Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Vitamin D3 (as Cholecalciferol)
10 mcg (400 IU)
50%
Calcium (as Calcium Carbonate)
600 mg
46%
Top Medical Research Studies
9
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
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7
We conducted a study to explore the connection between vitamin D3 levels and the impact of low back pain (LBP) on function and pain levels among a group of middle-aged Azeri individuals in North West Iran. Our case-control approach included 63 patients suffering from LBP and 55 healthy participants.
By analyzing blood samples, we found that the average serum concentration of 25-hydroxyvitamin D3 was notably lower in the LBP group compared to the healthy controls. This suggests that those with lower vitamin D levels are more likely to experience LBP.
Moreover, our analysis revealed a significant relationship between vitamin D3 levels and both pain intensity and disability. Specifically, we noted that lower vitamin D levels correlated with higher pain intensity as measured by a Visual Analogue Scale and greater functional disability assessed with the Modified Oswestry Questionnaire.
Overall, our findings highlight the potential role of vitamin D3 in managing back pain and suggest that addressing vitamin D deficiency could help improve outcomes for individuals suffering from LBP.
By analyzing blood samples, we found that the average serum concentration of 25-hydroxyvitamin D3 was notably lower in the LBP group compared to the healthy controls. This suggests that those with lower vitamin D levels are more likely to experience LBP.
Moreover, our analysis revealed a significant relationship between vitamin D3 levels and both pain intensity and disability. Specifically, we noted that lower vitamin D levels correlated with higher pain intensity as measured by a Visual Analogue Scale and greater functional disability assessed with the Modified Oswestry Questionnaire.
Overall, our findings highlight the potential role of vitamin D3 in managing back pain and suggest that addressing vitamin D deficiency could help improve outcomes for individuals suffering from LBP.
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7
We explored the potential benefits of vitamin D3 supplementation for alleviating back pain in overweight or obese adults who were also vitamin D deficient. In a controlled study, 65 participants with a body mass index (BMI) of 25 or higher and low vitamin D levels received either a high dose of vitamin D3 or a placebo for 16 weeks.
After the treatment, we found that while vitamin D levels significantly increased in those taking the supplement, there were no overall significant differences in back pain intensity or disability scores between the vitamin D group and the placebo group.
However, it was noteworthy that among participants whose vitamin D levels were particularly low—under 30 nmol/L—those taking vitamin D did experience a meaningful reduction in back pain disability compared to those receiving placebo. This indicates that addressing severe vitamin D deficiency might not only support bone health but also improve the quality of life for those suffering from back pain—especially in overweight individuals.
These insights invite consideration for regular vitamin D testing in this demographic, offering a potential pathway to managing back pain more effectively.
After the treatment, we found that while vitamin D levels significantly increased in those taking the supplement, there were no overall significant differences in back pain intensity or disability scores between the vitamin D group and the placebo group.
However, it was noteworthy that among participants whose vitamin D levels were particularly low—under 30 nmol/L—those taking vitamin D did experience a meaningful reduction in back pain disability compared to those receiving placebo. This indicates that addressing severe vitamin D deficiency might not only support bone health but also improve the quality of life for those suffering from back pain—especially in overweight individuals.
These insights invite consideration for regular vitamin D testing in this demographic, offering a potential pathway to managing back pain more effectively.
Read More
Most Useful Reviews
9
Cleared back pain
25 people found this helpful
They work! Since taking these, my back pain has resolved, and I've even gained energy. It seems my fatigue was due to a vitamin D deficiency, which is now corrected.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.1
- All Researches
9.5
We observed a rare condition known as pregnancy-associated osteoporosis, which affected a 38-year-old woman after she gave birth. Just a month postpartum, she experienced sudden back pain due to four vertebral fractures, and her bone density was notably low, especially in the spine.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
Read More
9.5
We explored the impact of various treatments, including vitamin D3, on severe back pain caused by pregnancy-related osteoporosis (PLO). In a significant case study, a 23-year-old woman experiencing debilitating back pain was treated after her first childbirth. By monitoring her bone mineral density, we noted low T- and Z-scores in her lumbar spine.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
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9
We looked into the impact of teriparatide therapy on back pain in postmenopausal women with osteoporosis. Participants receiving either teriparatide or placebo took part in a randomized study where the duration of treatment was carefully monitored.
The results showed that each additional month on teriparatide significantly decreased the risk of back pain. In fact, the relative hazard of back pain dropped by 8.3% for those on 20 microg and 8.7% for those on 40 microg of teriparatide. This suggests that longer treatment not only helps with fractures but also effectively alleviates back pain.
The results showed that each additional month on teriparatide significantly decreased the risk of back pain. In fact, the relative hazard of back pain dropped by 8.3% for those on 20 microg and 8.7% for those on 40 microg of teriparatide. This suggests that longer treatment not only helps with fractures but also effectively alleviates back pain.
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9
We explored the effectiveness of alfacalcidol, a hormonal therapy, versus plain vitamin D in treating osteoporosis caused by glucocorticoid use. In a study with patients on long-term glucocorticoid therapy, those taking alfacalcidol experienced significant improvements in bone density and fewer vertebral fractures compared to those receiving plain vitamin D.
Notably, the alfacalcidol group reported a greater reduction in back pain, highlighting its therapeutic advantage. We believe the results indicate that alfacalcidol plus calcium should replace plain vitamin D as a primary treatment, given its superior efficacy without major side effects.
