Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
 
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**

Top Medical Research Studies

8
5,6-DiHETE alleviates diarrhea
We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.

What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.

We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
Read More
Our exploration into the impact of fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on porcine coronaviruses revealed noteworthy findings. We found that these acids significantly reduce the viral load of several dangerous porcine viruses, including the ones responsible for diarrhea in pigs, like porcine epidemic diarrhea virus (PEDV). This reduction occurs during viral replication, rather than hindering the virus's ability to enter the cells, indicating a specific action against the viral lifecycle.

We confirmed that both DHA and EPA help in reducing inflammation and lowering reactive oxygen species (ROS) levels within cells infected by these viruses. By doing so, they also enhance the overall antioxidant capacity of the cells, providing a protective effect against the stress caused by the viruses. Overall, our findings suggest that EPA, along with DHA, could play a critical role in developing new approaches to managing infection and, consequently, controlling outbreaks of diarrhea-causing viruses in the swine industry.

These findings are particularly relevant as we look for effective treatments to combat the viral threats facing livestock and, by extension, the agricultural economy. Thus, the antiviral properties of these fatty acids provide a promising avenue for future research and therapeutic development.
Read More
8
Dietary ω3 fatty acids' benefits
We explored the effects of eicosapentaenoic acid (EPA), a crucial metabolite derived from dietary ω3 fatty acids, particularly α-linolenic acid (ALA). Our investigation aimed to understand how these compounds can potentially reduce allergic reactions, including those that lead to diarrhea.

In our study, we observed that mice consuming ALA-rich linseed oil exhibited lower instances of allergic diarrhea. This decrease seemed to stem from impaired mast cell degranulation, which is a process crucial for allergic responses. Interestingly, it didn’t affect allergen-specific serum IgE levels, suggesting a targeted response against the symptoms rather than the underlying allergy itself.

Through our detailed analyses, we identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a major metabolite produced in the gut from EPA. Notably, this compound demonstrated anti-allergic properties when administered in vivo, highlighting its potential role as a therapeutic target for managing intestinal allergies, including diarrhea.

While the research provides promising insights into the benefits of EPA, it's essential to note that the specific mechanisms and isolated effects need further clarity. Overall, our findings point to a compelling link between dietary ω3 fatty acids and their capability to ameliorate diarrhea through their metabolic pathways.
Read More

Most Useful Reviews

0
Caused diarrhoea
I used it for three weeks, but it caused diarrhoea every day. I've stopped it and I'm uncertain if I will try it again.
Read More
7.5
No bad breath
It tastes excellent, does not cause bad breath, and I’ve not experienced any diarrhoea.
Read More
7.5
Effective treatment
The effect is good and I’ve not had diarrhoea. This product seems suitable for most people.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
  • All Researches
Our exploration into the impact of fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on porcine coronaviruses revealed noteworthy findings. We found that these acids significantly reduce the viral load of several dangerous porcine viruses, including the ones responsible for diarrhea in pigs, like porcine epidemic diarrhea virus (PEDV). This reduction occurs during viral replication, rather than hindering the virus's ability to enter the cells, indicating a specific action against the viral lifecycle.

We confirmed that both DHA and EPA help in reducing inflammation and lowering reactive oxygen species (ROS) levels within cells infected by these viruses. By doing so, they also enhance the overall antioxidant capacity of the cells, providing a protective effect against the stress caused by the viruses. Overall, our findings suggest that EPA, along with DHA, could play a critical role in developing new approaches to managing infection and, consequently, controlling outbreaks of diarrhea-causing viruses in the swine industry.

These findings are particularly relevant as we look for effective treatments to combat the viral threats facing livestock and, by extension, the agricultural economy. Thus, the antiviral properties of these fatty acids provide a promising avenue for future research and therapeutic development.
Read More
8
Nutritional management in SAH patients
We explored the effect of early enteral nutrition on patients who suffered a subarachnoid hemorrhage (SAH). In a retrospective study involving 245 patients, we compared two different liquid diets: one rich in high-protein whey peptide and the other containing eicosapentaenoic acid (EPA).

Our focus was on understanding how these diets impacted patients' health outcomes, especially regarding diarrhea. While we noticed that the high-protein whey peptide group had a lower rate of diarrhea (about 15.8%) compared to the EPA group (34.3%), we couldn’t isolate the effects of EPA specifically on gastrointestinal issues.

