5/18/2025
Last update
5/18/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Medium or Average
Based on 11 Reviews
6.9
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Melatonin
10 mg
*
Top Medical Research Studies
9.5
We explored how melatonin-based treatments, particularly agomelatine, can affect headaches, focusing on hypnic headaches (HH). This form of headache typically occurs during sleep, disrupting the rest of those affected. A fascinating case of a 58-year-old woman who experienced these nocturnal headaches for three years demonstrated the potential benefits of agomelatine.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
Read More
8
We explored melatonin's role in preventing migraines through a comprehensive review of randomized control trials. Our research involved analyzing data from several studies, focusing on how effective melatonin can be compared to standard treatments and placebo.
The systematic review included seven trials and over 1,200 participants, all diagnosed with migraines. Participants received either melatonin or agomelatine, and outcomes were measured against those receiving conventional migraine prevention methods.
From the analyzed studies, we observed that melatonin appears to significantly reduce both the frequency and severity of migraine attacks. However, there is still some debate about the specifics of its dose-dependent effects. Interestingly, melatonin may also play a role in weight management, indicating further research could be beneficial in this area.
Overall, the potential of melatonin as an alternative or adjunct therapy for headache prevention seems promising. Yet, we recognize that more extensive studies are needed to fully understand its benefits and optimal usage.
The systematic review included seven trials and over 1,200 participants, all diagnosed with migraines. Participants received either melatonin or agomelatine, and outcomes were measured against those receiving conventional migraine prevention methods.
From the analyzed studies, we observed that melatonin appears to significantly reduce both the frequency and severity of migraine attacks. However, there is still some debate about the specifics of its dose-dependent effects. Interestingly, melatonin may also play a role in weight management, indicating further research could be beneficial in this area.
Overall, the potential of melatonin as an alternative or adjunct therapy for headache prevention seems promising. Yet, we recognize that more extensive studies are needed to fully understand its benefits and optimal usage.
Read More
8
Agomelatine effectively reduces migraines
We conducted a parallel, randomized controlled trial to evaluate the effectiveness of agomelatine, a melatonin antagonist, in managing episodic migraine without aura. In total, 400 patients were assessed, and from those, 100 met our inclusion criteria. These participants, aged between 18 and 60, had not previously received preventive migraine treatment and were free of specific medications for other conditions.
After random assignment, one group received 25 mg of agomelatine daily, while the control group received a placebo. Over three months, we measured the impact of agomelatine on the frequency and severity of migraine attacks using monthly migraine days and migraine disability assessments as key indicators. By the end of the study, we found that agomelatine was indeed effective in reducing migraine frequency and severity.
This promising outcome suggests that agomelatine could serve as a viable option for migraine prevention. We propose further research comparing it with other preventive medications to strengthen our findings and enhance treatment options for those suffering from migraines.
After random assignment, one group received 25 mg of agomelatine daily, while the control group received a placebo. Over three months, we measured the impact of agomelatine on the frequency and severity of migraine attacks using monthly migraine days and migraine disability assessments as key indicators. By the end of the study, we found that agomelatine was indeed effective in reducing migraine frequency and severity.
This promising outcome suggests that agomelatine could serve as a viable option for migraine prevention. We propose further research comparing it with other preventive medications to strengthen our findings and enhance treatment options for those suffering from migraines.
Read More
Most Useful Reviews
9
No side effects
Its effect is wonderful, and it does not cause any unwanted effects such as headache or nausea. It is very pleasing.
Read More
9
Wakes up refreshed
After taking it every night, I sleep well and do not have a headache when I wake up.
Read More
9
No more insomnia
This medication is great for insomnia. It has not resulted in a headache upon waking, and I feel healthy during the day. It affects me within half an hour of taking it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
- All Researches
9.5
We explored how melatonin-based treatments, particularly agomelatine, can affect headaches, focusing on hypnic headaches (HH). This form of headache typically occurs during sleep, disrupting the rest of those affected. A fascinating case of a 58-year-old woman who experienced these nocturnal headaches for three years demonstrated the potential benefits of agomelatine.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
Read More
9
We set out to understand how melatonin might help alleviate headaches in children suffering from migraines without sleep disorders. In our study, we worked with fifty-five children aged 5 to 15 years, dividing them into two groups for a three-month treatment period.
One group received propranolol, a standard migraine medication, while the other group combined propranolol with melatonin. We visited the children before treatment, as well as one and three months afterward, to gather and assess their progress.
