' 
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
5 mcg (200 IU)
25%
Calcium (as Calcium Carbonate)
333 mg
26%
Magnesium (as Magnesium Oxide)
133 mg
32%
Zinc (as Zinc Sulfate)
5 mg
45%
Top Medical Research Studies
8
Vitamin D3 aids cold recovery
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
High relevance to vitamin D research
We explored how 25-hydroxyvitamin D3 (25OHD), a form of vitamin D, influences upper respiratory tract infections (URTIs), commonly known as colds. In a carefully designed clinical study, we followed 428 participants aged 45 to 74 over a 16-week period. They were randomly assigned to receive either 10 μg of 25OHD daily or a placebo, all while maintaining a double-blind setup to ensure accurate results.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Read More
8
Zinc’s effects on colds
Zinc for prevention and treatment of the common cold: Summary of a Cochrane review.
High relevance to cold treatment
We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.
The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.
This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.
This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
Read More
8
Vitamin D enhances cold resilience
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Study focused on vitamin D3
We delved into the effects of vitamin D on cold symptoms among military recruits during their training. In two comprehensive studies, we observed over 1,600 military recruits to see how their vitamin D levels impacted their likelihood of upper respiratory tract infections (URTIs) throughout the seasons.
In the first study, only 21% of recruits were found to have sufficient vitamin D levels during winter. Notably, those with adequate vitamin D were 40% less likely to experience URTIs compared to those who were deficient. Each URTI typically caused three missed training days, indicating a significant impact on their training schedules.
Following this, we conducted a randomized controlled trial with 250 men simulating sunlight exposure or providing oral vitamin D3 supplementation. Our goal was to see how both methods affected overall vitamin D levels and, subsequently, URTI symptoms. Remarkably, both strategies successfully brought participants to sufficient vitamin D levels. Compared to those who received a placebo, those getting vitamin D3 experienced a 15% reduction in the severity of cold symptoms and a 36% decrease in the number of days with URTI.
Interestingly, we found that both methods—simulated sunlight and oral supplementation—were equally effective, and neither had a significant impact on specific immune response markers.
In the first study, only 21% of recruits were found to have sufficient vitamin D levels during winter. Notably, those with adequate vitamin D were 40% less likely to experience URTIs compared to those who were deficient. Each URTI typically caused three missed training days, indicating a significant impact on their training schedules.
Following this, we conducted a randomized controlled trial with 250 men simulating sunlight exposure or providing oral vitamin D3 supplementation. Our goal was to see how both methods affected overall vitamin D levels and, subsequently, URTI symptoms. Remarkably, both strategies successfully brought participants to sufficient vitamin D levels. Compared to those who received a placebo, those getting vitamin D3 experienced a 15% reduction in the severity of cold symptoms and a 36% decrease in the number of days with URTI.
Interestingly, we found that both methods—simulated sunlight and oral supplementation—were equally effective, and neither had a significant impact on specific immune response markers.
Read More
Most Useful Reviews
9.5
Greatly reduces colds
Awesome. It cured my magnesium deficiency. For years, I felt terrible: face flushing, anxiety, trouble sleeping, fatigue, and dizziness. I researched magnesium deficiency and asked my doctor about it. After a month of taking this supplement, I noticed a significant decrease in my issues. The zinc also helps prevent colds; I used to suffer 3-5 colds each winter, now I may get one. This supplement has been a tremendous help.
Read More
8.8
Boosts immunity
A great combination of minerals for me. In my late 40s, I exercise regularly and started cramping at night despite an adequate potassium intake. I learned magnesium could assist, so I tried this. It worked wonderfully! I've only had one twitch since I began taking these, and that was after skipping a dose. Following a low-carb diet, I lost minerals quickly, but this helps keep me balanced and active. I believe the zinc boosts my immune system too; I've had only one cold in the past 18 months.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
- All Researches
9
Magnesium enhances vascular preservation
Low Calcium-High Magnesium Krebs-Henseleit Solution Combined with Adenosine and Lidocaine Improved Rat Aortic Function and Structure Following Cold Preservation.
Combination effects complicate results
We examined the effectiveness of modified Krebs-Henseleit (KH) solutions with low calcium and high magnesium levels on preserving vascular function during cold storage. Our focus was on whether adding adenosine and lidocaine could further improve the preservation of rat aortic rings after six days of cold preservation.
In our study, we found that traditional preservation solutions often fail to maintain proper vascular function after just three days of cold storage. However, when we tested a modified KH solution with lower calcium and higher magnesium, we observed significant recovery of contraction and relaxation functions in the aortic rings. This suggests that magnesium plays a vital role in preserving these functions.
Interestingly, while adding adenosine and lidocaine did not enhance contraction, it did improve the aortic rings' ability to relax in response to a chemical called acetylcholine. Furthermore, a histological examination showed that the addition of adenosine positively affected the endothelial lining and structural integrity of the vessels, highlighting its importance in cold preservation.