Notably, the alfacalcidol group reported a greater reduction in back pain, highlighting its therapeutic advantage. We believe the results indicate that alfacalcidol plus calcium should replace plain vitamin D as a primary treatment, given its superior efficacy without major side effects.
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9
We explored the effectiveness of denosumab on alleviating back pain and enhancing quality of life in post-menopausal women suffering from vertebral fractures. This study, involving 140 women aged around 70, assessed participants who received denosumab alongside calcium and vitamin D3 for a year.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cleared back pain
25 people found this helpful
They work! Since taking these, my back pain has resolved, and I've even gained energy. It seems my fatigue was due to a vitamin D deficiency, which is now corrected.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Forni GL, Perrotta S, Giusti A, Quarta G, Pitrolo L, et al. Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis: results from a phase 2, randomized, parallel-arm, open-label study. Br J Haematol. 2012;158:274. doi:10.1111/j.1365-2141.2012.09152.x
- Lindsay R, Miller P, Pohl G, Glass EV, Chen P, et al. Relationship between duration of teriparatide therapy and clinical outcomes in postmenopausal women with osteoporosis. Osteoporos Int. 2009;20:943. doi:10.1007/s00198-008-0766-0
- Ringe JD, Farahmand P, Faber H, Dorst A. Sustained efficacy of risedronate in men with primary and secondary osteoporosis: results of a 2-year study. Rheumatol Int. 2009;29:311. doi:10.1007/s00296-008-0689-2
- Ringe JD, Faber H, Fahramand P, Schacht E. Alfacalcidol versus plain vitamin D in the treatment of glucocorticoid/inflammation-induced osteoporosis. J Rheumatol Suppl. 2005;76:33.
- Scaturro D, Vitagliani F, Tomasello S, Sconza C, Respizzi S, et al. Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial. Medicina (Kaunas). 2023;59. doi:10.3390/medicina59122197
- Ko S, Kim HC, Kwon J. The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study. Medicine (Baltimore). 2023;102:e32672. doi:10.1097/MD.0000000000032672
- Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. doi:10.1097/BRS.0000000000004309
- Ma Y, Wu X, Xiao X, Ma Y, Feng L, et al. Effects of teriparatide versus percutaneous vertebroplasty on pain relief, quality of life and cost-effectiveness in postmenopausal females with acute osteoporotic vertebral compression fracture: A prospective cohort study. Bone. 2020;131:115154. doi:10.1016/j.bone.2019.115154
- Pishgahi A, Dolatkhah N, Shakouri SK, Hashemian M, Amiri A, et al. Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study. BMC Res Notes. 2019;12:738. doi:10.1186/s13104-019-4768-0
- Krasowska K, Skrobot W, Liedtke E, Sawicki P, Flis DJ, et al. The Preoperative Supplementation With Vitamin D Attenuated Pain Intensity and Reduced the Level of Pro-inflammatory Markers in Patients After Posterior Lumbar Interbody Fusion. Front Pharmacol. 2019;10:527. doi:10.3389/fphar.2019.00527
- Moretti A, de Sire A, Curci C, Toro G, Gimigliano F, et al. Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures. Curr Med Res Opin. 2019;35:151. doi:10.1080/03007995.2018.1545636
- Brady SRE, Naderpoor N, de Courten MPJ, Scragg R, Cicuttini F, et al. Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults. J Steroid Biochem Mol Biol. 2019;185:212. doi:10.1016/j.jsbmb.2018.09.005
- Dzik K, Skrobot W, Flis DJ, Karnia M, Libionka W, et al. Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain. Eur J Appl Physiol. 2018;118:143. doi:10.1007/s00421-017-3755-1
- Englund M, Persson J, Bergström I. Lower pain and higher muscular strength in immigrant women with vitamin D deficiency following vitamin D treatment. Int J Circumpolar Health. 2017;76:1340547. doi:10.1080/22423982.2017.1340547
- Gaudio A, Fiore CE. Successful neridronate therapy in pregnancy-associated osteoporosis. Clin Cases Miner Bone Metab. 2016;13:241. doi:10.11138/ccmbm/2016.13.3.241
- Ghai B, Bansal D, Kanukula R, Gudala K, Sachdeva N, et al. Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial. Pain Physician. 2017;20:E99.
- Tanaka S, Yoshida A, Kono S, Oguma T, Hasegawa K, et al. Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures. J Bone Miner Metab. 2017;35:544. doi:10.1007/s00774-016-0791-6
- Polat SB, Evranos B, Aydin C, Cuhaci N, Ersoy R, et al. Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature. Gynecol Endocrinol. 2015;31:522. doi:10.3109/09513590.2015.1014787
- Gendelman O, Itzhaki D, Makarov S, Bennun M, Amital H. A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. Lupus. 2015;24:483. doi:10.1177/0961203314558676
- Shin MY, Kang YE, Kong SE, Ju SH, Back MK, et al. A case of low bone mineral density with vitamin d deficiency due to prolonged lactation and severe malnutrition. J Bone Metab. 2015;22:39. doi:10.11005/jbm.2015.22.1.39
- Liu J, Xu D, Liu L, Huang C, Guo Z, et al. Regular sling core stabilization training improves bone density based on calcium and vitamin D supplementation. BMC Musculoskelet Disord. 2023;24:815. doi:10.1186/s12891-023-06896-8
