' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.3
USERS' SCORE
Excellent
Based on 5 Reviews
9.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Directly improves arthritis symptoms
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Read More
9
l-Serine and EPA effective for pain
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study relevant for arthritis pain
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Read More
8
Dietary compliance and EPA impact
Dietary biomarkers and food records indicate compliance to study diets in the ADIRA (Anti-inflammatory Diet In Rheumatoid Arthritis) trial.
Focuses on dietary patterns
We observed participants in the ADIRA trial, which aimed to see how different diets could affect rheumatoid arthritis. The study divided fifty patients into two groups: one followed an anti-inflammatory diet rich in whole grains, fruits, vegetables, and seafood, while the other consumed a control diet heavy in meat and high-fat dairy products for ten weeks. After this period, participants switched diets, allowing researchers to monitor their compliance with the prescribed eating patterns.
Our focus was on how well participants adhered to their diets, particularly regarding important dietary components like eicosapentaenoic acid (EPA), a fatty acid found in seafood known for its potential anti-inflammatory benefits. By analyzing blood samples for dietary biomarkers, we could assess their intake of whole grains, cooking oils, seafood, and fats and how these relate to the expected positive effects on arthritis.
The findings suggested that participants generally complied well with the diet emphasizing whole grains, cooking fats, seafood, and overall dietary fat quality, which is where EPA features prominently. However, we noted some uncertainty about compliance regarding fruit and vegetable intake, making it unclear if these elements were adequately incorporated into their diets.
Overall, while our study highlighted the compliance to an anti-inflammatory diet's key components, the specific impact of eicosapentaenoic acid on arthritis symptoms requires further investigation to draw solid conclusions about its effectiveness.
Our focus was on how well participants adhered to their diets, particularly regarding important dietary components like eicosapentaenoic acid (EPA), a fatty acid found in seafood known for its potential anti-inflammatory benefits. By analyzing blood samples for dietary biomarkers, we could assess their intake of whole grains, cooking oils, seafood, and fats and how these relate to the expected positive effects on arthritis.
The findings suggested that participants generally complied well with the diet emphasizing whole grains, cooking fats, seafood, and overall dietary fat quality, which is where EPA features prominently. However, we noted some uncertainty about compliance regarding fruit and vegetable intake, making it unclear if these elements were adequately incorporated into their diets.
Overall, while our study highlighted the compliance to an anti-inflammatory diet's key components, the specific impact of eicosapentaenoic acid on arthritis symptoms requires further investigation to draw solid conclusions about its effectiveness.
Read More
Most Useful Reviews
9.5
Joint health
Fish oil is beneficial for the brain and boosts the immune system. It lowers blood pressure and improves joint mobility, which is vital for those suffering from arthritis. My therapist recommended it to stabilise my cholesterol. This is a high-quality product at a reasonable price. Our family takes it daily, and we notice no side effects. Highly recommended for everyone!
Read More
9.5
Inflammation reduction
Omega-3 supports joint health and can prevent osteoporosis. It alleviates joint pain and reduces inflammation associated with arthritis. I have not experienced any side effects and take it regularly, enjoying excellent value for my money.
Read More
9.5
Pain management
I take large Omega-3 capsules, which are easy to swallow and beneficial for my arthritis. Omega-3 fatty acids help produce hormones that control inflammation and blood clotting, aiding in my overall health and potentially preventing heart disease and related conditions.
Read More
Most Recommended Products for Arthritis
Solgar B-Complex "100"
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
Nature's Way Cranberry Fruit
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
North American Herb & Spice Oreganol
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.3
9
l-Serine and EPA effective for pain
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study relevant for arthritis pain
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Read More
9
Eicosapentaenoic acid aids arthritis
Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model.
Relevant but partly complex findings
We investigated the impact of eicosapentaenoic acid (EPA) on osteoarthritis (OA) progression through an innovative approach involving gelatin hydrogels. In our study, we divided ten-week-old male mice into six different groups, each receiving various treatments after undergoing surgery that mimicked OA. This design allowed us to effectively compare the benefits of EPA delivered directly and through hydrogels.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Read More
8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Directly improves arthritis symptoms
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Read More
8
Eicosapentaenoic acid benefits chondrocytes
Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte.
Dyslipidemia and hyperglycemia effects
We explored the effects of eicosapentaenoic acid (EPA) on chondrocytes, the cells responsible for maintaining cartilage health. Specifically, we examined how these cells respond to stress from palmitic acid (PA) and high glucose levels, both of which are linked to conditions like osteoarthritis.
Our research highlighted that exposure to PA increases inflammatory responses and degenerative processes in chondrocytes. These stresses lead to the overproduction of certain harmful enzymes and inflammatory compounds that can contribute to joint pain and degradation.
Encouragingly, when we introduced EPA, we observed a notable reduction in these inflammatory effects. Not only did EPA help suppress the detrimental responses caused by PA and high glucose, but it also significantly lowered the expression of enzymes associated with degeneration.