Our findings revealed that the combination of melatonin with propranolol led to a notable decrease in the frequency of headache attacks among the children receiving the added melatonin. In fact, three months after starting treatment, we observed a significant improvement in response rates and overall satisfaction among parents in the intervention group compared to those only on propranolol.
However, we did not find any significant difference in the intensity of headaches' impact on daily life between the two groups. Thankfully, the treatment was well-tolerated with no major side effects reported.
Overall, our research suggests that adding melatonin could be a beneficial strategy for reducing headache frequency in children with migraines without sleep issues, while also enhancing treatment satisfaction.
One group received propranolol, a standard migraine medication, while the other group combined propranolol with melatonin. We visited the children before treatment, as well as one and three months afterward, to gather and assess their progress.
Our findings revealed that the combination of melatonin with propranolol led to a notable decrease in the frequency of headache attacks among the children receiving the added melatonin. In fact, three months after starting treatment, we observed a significant improvement in response rates and overall satisfaction among parents in the intervention group compared to those only on propranolol.
However, we did not find any significant difference in the intensity of headaches' impact on daily life between the two groups. Thankfully, the treatment was well-tolerated with no major side effects reported.
Overall, our research suggests that adding melatonin could be a beneficial strategy for reducing headache frequency in children with migraines without sleep issues, while also enhancing treatment satisfaction.
Read More
9
Melatonin shows promise for migraines
We conducted a clinical trial to investigate whether melatonin can help reduce the frequency and severity of migraine attacks. In this study, 60 patients suffering from episodic migraines were divided into two groups. One group received 3 mg of melatonin, while the other group received a placebo, both alongside a standard treatment of propranolol for two months.
Over the course of the study, we monitored several factors related to migraines, including the frequency and duration of attacks, the severity of pain, the number of pain relievers used, and overall quality of sleep. Our results showed promising outcomes for those taking melatonin. Specifically, we found that the group receiving melatonin experienced a significant drop in the frequency and duration of their migraine attacks compared to the placebo group. Notably, the effectiveness of melatonin in decreasing the need for analgesics and improving scores on the Migraine Disability Assessment and Pittsburgh Sleep Quality Index was also evident.
While the severity of attacks did not differ greatly between the two groups, the side effects observed were minimal and comparable in both groups. This leads us to believe that melatonin could be a safe and effective option for preventive treatment of episodic migraine in adults.
Over the course of the study, we monitored several factors related to migraines, including the frequency and duration of attacks, the severity of pain, the number of pain relievers used, and overall quality of sleep. Our results showed promising outcomes for those taking melatonin. Specifically, we found that the group receiving melatonin experienced a significant drop in the frequency and duration of their migraine attacks compared to the placebo group. Notably, the effectiveness of melatonin in decreasing the need for analgesics and improving scores on the Migraine Disability Assessment and Pittsburgh Sleep Quality Index was also evident.
While the severity of attacks did not differ greatly between the two groups, the side effects observed were minimal and comparable in both groups. This leads us to believe that melatonin could be a safe and effective option for preventive treatment of episodic migraine in adults.
Read More
8
We explored treatment alternatives for paroxysmal hemicrania and hemicrania continua in patients who cannot tolerate indomethacin, a medication typically effective for these conditions. Recent findings have shown that melatonin, a naturally occurring hormone known for regulating sleep, also holds promise for alleviating headaches related to these disorders.
In studies conducted over the past 18 months, melatonin has been effectively used for managing hemicrania continua and is now suggested to be beneficial for paroxysmal hemicrania as well. This is significant since many patients experience side effects from indomethacin, including gastrointestinal issues and neuropsychiatric reactions.
We also noted the potential of non-invasive vagus nerve stimulation as a promising nonpharmacological option, which may help reduce the need for indomethacin while providing symptom relief. While alternative medications such as acemethacin and selective COX-2 inhibitors have shown some effectiveness, the research remains limited and calls for further investigation to establish more conclusive treatment guidelines.
Overall, while melatonin appears to be a helpful option, additional studies are necessary to better understand its role in headache management and develop reliable treatment protocols for those unable to take indomethacin.
In studies conducted over the past 18 months, melatonin has been effectively used for managing hemicrania continua and is now suggested to be beneficial for paroxysmal hemicrania as well. This is significant since many patients experience side effects from indomethacin, including gastrointestinal issues and neuropsychiatric reactions.
We also noted the potential of non-invasive vagus nerve stimulation as a promising nonpharmacological option, which may help reduce the need for indomethacin while providing symptom relief. While alternative medications such as acemethacin and selective COX-2 inhibitors have shown some effectiveness, the research remains limited and calls for further investigation to establish more conclusive treatment guidelines.
