Natrol Vitamin B12 5000mcg

We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.

By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.

Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.

9.5

Reduced back pain

Most Useful Review

I had severe back pain and numbness, and thanks to this supplement, the numbness has disappeared. Although the pain subsided temporarily, it has returned, so I take it during the worst times. I struggled to walk for quite a while, and I wish I had found this supplement sooner.

Knee Pain details

I've suffered from pain in my neck, shoulders, and arms for two years, trying various treatments without lasting success. When I was prescribed B12 in Japan, the dosage was low, so I searched for a better option and found this product. After taking it, my long-standing pain disappeared, and I graduated from the clinic I had attended for nine months. I believe this, combined with my treatment, was crucial for my recovery. I highly recommend it!

Anemia details

SCIENTIFIC SCORE

Moderately Effective

Based on 11 Researches

Vitamin B12 effectively treats anemia

An Unusual Case of Hemolytic Anemia: A Case Report.

Most Relevant Research

We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.

However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.

This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.

8.8

Improved vitamin levels

Most Useful Review

I had very low vitamin B-12, around 150 units, which caused me to feel unwell and showed signs of anemia. After taking this supplement, I raised my B-12 to 275 units. I appreciate that methylcobalamin is noted as a more natural form. This product has been very helpful for me.

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE

Questionable

Based on 7 Researches

Vitamin B12 ineffective for CFS

N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.

Most Relevant Research

We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.

In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.

These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.

8.8

Chronic fatigue relief

Most Useful Review

As I suffer from chronic fatigue syndrome, I started taking Vitamin B12, having read that it helps with nerve issues. The taste of this tablet is enjoyable, similar to a sweet. The price is very reasonable. I have been taking it for three years and will continue doing so.

Shingles details

SCIENTIFIC SCORE

Moderately Effective

Based on 7 Researches

Vitamin B12 aids shingles pain relief

Vitamin B12 for herpetic neuralgia: A meta-analysis of randomised controlled trials.

Most Relevant Research

We conducted a review of randomized controlled trials to determine the effectiveness of vitamin B12 in treating postherpetic neuralgia (PHN), a painful condition following shingles. Our analysis included data from databases such as PubMed and Cochrane Library, focusing specifically on trials that measured pain relief outcomes.

Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.

Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.

9.5

Good taste, effective

Most Useful Review

This can help those suffering from nerve pain and shingles. I experienced low energy from shingles and needed B12. I love this brand; it works well and tastes good! I'm tempted to take two because it's that pleasant.

Autoimmune Disorder details

SCIENTIFIC SCORE

Possibly Effective

Based on 13 Researches

Pernicious anemia treatment effectiveness

Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.

Most Relevant Research

We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.

Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.

This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.

9.5

Cognitive improvement

Most Useful Review

After my mother, in her 90s, took this for her numbness, she reported feeling much better, with no numbness now. The taste is pleasant, making it easy for the elderly to take, and it has been effective for her cognitive health.

Vertigo details

SCIENTIFIC SCORE

Possibly Effective

Based on 6 Researches

Vitamin B12 enhances acupuncture effects

[Observation of therapeutic effects on cervical vertigo treated with different methods].

Most Relevant Research

We explored the effectiveness of various treatments for cervical vertigo, specifically focusing on different acupuncture methods and the inclusion of Vitamin B12 in one of the therapy combinations. In our study, ninety-one participants were divided into three groups: one receiving routine acupuncture, another using electroacupuncture, and a third receiving a combination of electroacupuncture and Vitamin B12 injections along with local anesthetics.

Each therapy was administered over twenty sessions within a month. We measured changes in blood flow in the vertebral and basilar arteries and evaluated the participants' symptoms and overall function related to their vertigo. While all treatment methods showed some positive effects, the combination therapy, which included Vitamin B12, stood out as being the most effective.

This suggests that Vitamin B12 might play a significant role alongside acupuncture methods in treating cervical vertigo. However, it’s important to note that the specific impact of Vitamin B12 alone wasn’t isolated in this study, leaving us to consider its effects within the broader context of combined therapies.

8.8

Effective vertigo treatment

Most Useful Review

Natrol is a highly regarded quality product. The small size makes it easy to dissolve, which I need to help reduce my vertigo and support my nervous system.

Neuropathy details

SCIENTIFIC SCORE

Moderately Effective

Based on 13 Researches

Nitrous oxide affects B12 levels

Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report.

Most Relevant Research

We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.

In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.

Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.

6.8

Reduced symptoms

Most Useful Review

I have a Vitamin B-12 deficiency causing nerve neuropathy, primarily affecting my fingers, though my toes have started hurting too. My doctor diagnosed me with Pernicious Anaemia and suggested a trial of B-12 supplements before prescribing medication. I have been taking these chewables for over a week, and while the tingling and burning in my fingertips have lessened, they have not completely vanished. The doctor wants to continue the vitamins before determining the next steps. I hope they work well.

Blood Clot details

SCIENTIFIC SCORE

Moderately Effective

Based on 8 Researches

Vitamin B12's role in clotting

Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review.

Most Relevant Research

We observed a compelling case involving a 19-year-old female diagnosed with cerebral venous thrombosis (CVT) and intracerebral hemorrhage. This unusual situation stemmed from her history of nitrous oxide abuse, which led to a significant deficiency in vitamin B12. Nitrous oxide can interfere with vitamin B12's vital functions, particularly its role in breaking down homocysteine levels in the blood.

Our investigation revealed her serum vitamin B12 level was alarmingly low at less than 100 pg/mL, while her homocysteine levels soared to 100.6 µmol/L, far exceeding the normal range. After she began vitamin B12 supplementation, we were pleased to see her vitamin B12 levels return to normal, along with a drastic reduction in homocysteine.

This case highlights an essential connection: low vitamin B12 levels may contribute to hyperhomocysteinemia, which in turn could play a significant role in the formation of blood clots. While there were no other thrombophilia risk factors found, the evidence suggests that restoring vitamin B12 levels through supplementation can positively impact homocysteine levels and reduce the risk of clotting problems.

Overall, this finding underscores how important vitamin B12 is in maintaining healthy blood clotting mechanisms.

Improved neck pain

Most Useful Review

Doctors prescribe it for stiff shoulder headaches. I had stiffness in my shoulder, neck, and a headache, and the doctor recommended vitamin B12 (methicobal). It helps synthesise haemoglobin for oxygen transport in the blood, and improves pain and numbness. A lack of vitamin B12 may lead to issues like poor concentration and blood clot. Even after long hours at my desk, when painkillers fail, vitamin B12 provides relief. I find it cheaper than prescriptions and enjoy the subtle fruity taste, easily taken with water.

Heart Disease details

SCIENTIFIC SCORE

Questionable

Based on 4 Researches

Vitamin B12 helps heart recovery

Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.

Most Relevant Research

We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.

Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.

Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.

Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.

Eliminated pain

Most Useful Review

Vitamin B12 is crucial for combating pain and preventing heart disease, as well as pernicious anaemia and strokes. It aids in treating nervous disorders, depression, hypertension, and sclerosis.