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For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
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For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
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Frequently Asked Questions
Nausea is a sensation that often precedes vomiting and is characterized by an uneasy feeling in the stomach. It can be caused by a variety of factors, including motion sickness, certain medications, food poisoning, or underlying health conditions. The experience of nausea can range from mildly uncomfortable to intensely distressing and is often accompanied by other symptoms such as sweating, increased salivation, or a feeling of lightheadedness.
Many people experience nausea at some point in their lives, making it a common issue. Fortunately, there are several remedies and treatments available that can help alleviate this unpleasant sensation. Over-the-counter medications, home remedies like ginger tea, and lifestyle changes, such as eating smaller meals or avoiding certain triggers, can be effective in reducing nausea. However, if nausea is persistent or accompanied by severe symptoms like severe abdominal pain or fever, it’s essential to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc may play a role in alleviating certain types of nausea, especially when it is associated with specific conditions, such as pregnancy or certain gastrointestinal issues. Some studies have indicated that zinc supplements might help in reducing nausea symptoms due to their potential to support overall gut health and maintain immune function. However, the evidence is not conclusive, and results can vary from person to person.
It's important to note that while zinc supplementation might benefit some individuals, it is not universally effective for all types of nausea. If you're considering using zinc to address nausea, consult with a healthcare professional to ensure it's appropriate for your situation and to discuss the ideal dosage. Additionally, it's crucial to address the underlying cause of nausea rather than just treating the symptom itself.
Based on user reviews, the timeline for seeing results when taking zinc supplements can vary significantly. Some users mention that they have only been taking the supplement for a week and are still in the process of gauging its effects (Read Review). However, others have noted adjustments over longer periods, such as a month, where they reported improvements or adaptation (Read Review).
In terms of experiencing nausea specifically, several users advise that taking zinc with food can prevent discomfort (review id='f30e730c-9ed5-431c-8496-243dedbcb76c' and review id='641794dd-b2af-4398-a2e9-c307fd142abc'). Others have suggested that it might take a few days to fully adapt to the dosage without experiencing side effects such as nausea (Read Review). Overall, while some users experience benefits within days, most seem to find it takes a few weeks for their bodies to adjust and for the full effects to be appreciated.
When it comes to scientific support for using zinc supplements to alleviate nausea, the evidence presents a mixed picture. A study on zinc-impregnated pharyngeal packs showed that patients who received these packs experienced less severe nausea after surgery compared to those using standard saline packs, suggesting a potential benefit of zinc in reducing post-operative nausea [3]. Furthermore, a trial evaluating the tolerability of zinc tablets in children revealed that while many experienced side effects such as vomiting, only a small percentage (7.4%) reported nausea, indicating that zinc might not exacerbate this symptom in some demographics [4].
On the other hand, the effectiveness of zinc acetate dihydrate in treating nausea wasn't conclusively supported, as the study indicated that nausea was reported in 1.4% of patients without a definitive conclusion about zinc's isolated effectiveness for this issue [2]. The findings from a comparison of a new zinc form, NPC-25, with a traditional treatment indicated fewer digestive issues, including nausea, in patients using NPC-25 than those receiving the traditional treatment [1]. Overall, while there are hints that zinc might help with nausea in specific scenarios, the direct evidence is not strong enough to claim unqualified support for its use solely for this purpose.
Users have reported a variety of improvements in symptoms when taking zinc supplements, especially regarding overall health and immune support. Several reviewers noted that their supplements were highly absorbable and did not cause nausea, which is a common concern with zinc intake. For instance, one user mentioned their satisfaction with the zinc gluconate formula, stating it is "essential for health" and does not induce nausea ((Read Review)). Another user also highlighted that they experienced no side effects while taking the supplement ((Read Review)).
On the other hand, some users do report side effects like nausea when taking zinc on an empty stomach, suggesting taking it with food for better tolerance ((Read Review)). One reviewer shared an experience of nausea in the first few days, but noted that after a month, they had adapted to it, which ultimately led to improved sleep quality ((Read Review)). These anecdotal experiences underline that while many users find relief in symptoms and notable health benefits, individual results can vary significantly based on personal tolerance and dosage.
Users have reported mixed experiences when combining zinc supplements with other remedies for handling nausea. Several reviews highlight that taking zinc in a highly absorbable form, such as the gluconate variant, has not led to any nausea. For example, one user stated that this form of zinc does not cause nausea and is essential for health ((Read Review)). Many others echoed this sentiment, emphasizing their satisfaction with the supplement's high absorption and low side effect profile. Users also noted the small size of the tablets facilitates easier consumption, contributing to an overall positive experience ((Read Review); (Read Review)).
However, some users cautioned against taking zinc on an empty stomach, as it can lead to discomfort and nausea, suggesting that it’s best taken with food for better tolerance ((Read Review); (Read Review)). One user, after experiencing nausea for the first few days, found that their mother adapted to the supplement over the course of a month, which ultimately resulted in improved sleep quality when taken after meals ((Read Review)). Overall, while many users report a straightforward experience with little to no side effects, individual reactions vary, and combining zinc with food appears to mitigate nausea effectively.
Based on user reviews, the right dose of Zinc for treating nausea appears to hover around the 30 mg mark. Many users reported that this dosage is both effective and generally well-tolerated. For instance, users noted that a daily intake of 30 mg of zinc gluconate does not cause nausea and is recommended for its health benefits (Read Review). Additionally, those who prefer smaller tablets found a 30 mg zinc supplement to be manageable and without negative side effects like nausea (Read Review).
However, some users highlighted the importance of taking zinc with food to mitigate the risk of nausea. For example, one reviewer experienced nausea and headaches when taking zinc on an empty stomach and noted better tolerance when taken after meals (Read Review). Another user echoed this advice, stating that taking zinc with food is a crucial step to avoid nausea (Read Review). Thus, while 30 mg seems to be an effective dose, taking it at the right time—specifically with meals—can enhance its tolerability and effectiveness.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
References
- Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. doi:10.1016/j.jtemb.2024.127558
- Ezoe S, Ishihara T, Hosogai T, Kokubo T. Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan. Pharmazie. 2024;79:29. doi:10.1691/ph.2024.3630
- Parvizi A, Haddadi S, Akbari M, Akbarpour M, Taghipour Rudsari F, et al. Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty. Anesth Pain Med. 2022;12:e127262. doi:10.5812/aapm-127262
- Nuzhat S, Ahmed T, Alam J, Billal SM, Khan AI, et al. New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh. J Paediatr Child Health. 2022;58:1215. doi:10.1111/jpc.15953
