Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Biotin
10,000 mcg
33,333%
Top Medical Research Studies
9.5
We explored the effects of biotin therapy on a neonate suffering from a rare metabolic disorder known as holocarboxylase synthetase deficiency. After initiating a biotin mega-dose regimen, we observed impressive results, with the baby showing notable clinical improvement just one day later.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
9.5
Biotin treatment showed significant effect
We examined a patient diagnosed with holocarboxylase synthetase (HCS) deficiency, who presented with a notable rash and other severe symptoms. This condition disrupts biotin's incorporation into enzymes, leading to serious health challenges.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
8
Biotin treatment mitigates rash symptoms
This study looked at children with partial biotinidase deficiency to understand its effects and inheritance. While many were healthy at diagnosis, we found that one child developed skin rash, hair loss, and muscle weakness—symptoms that improved following biotin treatment.
Notably, other family members also displayed partial deficiency without symptoms, but one adult had minor issues that were alleviated with biotin. Overall, while most individuals are symptom-free at birth, this research suggests that biotin therapy could be beneficial for preventing future complications.
Notably, other family members also displayed partial deficiency without symptoms, but one adult had minor issues that were alleviated with biotin. Overall, while most individuals are symptom-free at birth, this research suggests that biotin therapy could be beneficial for preventing future complications.
Most Useful Reviews
9
Fewer rashes noted
56 people found this helpful
Excellent! After two months of application, I've noticed my skin has lightened, and the rashes have reduced. My nails have stopped flaking. I recommend this biotin to everyone.
9
Less hair loss
8 people found this helpful
This additive worked excellently. I decided to try it as my hair was falling out significantly. I can say it truly is effective; hair loss has reduced markedly, and there's a noticeable shine to my hair. My skin is clearer with no rashes, and my nails have stopped flaking. They grow back quickly, and it's a very convenient once-a-day dosage. I highly recommend it.
0
Subcutaneous rashes
1 people found this helpful
The biotin has some effects, yet I experienced side effects. I bought this biotin due to many positive reviews and split the large dosage. After about a month, my hair growth improved by about 0.5 cm faster monthly, and my nails became less brittle. However, I developed sore subcutaneous rashes on my face that only disappeared after I stopped taking it. It may be due to the high dosage or the many excipients present.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
- All Researches
9.5
We explored the effects of biotin therapy on a neonate suffering from a rare metabolic disorder known as holocarboxylase synthetase deficiency. After initiating a biotin mega-dose regimen, we observed impressive results, with the baby showing notable clinical improvement just one day later.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
9.5
We reviewed the clinical and biochemical characteristics of 28 Chinese patients with holocarboxylase synthetase (HLCS) deficiency. Through this retrospective analysis, we observed that most patients exhibited symptoms like rash, seizures, and vomiting. However, after timely biotin supplementation, almost all showed remarkable improvement in their symptoms and overall health.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
9.5
We explored a fascinating case involving a 6-year-old Vietnamese boy diagnosed with holocarboxylase synthetase deficiency, which is linked to biotin metabolism issues. The boy had a significant skin rash and metabolic acidosis, raising suspicion of multiple carboxylase deficiency. After confirming the diagnosis through urine and genetic tests, he began treatment with biotin.
Remarkably, he experienced a dramatic improvement in his condition within just days of starting the treatment. This strongly suggests that biotin can effectively address symptoms related to this deficiency, including skin rashes.
Remarkably, he experienced a dramatic improvement in his condition within just days of starting the treatment. This strongly suggests that biotin can effectively address symptoms related to this deficiency, including skin rashes.
9.5
We explored a case involving a 2-month-old boy who presented with severe symptoms, including seizures and rash, and was quickly suspected of having biotinidase deficiency. After starting him on biotin supplements, we observed remarkable improvement within just 48 hours. His skin conditions, including perioral and perianal rashes, as well as overall health, significantly improved after regular biotin intake. At 10 months, the child is thriving and seizure-free, showcasing how effective timely biotin treatment can be in alleviating symptoms and resolving rash in such cases.
9.5
Biotin treatment showed significant effect
We examined a patient diagnosed with holocarboxylase synthetase (HCS) deficiency, who presented with a notable rash and other severe symptoms. This condition disrupts biotin's incorporation into enzymes, leading to serious health challenges.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Fewer rashes noted
56 people found this helpful
Excellent! After two months of application, I've noticed my skin has lightened, and the rashes have reduced. My nails have stopped flaking. I recommend this biotin to everyone.
