We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
8
Magnesium improves diarrhea symptoms
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia.
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
Read More
9
Magnesium improves diarrhea-related symptoms
Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature.
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
Most Useful Reviews
0
Supplement concerns
252 people found this helpful
I've taken magnesium glycinate for severe anxiety for three years, but after switching to this brand, I faced unexpected diarrhoea and stomach cramps. I now realise that magnesium oxide in this supplement might be causing these problems, making it ineffective for my anxiety management.
Read More
2
Sleep disruption
8 people found this helpful
I purchased this product to aid my sleep, but I have had persistent diarrhoea every morning and throughout the day. Unfortunately, doubling my intake did not improve my sleep or symptoms. I'm disappointed that this vitamin failed to deliver the desired effects, leaving me exhausted.
Read More
0
Forceful side effects
4 people found this helpful
Consumers should be cautious. If you're considering this for anxiety or sleep, be prepared for uncontrollable diarrhoea due to its magnesium oxide content. I experienced days of severe diarrhoea, initially mistaking it for the stomach flu, but now I know it was due to this supplement combination.
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
9
Magnesium improves diarrhea-related symptoms
Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature.
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
9
Magnesium reduces diarrhea incidence
Dietary supplementation with potassium-magnesium sulfate modulates the antioxidant capacity, immunity, and gut microbiota in weaned piglets.
In our exploration of how potassium-magnesium sulfate (PMS) impacts diarrhea in weaned piglets, we set out to understand its effects on growth performance, immunity, and gut health. A total of 216 piglets were divided into six groups, with varying levels of PMS in their diets.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Read More
9
Impact of magnesium on diarrhea
Bioactivities of (Wall.) and Study against Cyclooxygenase Enzymes.
We conducted a study to assess the effectiveness of magnesium in treating diarrhea, particularly focusing on its role in extracts from (Wall.) leaves. To evaluate this, we utilized several tests that mimic diarrhea conditions. Our findings showed that while magnesium was mentioned in connection with the extracts, it was administered alongside other treatments. This means we're not entirely sure how much of the anti-diarrheal effect was due to magnesium itself.
In our tests, the methanol extract of (Wall.) leaves was particularly noteworthy, showing significant inhibition of diarrhea at a dose of 400 mg/kg. However, the role of magnesium in this context remains ambiguous since it wasn't given alone. In essence, while the extract worked well against diarrhea, the individual contribution of magnesium to this benefit is unclear.
Overall, we support the traditional use of (Wall.) plants in managing diarrhea and pain, but we need more focused research to isolate the effects of magnesium.
Read More
8
Magnesium improves diarrhea symptoms
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia.
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
I've taken magnesium glycinate for severe anxiety for three years, but after switching to this brand, I faced unexpected diarrhoea and stomach cramps. I now realise that magnesium oxide in this supplement might be causing these problems, making it ineffective for my anxiety management.
Read More
2
Sleep disruption
8 people found this helpful
I purchased this product to aid my sleep, but I have had persistent diarrhoea every morning and throughout the day. Unfortunately, doubling my intake did not improve my sleep or symptoms. I'm disappointed that this vitamin failed to deliver the desired effects, leaving me exhausted.
Read More
0
Forceful side effects
4 people found this helpful
Consumers should be cautious. If you're considering this for anxiety or sleep, be prepared for uncontrollable diarrhoea due to its magnesium oxide content. I experienced days of severe diarrhoea, initially mistaking it for the stomach flu, but now I know it was due to this supplement combination.
Read More
0
Caused stomach issues
1 people found this helpful
Unfortunately, this product did not work for me. It troubled my stomach and caused diarrhoea, so I had to stop using it.
Read More
10
Diarrhea stopped
After taking this magnesium, I feel comfortable in my stomach. The ingredients are good quality, and I have not experienced any diarrhoea since I started using it.
Diarrhea is a condition characterized by the frequent passage of loose or watery stools, which can occur due to various factors, including infections, dietary choices, and underlying health conditions. It often results from the body's response to an irritation of the gastrointestinal tract, which can be caused by viruses, bacteria, parasites, or certain medications. While most cases tend to be short-lived and resolve on their own, diarrhea can lead to dehydration, especially in vulnerable populations such as young children and the elderly.
Managing diarrhea typically involves staying hydrated by drinking clear fluids and, when necessary, replenishing lost electrolytes. In some cases, over-the-counter medications may provide relief, although it’s essential to consult a healthcare professional for persistent or severe symptoms. A focus on bland, easy-to-digest foods can also help during recovery. Remember, if diarrhea persists for more than a couple of days or is accompanied by other concerning symptoms—like high fever, severe abdominal pain, or blood in stools—seeking medical attention is crucial.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium can have an effect on digestive health, but its role in managing diarrhea is complex. Magnesium is known to have a laxative effect, especially in higher doses or in certain forms, such as magnesium citrate or magnesium sulfate. This means that while magnesium can be beneficial for individuals suffering from constipation, it may exacerbate diarrhea for those who are already experiencing loose stools.
