We explored the effects of vitamin E supplementation on patients with Smith-Lemli-Opitz Syndrome (SLOS), particularly focusing on symptoms like eczema. In a three-year study, six patients who were already on dietary cholesterol treatment received vitamin E. Their vitamin E levels were initially low, but following supplementation, all patients showed a significant increase in plasma vitamin E concentrations.
Among the various symptoms assessed, including aggression, irritability, and skin issues like eczema, some patients reported improvements. Our findings indicated that three out of the six patients experienced a reduction in symptoms, including skin photosensitivity and eczema. Notably, those who responded best to therapy had lower baseline ratios of certain cholesterol-related compounds.
While the study suggests that vitamin E could provide benefits to SLOS patients鈥攑ossibly contributing to improvements in skin conditions like eczema鈥攊ndividual responses varied. Thus, vitamin E supplementation may be worth considering in the management of SLOS, especially for those with low initial vitamin E levels and certain biochemical markers.
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Most Useful Reviews
10
Eczema cleared up
12 people found this helpful
The pretty little liquid gels are easy to swallow. My doctor suggested taking Vitamin E for eczema, and shortly after starting daily doses, my eczema cleared up. It's been 2 years, and I鈥檓 now eczema free.
We explored the effects of vitamin E supplementation on patients with Smith-Lemli-Opitz Syndrome (SLOS), particularly focusing on symptoms like eczema. In a three-year study, six patients who were already on dietary cholesterol treatment received vitamin E. Their vitamin E levels were initially low, but following supplementation, all patients showed a significant increase in plasma vitamin E concentrations.
Among the various symptoms assessed, including aggression, irritability, and skin issues like eczema, some patients reported improvements. Our findings indicated that three out of the six patients experienced a reduction in symptoms, including skin photosensitivity and eczema. Notably, those who responded best to therapy had lower baseline ratios of certain cholesterol-related compounds.
While the study suggests that vitamin E could provide benefits to SLOS patients鈥攑ossibly contributing to improvements in skin conditions like eczema鈥攊ndividual responses varied. Thus, vitamin E supplementation may be worth considering in the management of SLOS, especially for those with low initial vitamin E levels and certain biochemical markers.
Read More
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10
Eczema cleared up
12 people found this helpful
The pretty little liquid gels are easy to swallow. My doctor suggested taking Vitamin E for eczema, and shortly after starting daily doses, my eczema cleared up. It's been 2 years, and I鈥檓 now eczema free.
Read More
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References
Koczok K, Horv谩th L, Korade Z, Mezei ZA, Szab贸 GP, et al. Biochemical and Clinical Effects of Vitamin E Supplementation in Hungarian Smith-Lemli-Opitz Syndrome Patients. Biomolecules. 2021;11. 10.3390/biom11081228