Our findings suggest that maintaining a balance between saturated fats and omega-3 fatty acids like EPA is crucial for cartilage health. This emphasizes the importance of dietary choices in managing conditions like osteoarthritis, particularly in individuals with metabolic disorders.
Our research highlighted that exposure to PA increases inflammatory responses and degenerative processes in chondrocytes. These stresses lead to the overproduction of certain harmful enzymes and inflammatory compounds that can contribute to joint pain and degradation.
Encouragingly, when we introduced EPA, we observed a notable reduction in these inflammatory effects. Not only did EPA help suppress the detrimental responses caused by PA and high glucose, but it also significantly lowered the expression of enzymes associated with degeneration.
Our findings suggest that maintaining a balance between saturated fats and omega-3 fatty acids like EPA is crucial for cartilage health. This emphasizes the importance of dietary choices in managing conditions like osteoarthritis, particularly in individuals with metabolic disorders.
Read More
8
Dietary compliance and EPA impact
Dietary biomarkers and food records indicate compliance to study diets in the ADIRA (Anti-inflammatory Diet In Rheumatoid Arthritis) trial.
Focuses on dietary patterns
We observed participants in the ADIRA trial, which aimed to see how different diets could affect rheumatoid arthritis. The study divided fifty patients into two groups: one followed an anti-inflammatory diet rich in whole grains, fruits, vegetables, and seafood, while the other consumed a control diet heavy in meat and high-fat dairy products for ten weeks. After this period, participants switched diets, allowing researchers to monitor their compliance with the prescribed eating patterns.
Our focus was on how well participants adhered to their diets, particularly regarding important dietary components like eicosapentaenoic acid (EPA), a fatty acid found in seafood known for its potential anti-inflammatory benefits. By analyzing blood samples for dietary biomarkers, we could assess their intake of whole grains, cooking oils, seafood, and fats and how these relate to the expected positive effects on arthritis.
The findings suggested that participants generally complied well with the diet emphasizing whole grains, cooking fats, seafood, and overall dietary fat quality, which is where EPA features prominently. However, we noted some uncertainty about compliance regarding fruit and vegetable intake, making it unclear if these elements were adequately incorporated into their diets.
Overall, while our study highlighted the compliance to an anti-inflammatory diet's key components, the specific impact of eicosapentaenoic acid on arthritis symptoms requires further investigation to draw solid conclusions about its effectiveness.
Our focus was on how well participants adhered to their diets, particularly regarding important dietary components like eicosapentaenoic acid (EPA), a fatty acid found in seafood known for its potential anti-inflammatory benefits. By analyzing blood samples for dietary biomarkers, we could assess their intake of whole grains, cooking oils, seafood, and fats and how these relate to the expected positive effects on arthritis.
The findings suggested that participants generally complied well with the diet emphasizing whole grains, cooking fats, seafood, and overall dietary fat quality, which is where EPA features prominently. However, we noted some uncertainty about compliance regarding fruit and vegetable intake, making it unclear if these elements were adequately incorporated into their diets.
Overall, while our study highlighted the compliance to an anti-inflammatory diet's key components, the specific impact of eicosapentaenoic acid on arthritis symptoms requires further investigation to draw solid conclusions about its effectiveness.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 5 Reviews
9.1
9.5
Joint health
Fish oil is beneficial for the brain and boosts the immune system. It lowers blood pressure and improves joint mobility, which is vital for those suffering from arthritis. My therapist recommended it to stabilise my cholesterol. This is a high-quality product at a reasonable price. Our family takes it daily, and we notice no side effects. Highly recommended for everyone!
Read More
9.5
Inflammation reduction
Omega-3 supports joint health and can prevent osteoporosis. It alleviates joint pain and reduces inflammation associated with arthritis. I have not experienced any side effects and take it regularly, enjoying excellent value for my money.
9.5
Pain management
I take large Omega-3 capsules, which are easy to swallow and beneficial for my arthritis. Omega-3 fatty acids help produce hormones that control inflammation and blood clotting, aiding in my overall health and potentially preventing heart disease and related conditions.
8.8
Pain relief
"Mega" omega!!! An excellent fish oil with natural concentrate, rich in polyunsaturated fatty acids. It dramatically reduces cholesterol and acts as a preventive measure for cardiovascular diseases. Omega-3 aids in joint pain from arthritis and improves skin conditions. It also enhances brain function, regulating metabolism and the immune system. I take 3-4 capsules daily with meals. If my review was useful, please click "YES" at the bottom. Wishing you health and happy shopping on iHerb!
Read More
8.8
Joint flexibility
Omega-3 fish oil may prevent osteoporosis, especially in menopausal women. It improves joint health and mobility while reducing inflammation and discomfort from arthritis. The anti-inflammatory effects are notable, especially under menstrual pain.