9
Less hair loss
8 people found this helpful
This additive worked excellently. I decided to try it as my hair was falling out significantly. I can say it truly is effective; hair loss has reduced markedly, and there's a noticeable shine to my hair. My skin is clearer with no rashes, and my nails have stopped flaking. They grow back quickly, and it's a very convenient once-a-day dosage. I highly recommend it.
0
Subcutaneous rashes
1 people found this helpful
The biotin has some effects, yet I experienced side effects. I bought this biotin due to many positive reviews and split the large dosage. After about a month, my hair growth improved by about 0.5 cm faster monthly, and my nails became less brittle. However, I developed sore subcutaneous rashes on my face that only disappeared after I stopped taking it. It may be due to the high dosage or the many excipients present.
7.5
Improves overall health
Biotin, known as the beauty vitamin, is vital for metabolism, benefiting hair, nails, and skin. Increasing biotin intake can enhance hair quality, thickness, and shine. It tackles dullness, dryness, peeling skin, and rashes around the eyes, nose, and mouth, nourishing hair follicles and tackling seborrhea effectively.
7.5
Skin healing
This supplement is effective for hair and skin growth. Biotin enhances skin appearance, especially if rashes or dermatitis are present, and promotes hair growth. I also noticed increased energy during use. It is quite pleasant tasting.
Frequently Asked Questions
9
Fewer rashes noted
56 people found this helpful
Excellent! After two months of application, I've noticed my skin has lightened, and the rashes have reduced. My nails have stopped flaking. I recommend this biotin to everyone.
9
Less hair loss
8 people found this helpful
This additive worked excellently. I decided to try it as my hair was falling out significantly. I can say it truly is effective; hair loss has reduced markedly, and there's a noticeable shine to my hair. My skin is clearer with no rashes, and my nails have stopped flaking. They grow back quickly, and it's a very convenient once-a-day dosage. I highly recommend it.
0
Subcutaneous rashes
1 people found this helpful
The biotin has some effects, yet I experienced side effects. I bought this biotin due to many positive reviews and split the large dosage. After about a month, my hair growth improved by about 0.5 cm faster monthly, and my nails became less brittle. However, I developed sore subcutaneous rashes on my face that only disappeared after I stopped taking it. It may be due to the high dosage or the many excipients present.
1
Caused acne
After reading reviews about biotin, I had not expected it would cause rashes, yet I experienced it myself—likely due to high dosage. I intended to use it to prevent hair loss but ultimately had to stop because of the rash. Once I ceased taking it, the rash soon disappeared.
8
Biotin shows variable rash improvement
We investigated the effects of biotin therapy on patients suffering from a rare condition affecting holocarboxylase formation. Among the five patients, four showed a significant improvement in their rashes with doses ranging from 10 to 20 mg daily.
However, one patient required a much higher dose of 100 mg daily for her skin rash to improve. While biotin was effective in alleviating some symptoms, it did not completely resolve all clinical issues for everyone involved in the study. We concluded that biotin can help with rashes in certain cases, but the benefits vary greatly among individuals.
However, one patient required a much higher dose of 100 mg daily for her skin rash to improve. While biotin was effective in alleviating some symptoms, it did not completely resolve all clinical issues for everyone involved in the study. We concluded that biotin can help with rashes in certain cases, but the benefits vary greatly among individuals.
9.5
We explored the effects of biotin treatment on a young boy diagnosed with biotinidase deficiency, which presented with neurological issues and a skin rash. Upon administration of 20 mg of biotin daily, we observed a significant and rapid improvement in both his clinical condition and biochemical markers, leading to the cessation of antiseizure medications. Importantly, despite the presence of a rash, biotin showed clear efficacy in improving the patient's overall health without developmental delays by 18 months.
We evaluated two premature twin infants who experienced serious health issues due to riboflavin and biotin deficiencies. They presented with skin rash and other severe complications while receiving prolonged parenteral nutrition.
After starting biotin and riboflavin supplementation, the surviving twin showed significant improvement within a few days. Remarkably, the rash and other clinical signs improved, allowing him to be discharged in stable condition.
