' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 6 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
588%
Calcium (as Calcium Carbonate)
60 mg
5%
Melatonin
5 mg
*
Top Medical Research Studies
8
Melatonin improves MS-related symptoms
12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial.
Relevant findings for MS treatment
We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
Read More
8
Melatonin improves MS-related symptoms
12-week melatonin supplementation improved dynamic postural stability and walking performance in persons living with multiple sclerosis: A randomized controlled trial.
Moderate therapeutic relevance noted
We explored the effects of a 12-week melatonin treatment in individuals with multiple sclerosis (MS), focusing on postural stability, walking performance, and overall quality of life. Our study involved 27 participants divided into two groups: one received melatonin while the other got a placebo.
After the intervention, we observed notable improvements in dynamic balance and walking performance among those taking melatonin. Additionally, participants reported better sleep quality, reduced fatigue, and less neuropathic pain.
Overall, melatonin appears to be a supportive treatment option for addressing some symptoms associated with MS.
After the intervention, we observed notable improvements in dynamic balance and walking performance among those taking melatonin. Additionally, participants reported better sleep quality, reduced fatigue, and less neuropathic pain.
Overall, melatonin appears to be a supportive treatment option for addressing some symptoms associated with MS.
Read More
7
Melatonin improves balance and strength
Effects of a nighttime melatonin ingestion on dynamic postural balance and muscle strength the following morning in people living with multiple sclerosis: A preliminary study.
Relevance score: moderate impact.
We investigated the effects of melatonin on postural balance and muscle strength in individuals with multiple sclerosis. Fourteen participants took either melatonin or a placebo before bedtime. The next morning, we measured their balance, leg strength, pain levels, sleep quality, and fatigue perception.
We found that acute melatonin intake was safe and showed promising results in improving dynamic postural stability and lower-extremity muscle strength. This suggests that melatonin may help alleviate some challenges faced by those with this condition.
We found that acute melatonin intake was safe and showed promising results in improving dynamic postural stability and lower-extremity muscle strength. This suggests that melatonin may help alleviate some challenges faced by those with this condition.
Read More
Most Useful Reviews
9.5
Effective treatment
I’m currently in the hospital for a sleep disorder (insomnia). My doctor recommended melatonin, which makes me feel drowsy about an hour after taking it. The effect is remarkable!
Read More
8.8
Improved sleep quality
The difficulty I experienced falling asleep has improved significantly. I purchased this to help with sleep issues before my period, and it was challenging to manage day and night. Taking 1 to 2 tablets before bedtime allowed me to drift off in about half an hour to an hour, which was highly effective. I was uncertain about needing a sleeping pill, but this product has proven beneficial. I'm nearly out and will be ordering more.
Read More
8.3
Reduced sleeplessness
I was struggling to get enough sleep, so I purchased this product to improve my sleep. Gradually, my sleeplessness is diminishing. I intend to continue using it. Thank you!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9.5
Effective early diagnosis biomarkers identified
Metabolomics study reveals blood biomarkers for early diagnosis of chronic kidney disease and IgA nephropathy: A retrospective cross-sectional study.
High relevance due to novel findings
We explored how plasma metabolites can help us diagnose chronic kidney disease (CKD) and IgA nephropathy (IgAN) early on. By analyzing blood samples using advanced techniques, we found that melatonin itself can identify early CKD with over 95% accuracy.
Additionally, combining melatonin with tryptophan achieved a remarkable 100% accuracy for CKD diagnoses. Indole-3-lactic acid also showed great potential in distinguishing IgAN in CKD patients, reaching over 85% accuracy for early IgAN diagnosis.
Additionally, combining melatonin with tryptophan achieved a remarkable 100% accuracy for CKD diagnoses. Indole-3-lactic acid also showed great potential in distinguishing IgAN in CKD patients, reaching over 85% accuracy for early IgAN diagnosis.
Read More
9
Melatonin improves MS-related functions
Effects of Melatonin Supplementation on Muscle Strength, Manual Dexterity, and Postural Balance in Patients Living with Multiple sclerosis - A Randomized Controlled Trial.
High relevance for MS management
We investigated how melatonin supplementation impacts motor skills and cognitive function in patients with multiple sclerosis. In a controlled trial, 27 participants were divided into a melatonin group and a placebo group for a 12-week period.