In some cases, magnesium may be helpful in alleviating diarrhea due to its overall importance in digestive function and maintaining electrolyte balance. However, if diarrhea is persistent or severe, it's crucial to consult a healthcare professional for proper evaluation and treatment. Overall, magnesium should not be seen as a primary treatment for diarrhea, and those experiencing digestive discomfort should consider other remedies and strategies alongside any magnesium supplementation.
According to user reviews, the time it typically takes to see results from magnesium supplements can vary significantly. Some users have reported feeling comfortable and free from diarrhea soon after starting the supplement, while others experienced immediate adverse reactions, such as stomach discomfort and diarrhea. For instance, one user noted that after a few days, they felt uncomfortable and ended up with diarrhea and vomiting, which led them to discontinue use Read Review. In contrast, another user suggested that they have not experienced diarrhea since beginning the supplement, indicating that for some, results may be noticeable almost immediately Read Review.
Despite these mixed experiences, several users highlighted that following the recommended usage instructions can lead to positive results. They reported that the supplement worked effectively without causing any digestive upset when taken correctly Read Review. While the variance in individual responses makes it challenging to pinpoint an exact timeframe for results, starting with a cautious approach may help mitigate potential stomach issues and enhance the likelihood of a positive experience.Read Review
Recent research presents compelling evidence that magnesium supplementation may be effective in managing various forms of diarrhea. A study focused on secretory diarrhea, particularly in cholera, found that increasing magnesium levels led to a significant reduction in chloride secretion in intestinal cells, which is crucial during diarrhea episodes. The researchers observed a remarkable 65% inhibition of chloride secretion and a 40% reduction in fluid loss associated with cholera when magnesium was administered. These findings suggest that oral magnesium supplementation could serve as a straightforward therapeutic option for cholera and potentially other types of secretory diarrhea [1].
Moreover, patients with genetic conditions like HNF1B syndrome, which often involve hypomagnesemia, have shown marked improvements in diarrhea symptoms after magnesium supplementation, indicating a strong connection between magnesium deficiency and gastrointestinal issues. Another intriguing case involving an infant suffering from severe hypomagnesemia linked magnesium treatment to the resolution of persistent watery diarrhea. Collectively, these studies underscore the importance of magnesium, not only as a dietary supplement but also as a potential therapeutic strategy to alleviate diarrhea symptoms across different contexts [2][4].
Based on user reviews, experiences with magnesium supplements show a range of improvements and discomforts. Some users have reported significant benefits, such as better sleep quality and comfort in their stomachs, when taking the supplement as directed. One user shared that the product helped them with sleep issues, allowing for long, quality rest without causing diarrhea, contrasting it with magnesium oxide which they've had negative experiences with in the past Read Review. Another noted feeling comfortable without any gastrointestinal issues, further attesting to the quality and effectiveness of the ingredients Read Review.
However, not all reports are favorable, as some users experienced adverse reactions such as stomach discomfort, vomiting, and diarrhea, leading them to discontinue use Read ReviewRead Review. Another user specifically appreciated that this particular magnesium product did not cause the typical digestive issues associated with magnesium oxide, which highlights the importance of formulation differences in how they affect individual users Read Review. While many report positive effects, it's important to remember that individual results can vary significantly.
Users report mixed experiences when combining this magnesium supplement with other supplements for managing diarrhea. While some individuals found relief and comfort, others encountered significant digestive issues. For instance, one user mentioned that they experienced stomach trouble and diarrhea, which compelled them to discontinue use of the supplement Read Review. Another user reported that although they initially felt well, they later experienced cold discomfort in their stomach leading to vomiting and diarrhea after taking it Read Review.
Conversely, several users highlighted positive interactions when using the supplement correctly. One user noted that they felt comfortable without any gastrointestinal distress and found the ingredients to be of good quality, resulting in no diarrhea since starting the supplement Read Review. Additionally, another user praised this magnesium product for alleviating sleep problems without causing any digestive issues typically associated with magnesium oxide Read Review. Overall, while the supplement may provide benefits, users are advised to monitor their reactions, especially if combining it with other products.
According to recent studies exploring magnesium's role in treating diarrhea, there is no clearly defined "optimal" dose across different contexts. For instance, one study indicated that higher doses, up to 1200 mg per day, showed no significant increase in diarrhea incidents among participants, suggesting that adults can often consume magnesium supplements beyond the typical upper intake limits without adverse gastrointestinal effects [3]. Moreover, other research highlighted that supplemental magnesium could significantly reduce fluid loss associated with cholera by effectively inhibiting chloride secretion in intestinal cells, with certain dosages promoting absorption during episodes of diarrhea [1].
