Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
5 mcg (200 IU)
25%
Calcium (as Calcium Carbonate)
333 mg
26%
Magnesium (as Magnesium Oxide)
133 mg
32%
Zinc (as Zinc Sulfate)
5 mg
45%
Top Medical Research Studies
9
We set out to explore how different doses of vitamin D3, specifically Cholecalciferol, impact the healing of chronic diabetic foot ulcers. Our study included patients with diabetes who had one or more foot ulcers present for longer than six weeks. We assigned participants at random to receive either a high dose of 170 micrograms or a low dose of 20 micrograms daily. Throughout the experiment, both patients and assessors were kept unaware of who was receiving which treatment to ensure unbiased results.
Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.
In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.
Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.
In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.
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9
We delved into an interesting case of a 76-year-old man who developed severe esophageal ulcers, likely due to zinc deficiency following a total gastrectomy. His symptoms included sore throat, heartburn, and difficulty swallowing.
After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.
After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.
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We moved forward with a double-blind, placebo-controlled study to see how zinc affects ulcers in patients with Behçet's disease. Over 12 weeks, 50 participants received either zinc gluconate or a placebo.
The results revealed that zinc significantly reduced the occurrence of genital ulcers and inflammation markers like NLRP3 and caspase-1. In fact, zinc supplementation improved clinical conditions and decreased inflammatory markers, showing promise as an additional therapy for managing Behçet's disease.
The results revealed that zinc significantly reduced the occurrence of genital ulcers and inflammation markers like NLRP3 and caspase-1. In fact, zinc supplementation improved clinical conditions and decreased inflammatory markers, showing promise as an additional therapy for managing Behçet's disease.
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Most Useful Reviews
9
Immediate relief
17 people found this helpful
Great for Restless Leg Syndrome. I suffered so much that I was taking 4 ibuprofen a night to sleep. I developed an ulcer from excessive ibuprofen, so I had to find an alternative. A friend suggested this, and I'm so glad she did! I had immediate relief. I take three a day, and it can cause stomach upset if taken on an empty stomach. I love this brand and have used it for over 3 years.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 39 Researches
8.1
- All Researches
9.5
We explored the impact of zinc when incorporated into first-line treatments for Helicobacter pylori infections, particularly in patients suffering from ulcers. In a multicenter registry study involving 800 patients, we noted that the most common factors leading to treatment were dyspepsia and gastroduodenal ulcers.
The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.
We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
The findings indicated that quadruple therapy—both with and without bismuth—improved eradication rates significantly, achieving about 94.9%. Meanwhile, zinc as a part of a sequential therapy showed an impressive effectiveness of 95.6%. However, since zinc was combined with other treatments, it’s challenging to pinpoint its isolated effects on ulcer healing or eradication efficacy.
We also observed that adverse events, though reported in nearly 29% of cases, were generally mild, suggesting that the treatments were well-tolerated. Overall, the report highlighted that while zinc may enhance treatment effectiveness when combined, its individual contribution remains undetermined.
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9
Calcium-based antibiotic delivery effective
We conducted a randomized, double-blind, placebo-controlled trial to investigate the effectiveness of calcium-sulphate granules as a local delivery system for antibiotics in treating diabetic foot osteomyelitis (DFO). This condition poses significant risks, including severe infections, potential amputations, and even death. Our goal was to determine whether this innovative treatment could reduce post-surgical infectious complications in patients suffering from DFO.
The trial included adult participants with diabetes and specifically targeted Texas grade 3 ulcers that were complicated by osteomyelitis and deep tissue infections. We monitored the primary outcomes over a period of 12 weeks, focusing on the percentage of patients experiencing various infectious complications like wound dehiscence, recurrence of DFO, and the emergence of new infections in nearby areas.
Remarkably, our findings revealed that the use of antibiotic-impregnated calcium-sulphate granules showed promising results. Out of the first 20 cases, only 25% developed the primary composite end-point of infection complications. All post-surgical complications were confined to the placebo group, highlighting a significant difference in outcomes based on the treatment administered.
This study stands out in demonstrating the potential benefits of using calcium-sulphate granules to improve the prognosis for patients with DFO, while also being economically sustainable.
The trial included adult participants with diabetes and specifically targeted Texas grade 3 ulcers that were complicated by osteomyelitis and deep tissue infections. We monitored the primary outcomes over a period of 12 weeks, focusing on the percentage of patients experiencing various infectious complications like wound dehiscence, recurrence of DFO, and the emergence of new infections in nearby areas.
Remarkably, our findings revealed that the use of antibiotic-impregnated calcium-sulphate granules showed promising results. Out of the first 20 cases, only 25% developed the primary composite end-point of infection complications. All post-surgical complications were confined to the placebo group, highlighting a significant difference in outcomes based on the treatment administered.
