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Supplement Facts
Serving Size:  2 softgels
Amount Per Serving
%DV
Calories
15
 
Total Fat
1 g
1%*
Saturated Fat
1 g
5%*
Total Carbohydrate
2 g
1%*
Protein less than
1 g
 
Magnesium (as Magnesium Citrate)
250 mg
60%

The product is found useful for the following medical conditions

Kidney Stones details

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
Magnesium reduces kidney stone risk
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.

After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.

Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
10
Effective prevention
Most Useful Review
This supplement has completely changed my life regarding kidney stones. Previously, I faced them every three months for 20 years, resulting in numerous ER visits. Since taking this pill daily, I haven't had any kidney stones, much to my doctor's surprise. It has become my favourite supplement, and I highly recommend it to anyone struggling with kidney stones.

Anxiety details

SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.9
USERS' SCORE
Good
Based on 1 Review
8.6
8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
Most Relevant Research
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.

We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.

Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.

In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
10
Changed life
Most Useful Review
This supplement is life-changing for anxiety! I’ve purchased two bottles of Magnesium Citrate for myself and my son, who suffers from severe anxiety. This product has transformed his life; after a month, his anxiety is controlled, his hair is thriving and clear, and he’s reverted to his former cheerful self. I can't praise this enough; it may change your life too!

Back Pain details

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Magnesium reduces postoperative back pain
Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting.
Most Relevant Research
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.

Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.

Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
9.5
Natural pain relief
Most Useful Review
Great as a gentle muscle relaxant, I take this before bed. It helps with my back pain and serves as a 100% natural alternative to paracetamol and ibuprofen. One (250mg) before night means I hardly need to take painkillers. I've read that magnesium is known for relaxing muscles. This is also approved by the USP, an independent group that verifies quality and potency. Whenever possible, I prefer products from them.

Cold details

SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
USERS' SCORE
Good
Based on 1 Review
8.6
8
MPM performance in cold environments
Effect of fly ash and curing temperature on the properties of magnesium phosphate repair mortar.
Most Relevant Research
We examined how incorporating fly ash into magnesium phosphate repair mortar (MPM) influences its effectiveness in cold environments. Our investigation revealed that fly ash modifies the microstructure of the MPM, enhancing its performance without affecting the setting time or fluidity significantly.

We discovered that adding 10% to 15% fly ash improves the mechanical strength, adhesion, water resistance, and stability of the mortar. Notably, we found that the curing temperature plays a critical role; as the temperature rises, compressive strength increases, while properties like flexural strength decrease.

Interestingly, even when cured in icy conditions at -20°C or 0°C, MPM with fly ash retains good early strength and strong adhesion properties. This suggests magnesium phosphate repair mortar modified with fly ash is suitable for emergency repairs in cold weather, showcasing its potential for use in challenging environments.
9.5
No kidney stones
Most Useful Review
This prevents me from getting kidney stones. I'd marry it if they let me! I progressively developed kidney stones every three months over the past 20 years, which are incredibly painful. This pill, taken daily, has stopped them cold. My kidney stone doctor was astonished during my last check-up to see I had no stones. Normally, my X-rays show gravel in my kidneys. This is my favourite supplement ever. Thank you!

Irritable Bowel Syndrome details

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 1 Review
8.6
8
Magnesium boosts colonic activity
Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome.
Most Relevant Research
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.

Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.

Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
9.5
Very successful treatment
Most Useful Review
If pills are a problem for you, these might be challenging due to their size. I was recommended this by an internet group for irritable bowel syndrome, and it has been very successful for me.

Leg Cramps details

SCIENTIFIC SCORE
Likely Ineffective
Based on 16 Researches
4.7
USERS' SCORE
Good
Based on 6 Reviews
8.6
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Most Relevant Research
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.

Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.

The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
9.5
Effective for cramps
Most Useful Review
It genuinely helps with leg cramps! I'm on Keto and take these nightly to alleviate leg cramps. I notice a significant difference on nights I forget to take them. A good product that I've reordered several times.

Sleep Apnea details

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 9 Reviews
8.5
7
Magnesium's role in sleep apnea
Association between magnesium deficiency score and sleep quality in adults: A population-based cross-sectional study.
Most Relevant Research
We aimed to uncover the relationship between magnesium levels and sleep quality, particularly focusing on sleep apnea. Our study analyzed data from a large group of adults aged 20 and older, using a well-structured method to assess magnesium levels and the prevalence of sleep issues.

We found a notable connection between lower magnesium levels, measured as the magnesium depletion score (MDS), and the likelihood of experiencing sleep apnea. Specifically, individuals with higher MDS levels were significantly more likely to report sleep apnea, showing over three times the odds compared to those with adequate magnesium levels.

Interestingly, our research did not link magnesium deficiency to other sleep problems like insomnia or restless legs syndrome, suggesting a more complex relationship with sleep apnea alone. Additionally, we noticed that older adults with depressive symptoms showed a tendency toward excessive sleep rather than insufficient sleep.