The results were promising: the melatonin group showed improvements in knee muscle strength, manual dexterity, and balance, alongside better mood and cognitive performance. This suggests that melatonin may be beneficial for enhancing quality of life in those managing multiple sclerosis symptoms.
The results were promising: the melatonin group showed improvements in knee muscle strength, manual dexterity, and balance, alongside better mood and cognitive performance. This suggests that melatonin may be beneficial for enhancing quality of life in those managing multiple sclerosis symptoms.
Read More
9
Melatonin reduces inflammation and atrophy
Melatonin Regulates Rheumatoid Synovial Fibroblasts-Related Inflammation: Implications for Pathological Skeletal Muscle Treatment.
High relevance for autoimmune research
We explored how melatonin affects rheumatoid arthritis-related muscle atrophy. By analyzing its anti-inflammatory properties, we found that melatonin can significantly decrease inflammation in rheumatoid synovial fibroblasts and enhance muscle cell growth.
Our research included the use of a collagen-induced arthritis mouse model, showing improvements in swelling and muscle strength after melatonin treatment. This study highlights melatonin’s potential in combating muscle atrophy and fostering muscle growth in autoimmune conditions like rheumatoid arthritis.
Our research included the use of a collagen-induced arthritis mouse model, showing improvements in swelling and muscle strength after melatonin treatment. This study highlights melatonin’s potential in combating muscle atrophy and fostering muscle growth in autoimmune conditions like rheumatoid arthritis.
Read More
9
Melatonin shows promise in MS treatment
Melatonin synergistically potentiates the effect of methylprednisolone on reducing neuroinflammation in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.
High relevance in autoimmune research.
We investigated how melatonin may influence autoimmune disorders, specifically in a mouse model of multiple sclerosis. By combining melatonin with methylprednisolone, a common glucocorticoid treatment, we noticed a protective effect in reducing neuroinflammation. This combination therapy not only decreased harmful immune cells in the central nervous system but also shifted the immune response towards a more regulated state.
Notably, melatonin seems to improve the effects of methylprednisolone, suggesting it could be a promising complement in treating relapses of multiple sclerosis.
Notably, melatonin seems to improve the effects of methylprednisolone, suggesting it could be a promising complement in treating relapses of multiple sclerosis.
Read More
9
Melatonin improves rheumatoid arthritis treatment
Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route.
Highly relevant study findings
In our exploration of melatonin's potential in rheumatoid arthritis (RA) treatment, we utilized hyalurosomes within a collagen gel to enhance its therapeutic effects. The study involved both laboratory and animal testing, showing that melatonin encapsulated in these carriers significantly improved joint healing and cartilage repair in rats.
While traditional RA treatments often have limited effectiveness and side effects, our findings suggest that this innovative approach may offer a safer alternative. Importantly, no adverse interactions were found, indicating a promising future for melatonin in RA management.
While traditional RA treatments often have limited effectiveness and side effects, our findings suggest that this innovative approach may offer a safer alternative. Importantly, no adverse interactions were found, indicating a promising future for melatonin in RA management.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Effective treatment
I’m currently in the hospital for a sleep disorder (insomnia). My doctor recommended melatonin, which makes me feel drowsy about an hour after taking it. The effect is remarkable!
8.8
Improved sleep quality
The difficulty I experienced falling asleep has improved significantly. I purchased this to help with sleep issues before my period, and it was challenging to manage day and night. Taking 1 to 2 tablets before bedtime allowed me to drift off in about half an hour to an hour, which was highly effective. I was uncertain about needing a sleeping pill, but this product has proven beneficial. I'm nearly out and will be ordering more.
Read More
8.3
Reduced sleeplessness
I was struggling to get enough sleep, so I purchased this product to improve my sleep. Gradually, my sleeplessness is diminishing. I intend to continue using it. Thank you!
8
Enhanced sleep experience
I regularly purchase this for my son, who has an autoimmune disorder. My son struggled with sleep, but after starting this melatonin at about 15, his sleep quality improved. Although mornings are still tough, he now falls asleep more easily and wakes up feeling better. This product is truly aiding his situation.
Read More
2.3
Leg swelling issue
I initially tried melatonin for my sleep disorder. While it helped me fall asleep, I often found myself waking up to use the toilet. Additionally, it caused swelling in my legs, leading to discomfort the following day. Now, I've switched to a different brand with lower melatonin content, and I'm no longer experiencing leg pain.
Read More