It’s also been noted that individuals suffering from conditions like HNF1B syndrome often exhibit significant improvements in diarrhea symptoms following magnesium supplementation, thereby emphasizing the importance of monitoring magnesium levels in affected patients [2]. However, the specific therapeutic dosage can vary based on individual health conditions and needs, which underscores the necessity to consult with healthcare providers before starting any supplementation regimen.
9
Avoid due to discomfort
This made me feel fine for the first few days, but then I felt cold and uncomfortable in my stomach. I ended up vomiting and having diarrhoea after eating it. I don't know why it affected me like this, so I don't dare eat it anymore.
10
Diarrhea stopped
After taking this magnesium, I feel comfortable in my stomach. The ingredients are good quality, and I have not experienced any diarrhoea since I started using it.
9
No stomach issues
This is the best magnesium I have tried among different brands. It does not cause diarrhoea or any stomach problems, and works effectively when used according to the instructions.
9
Improves sleep quality
This product is brilliant! It has helped me with my sleep problems significantly, allowing for long, quality sleep. Unlike magnesium oxide, it didn’t cause any diarrhoea. I'm hopeful it will also help alleviate stress.
0
Caused stomach issues
1 people found this helpful
Unfortunately, this product did not work for me. It troubled my stomach and caused diarrhoea, so I had to stop using it.
9
Avoids diarrhea
This complex magnesium combination turned out to have magnesium oxide, which I usually avoid due to its propensity to cause diarrhoea. Thankfully, I didn’t experience that issue with this product, and I appreciate the inclusion of magnesium-rich plant blends.
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
8
Magnesium improves diarrhea symptoms
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia.
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
9
Magnesium improves diarrhea-related symptoms
Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature.
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
4
Magnesium and diarrhea analysis
Perspective: Call for Re-evaluation of the Tolerable Upper Intake Level for Magnesium Supplementation in Adults.
We explored how magnesium supplementation affects diarrhea, particularly in adults. In recent research, we carefully reviewed data from intervention studies conducted between 1997 and 2022, focusing mainly on single-ingredient magnesium products. Our goal was to determine whether higher doses of magnesium cause significant gastrointestinal issues, especially diarrhea, which had previously shaped the established upper intake limit.
The findings were enlightening. Out of ten studies we analyzed, including five meta-analyses and five randomized controlled trials, seven indicated no significant difference in diarrhea incidents between those receiving magnesium and those given a placebo. It was interesting to note that even at doses as high as 1200 mg per day, participants generally did not report diarrhea.
When reviewing adverse event data reported to the FDA, we found just 40 cases of gastrointestinal issues linked to magnesium supplementation. Quite tellingly, only one-third of these involved complaints about diarrhea. This suggests that the concern regarding magnesium causing significant gastrointestinal problems may be overstated.
Overall, our evaluation indicates that adults can often consume magnesium supplements above the current upper intake level without significant adverse effects related to diarrhea. This opens up opportunities for increasing magnesium intake, which could help address inadequacies in this essential nutrient for many individuals.
References
de Souza Goncalves L, Chu T, Master R, Chhetri PD, Gao Q, et al. Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells. J Clin Invest. 2024;134. doi:10.1172/JCI171249
Wang Y, Xiao X, Lin Q, Song R, Wang X, et al. Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia. J Diabetes Investig. 2024;15:121. doi:10.1111/jdi.14084
Costello R, Rosanoff A, Nielsen F, West C. Perspective: Call for Re-evaluation of the Tolerable Upper Intake Level for Magnesium Supplementation in Adults. Adv Nutr. 2023;14:973. doi:10.1016/j.advnut.2023.06.008
Kamali F, Jamee M, Sayer JA, Sadeghi-Bojd S, Golchehre Z, et al. Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature. CEN Case Rep. 2023;12:413. doi:10.1007/s13730-023-00785-8
Cao S, Huang K, Wen X, Gao J, Cui B, et al. Dietary supplementation with potassium-magnesium sulfate modulates the antioxidant capacity, immunity, and gut microbiota in weaned piglets. Front Microbiol. 2022;13:961989. doi:10.3389/fmicb.2022.961989
Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. doi:10.1136/spcare-2022-003685
Sarkar KK, Mitra T, Rahman MA, Raja IM, Aktaruzzaman M, et al. Bioactivities of (Wall.) and Study against Cyclooxygenase Enzymes. Biomed Res Int. 2022;2022:1331758. doi:10.1155/2022/1331758