Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.6
USERS' SCORE
Moderately Good
Based on 139 Reviews
7.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
588%
Calcium (as Calcium Carbonate)
60 mg
5%
Melatonin
5 mg
*
Top Medical Research Studies
9.5
Melatonin improves sleep apnea outcomes
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
Read More
7
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
Read More
7
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
Read More
Most Useful Reviews
9
Improves sleep quality
30 people found this helpful
Excellent! It aids in improving sleep and helps me fall asleep faster.
Read More
9
Reduces insomnia symptoms
22 people found this helpful
Perfect for insomnia! I've tried many melatonin products due to severe insomnia, but this one induces sleepiness effectively without leaving me groggy if I stay up late. It has improved my insomnia significantly.
Read More
9
Restful sleep achieved
8 people found this helpful
I'm really pleased with this product. Taking one each night, I finally enjoy a restful sleep after years of insomnia. Thank you for this excellent product and service.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.6
- All Researches
9.5
Melatonin improves sleep apnea outcomes
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
Read More
7
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
Read More
7
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
Read More
7
We explored REM sleep behavior disorder (RBD) as a complex condition that can be linked to a variety of underlying disorders. Through a literature review and insights from foundational texts, we recognized that RBD may emerge at any age and can initially appear as an isolated issue or be associated with other significant conditions like Parkinson’s and narcolepsy.
Our findings highlighted that effective management often includes melatonin or clonazepam as treatment options. Furthermore, ongoing research into the connections between RBD and other sleep disorders, such as obstructive sleep apnea, remains vital for enhancing diagnostics and treatment strategies.
Our findings highlighted that effective management often includes melatonin or clonazepam as treatment options. Furthermore, ongoing research into the connections between RBD and other sleep disorders, such as obstructive sleep apnea, remains vital for enhancing diagnostics and treatment strategies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 139 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves sleep quality
30 people found this helpful
Excellent! It aids in improving sleep and helps me fall asleep faster.
Read More
9
Reduces insomnia symptoms
22 people found this helpful
Perfect for insomnia! I've tried many melatonin products due to severe insomnia, but this one induces sleepiness effectively without leaving me groggy if I stay up late. It has improved my insomnia significantly.
Read More
9
Restful sleep achieved
8 people found this helpful
I'm really pleased with this product. Taking one each night, I finally enjoy a restful sleep after years of insomnia. Thank you for this excellent product and service.
Read More
9
Insomnia relief
7 people found this helpful
This product has completely eliminated my difficulty falling asleep. I now nod off within 15-20 minutes, enjoying restful sleep without waking up. It has resolved my struggles with sleep apnea, and I feel rejuvenated every morning.
Read More
9
Great results
5 people found this helpful
I take this supplement and fall asleep within 1-2 hours. I wake up feeling refreshed, which I haven’t experienced in 10 years. This product is excellent for my sleep apnea as I no longer feel drowsy during the day.
Read More
Frequently Asked Questions
9
Insomnia relief
7 people found this helpful
This product has completely eliminated my difficulty falling asleep. I now nod off within 15-20 minutes, enjoying restful sleep without waking up. It has resolved my struggles with sleep apnea, and I feel rejuvenated every morning.
9
Easier sleep onset
1 people found this helpful
I can now fall asleep within about 30 minutes, compared to my previous struggles of waking at night. I'm pleased that I can return to sleep even if disturbed.
9
Improved sleep quality
3 people found this helpful
As a 70-year-old man, I took melatonin for two months and feel my sleep has improved. Previously, I'd struggle to sleep after waking up for the toilet at 3am. Following a doctor’s suggestion, melatonin helped me sleep again, making me feel much more rested.
9
Refreshed mornings
2 people found this helpful
Since taking melatonin, I experienced deeper sleep and woke up feeling refreshed. Good sleep is essential for health, and melatonin has become a crucial part of my routine for combating sleep apnea.
9
Improves sleep quality
30 people found this helpful
Excellent! It aids in improving sleep and helps me fall asleep faster.
9
Reduces insomnia symptoms
22 people found this helpful
Perfect for insomnia! I've tried many melatonin products due to severe insomnia, but this one induces sleepiness effectively without leaving me groggy if I stay up late. It has improved my insomnia significantly.
7.5
Quality sleep improvement
4 people found this helpful
Despite struggling with poor sleep, I've seen significant improvements after trying Natrol's melatonin. It doesn’t lead to dependency and has enhanced the quality of my sleep, allowing me to awaken refreshed without lingering effects the next day.
9
Better sleep quality
2 people found this helpful
The best melatonin supplement I've tried. It helps me fall asleep better and encourages deeper sleep. I also take 5-HTP and glycine 15 minutes before bedtime.
9
Reduced sleep medications
3 people found this helpful
After struggling with sleep aids, I now rely on just 10mg of zopiclone and 5mg of melatonin. I can fall asleep naturally and enjoy longer rest, which makes it a supplement I can't do without.
9.5
Melatonin improves sleep apnea outcomes
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
7
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
References
- Wei Z, Shen H, Wang F, Huang W, Li X, et al. Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients. Ann Med. 2024;56:2361825. doi:10.1080/07853890.2024.2361825
- Motlaq TM, Rahimi B, Amini S. Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial. J Pharm Health Care Sci. 2024;10:25. doi:10.1186/s40780-024-00347-9
- Dastan F, Gholizadeh Niari B, Adimi Naghan P, Barati S, Eskandari R. Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea. J Pharm Pharm Sci. 2023;25:418. doi:10.18433/jpps33252
- Schenck CH. REM sleep behavior disorder as a complex condition with heterogeneous underlying disorders: clinical management and prognostic implications [Commentary]. Sleep Breath. 2022;26:1289. doi:10.1007/s11325-022-02574-6