This study stands out in demonstrating the potential benefits of using calcium-sulphate granules to improve the prognosis for patients with DFO, while also being economically sustainable.
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9
We observed a unique case involving a healthy 42-year-old woman who presented with recent monophasic Raynaud's phenomenon (RP) and digital ulcers. Despite the absence of other classic signs of systemic autoimmune disease, we found that the diagnosis of preclinical systemic sclerosis was possible due to abnormalities detected through capillaroscopy.
The treatment regimen included hydroxychloroquine, a statin, and a calcium antagonist. While calcium was part of this trio, it is important to note that the specific impact of calcium on ulcer healing couldn't be isolated since it was administered with other medications.
Ultimately, four years after starting the treatment, the patient had no further instances of digital ulcers and experienced notable improvement in her RP. This case illustrates how pre-scleroderma can unfold without the typical clinical or immunological markers and highlights the need for awareness of microvascular changes in diagnosing early stages of systemic sclerosis.
The treatment regimen included hydroxychloroquine, a statin, and a calcium antagonist. While calcium was part of this trio, it is important to note that the specific impact of calcium on ulcer healing couldn't be isolated since it was administered with other medications.
Ultimately, four years after starting the treatment, the patient had no further instances of digital ulcers and experienced notable improvement in her RP. This case illustrates how pre-scleroderma can unfold without the typical clinical or immunological markers and highlights the need for awareness of microvascular changes in diagnosing early stages of systemic sclerosis.
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9
Calcium accelerates ulcer healing
Addressing the challenge of diabetic foot ulcers (DFUs) is critical, as these chronic wounds affect individuals of all ages and can lead to severe complications. In our exploration, we investigated the potential of calcium alginate sulfate scaffolds as a new biomaterial for promoting wound healing in a diabetic mouse model.
We created alginate sulfate solutions with varying degrees of sulfation and then transformed them into scaffolds suitable for use as wound dressings. These scaffolds demonstrated favorable properties in terms of swelling, porosity, and mechanical strength, indicating they could effectively manage exudate while enhancing healing.
After confirming their safety and compatibility through testing, we applied these calcium alginate sulfate scaffolds to treat full-thickness ulcers. The results were promising; wounds treated with these scaffolds healed significantly faster than those treated with traditional alginate or untreated wounds. Histological analysis revealed that the healed skin tissue had regenerative properties similar to healthy tissue, with normal layer structure and collagen deposition.
Overall, the study suggests that calcium in the form of alginate sulfate plays a crucial role in wound healing in diabetic mice, potentially paving the way for new treatment options for DFUs.
We created alginate sulfate solutions with varying degrees of sulfation and then transformed them into scaffolds suitable for use as wound dressings. These scaffolds demonstrated favorable properties in terms of swelling, porosity, and mechanical strength, indicating they could effectively manage exudate while enhancing healing.
After confirming their safety and compatibility through testing, we applied these calcium alginate sulfate scaffolds to treat full-thickness ulcers. The results were promising; wounds treated with these scaffolds healed significantly faster than those treated with traditional alginate or untreated wounds. Histological analysis revealed that the healed skin tissue had regenerative properties similar to healthy tissue, with normal layer structure and collagen deposition.
Overall, the study suggests that calcium in the form of alginate sulfate plays a crucial role in wound healing in diabetic mice, potentially paving the way for new treatment options for DFUs.
