other sleep disorders, such as obstructive sleep apnea, remains vital for enhancing diagnostics and treatment strategies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 57 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Sound sleep achieved
I bought this for my son, who faced a sleep disorder causing him to reverse day and night; now, I use it myself. Consuming it guarantees a restful night’s sleep yet seems to wear off after about 6 hours. A dose taken 6 hours before waking makes a significant difference. The taste is delightful; even one drop is effective.
Read More
9.5
Fast asleep experience
This is fantastic! Taking it half an hour before bed means I fall asleep almost instantly. Everyone in my family has started taking it since my husband suffers from insomnia. It greatly assists him, allowing him to fall asleep quickly and combat his sleep apnea effectively.
8.8
No more tiredness
This product proves to be very effective; I take it 15 minutes before bed. It makes me feel very sleepy, ensuring a comfortable, prolonged slumber. I wake up refreshed without feeling tired, and I appreciate that it doesn't create an addiction. I enjoy the taste and quality; it has become a staple for addressing my sleep apnea.
Read More
10
Supports restful sleep
I bought this melatonin for my autistic son, and it’s been the best purchase I've made. It aids his sleep significantly, and he now rests well. I've already ordered more, as they are truly effective.
9.5
Relieves insomnia
I’ve tried many melatonin supplements, but this one is the best. I suffer from severe insomnia and often lay awake for hours. These gummies have been a godsend. I take two at a time, which helps me sleep through the night without vivid dreams. My daughter also benefits from one each night.
Read More
