' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
8.4
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
9
Eicosapentaenoic acid aids ulcer healing
Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-κB and TGF-β/ EGFR signaling pathways.
Directly addresses EPA effects
We examined how Eicosapentaenoic acid (EPA) could protect against ulcerative colitis (UC), a chronic condition that inflames the large intestine. In our research, we used acetic acid to induce UC in rats, administering oral EPA for 28 days in doses of 300 and 1000 mg/kg before the acetic acid treatment.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Read More
9
Eicosapentaenoic Acid Improves UC
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Significant effects on ulcerative colitis
In our investigation, we focused on the effects of eicosapentaenoic acid (EPA) on ulcerative colitis (UC), a chronic condition characterized by inflammation in the colon. We conducted experiments using mice with dextran sodium sulfate (DSS)-induced colitis to understand how EPA might improve this condition compared to docosahexaenoic acid (DHA).
What we found was quite striking. Mice treated with high doses of EPA showed a significantly reduced severity of colitis symptoms. This improvement was linked to the presence of a stronger mucus barrier in the gut, which is essential for protecting the colon and managing interactions between the host and gut bacteria.
Additionally, we observed that EPA encouraged the production of mucin and enhanced the diversity of beneficial gut microbiota. This suggests that EPA not only helps to fortify the mucus lining of the colon but also supports a healthy balance of gut bacteria, which may further alleviate UC symptoms.
Therefore, our results highlight the potential of EPA as a promising therapeutic option for those suffering from ulcerative colitis.
What we found was quite striking. Mice treated with high doses of EPA showed a significantly reduced severity of colitis symptoms. This improvement was linked to the presence of a stronger mucus barrier in the gut, which is essential for protecting the colon and managing interactions between the host and gut bacteria.
Additionally, we observed that EPA encouraged the production of mucin and enhanced the diversity of beneficial gut microbiota. This suggests that EPA not only helps to fortify the mucus lining of the colon but also supports a healthy balance of gut bacteria, which may further alleviate UC symptoms.
Therefore, our results highlight the potential of EPA as a promising therapeutic option for those suffering from ulcerative colitis.
Read More
9
Eicosapentaenoic acid reduces inflammation
Eicosapentaenoic Acid Reduces Fecal Levels of Calprotectin and Prevents Relapse in Patients With Ulcerative Colitis.
High relevance to UC management
We conducted a study to figure out how eicosapentaenoic acid (EPA) affects patients with ulcerative colitis (UC), particularly its role in reducing inflammation and preventing relapse. This was a well-structured trial involving 60 participants who had stable UC therapy for at least three months. They were randomly assigned to receive either EPA in its free fatty acid form (500 mg, twice daily) or a placebo over six months.
Throughout the study, we tracked levels of calprotectin in fecal samples, a marker indicating inflammation in the intestines. Our goal was to see if EPA could lead to a significant reduction in these levels, as well as maintain remission from symptoms. The results were promising—after six months, we found that those taking EPA had lower calprotectin levels, suggesting less inflammation and contributing to fewer relapses.
Importantly, no serious side effects were reported during the study, which adds to the potential appeal of using EPA as a treatment option. Overall, our findings suggest that EPA could be a useful component in the management of UC, helping patients achieve and sustain symptom-free periods.
Throughout the study, we tracked levels of calprotectin in fecal samples, a marker indicating inflammation in the intestines. Our goal was to see if EPA could lead to a significant reduction in these levels, as well as maintain remission from symptoms. The results were promising—after six months, we found that those taking EPA had lower calprotectin levels, suggesting less inflammation and contributing to fewer relapses.
Importantly, no serious side effects were reported during the study, which adds to the potential appeal of using EPA as a treatment option. Overall, our findings suggest that EPA could be a useful component in the management of UC, helping patients achieve and sustain symptom-free periods.
Read More
Most Useful Reviews
9.5
Healed gastric ulcers
Omega 3 is an excellent remedy for treating ulcers. After starting the supplement, I found that my ulcer pain diminished in just a few days, and healing began swiftly. Omega 3 not only aids digestion but also normalises fat metabolism. Additionally, it is beneficial for joint health and helps reduce inflammation. It plays a crucial role in brain function, making it easier to think and store memories. I highly recommend taking 3-4 capsules daily with meals for optimal effects.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
8.4
9
Eicosapentaenoic acid aids ulcer healing
Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-κB and TGF-β/ EGFR signaling pathways.
