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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Calcium (as Dibasic Calcium Phosphate)
65 mg
5%
Melatonin
3 mg
*
The product is found useful for the following medical conditions
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.2
USERS' SCORE
Good
Based on 11 Reviews
8.9
9
Melatonin delivery enhances sleep
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
Most Relevant Research
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
9.5
Wonderful insomnia relief
Most Useful Review
Helped with my insomnia. I have been using melatonin for my insomnia for about a month, as my doctor recommended. Thankfully, it has been working wonderfully! It’s crucial to take it 1-2 hours before you plan to fall asleep and not to overdo it, as a tolerance can build. I’ve always trusted this brand of supplements and have never been let down.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
9.5
Agomelatine relieves hypnic headaches
Case report: Hypnic headache responds to agomelatine-a potential prophylactic treatment option.
Most Relevant Research
We explored how melatonin-based treatments, particularly agomelatine, can affect headaches, focusing on hypnic headaches (HH). This form of headache typically occurs during sleep, disrupting the rest of those affected. A fascinating case of a 58-year-old woman who experienced these nocturnal headaches for three years demonstrated the potential benefits of agomelatine.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
After being prescribed 25 mg of agomelatine at bedtime, she reported an impressive 80% reduction in headache frequency and severity within a month. Remarkably, her headaches completely resolved after three months, allowing her to discontinue the medication.
This case highlights the importance of exploring prophylactic treatments aimed at reducing nighttime awakenings caused by HH. Given the significant impact these headaches can have on sleep quality in older populations, treatments that target melatonin receptors could offer a promising avenue for relieving this condition.
3.5
3mg dosage issues
Most Useful Review
The product is as described, however, I always experience headaches with 3 mg of melatonin. If you're trying melatonin for the first time, I recommend starting with 1 mg and increasing as needed. I have switched to valerian root, which is milder and does not cause headaches.