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9
Vitamin D3 mitigates gastric injury
We explored the effects of Vitamin D3 on stomach ulcers caused by aspirin, focusing specifically on how it influences certain molecules in the stomach lining. In our study, we divided 24 rats into four groups: a control group, a group receiving Vitamin D3 without any gastric injury, a group with aspirin-induced gastric injuries, and a group treated with Vitamin D3 after such injuries occurred.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
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User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Immediate relief
17 people found this helpful
Great for Restless Leg Syndrome. I suffered so much that I was taking 4 ibuprofen a night to sleep. I developed an ulcer from excessive ibuprofen, so I had to find an alternative. A friend suggested this, and I'm so glad she did! I had immediate relief. I take three a day, and it can cause stomach upset if taken on an empty stomach. I love this brand and have used it for over 3 years.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Monami M, Bordoni L, Ragghianti B, Silverii GA, Mannucci E. Efficacy and safety of a bio-absorbable antibiotic delivery in calcium sulphate granules for the treatment of osteomyelitis in patients with diabetic foot: A randomized, double blinded, controlled clinical study The BIG D-FOOT study. Diabetes Obes Metab. 2025. doi:10.1111/dom.16254
- D'Haens G, Stardelova KG, Sadiku E, Kizlova N, Skybalo S, et al. Vidofludimus Calcium in Patients With Moderate-to-Severe Ulcerative Colitis: A Randomized, Placebo-Controlled, Phase 2 Trial. Clin Transl Gastroenterol. 2025. doi:10.14309/ctg.0000000000000813
- Arango A, Yaman RN, Mumtaz S, Abril A, Berianu F. Digital Ulcers and Microvascular Abnormalities Presenting As the Initial Manifestations of Pre-scleroderma. Cureus. 2024;16:e75061. doi:10.7759/cureus.75061
- Zare-Gachi M, Sadeghi A, Choshali MA, Ghadimi T, Forghani SF, et al. Degree of sulfation of freeze-dried calcium alginate sulfate scaffolds dramatically influence healing rate of full-thickness diabetic wounds. Int J Biol Macromol. 2024;283:137557. doi:10.1016/j.ijbiomac.2024.137557
- Zhang J, Shang S, Liu W, Cheng Y, Hu F, et al. Effect of aspirin on platelet-rich plasma of diabetes mellitus with lower extremity atherosclerosis. Future Sci OA. 2024;10:2413827. doi:10.1080/20565623.2024.2413827
- El-Sayed SF, Mahmoud SM, Samy W, Wahid RM, Talaat A, et al. Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway. Tissue Cell. 2025;93:102724. doi:10.1016/j.tice.2025.102724
- Hu Y, Wang Y, Chen Y, Li C, Long Y, et al. Co-administration of 1,25-dihydroxyvitamin D3 and infliximab improves colitis in mice by modulating Treg differentiation. Iran J Basic Med Sci. 2024;27:1172. doi:10.22038/IJBMS.2024.74640.16209
- Wang L, Wei Z, Lv L, Xue C. An efficient co-delivery system based on multilayer structural nanoparticles for programmed sequential release of resveratrol and vitamin D3 to combat dextran sodium sulfate-induced colitis in mice. Int J Biol Macromol. 2024;254:127962. doi:10.1016/j.ijbiomac.2023.127962
- Siregar FD, Hidayat W. The Role of Vitamin D on the Wound Healing Process: A Case Series. Int Med Case Rep J. 2023;16:227. doi:10.2147/IMCRJ.S402005
- Gao H, Zhou H, Zhang Z, Gao J, Li J, et al. Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway. Front Immunol. 2023;14:1135930. doi:10.3389/fimmu.2023.1135930
- Zhu C, Fan M, Zhu J, Cao L, Duan X, et al. Vitamin D Reduces the Helper T Cells 17 (Th17) Differentiation in Patients with Ulcerative Colitis by Targeting Long Non-coding RNA (lncRNA) OIP5-AS1/miR-26a-5p/IL-6 Axis. Iran J Immunol. 2022;19:150. doi:10.22034/iji.2022.90562.2014
- Ma GL, Cao SG, Xia SL, Zhu HQ, Jiang Y. [A preliminary study on the improved efficacy of mesalazine combined with vitamin D in ulcerative colitis]. Zhonghua Nei Ke Za Zhi. 2022;61:785. doi:10.3760/cma.j.cn112138-20210903-00613
- MacLeod BG, Klarich CS, Wessman LL, Gaddis KJ, Konstantinov NK, et al. Fluorescent Imaging as a Component of Diagnosing Pyoderma Gangrenosum: A Case Report. Adv Skin Wound Care. 2022;35:1. doi:10.1097/01.ASW.0000820248.26138.bc
- Lu Y, Chen J, He X, Xu S, Chen YE, et al. Combined Administration of Vitamin D and Geniposide Is Less Effective than Single Use of Vitamin D or Geniposide in the Treatment of Ulcerative Colitis. Front Pharmacol. 2021;12:714065. doi:10.3389/fphar.2021.714065
- Dash KR, Panda C, Das HS, Mishra D, Behera SK, et al. Association of Vitamin D Level With Disease Severity and Quality of Life in Newly Diagnosed Patients of Ulcerative Colitis: A Cross-Sectional Analysis. Cureus. 2021;13:e16481. doi:10.7759/cureus.16481
- Halschou-Jensen PM, Sauer J, Bouchelouche P, Fabrin J, Brorson S, et al. Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial. Int J Low Extrem Wounds. 2023;22:466. doi:10.1177/15347346211020268
- Qiu F, Zhang Z, Yang L, Li R, Ma Y. Combined effect of vitamin C and vitamin D on intestinal epithelial barrier by regulating Notch signaling pathway. Nutr Metab (Lond). 2021;18:49. doi:10.1186/s12986-021-00576-x
- Osikov MV, Simonyan EV, Boyko MS, Ogneva OI, Ilyinykh MA, et al. Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis. Bull Exp Biol Med. 2021;170:608. doi:10.1007/s10517-021-05116-4
- Domazetovic V, Iantomasi T, Bonanomi AG, Stio M. Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling. Int J Colorectal Dis. 2020;35:1231. doi:10.1007/s00384-020-03576-0
- Cao R, Ma Y, Li S, Shen D, Yang S, et al. 1,25(OH) D alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation. J Leukoc Biol. 2020;108:283. doi:10.1002/JLB.3MA0320-406RR
- Cao S, Muniyappan M, Kim S, Kim IH. Co-Administration of Vitamin U and Antacids in Diets Relieves Gastric Ulcers in Finishing Pigs. J Anim Physiol Anim Nutr (Berl). 2024. doi:10.1111/jpn.14073
- Berkelhammer C, Ekambaram A, Silva RG. Low-volume oral colonoscopy bowel preparation: sodium phosphate and magnesium citrate. Gastrointest Endosc. 2002;56:89.