Overall, our findings suggest that magnesium in combination with adenosine significantly enhances the preservation of vascular structures and functionalities during extended cold storage, making it an important consideration for vascular grafts.
In our study, we found that traditional preservation solutions often fail to maintain proper vascular function after just three days of cold storage. However, when we tested a modified KH solution with lower calcium and higher magnesium, we observed significant recovery of contraction and relaxation functions in the aortic rings. This suggests that magnesium plays a vital role in preserving these functions.
Interestingly, while adding adenosine and lidocaine did not enhance contraction, it did improve the aortic rings' ability to relax in response to a chemical called acetylcholine. Furthermore, a histological examination showed that the addition of adenosine positively affected the endothelial lining and structural integrity of the vessels, highlighting its importance in cold preservation.
Overall, our findings suggest that magnesium in combination with adenosine significantly enhances the preservation of vascular structures and functionalities during extended cold storage, making it an important consideration for vascular grafts.
Read More
9
Magnesium improves beef storage safety
Incorporation of hydrogen-producing magnesium into minced beef meat protects the quality attributes and safety of the product during cold storage.
Limited isolation of magnesium's impact
We explored the effects of incorporating hydrogen-producing magnesium into minced beef meat (MBM) to see how it affects quality and safety during cold storage. The study involved vacuum packaging the MBMs and storing them at 4°C for 12 days while comparing them with other treatments, such as gassing with hydrogen or nitrogen.
What we found was quite promising. The samples with magnesium showed the lowest browning index values, which indicates less color change and better visual quality. Additionally, these samples exhibited reduced bacterial counts, including mesophilic and psychrotrophic bacteria, as well as yeast and molds. This suggests that magnesium can help in maintaining the freshness and safety of the meat.
Interestingly, the magnesium treatment also limited the formation of potentially harmful compounds, such as thiobarbituric acid reactive substances and biogenic amines, which can negatively impact meat quality. By the end of the storage period, the control samples had the highest levels of volatile compounds, hinting at spoilage, while magnesium-enhanced and vacuum-packaged samples fared better.
Overall, we observed that using hydrogen-producing magnesium while handling minced beef could be an effective way to protect important quality attributes and safety during cold storage.
What we found was quite promising. The samples with magnesium showed the lowest browning index values, which indicates less color change and better visual quality. Additionally, these samples exhibited reduced bacterial counts, including mesophilic and psychrotrophic bacteria, as well as yeast and molds. This suggests that magnesium can help in maintaining the freshness and safety of the meat.
Interestingly, the magnesium treatment also limited the formation of potentially harmful compounds, such as thiobarbituric acid reactive substances and biogenic amines, which can negatively impact meat quality. By the end of the storage period, the control samples had the highest levels of volatile compounds, hinting at spoilage, while magnesium-enhanced and vacuum-packaged samples fared better.
Overall, we observed that using hydrogen-producing magnesium while handling minced beef could be an effective way to protect important quality attributes and safety during cold storage.
Read More
9
CuMg alloys enhance cold working
Prospective cold metal working and analysis of deformation susceptibility of CuMg alloys with high magnesium content.
Magnesium impacts alloy deformation
We examined the use of copper-magnesium (CuMg) alloys, particularly focusing on those with higher magnesium content, to understand how they perform during cold metal working processes. Our testing aimed to identify the effects of magnesium on the mechanical properties and workability of these alloys, as they’re known to provide significant solid-solution hardening.
The results revealed that CuMg alloys with 2 to 4 weight percent (wt%) magnesium displayed impressive strength characteristics, outperforming commonly used materials like pure copper and aluminum. We calculated improvements in hardness and Ultimate Tensile Strength (UTS), showing increases of up to two and a half times compared to pure copper. However, we noted that while magnesium enhances strength, it also raises friction during processing, which can complicate metal forming.
We learned that increasing magnesium content could lead to brittleness when it exceeded approximately 3.6 wt%, introducing challenges for cold working. This brittleness arises from the formation of specific phases, making it challenging to use these alloys in practical applications. Our findings suggest that while magnesium can significantly boost the mechanical properties of CuMg alloys, careful consideration is needed regarding its maximum content to maintain ductility and workability.
The results revealed that CuMg alloys with 2 to 4 weight percent (wt%) magnesium displayed impressive strength characteristics, outperforming commonly used materials like pure copper and aluminum. We calculated improvements in hardness and Ultimate Tensile Strength (UTS), showing increases of up to two and a half times compared to pure copper. However, we noted that while magnesium enhances strength, it also raises friction during processing, which can complicate metal forming.