Overall, while melatonin appears to be a helpful option, additional studies are necessary to better understand its role in headache management and develop reliable treatment protocols for those unable to take indomethacin.
Read More
8
We explored melatonin's role in preventing migraines through a comprehensive review of randomized control trials. Our research involved analyzing data from several studies, focusing on how effective melatonin can be compared to standard treatments and placebo.
The systematic review included seven trials and over 1,200 participants, all diagnosed with migraines. Participants received either melatonin or agomelatine, and outcomes were measured against those receiving conventional migraine prevention methods.
From the analyzed studies, we observed that melatonin appears to significantly reduce both the frequency and severity of migraine attacks. However, there is still some debate about the specifics of its dose-dependent effects. Interestingly, melatonin may also play a role in weight management, indicating further research could be beneficial in this area.
Overall, the potential of melatonin as an alternative or adjunct therapy for headache prevention seems promising. Yet, we recognize that more extensive studies are needed to fully understand its benefits and optimal usage.
The systematic review included seven trials and over 1,200 participants, all diagnosed with migraines. Participants received either melatonin or agomelatine, and outcomes were measured against those receiving conventional migraine prevention methods.
From the analyzed studies, we observed that melatonin appears to significantly reduce both the frequency and severity of migraine attacks. However, there is still some debate about the specifics of its dose-dependent effects. Interestingly, melatonin may also play a role in weight management, indicating further research could be beneficial in this area.
Overall, the potential of melatonin as an alternative or adjunct therapy for headache prevention seems promising. Yet, we recognize that more extensive studies are needed to fully understand its benefits and optimal usage.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 11 Reviews
6.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
No side effects
Its effect is wonderful, and it does not cause any unwanted effects such as headache or nausea. It is very pleasing.
Read More
9
Wakes up refreshed
After taking it every night, I sleep well and do not have a headache when I wake up.
Read More
9
No more insomnia
This medication is great for insomnia. It has not resulted in a headache upon waking, and I feel healthy during the day. It affects me within half an hour of taking it.
Read More
0
Avoid due to headaches
It causes nightmares if you don't sleep well, and it gives me headaches. I won't be buying it again.
Read More
0
Highly discouraged
I do not recommend it as it causes headaches.
Read More
Frequently Asked Questions
9
No more insomnia
This medication is great for insomnia. It has not resulted in a headache upon waking, and I feel healthy during the day. It affects me within half an hour of taking it.
0
Avoid due to headaches
It causes nightmares if you don't sleep well, and it gives me headaches. I won't be buying it again.
9
Wakes up refreshed
After taking it every night, I sleep well and do not have a headache when I wake up.
0
Highly discouraged
I do not recommend it as it causes headaches.
9
Effective sleep aid
These pills are among the best for inducing sleep quickly. With the 10mg dose, I wake up without a headache, and the quality of sleep is excellent. I appreciate the pleasant taste, and I will try the gummy bears next.
6
No morning headaches
1 people found this helpful
This is not the first time I have purchased this type of melatonin. It dissolves quickly, and I fall asleep immediately without the headache I experience from pharmaceutical drugs. I have not noticed any addiction, and I recommend it for healthy sleep!
4
Causes headaches
It helps me sleep, but I do experience a slight headache.
6
Not beneficial
It is suitable for those who sleep lightly, but it can cause drowsiness and a strong headache, making one feel tired and sluggish.
8
We explored melatonin's role in preventing migraines through a comprehensive review of randomized control trials. Our research involved analyzing data from several studies, focusing on how effective melatonin can be compared to standard treatments and placebo.
The systematic review included seven trials and over 1,200 participants, all diagnosed with migraines. Participants received either melatonin or agomelatine, and outcomes were measured against those receiving conventional migraine prevention methods.
From the analyzed studies, we observed that melatonin appears to significantly reduce both the frequency and severity of migraine attacks. However, there is still some debate about the specifics of its dose-dependent effects. Interestingly, melatonin may also play a role in weight management, indicating further research could be beneficial in this area.
Overall, the potential of melatonin as an alternative or adjunct therapy for headache prevention seems promising. Yet, we recognize that more extensive studies are needed to fully understand its benefits and optimal usage.
The systematic review included seven trials and over 1,200 participants, all diagnosed with migraines. Participants received either melatonin or agomelatine, and outcomes were measured against those receiving conventional migraine prevention methods.