- Prod'hom G, Leuenberger P, Koerfer J, Blum A, Chiolero R, et al. Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis for stress ulcer. A randomized controlled trial. Ann Intern Med. 1994;120:653.
- Zhang L, Fu X, Li J, Xiao W, Xiong X, et al. Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice. J Microbiol Biotechnol. 2025;35:e2408050. doi:10.4014/jmb.2408.08050
- Seo HR, Chung KB, Kim DY. The Possible Impact of Zinc-Enriched Multivitamins on Treatment-Naïve Recurrent Aphthous Stomatitis Patients. J Clin Med. 2025;14. doi:10.3390/jcm14010260
- Wu Z, Wu W, Zhang C, Zhang W, Li Y, et al. Enhanced diabetic foot ulcer treatment with a chitosan-based thermosensitive hydrogel loaded self-assembled multi-functional nanoparticles for antibacterial and angiogenic effects. Carbohydr Polym. 2025;347:122740. doi:10.1016/j.carbpol.2024.122740
- Grimm K, Fiedler A, Kröger C. Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds. J Dairy Sci. 2025;108:1869. doi:10.3168/jds.2024-25134
- Laudanno O, Ahumaran G, Thome M, Adami P, Ustares F, et al. [Argentinean registry on the management of Helicobacter pylori infection: effectiveness and safety of first line treatment]. Medicina (B Aires). 2024;84:884.
- Huang Y, Shang S, Du H. Causal association of micronutrients and supplements with pressure ulcer: A Mendelian randomization study. Skin Res Technol. 2024;30:e13904. doi:10.1111/srt.13904
- Ban F, Zhou L, Yang Z, Liu Y, Zhang Y. Aspergillusidone G Potentiates the Anti-Inflammatory Effects of Polaprezinc in LPS-Induced BV2 Microglia: A Bioinformatics and Experimental Study. Mar Drugs. 2024;22. doi:10.3390/md22070324
- Govindarasu M, Vaiyapuri M, Kim JC. Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model. Bioprocess Biosyst Eng. 2024;47:1393. doi:10.1007/s00449-024-03047-8
- Zheng M, Xie C, Ye D, Chen Y, Wang Z, et al. Qingzhuan dark tea polysaccharides-zinc alleviates dextran sodium sulfate-induced ulcerative colitis. J Sci Food Agric. 2024;104:7617. doi:10.1002/jsfa.13597
- Santo ACSDE, Sugizaki CSA, de Morais Junior AC, Costa NA, Bachion MM, et al. Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. Nutrition. 2024;124:112449. doi:10.1016/j.nut.2024.112449
- Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999
- Faghfouri AH, Baradaran B, Khabbazi A, Abdoli Shadbad M, Papi S, et al. Regulation of NLRP3 inflammasome by zinc supplementation in Behçet's disease patients: A double-blind, randomized placebo-controlled clinical trial. Int Immunopharmacol. 2022;109:108825. doi:10.1016/j.intimp.2022.108825
- Jung DH, Park JC, Lee YC, Lee SK, Shin SK, et al. Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers. J Clin Gastroenterol. 2021;55:233. doi:10.1097/MCG.0000000000001357
- Scheid PL, Lâm TT, Sinsch U, Balczun C. Vermamoeba vermiformis as etiological agent of a painful ulcer close to the eye. Parasitol Res. 2019;118:1999. doi:10.1007/s00436-019-06312-y
- Ficarra G, Cicchi P, Amorosi A, Piluso S. Oral Crohn's disease and pyostomatitis vegetans. An unusual association. Oral Surg Oral Med Oral Pathol. 1993;75:220.
- Cho CH, Ogle CW, Dai S. Effects of zinc chloride on gastric secretion and ulcer formation in pylorus-occluded rats. Eur J Pharmacol. 1976;38:337.
