Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.4
Top Medical Research Studies
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Read More
8
We conducted a randomized placebo-controlled trial involving 48 healthy postmenopausal women, testing the impact of folic acid on plasma homocysteine levels—a potential risk factor for cardiovascular issues and osteoporosis. After 16-17 weeks, we observed that those taking folic acid had significantly lower homocysteine levels compared to the placebo group (10.33 μmol/l vs 13.21 μmol/l).
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
Read More
7
We aimed to explore how folic acid influences sexual function in postmenopausal women. This triple-blind randomized controlled trial, conducted in Tehran, involved 100 women receiving either a daily folic acid supplement or a placebo for eight weeks.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
Read More
Most Useful Reviews
7.5
Boosts energy levels
9 people found this helpful
This helps with brain fog and low energy levels. After menopause hit, my energy plummeted, accompanied by significant brain fog. Adding B100 to my routine made a noticeable difference. Though my multivitamin provided some Bs, they are water-soluble and leave the body every three hours if not used. During mentally taxing tasks, B100 combats brain fatigue and offers a boost. I only take them with food, as they can be harsh on an empty stomach, but this has been a fantastic and relatively inexpensive addition to my routine.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
- All Researches
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Read More
8
We conducted a randomized placebo-controlled trial involving 48 healthy postmenopausal women, testing the impact of folic acid on plasma homocysteine levels—a potential risk factor for cardiovascular issues and osteoporosis. After 16-17 weeks, we observed that those taking folic acid had significantly lower homocysteine levels compared to the placebo group (10.33 μmol/l vs 13.21 μmol/l).
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
However, we found no significant correlations between homocysteine levels and factors like BMI and parity, though slight correlations with age and duration of menopause were noted. This suggests folic acid may help manage homocysteine, beneficial for heart health and bone density after menopause.
Read More
7
Vitamin C may reduce oxidative stress
We conducted a randomized, double-blind clinical trial to explore the combined effects of resveratrol and vitamin C on oxidative stress in postmenopausal women. The study included forty-six women who faced insulin resistance and were divided into three groups: one received resveratrol alone, another received both resveratrol and vitamin C, and the third group got only vitamin C.
After the treatment, we observed notable results, particularly in the group that took the combination of resveratrol and vitamin C. This group exhibited a significant reduction in harmful oxidative stress markers. For instance, markers like lipohydroperoxides dropped by 33%. Additionally, malondialdehyde levels decreased by remarkable rates in all groups. Group B, which received both antioxidants, showed the most pronounced improvements, including a 39% decrease in protein damage.
While vitamin C showed benefits when combined with resveratrol, it’s crucial to note that the study did not reveal significant differences in insulin resistance among the groups. This finding suggests that while vitamin C may enhance antioxidant capacity and reduce oxidative stress, its isolated effects on menopause-related conditions were not conclusively established. Overall, our study highlights the potential of combining these antioxidants for managing oxidative stress in postmenopausal women.
After the treatment, we observed notable results, particularly in the group that took the combination of resveratrol and vitamin C. This group exhibited a significant reduction in harmful oxidative stress markers. For instance, markers like lipohydroperoxides dropped by 33%. Additionally, malondialdehyde levels decreased by remarkable rates in all groups. Group B, which received both antioxidants, showed the most pronounced improvements, including a 39% decrease in protein damage.
While vitamin C showed benefits when combined with resveratrol, it’s crucial to note that the study did not reveal significant differences in insulin resistance among the groups. This finding suggests that while vitamin C may enhance antioxidant capacity and reduce oxidative stress, its isolated effects on menopause-related conditions were not conclusively established. Overall, our study highlights the potential of combining these antioxidants for managing oxidative stress in postmenopausal women.
Read More
7
We aimed to explore how folic acid influences sexual function in postmenopausal women. This triple-blind randomized controlled trial, conducted in Tehran, involved 100 women receiving either a daily folic acid supplement or a placebo for eight weeks.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
While results indicated that folic acid may positively affect sexual function according to the Female Sexual Function Index, the small sample size and short duration mean we should interpret these findings with caution. More extensive studies are necessary to validate these promising initial results.
Read More
7
We examined how folic acid supplements impact homocysteine levels in postmenopausal women over six months. Our findings suggest that after menopause, homocysteine levels rise significantly, presenting a cardiovascular risk.
While folic acid is a safe and affordable option, our study indicates that it may help lower homocysteine, potentially offering some protection against heart disease in this group. However, more research is needed to fully understand its effectiveness.
While folic acid is a safe and affordable option, our study indicates that it may help lower homocysteine, potentially offering some protection against heart disease in this group. However, more research is needed to fully understand its effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Boosts energy levels
9 people found this helpful
This helps with brain fog and low energy levels. After menopause hit, my energy plummeted, accompanied by significant brain fog. Adding B100 to my routine made a noticeable difference. Though my multivitamin provided some Bs, they are water-soluble and leave the body every three hours if not used. During mentally taxing tasks, B100 combats brain fatigue and offers a boost. I only take them with food, as they can be harsh on an empty stomach, but this has been a fantastic and relatively inexpensive addition to my routine.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Montoya-Estrada A, García-Cortés AY, Romo-Yañez J, Ortiz-Luna GF, Arellano-Eguiluz A, et al. The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial. Nutrients. 2024;16. doi:10.3390/nu16213775
- Asadi M, Riazi H, Abbasinazari M, Majd HA, Montazeri A. Effect of folic acid on the sexual function of postmenopausal women: a triple-blind randomized controlled trial. J Sex Med. 2023;20:1180. doi:10.1093/jsxmed/qdad086
- Almassinokiani F, Kashanian M, Akbari P, Mossayebi E, Sadeghian E. Folic acid supplementation reduces plasma homocysteine in postmenopausal women. J Obstet Gynaecol. 2016;36:492. doi:10.3109/01443615.2015.1091811
- Bani S, Hasanpour S, Farzad Rik L, Hasankhani H, Sharami SH. The effect of folic Acid on menopausal hot flashes: a randomized clinical trial. J Caring Sci. 2013;2:131. doi:10.5681/jcs.2013.016
- Sultan N, Khan MA, Malik S. Effect of folic acid supplementation on homocysteine level in postmenopausal women. J Ayub Med Coll Abbottabad. 2007;19:78.
- Cagnacci A, Bagni B, Zini A, Cannoletta M, Generali M, et al. Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone. 2008;42:314. doi:10.1016/j.bone.2007.10.022
- Rejnmark L, Vestergaard P, Hermann AP, Brot C, Eiken P, et al. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women. Calcif Tissue Int. 2008;82:1. doi:10.1007/s00223-007-9087-0
- Villa P, Suriano R, Costantini B, Macrì F, Ricciardi L, et al. Hyperhomocysteinemia and cardiovascular risk in postmenopausal women: the role of folate supplementation. Clin Chem Lab Med. 2007;45:130.