Overall, the study indicated that the choice of nutrients in enteral feeding could influence recovery and comfort for SAH patients. However, it’s important to note that the findings on eicosapentaenoic acid alone did not demonstrate any significant benefit regarding diarrhea in this context.
Read More
8
5,6-DiHETE alleviates diarrhea
We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.

What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.

We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
Read More
8
Fiber and EPA benefit GI health
We conducted a randomized controlled trial to explore how a fiber, fish oil, and carotenoid-enriched tube feed formula might impact gastrointestinal (GI) health, particularly diarrhea, among hospitalized patients starting tube nutrition.

In this study, we compared the enriched formula to a standard, non-enriched tube feed. Daily records were kept on incidences of diarrhea and constipation based on stool frequency and consistency. After a week, we also measured levels of essential nutrients, including eicosapentaenoic acid (EPA), in the patients' plasma.

Our findings suggest that the nutrient-enriched formula may positively influence GI tolerance. We observed a reduced incidence of diarrhea among those receiving the enriched formula, along with a significant improvement in plasma levels of EPA, as well as DHA and carotenoids.

It’s important to note, however, that while the results point to benefits, the isolated effect of EPA on diarrhea couldn’t be definitively determined due to the combination of other treatments included in the formula.

Overall, this study showcases the potential advantages of using a specially formulated tube feed to support nutritional status and improve gastrointestinal outcomes for patients in need.
Read More
8
Dietary ω3 fatty acids' benefits
We explored the effects of eicosapentaenoic acid (EPA), a crucial metabolite derived from dietary ω3 fatty acids, particularly α-linolenic acid (ALA). Our investigation aimed to understand how these compounds can potentially reduce allergic reactions, including those that lead to diarrhea.

In our study, we observed that mice consuming ALA-rich linseed oil exhibited lower instances of allergic diarrhea. This decrease seemed to stem from impaired mast cell degranulation, which is a process crucial for allergic responses. Interestingly, it didn’t affect allergen-specific serum IgE levels, suggesting a targeted response against the symptoms rather than the underlying allergy itself.

Through our detailed analyses, we identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a major metabolite produced in the gut from EPA. Notably, this compound demonstrated anti-allergic properties when administered in vivo, highlighting its potential role as a therapeutic target for managing intestinal allergies, including diarrhea.

While the research provides promising insights into the benefits of EPA, it's essential to note that the specific mechanisms and isolated effects need further clarity. Overall, our findings point to a compelling link between dietary ω3 fatty acids and their capability to ameliorate diarrhea through their metabolic pathways.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
0
Caused diarrhoea
I used it for three weeks, but it caused diarrhoea every day. I've stopped it and I'm uncertain if I will try it again.
Read More
7.5
No bad breath
It tastes excellent, does not cause bad breath, and I’ve not experienced any diarrhoea.
Read More
7.5
Effective treatment
The effect is good and I’ve not had diarrhoea. This product seems suitable for most people.
Read More

Frequently Asked Questions

0
Caused diarrhoea
I used it for three weeks, but it caused diarrhoea every day. I've stopped it and I'm uncertain if I will try it again.
7.5
No bad breath
It tastes excellent, does not cause bad breath, and I’ve not experienced any diarrhoea.
7.5
Effective treatment
The effect is good and I’ve not had diarrhoea. This product seems suitable for most people.
8
5,6-DiHETE alleviates diarrhea
We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.

What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.

We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.
8
Dietary ω3 fatty acids' benefits
We explored the effects of eicosapentaenoic acid (EPA), a crucial metabolite derived from dietary ω3 fatty acids, particularly α-linolenic acid (ALA). Our investigation aimed to understand how these compounds can potentially reduce allergic reactions, including those that lead to diarrhea.

In our study, we observed that mice consuming ALA-rich linseed oil exhibited lower instances of allergic diarrhea. This decrease seemed to stem from impaired mast cell degranulation, which is a process crucial for allergic responses. Interestingly, it didn’t affect allergen-specific serum IgE levels, suggesting a targeted response against the symptoms rather than the underlying allergy itself.

Through our detailed analyses, we identified 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) as a major metabolite produced in the gut from EPA. Notably, this compound demonstrated anti-allergic properties when administered in vivo, highlighting its potential role as a therapeutic target for managing intestinal allergies, including diarrhea.