Directly addresses EPA effects
We examined how Eicosapentaenoic acid (EPA) could protect against ulcerative colitis (UC), a chronic condition that inflames the large intestine. In our research, we used acetic acid to induce UC in rats, administering oral EPA for 28 days in doses of 300 and 1000 mg/kg before the acetic acid treatment.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.
Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.
Read More
9
Effective treatment for ulcerative colitis
Icosapent ethyl alleviates acetic acid-induced ulcerative colitis via modulation of SIRT1 signaling pathway in rats.
Relevant but not isolated findings
We explored how icosapent ethyl, a form of eicosapentaenoic acid, affects ulcerative colitis, a significant inflammatory bowel disease impacting many individuals globally. In our assessment involving 36 male Wistar rats, we divided them into six groups, including a control, those with ulcerative colitis induced by acetic acid, and various treatment groups receiving either mesalamine or different doses of icosapent ethyl.
Through this structured approach, we observed that the rats with colitis displayed higher levels of harmful substances and lower levels of protective ones. However, upon administering icosapent ethyl, we noted a remarkable reduction in the severity of the inflammation, along with improvements in several biological markers, including reduced levels of malondialdehyde and certain inflammatory cytokines. The more significant dosage of icosapent, at 300 mg/kg, produced effects similar to the widely used drug, mesalamine.
We must highlight that the beneficial effects of icosapent were partially reversed by EX527, which suggests that its protective actions may involve activation of the SIRT1 signaling pathway. Our findings point toward the potential of icosapent ethyl to be an effective treatment option for ulcerative colitis, showcasing its anti-inflammatory and antioxidant properties.
Through this structured approach, we observed that the rats with colitis displayed higher levels of harmful substances and lower levels of protective ones. However, upon administering icosapent ethyl, we noted a remarkable reduction in the severity of the inflammation, along with improvements in several biological markers, including reduced levels of malondialdehyde and certain inflammatory cytokines. The more significant dosage of icosapent, at 300 mg/kg, produced effects similar to the widely used drug, mesalamine.
We must highlight that the beneficial effects of icosapent were partially reversed by EX527, which suggests that its protective actions may involve activation of the SIRT1 signaling pathway. Our findings point toward the potential of icosapent ethyl to be an effective treatment option for ulcerative colitis, showcasing its anti-inflammatory and antioxidant properties.
Read More
9
Long-chain fatty acids and ulcers
Long-chain polyunsaturated fatty acid supplementation increases levels in red blood cells and reduces the prevalence and severity of squamous gastric ulcers in exercised Thoroughbreds.
Moderate relevance due to mixture limits
We set out to understand how different types of fatty acids might affect the development and severity of gastric ulcers in fit Thoroughbred horses. Our research involved 13 horses undergoing strenuous training, and we assessed their gastric health before and after three months of supplementation with two types of polyunsaturated fatty acids.
The horses completed a standardized exercise test to simulate the stress of racing. We specifically looked at the impact of long-chain polyunsaturated fatty acids (like eicosapentaenoic acid) found in fish oil, compared to short-chain fatty acids derived from a blend of corn and flax oil.
We observed that the long-chain fatty acid supplementation resulted in higher levels of important fatty acids, including eicosapentaenoic acid, and was linked to a reduced incidence and severity of gastric ulcers. This suggests that eicosapentaenoic acid may play a beneficial role in gastric health for high-performance horses.
However, since our findings were based on a blend of various fatty acids, isolating the specific effects of eicosapentaenoic acid on ulcers required further investigation. Thus, while our study indicates a promising trend, more research will be essential to explore this area thoroughly.
The horses completed a standardized exercise test to simulate the stress of racing. We specifically looked at the impact of long-chain polyunsaturated fatty acids (like eicosapentaenoic acid) found in fish oil, compared to short-chain fatty acids derived from a blend of corn and flax oil.
We observed that the long-chain fatty acid supplementation resulted in higher levels of important fatty acids, including eicosapentaenoic acid, and was linked to a reduced incidence and severity of gastric ulcers. This suggests that eicosapentaenoic acid may play a beneficial role in gastric health for high-performance horses.
