Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 12 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Vitamin D3 (as Cholecalciferol)
10 mcg (400 IU)
50%
Calcium (as Calcium Carbonate)
600 mg
46%
Top Medical Research Studies
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
8
We explored a unique case of a 3-year-old Iranian girl with Juvenile Paget's disease (JPD) linked to a new mutation and vitamin D deficiency. This rare condition led to her experiencing significant bone pain, fractures, and deformities from an early age.
Our findings revealed that she had a unique mutation in the TNFRSF11B gene, which contributes to OPG deficiency. Remarkably, she showed improvement following treatment with oral vitamin D and intravenous pamidronate. This case highlights both the impact of genetic factors and the importance of vitamin D in managing JPD effectively.
Our findings revealed that she had a unique mutation in the TNFRSF11B gene, which contributes to OPG deficiency. Remarkably, she showed improvement following treatment with oral vitamin D and intravenous pamidronate. This case highlights both the impact of genetic factors and the importance of vitamin D in managing JPD effectively.
Read More
Most Useful Reviews
10
Bone healing support
2 people found this helpful
My husband broke his leg and struggled with a difficult fracture. After nearly three months in a cast, nothing seemed to help until we found liquid calcium. Within two weeks of taking these pills, the doctor allowed the plaster to be removed. Now, they are a staple in our first aid kit for support, and I take them too. My nails grow quickly as well.
Read More
7.5
Supports nail growth
2 people found this helpful
I am taking this for the second time. It helps my nails grow well. My parents took it and it doesn’t hurt the bones.
Read More
9
Joint pain relief
1 people found this helpful
I noticed a good effect from calcium intake; during breastfeeding, I had no joint pain.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
8
We explored a unique case of a 3-year-old Iranian girl with Juvenile Paget's disease (JPD) linked to a new mutation and vitamin D deficiency. This rare condition led to her experiencing significant bone pain, fractures, and deformities from an early age.
Our findings revealed that she had a unique mutation in the TNFRSF11B gene, which contributes to OPG deficiency. Remarkably, she showed improvement following treatment with oral vitamin D and intravenous pamidronate. This case highlights both the impact of genetic factors and the importance of vitamin D in managing JPD effectively.
Our findings revealed that she had a unique mutation in the TNFRSF11B gene, which contributes to OPG deficiency. Remarkably, she showed improvement following treatment with oral vitamin D and intravenous pamidronate. This case highlights both the impact of genetic factors and the importance of vitamin D in managing JPD effectively.
Read More
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
10
Bone healing support
2 people found this helpful
My husband broke his leg and struggled with a difficult fracture. After nearly three months in a cast, nothing seemed to help until we found liquid calcium. Within two weeks of taking these pills, the doctor allowed the plaster to be removed. Now, they are a staple in our first aid kit for support, and I take them too. My nails grow quickly as well.
Read More
7.5
Supports nail growth
2 people found this helpful
I am taking this for the second time. It helps my nails grow well. My parents took it and it doesn’t hurt the bones.
Read More
9
Joint pain relief
1 people found this helpful
I noticed a good effect from calcium intake; during breastfeeding, I had no joint pain.
Read More
9
Bone health improvement
1 people found this helpful
I ordered this product for my grandmother, who finds it beneficial for her bone health. The addition of vitamin D3 aids calcium absorption. Overall, Nature Made's Calcium with Vitamin D3 is a dependable supplement for supporting bone health.
Read More
7.5
Symptoms alleviated
1 people found this helpful
I bought these for use during breastfeeding as I suffered from bone pain during pregnancy. The capsules are large but I consistently take 1-2 a day. I noticed improvement after a week; the pain returns if I stop. They contain calcium carbonate which is well absorbed, especially with more vitamin D.
Read More
Frequently Asked Questions
7.5
Symptoms alleviated
1 people found this helpful
I bought these for use during breastfeeding as I suffered from bone pain during pregnancy. The capsules are large but I consistently take 1-2 a day. I noticed improvement after a week; the pain returns if I stop. They contain calcium carbonate which is well absorbed, especially with more vitamin D.
7.5
Pain relief achieved
Big bottle! It arrived promptly. I read reviews and decided to try it postpartum for my sore foot. I took two drops a day for about ten days and noticed a significant reduction in bone pain. Switching to a different dosage should still prove useful.
10
Bone healing support
2 people found this helpful
My husband broke his leg and struggled with a difficult fracture. After nearly three months in a cast, nothing seemed to help until we found liquid calcium. Within two weeks of taking these pills, the doctor allowed the plaster to be removed. Now, they are a staple in our first aid kit for support, and I take them too. My nails grow quickly as well.
9
Joint pain relief
1 people found this helpful
I noticed a good effect from calcium intake; during breastfeeding, I had no joint pain.
7.5
Effective with exercise
This is an incredibly large bottle. I've heard it’s quite effective. After trying it, I felt less bone pain when combined with exercise.
9
Bone health improvement
1 people found this helpful
I ordered this product for my grandmother, who finds it beneficial for her bone health. The addition of vitamin D3 aids calcium absorption. Overall, Nature Made's Calcium with Vitamin D3 is a dependable supplement for supporting bone health.
7.5
Convenient calcium source
I've needed supplemental calcium for bone strengthening. The pills are consistent in size, and I appreciate the convenience of only having to take one per day. The price is also reasonable.
8
We explored a unique case of a 3-year-old Iranian girl with Juvenile Paget's disease (JPD) linked to a new mutation and vitamin D deficiency. This rare condition led to her experiencing significant bone pain, fractures, and deformities from an early age.
Our findings revealed that she had a unique mutation in the TNFRSF11B gene, which contributes to OPG deficiency. Remarkably, she showed improvement following treatment with oral vitamin D and intravenous pamidronate. This case highlights both the impact of genetic factors and the importance of vitamin D in managing JPD effectively.
Our findings revealed that she had a unique mutation in the TNFRSF11B gene, which contributes to OPG deficiency. Remarkably, she showed improvement following treatment with oral vitamin D and intravenous pamidronate. This case highlights both the impact of genetic factors and the importance of vitamin D in managing JPD effectively.
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
References
- Saki F, Karamizadeh Z, Nasirabadi S, Mumm S, McAlister WH, et al. Juvenile paget's disease in an Iranian kindred with vitamin D deficiency and novel homozygous TNFRSF11B mutation. J Bone Miner Res. 2013;28:1501. 10.1002/jbmr.1868
- von Brackel FN, Grambeck J, Barvencik F, Amling M, Oheim R. In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution. JBMR Plus. 2024;8:ziae139. 10.1093/jbmrpl/ziae139