From the analyzed studies, we observed that melatonin appears to significantly reduce both the frequency and severity of migraine attacks. However, there is still some debate about the specifics of its dose-dependent effects. Interestingly, melatonin may also play a role in weight management, indicating further research could be beneficial in this area.
Overall, the potential of melatonin as an alternative or adjunct therapy for headache prevention seems promising. Yet, we recognize that more extensive studies are needed to fully understand its benefits and optimal usage.
9
We set out to understand how melatonin might help alleviate headaches in children suffering from migraines without sleep disorders. In our study, we worked with fifty-five children aged 5 to 15 years, dividing them into two groups for a three-month treatment period.
One group received propranolol, a standard migraine medication, while the other group combined propranolol with melatonin. We visited the children before treatment, as well as one and three months afterward, to gather and assess their progress.
Our findings revealed that the combination of melatonin with propranolol led to a notable decrease in the frequency of headache attacks among the children receiving the added melatonin. In fact, three months after starting treatment, we observed a significant improvement in response rates and overall satisfaction among parents in the intervention group compared to those only on propranolol.
However, we did not find any significant difference in the intensity of headaches' impact on daily life between the two groups. Thankfully, the treatment was well-tolerated with no major side effects reported.
Overall, our research suggests that adding melatonin could be a beneficial strategy for reducing headache frequency in children with migraines without sleep issues, while also enhancing treatment satisfaction.
One group received propranolol, a standard migraine medication, while the other group combined propranolol with melatonin. We visited the children before treatment, as well as one and three months afterward, to gather and assess their progress.
Our findings revealed that the combination of melatonin with propranolol led to a notable decrease in the frequency of headache attacks among the children receiving the added melatonin. In fact, three months after starting treatment, we observed a significant improvement in response rates and overall satisfaction among parents in the intervention group compared to those only on propranolol.
However, we did not find any significant difference in the intensity of headaches' impact on daily life between the two groups. Thankfully, the treatment was well-tolerated with no major side effects reported.
Overall, our research suggests that adding melatonin could be a beneficial strategy for reducing headache frequency in children with migraines without sleep issues, while also enhancing treatment satisfaction.
7
We conducted a case-control study focusing on serum melatonin levels in patients experiencing migraine. The research involved participants aged 18-65 from a headache clinic in Tehran, Iran, specifically looking at those with both episodic and chronic migraine diagnoses.
Our findings revealed that patients with both types of migraine had significantly lower serum melatonin levels compared to healthy individuals. On average, episodic migraine patients had melatonin levels around 72.83, while chronic migraine patients had levels of about 70.38. In contrast, the healthy controls had levels close to 280.
Despite these differences, we did not find significant variations in melatonin levels between episodic and chronic migraine patients. Overall, our study highlights that while individuals with migraines have lower melatonin levels, it does not provide evidence for melatonin being an effective standalone treatment for reducing headache frequency or severity.
Our findings revealed that patients with both types of migraine had significantly lower serum melatonin levels compared to healthy individuals. On average, episodic migraine patients had melatonin levels around 72.83, while chronic migraine patients had levels of about 70.38. In contrast, the healthy controls had levels close to 280.
Despite these differences, we did not find significant variations in melatonin levels between episodic and chronic migraine patients. Overall, our study highlights that while individuals with migraines have lower melatonin levels, it does not provide evidence for melatonin being an effective standalone treatment for reducing headache frequency or severity.
9
Melatonin shows promise for migraines
We conducted a clinical trial to investigate whether melatonin can help reduce the frequency and severity of migraine attacks. In this study, 60 patients suffering from episodic migraines were divided into two groups. One group received 3 mg of melatonin, while the other group received a placebo, both alongside a standard treatment of propranolol for two months.
Over the course of the study, we monitored several factors related to migraines, including the frequency and duration of attacks, the severity of pain, the number of pain relievers used, and overall quality of sleep. Our results showed promising outcomes for those taking melatonin. Specifically, we found that the group receiving melatonin experienced a significant drop in the frequency and duration of their migraine attacks compared to the placebo group. Notably, the effectiveness of melatonin in decreasing the need for analgesics and improving scores on the Migraine Disability Assessment and Pittsburgh Sleep Quality Index was also evident.
While the severity of attacks did not differ greatly between the two groups, the side effects observed were minimal and comparable in both groups. This leads us to believe that melatonin could be a safe and effective option for preventive treatment of episodic migraine in adults.
