Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel 
Amount Per Serving
%DV
Vitamin E (as dl-Alpha Tocopheryl Acetate)
180 mg
1200%

Top Medical Research Studies

9
Vitamin E alleviates leg cramps
We investigated the impact of vitamin E on treating frequent and severe nocturnal leg cramps. Patients received 100 I.U. of d, alpha-tocopheryl acetate three times daily before meals.

Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.

Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
Read More
7
Vitamin E effective for leg cramps
We explored the effects of vitamin E on leg cramps through a controlled double-blind study involving 40 dialysis patients.

After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.

Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.

However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.
Read More
7
Vitamin E shows limited effectiveness
We examined the effectiveness of various treatments for leg cramps, focusing particularly on vitamin E. While quinine has long been a go-to option, its use has significantly decreased due to safety concerns and mixed results in studies. Our review highlighted that although vitamin E might show potential benefits for leg cramps in patients on dialysis, the evidence is not robust across all populations. Therefore, we should consider other medications, like verapamil or gabapentin, before reverting to quinine.
Read More

Most Useful Reviews

9
Tremendous help
5 people found this helpful
Use for cramps in legs. I take vitamin E and calcium before bed to alleviate leg cramps. This combination has helped tremendously!
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
  • All Researches
9
Vitamin E alleviates leg cramps
We investigated the impact of vitamin E on treating frequent and severe nocturnal leg cramps. Patients received 100 I.U. of d, alpha-tocopheryl acetate three times daily before meals.

Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.

Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
Read More
7
Vitamin E shows limited effectiveness
We examined the effectiveness of various treatments for leg cramps, focusing particularly on vitamin E. While quinine has long been a go-to option, its use has significantly decreased due to safety concerns and mixed results in studies. Our review highlighted that although vitamin E might show potential benefits for leg cramps in patients on dialysis, the evidence is not robust across all populations. Therefore, we should consider other medications, like verapamil or gabapentin, before reverting to quinine.
Read More
7
Vitamin E effective for leg cramps
We explored the effects of vitamin E on leg cramps through a controlled double-blind study involving 40 dialysis patients.

After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.

Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.

However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.
Read More

User Reviews

USERS' SCORE
Good
Based on 1 Review
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Tremendous help
5 people found this helpful
Use for cramps in legs. I take vitamin E and calcium before bed to alleviate leg cramps. This combination has helped tremendously!
Read More

Frequently Asked Questions

No FAQs are available for this product and symptom.

References

  1. Guay DR. Are there alternatives to the use of quinine to treat nocturnal leg cramps?. Consult Pharm. 2008;23:141.
  2. Roca AO, Jarjoura D, Blend D, Cugino A, Rutecki GW, et al. Dialysis leg cramps. Efficacy of quinine versus vitamin E. ASAIO J. 1992;38:M481.
  3. Ayres S, Mihan R. Leg cramps (systremma0 and "restless legs" syndrome. Response to vitamin E (tocopherol). Calif Med. 1969;111:87.
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