This case highlights the positive impact of biotin on rash resolution in the context of vitamin deficiencies.
After starting biotin and riboflavin supplementation, the surviving twin showed significant improvement within a few days. Remarkably, the rash and other clinical signs improved, allowing him to be discharged in stable condition.
This case highlights the positive impact of biotin on rash resolution in the context of vitamin deficiencies.
References
- Zou H, Yang L, Zhang R, Qin Y. Case report: A case of holocarboxylase synthetase deficiency with respiratory tract as the initial symptom. Front Genet. 2024;15:1439343. doi:10.3389/fgene.2024.1439343
- Kim SW, Lee HJ, Choi N, Kim EK, Ko JM. Dramatic Clinical Improvement With Biotin Mega-Dose Therapy in a Neonate With Holocarboxylase Synthetase Deficiency. Mol Genet Genomic Med. 2024;12:e70002. doi:10.1002/mgg3.70002
- Adie MA, Martes Gomez M, Yom J, Durand M, Wertheimer F, et al. Twin Premature Infants With Riboflavin and Biotin Deficiency Presenting With Refractory Lactic Acidosis, Rash, and Multiorgan Failure During Prolonged Parenteral Nutrition. J Investig Med High Impact Case Rep. 2023;11:23247096231168111. doi:10.1177/23247096231168111
- Ling S, Qiu W, Zhang H, Liang L, Lu D, et al. Clinical, biochemical, and genetic analysis of 28 Chinese patients with holocarboxylase synthetase deficiency. Orphanet J Rare Dis. 2023;18:48. doi:10.1186/s13023-023-02656-y
- Shoaib M, Faraz A, Ahmed SA, Jamil M, Aijaz Z. Diagnostic Dilemma Of Biotinidase Deficiency: Case Of A Child From Pakistan. J Ayub Med Coll Abbottabad. 2016;28:821.
- Ogawa Y, Kiba T, Nakano K, Fujiwara K, Taniguchi H, et al. [Prospective study of biotin treatment in patients with erythema due to gefitinib or erlotinib]. Gan To Kagaku Ryoho. 2014;41:517.
- Hui J, Law E, Chung C, Fung S, Yuen P, et al. The first reported HLCS gene mutation causing holocarboxylase synthetase deficiency in a Vietnamese patient. World J Pediatr. 2012;8:278. doi:10.1007/s12519-011-0301-9
- Rajendiran A, Sampath S. Biotinidase deficiency--clinching the diagnosis rapidly can make all the difference!. BMJ Case Rep. 2011;2011. doi:10.1136/bcr.07.2011.4494
- Chou IC, Wang CS, Lin WD, Lin HC, Tsai CH, et al. Holocarboxylase synthetase deficiency: report of one case. Acta Paediatr Taiwan. 2006;47:309.
- Kimura M, Fukui T, Tagami Y, Fujiwaki T, Yokoyama M, et al. Normalization of low biotinidase activity in a child with biotin deficiency after biotin supplementation. J Inherit Metab Dis. 2003;26:715.
- Schulpis KH, Karikas GA, Tjamouranis J, Regoutas S, Tsakiris S. Low serum biotinidase activity in children with valproic acid monotherapy. Epilepsia. 2001;42:1359.
- Gulati S, Passi GR, Kumar A, Kabra M, Kalra V, et al. Biotinidase deficiency--a treatable entity. Indian J Pediatr. 2000;67:464.
- Suormala T, Fowler B, Duran M, Burtscher A, Fuchshuber A, et al. Five patients with a biotin-responsive defect in holocarboxylase formation: evaluation of responsiveness to biotin therapy in vivo and comparative biochemical studies in vitro. Pediatr Res. 1997;41:666.
- Livne M, Gibson KM, Amir N, Eshel G, Elpeleg ON. Holocarboxylase synthetase deficiency: a treatable metabolic disorder masquerading as cerebral palsy. J Child Neurol. 1994;9:170.
- Héron B, Gautier A, Dulac O, Ponsot G. [Biotinidase deficiency. Progressive encephalopathy curable with biotin]. Arch Fr Pediatr. 1993;50:875.
- McVoy JR, Levy HL, Lawler M, Schmidt MA, Ebers DD, et al. Partial biotinidase deficiency: clinical and biochemical features. J Pediatr. 1990;116:78.