Over the course of the study, we monitored several factors related to migraines, including the frequency and duration of attacks, the severity of pain, the number of pain relievers used, and overall quality of sleep. Our results showed promising outcomes for those taking melatonin. Specifically, we found that the group receiving melatonin experienced a significant drop in the frequency and duration of their migraine attacks compared to the placebo group. Notably, the effectiveness of melatonin in decreasing the need for analgesics and improving scores on the Migraine Disability Assessment and Pittsburgh Sleep Quality Index was also evident.
While the severity of attacks did not differ greatly between the two groups, the side effects observed were minimal and comparable in both groups. This leads us to believe that melatonin could be a safe and effective option for preventive treatment of episodic migraine in adults.
References
- Osiowski A, Stolarz K, Taterra D. How can you manage an indomethacin-responsive headache in someone who cannot take indomethacin?. Curr Opin Neurol. 2025. 10.1097/WCO.0000000000001347
- Nelakuditi B, Dandamudi BJ, Dimaano KAM, Shah N, AlQassab O, et al. Efficacy of Melatonin as a Promising Intervention for Migraine Prevention: A Systematic Review of Randomized Control Trials. Cureus. 2024;16:e72559. 10.7759/cureus.72559
- Togha M, Noormohammadi M, Ghorbani Z, Karimzadeh F, Bathaie SZ. Serum melatonin levels and in a sample of Iranian patients with migraine. Sci Rep. 2024;14:22883. 10.1038/s41598-024-73278-y
- Fayyazi A, Abbasian P, Hosseini SMS, Mohammadi Y, Bazmamoum H. Efficacy of Melatonin Administration in Reducing Headaches in Children with Migraines without Sleep Disorders. Iran J Child Neurol. 2024;18:57. 10.22037/ijcn.v18i3.42197
- Mehramiri A, Shalilahmadi D, Mohamadianinejad SE, Kouti L, Hosseinpour Y. The Effect of Melatonin on Reducing the Frequency and Severity of Migraine Attacks: A Double-Blind, Randomized Clinical Trial. Iran J Med Sci. 2024;49:313. 10.30476/ijms.2023.97782.2965
- Cheung SN, Oliveira R, Goadsby PJ. Melatonin in hemicrania continua and paroxysmal hemicrania. Cephalalgia. 2024;44:3331024231226196. 10.1177/03331024231226196
- Farzin K, Kheiltash A, Tafakhori A, Nakhjiri NE, Sabet MS, et al. The effectiveness of agomelatine on headache severity and frequency in episodic migraine without aura; a parallel randomized controlled trial study. BMC Neurol. 2024;24:2. 10.1186/s12883-023-03516-9
- Tao H, Wan Q, Sun M, Cai K, Song Y, et al. Involvement of Plasma Melatonin in Medication-Overuse Headache: A Cross-Sectional Study. Clin Neuropharmacol. 2024;47:12. 10.1097/WNF.0000000000000573
- Gelfand AA, Allen IE, Grimes B, Irwin S, Qubty W, et al. Melatonin for migraine prevention in children and adolescents: A randomized, double-blind, placebo-controlled trial after single-blind placebo lead-in. Headache. 2023;63:1314. 10.1111/head.14600
- Xu SY, Li L, Sun WX, Shen JY, Li CX. Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option. Front Neurol. 2023;14:1179391. 10.3389/fneur.2023.1179391
- Fayyazi A, Abdollahi A, Moradi A, Bazmamoun H. Administration in Efficacy of Melatonin Reducing Headaches in Children With Migraines and Sleep Disorders: A Randomized Clinical Trial Study. Iran J Child Neurol. 2022;16:55. 10.22037/ijcn.v17i2.37918
- Puliappadamb HM, Maiti R, Mishra A, Jena M, Mishra BR. Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis. J Oral Facial Pain Headache. 2022;36:207–219. 10.11607/ofph.3211
- Zduńska A, Cegielska J, Domitrz I. The Pathogenetic Role of Melatonin in Migraine and Its Theoretic Implications for Pharmacotherapy: A Brief Overview of the Research. Nutrients. 2022;14. 10.3390/nu14163335
- Moreno-Ajona D, Hoffmann J. From basic mechanisms to therapeutic perspectives in cluster headache. Curr Opin Neurol. 2022;35:336. 10.1097/WCO.0000000000001055
- Hvingelby V, Tsigka E, Jensen RH, Hylin S, Mathiesen T. Natural Progression of Pineal Cysts in Relation to Headache: A Prospective Observational Study. Eur J Neurol. 2025;32:e70120. 10.1111/ene.70120