We learned that increasing magnesium content could lead to brittleness when it exceeded approximately 3.6 wt%, introducing challenges for cold working. This brittleness arises from the formation of specific phases, making it challenging to use these alloys in practical applications. Our findings suggest that while magnesium can significantly boost the mechanical properties of CuMg alloys, careful consideration is needed regarding its maximum content to maintain ductility and workability.
Read More
9
Zinc enhances rice cold resistance
Effects of different cold-resistant agents and application methods on yield and cold-resistance of machine-transplanted early rice.
Study highlights zinc's effectiveness
We explored the impact of zinc-amino acids chelate on cold stress resistance in machine-transplanted early rice. Our investigation included other cold-resistant agents like uniconazole and abscisic acid, but we found zinc to be particularly effective. When applied during the regreening stage, zinc notably enhanced rice growth by promoting tillering and increasing the leaf area, which led to better yields.
We noted that zinc-amino acids chelate improved antioxidant enzyme activities, which are crucial for helping rice withstand cold temperatures. The yield of rice treated with zinc was approximately 9.22% higher than with uniconazole and 7.14% higher than with abscisic acid.
Additionally, we observed that using 750 g/ha of zinc-amino acids chelate during the transplanting and regreening stages yielded the best results. The timing of the application played a critical role, as spraying during these specific phases maximized both yield and cold resistance.
Overall, zinc treatments stand out as a promising option for improving cold stress resilience in early rice, making it a key consideration for farmers dealing with cold climate conditions.
We noted that zinc-amino acids chelate improved antioxidant enzyme activities, which are crucial for helping rice withstand cold temperatures. The yield of rice treated with zinc was approximately 9.22% higher than with uniconazole and 7.14% higher than with abscisic acid.
Additionally, we observed that using 750 g/ha of zinc-amino acids chelate during the transplanting and regreening stages yielded the best results. The timing of the application played a critical role, as spraying during these specific phases maximized both yield and cold resistance.
Overall, zinc treatments stand out as a promising option for improving cold stress resilience in early rice, making it a key consideration for farmers dealing with cold climate conditions.
Read More
8
Vitamin D enhances cold resilience
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Study focused on vitamin D3
We delved into the effects of vitamin D on cold symptoms among military recruits during their training. In two comprehensive studies, we observed over 1,600 military recruits to see how their vitamin D levels impacted their likelihood of upper respiratory tract infections (URTIs) throughout the seasons.
In the first study, only 21% of recruits were found to have sufficient vitamin D levels during winter. Notably, those with adequate vitamin D were 40% less likely to experience URTIs compared to those who were deficient. Each URTI typically caused three missed training days, indicating a significant impact on their training schedules.
Following this, we conducted a randomized controlled trial with 250 men simulating sunlight exposure or providing oral vitamin D3 supplementation. Our goal was to see how both methods affected overall vitamin D levels and, subsequently, URTI symptoms. Remarkably, both strategies successfully brought participants to sufficient vitamin D levels. Compared to those who received a placebo, those getting vitamin D3 experienced a 15% reduction in the severity of cold symptoms and a 36% decrease in the number of days with URTI.
Interestingly, we found that both methods—simulated sunlight and oral supplementation—were equally effective, and neither had a significant impact on specific immune response markers.
In the first study, only 21% of recruits were found to have sufficient vitamin D levels during winter. Notably, those with adequate vitamin D were 40% less likely to experience URTIs compared to those who were deficient. Each URTI typically caused three missed training days, indicating a significant impact on their training schedules.
Following this, we conducted a randomized controlled trial with 250 men simulating sunlight exposure or providing oral vitamin D3 supplementation. Our goal was to see how both methods affected overall vitamin D levels and, subsequently, URTI symptoms. Remarkably, both strategies successfully brought participants to sufficient vitamin D levels. Compared to those who received a placebo, those getting vitamin D3 experienced a 15% reduction in the severity of cold symptoms and a 36% decrease in the number of days with URTI.
Interestingly, we found that both methods—simulated sunlight and oral supplementation—were equally effective, and neither had a significant impact on specific immune response markers.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Greatly reduces colds
Awesome. It cured my magnesium deficiency. For years, I felt terrible: face flushing, anxiety, trouble sleeping, fatigue, and dizziness. I researched magnesium deficiency and asked my doctor about it. After a month of taking this supplement, I noticed a significant decrease in my issues. The zinc also helps prevent colds; I used to suffer 3-5 colds each winter, now I may get one. This supplement has been a tremendous help.
Read More
8.8
Boosts immunity
A great combination of minerals for me. In my late 40s, I exercise regularly and started cramping at night despite an adequate potassium intake. I learned magnesium could assist, so I tried this. It worked wonderfully! I've only had one twitch since I began taking these, and that was after skipping a dose. Following a low-carb diet, I lost minerals quickly, but this helps keep me balanced and active. I believe the zinc boosts my immune system too; I've had only one cold in the past 18 months.
Read More