However, since our findings were based on a blend of various fatty acids, isolating the specific effects of eicosapentaenoic acid on ulcers required further investigation. Thus, while our study indicates a promising trend, more research will be essential to explore this area thoroughly.
Read More
9
Eicosapentaenoic acid aids ulcer healing
Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic Mice through Angiogenesis and Macrophage Polarization.
Relevant but includes other components
We set out to explore the effects of eicosapentaenoic acid (EPA), a key ingredient in a marine oil supplement called LIPINOVA, on wound healing in diabetic mice. This study focused on chronic inflammation, a common issue in type 2 diabetes that often hinders the healing of ulcers.
To understand how EPA influences healing, we applied LIPINOVA to wounds created in test mice. We observed that this marine oil not only helped in closing the wounds faster but also reduced pro-inflammatory macrophages—potentially harmful immune cells that can slow down healing. Additionally, the oil encouraged better blood vessel formation and helped to balance macrophage polarization, transitioning from the inflammatory type (Mφ1) to the healing type (Mφ2).
Our findings highlight the promising role of EPA-rich marine oil in improving wound healing for diabetic patients. With its unique ability to resolve inflammation and speed up tissue repair, LIPINOVA may serve as a valuable therapeutic option for treating diabetic ulcers.
To understand how EPA influences healing, we applied LIPINOVA to wounds created in test mice. We observed that this marine oil not only helped in closing the wounds faster but also reduced pro-inflammatory macrophages—potentially harmful immune cells that can slow down healing. Additionally, the oil encouraged better blood vessel formation and helped to balance macrophage polarization, transitioning from the inflammatory type (Mφ1) to the healing type (Mφ2).
Our findings highlight the promising role of EPA-rich marine oil in improving wound healing for diabetic patients. With its unique ability to resolve inflammation and speed up tissue repair, LIPINOVA may serve as a valuable therapeutic option for treating diabetic ulcers.
Read More
9
EPA shows promise in ulcer healing
Fish Skin Grafts with Omega-3 for Treatment of Chronic Wounds: Exploring the Role of Omega-3 Fatty Acids in Wound Healing and A Review of Clinical Healing Outcomes.
Moderate relevance for EPA effects
We explored how eicosapentaenoic acid (EPA), a key omega-3 fatty acid found in fish skin grafts, plays a role in treating chronic ulcers. Specifically, we were interested in its effects on conditions like diabetic foot ulcers that notoriously resist standard treatments. Our focus was on understanding whether EPA could significantly speed up the healing process.
Research indicates that EPA may help wounds heal faster by influencing various biological processes. Its properties enhance wound closure by providing a protective barrier against bacteria and modifying the wound's inflammatory response. When fish skin grafts rich in omega-3s were used for ulcers, patients experienced improved healing rates compared to traditional methods. This suggests that EPA's inclusion could be a valuable aspect of treatment.
While our findings highlight EPA's beneficial effects, it's essential to note that these results are part of a composite treatment approach that includes other factors at play. Thus, while EPA shows promise, the isolating impact of this specific fatty acid on wound healing remains an area for further investigation.
Research indicates that EPA may help wounds heal faster by influencing various biological processes. Its properties enhance wound closure by providing a protective barrier against bacteria and modifying the wound's inflammatory response. When fish skin grafts rich in omega-3s were used for ulcers, patients experienced improved healing rates compared to traditional methods. This suggests that EPA's inclusion could be a valuable aspect of treatment.
While our findings highlight EPA's beneficial effects, it's essential to note that these results are part of a composite treatment approach that includes other factors at play. Thus, while EPA shows promise, the isolating impact of this specific fatty acid on wound healing remains an area for further investigation.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
9.5
Healed gastric ulcers
Omega 3 is an excellent remedy for treating ulcers. After starting the supplement, I found that my ulcer pain diminished in just a few days, and healing began swiftly. Omega 3 not only aids digestion but also normalises fat metabolism. Additionally, it is beneficial for joint health and helps reduce inflammation. It plays a crucial role in brain function, making it easier to think and store memories. I highly recommend taking 3-4 capsules daily with meals for optimal effects.
Read More