While our findings highlight the association between magnesium deficiency and sleep apnea, they also point towards the potential of adequate magnesium intake in reducing this risk. This emphasizes the importance of maintaining proper magnesium levels for better sleep quality, especially in those at higher risk for sleep apnea.
8.8
Better sleep quality
Most Useful Review
Excellent magnesium; I take it in conjunction with other vitamins as advised by my doctor due to its positive impact on bowel function. I consume three capsules daily, with no pronounced laxative effect. The streamlined purple capsules are large yet manageable. I appreciate the absence of stearate in the shell, unlike other brands. Since using this magnesium, I've noticed an improvement in my sleep. I highly recommend it!

Diabetes details

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
8
Magnesium deficiency affects diabetes control
Hypomagnesemia in adults with type 2 diabetes mellitus in Riyadh, Saudi Arabia: A cross-sectional study.
Most Relevant Research
We looked into how magnesium levels relate to diabetes, specifically focusing on adults with type 2 diabetes mellitus (T2DM) in Riyadh, Saudi Arabia. Conducted as a cross-sectional study, we analyzed data from 294 individuals, including T2DM patients, prediabetics, and nondiabetic controls. Our goal was to uncover the prevalence of magnesium deficiency and its potential effects on various metabolic factors.

The findings revealed a striking difference in magnesium levels across the groups. T2DM patients exhibited notably lower magnesium than those with prediabetes and nondiabetic controls. This deficiency was linked to worse metabolic outcomes, including higher fasting glucose and glycated hemoglobin (HbA1c) levels, as well as increased insulin resistance.

We noted a strong negative correlation between magnesium levels and both glucose and HbA1c, suggesting that as magnesium levels decrease, diabetes control worsens. Interestingly, our analysis indicated that magnesium levels could effectively predict higher HbA1c values, highlighting the need for regular monitoring of magnesium in diabetes management.

While our study emphasizes the significant impact of magnesium deficiency on the metabolic health of T2DM patients, it also opens the door for further exploration regarding the benefits of magnesium supplementation in diabetes care. Overall, these insights push us to consider the broader implications of maintaining proper magnesium levels for better diabetes management.
8.8
Controls diabetes effectively
Most Useful Review
Excellent product. It helps me control my diabetes.

Diarrhea details

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8.5
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
Most Relevant Research
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.

We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.

Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
8.3
Daily movements enhanced
Most Useful Review
This product is effective for daily bowel movements, and I can manage multiple without experiencing cramps or diarrhoea, even at half the usual dose.

Osteoporosis details

SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.5
9
Magnesium's role in osteoporosis therapy
Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism.
Most Relevant Research
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.

Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.

In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.

Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
8.8
Bone health improvement
Most Useful Review
Contributes to bone health. Magnesium citrate is part of my regimen to reverse osteoporosis. For further information, consider the book "Your Bones".

Atrial Fibrillation details

SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.4
USERS' SCORE
Good
Based on 1 Review
8.4
7
Magnesium supplementation reduces atrial fibrillation
Clinician preference instrumental variable analysis of the effectiveness of magnesium supplementation for atrial fibrillation prophylaxis in critical care.
Most Relevant Research
We wanted to understand the effectiveness of magnesium supplementation in preventing atrial fibrillation, a common heart rhythm issue in critical care patients. In our study, we looked at patient data from a single center, analyzing the varied practices of bedside nurses regarding magnesium treatment.

By examining the approach of individual nurses, we identified two groups: those who tended to be liberal with magnesium administration and those who were more restrictive. Through rigorous analysis, we found that magnesium supplementation was linked to a 3% decrease in the relative risk of developing atrial fibrillation. This suggests that implementing routine magnesium treatment could be beneficial for patients.

While our findings support the idea of using magnesium to help prevent atrial fibrillation, we recognize that more research is needed to determine the best serum magnesium levels for maximum benefit. Overall, our study offers promising insights into how magnesium can play a role in improving patient care in critical settings.
7.5
Reduced A-Fib episodes
Most Useful Review
Excellent product, with two capsules daily providing slightly more than the minimum daily requirement of magnesium. Unlike magnesium oxide, it produces no gastrointestinal irritation. Some cardiologists believe that increasing intracellular magnesium in heart muscle cells may reduce or eliminate episodes of atrial fibrillation. It also aids regular bowel movements. Minor complaint: arrived two days after the promised date. Re-order: Same quality product, timely delivery as promised.

Constipation details

SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.6
USERS' SCORE
Good
Based on 2 Reviews
8.4
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
Most Relevant Research
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.

Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.

Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
7.5
Difficult to swallow
Most Useful Review
I've relied on magnesium citrate for years to manage my constipation, as recommended by my gastroenterologist. This form pulls fluids into the intestines, making it easier to pass stools. However, I need to take 800mg for effectiveness, which means using several pills due to their lower milligram content. While easier to swallow than tablets, they remain large. Despite the misleading labelling on the packaging regarding dosage, I appreciate that they're softgels.

Headache details

SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.4
9
Magnesium aids migraine management
Magnesium and Migraine.
Most Relevant Research
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.

A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.

This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
7.5
Reduced headache frequency
Most Useful Review
I purchased these at my doctor's suggestion to help with my frequent headaches, nearly daily. Since starting them a month ago for my magnesium deficiency, the days I experience headaches have reduced to about two per week. They aren’t difficult to swallow once you adjust – similar in size to standard multivitamins.
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