' 
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.6
USERS' SCORE
Good
Based on 17 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Calcium (as Dibasic Calcium Phosphate)
65 mg
5%
Melatonin
3 mg
*
Top Medical Research Studies
9.5
Melatonin improves sleep apnea outcomes
Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
Relevant and promising findings
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
Read More
7
Agomelatine shows promise for OSA
Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.
Moderate relevance to sleep therapies.
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
Read More
7
Melatonin's role in sleep apnea
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
Significance of melatonin in OSA
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
Read More
Most Useful Reviews
9.5
Improved sleep quality
Long live melatonin! It, along with GABA, has been my foundation for half a year and has made me feel like a new person! Only those who have grappled with sleep issues for years will understand my joy. For nearly twenty years, I struggled to sleep as well as I do now! The price of "Melaxen", which contains melatonin, in our pharmacies is so high that it’s hard to feel relaxed about buying it. Do not enrich our pharmacy hucksters, buy here! I duplicated my review on Melatonin from Now because both work perfectly for me and provide excellent sleep.
Read More
9.5
Quality sleep achieved
The key to quality sleep! After a month, I can confidently say this melatonin is excellent. An optimal and safe dosage of 3mg is all I need at night; one capsule suffices. It's suitable for adults with sleep disturbances, anxiety, and restlessness, and it’s non-addictive. I recommend buying in bulk to wake up refreshed in the morning.
Read More
9.5
Vigorous mornings
I take one tablet an hour before bedtime, and my sleep has greatly improved. I wake up feeling vigorous and healthy each morning, thanks to the effective treatment of my sleep apnea.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.6
- All Researches
9.5
Melatonin improves sleep apnea outcomes
Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
Relevant and promising findings
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
Read More
7
Melatonin's role in sleep apnea
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
Significance of melatonin in OSA
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
Read More
7
Agomelatine shows promise for OSA
Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.
Moderate relevance to sleep therapies.
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
Read More
7
REM Sleep Behavior Disorder Overview
REM sleep behavior disorder as a complex condition with heterogeneous underlying disorders: clinical management and prognostic implications [Commentary].
Highly relevant clinical insights
We explored REM sleep behavior disorder (RBD) as a complex condition that can be linked to a variety of underlying disorders. Through a literature review and insights from foundational texts, we recognized that RBD may emerge at any age and can initially appear as an isolated issue or be associated with other significant conditions like Parkinson’s and narcolepsy.
Our findings highlighted that effective management often includes melatonin or clonazepam as treatment options. Furthermore, ongoing research into the connections between RBD and other sleep disorders, such as obstructive sleep apnea, remains vital for enhancing diagnostics and treatment strategies.
Our findings highlighted that effective management often includes melatonin or clonazepam as treatment options. Furthermore, ongoing research into the connections between RBD and other sleep disorders, such as obstructive sleep apnea, remains vital for enhancing diagnostics and treatment strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved sleep quality
Long live melatonin! It, along with GABA, has been my foundation for half a year and has made me feel like a new person! Only those who have grappled with sleep issues for years will understand my joy. For nearly twenty years, I struggled to sleep as well as I do now! The price of "Melaxen", which contains melatonin, in our pharmacies is so high that it’s hard to feel relaxed about buying it. Do not enrich our pharmacy hucksters, buy here! I duplicated my review on Melatonin from Now because both work perfectly for me and provide excellent sleep.
Read More
9.5
Quality sleep achieved
The key to quality sleep! After a month, I can confidently say this melatonin is excellent. An optimal and safe dosage of 3mg is all I need at night; one capsule suffices. It's suitable for adults with sleep disturbances, anxiety, and restlessness, and it’s non-addictive. I recommend buying in bulk to wake up refreshed in the morning.
Read More
9.5
Vigorous mornings
I take one tablet an hour before bedtime, and my sleep has greatly improved. I wake up feeling vigorous and healthy each morning, thanks to the effective treatment of my sleep apnea.
9.5
Refreshed mornings
Nature Made Melatonin 3mg/240 capsules has been a staple for my mild insomnia. This dose is perfect for my sleep, not too strong, and I wake up feeling refreshed. It’s highly effective, and I recommend it to everyone struggling with sleep apnea.
8.3
Effective remedy identified
This is a proven product that helps achieve quality sleep quickly with no side effects. It’s more effective than some medications. One pill is adequate, especially if you avoid excessive coffee and caffeine consumption, positively influencing my sleep apnea.