While the research provides promising insights into the benefits of EPA, it's essential to note that the specific mechanisms and isolated effects need further clarity. Overall, our findings point to a compelling link between dietary ω3 fatty acids and their capability to ameliorate diarrhea through their metabolic pathways.
4
Omega-3 fatty acids and diarrhea effects
In a double-blind study, we explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid found in fish oil, on patients with cystic fibrosis (CF) who experience pancreatic insufficiency. We compared their response to that of healthy individuals over a 6-week period. Both groups were given either fish oil or olive oil ethyl esters as a control.

Throughout the study, we observed that some participants, particularly those with CF, reported experiencing gastrointestinal issues, such as eructation and diarrhea, leading to some discontinuing the capsules before the duration was complete. While we confirmed that there was significant incorporation of omega-3 fatty acids into the plasma and cell membranes in both patient groups, our findings showed no clinically significant changes related to diarrhea or platelet aggregation in the subjects.

Therefore, we conclude that while eicosapentaenoic acid can be absorbed effectively by CF patients, it doesn't seem to provide a significant benefit in terms of managing diarrhea. This outcome suggests that further research is necessary to fully understand the relationship between omega-3 fatty acids and gastrointestinal health in individuals with CF.
8
Fiber and EPA benefit GI health
We conducted a randomized controlled trial to explore how a fiber, fish oil, and carotenoid-enriched tube feed formula might impact gastrointestinal (GI) health, particularly diarrhea, among hospitalized patients starting tube nutrition.

In this study, we compared the enriched formula to a standard, non-enriched tube feed. Daily records were kept on incidences of diarrhea and constipation based on stool frequency and consistency. After a week, we also measured levels of essential nutrients, including eicosapentaenoic acid (EPA), in the patients' plasma.

Our findings suggest that the nutrient-enriched formula may positively influence GI tolerance. We observed a reduced incidence of diarrhea among those receiving the enriched formula, along with a significant improvement in plasma levels of EPA, as well as DHA and carotenoids.

It’s important to note, however, that while the results point to benefits, the isolated effect of EPA on diarrhea couldn’t be definitively determined due to the combination of other treatments included in the formula.

Overall, this study showcases the potential advantages of using a specially formulated tube feed to support nutritional status and improve gastrointestinal outcomes for patients in need.

References

  1. Suo X, Wang J, Wang D, Fan G, Zhu M, et al. DHA and EPA inhibit porcine coronavirus replication by alleviating ER stress. J Virol. 2023;97:e0120923. doi:10.1128/jvi.01209-23
  2. Suzuki K, Sato H, Mori H, Matsumoto R, Arimoto Y, et al. Early Enteral Nutrition with High-Protein Whey Peptide Digestive Nutrients May Improve Prognosis in Subarachnoid Hemorrhage Patients. Medicina (Kaunas). 2022;58. doi:10.3390/medicina58091264
  3. Takenouchi S, Imai D, Nakamura T, Murata T. Efficient Attenuation of Dextran Sulfate Sodium-Induced Colitis by Oral Administration of 5,6-Dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid in Mice. Int J Mol Sci. 2021;22. doi:10.3390/ijms22179295
  4. Jakobsen LH, Wirth R, Smoliner C, Klebach M, Hofman Z, et al. Gastrointestinal tolerance and plasma status of carotenoids, EPA and DHA with a fiber-enriched tube feed in hospitalized patients initiated on tube nutrition: Randomized controlled trial. Clin Nutr. 2017;36:380. doi:10.1016/j.clnu.2016.02.001
  5. Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, et al. Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut. Sci Rep. 2015;5:9750. doi:10.1038/srep09750
  6. Henderson WR, Astley SJ, McCready MM, Kushmerick P, Casey S, et al. Oral absorption of omega-3 fatty acids in patients with cystic fibrosis who have pancreatic insufficiency and in healthy control subjects. J Pediatr. 1994;124:400.
  7. Stenson WF, Cort D, Rodgers J, Burakoff R, DeSchryver-Kecskemeti K, et al. Dietary supplementation with fish oil in ulcerative colitis. Ann Intern Med. 1992;116:609.
  8. Lapillonne A, Pastor N, Zhuang W, Scalabrin DM. Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life. BMC Pediatr. 2014;14:168. doi:10.1186/1471-2431-14-168
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