We explored how melatonin could affect nausea in patients with small intestinal neuroendocrine tumors (SI-NETs). Our research involved studying tumor tissue from 26 patients, examining their primary tumors alongside metastases for the presence of melatonin and its receptors.
Interestingly, we found that higher melatonin levels in the body were linked to reported experiences of nausea. Specifically, patients with higher plasma melatonin levels at both time points indicated more frequent nausea occurrences. This underscores the potential role of melatonin in influencing nausea symptoms.
However, it's notable that in those cases where the disease was stable or improving, plasma levels of melatonin dropped after treatment, suggesting a complicated relationship between melatonin levels and treatment responses. These findings provide some valuable insights into the endocrine roles of melatonin in SI-NETs and signal a need for future studies to further dissect these relationships.
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Melatonin may reduce postoperative nauseaComparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial.
Moderate relevance for nausea assessment.
In a recent clinical trial involving 99 patients undergoing laminectomy, we explored the effectiveness of melatonin on postoperative nausea. Participants were divided into three groups: one received melatonin, another had gabapentin, and the third was given a starch placebo. The goal was to compare how each treatment affected both pain and anxiety following surgery.
Interestingly, we found that patients in the melatonin group reported less nausea and vomiting compared to other groups. This suggests that melatonin might play a role in easing nausea following surgical procedures.
However, it's important to note that while melatonin showed some benefits for nausea, the overall emphasis of the study was on its comparative effectiveness against gabapentin and dexmedetomidine for pain and anxiety management. Thus, while melatonin seems to help minimize nausea, more research could further clarify its role and effectiveness in diverse settings.
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