5/7/2025
Last update
5/7/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.4
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.9
Top Medical Research Studies
8
Zinc may alleviate anxiety symptoms
We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.
What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.
In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.
What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.
In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.
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7
Zinc alleviates acrylamide-induced anxiety
We explored the effects of zinc treatment on anxiety caused by exposure to acrylamide, a harmful chemical found in some foods that can lead to cognitive decline and emotional distress. In our study, twenty male Wistar rats were divided into four groups; one group received water, while the other groups were given a daily oral dose of acrylamide.
Among those exposed to acrylamide, some were treated with low and high doses of zinc for eight weeks. We observed that zinc significantly improved anxiety-like behavior in the treated groups. This suggests that zinc acts not only as a protector against cognitive impairment but also helps in alleviating anxiety symptoms associated with acrylamide exposure.
Furthermore, zinc demonstrated antioxidant and anti-inflammatory effects, which could contribute to its ability to improve mood and mental function. Overall, zinc emerged as a promising contender in mitigating anxiety and cognitive challenges posed by acrylamide, leading to better mental clarity and emotional well-being.
Among those exposed to acrylamide, some were treated with low and high doses of zinc for eight weeks. We observed that zinc significantly improved anxiety-like behavior in the treated groups. This suggests that zinc acts not only as a protector against cognitive impairment but also helps in alleviating anxiety symptoms associated with acrylamide exposure.
Furthermore, zinc demonstrated antioxidant and anti-inflammatory effects, which could contribute to its ability to improve mood and mental function. Overall, zinc emerged as a promising contender in mitigating anxiety and cognitive challenges posed by acrylamide, leading to better mental clarity and emotional well-being.
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8
Magnesium treats anxiety in MS
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
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Most Useful Reviews
7.5
Curbed anxiety
149 people found this helpful
I bought this as part of my vitamin regimen. I didn’t realise how much it would help. It seems to have curbed my anxiety, for which I am otherwise medicated. I’m sleeping exceptionally well and feeling rested, even when getting up multiple times at night. My acne has also cleared up—it must be related to these vitamins! I definitely have no intention of stopping them soon!
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2
Mixed effects
50 people found this helpful
I specifically got this to help with my anxiety, as I read that these vitamins are meant to ease it. Initially, I felt a positive effect, but soon it led to adverse effects that worsened my anxiety. However, this isn’t due to the brand itself. The shipping was quick, packaging was excellent, and I had no stomach issues, which often happen with vitamins.
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7.5
Relaxed mindset
2 people found this helpful
So far so good! After a few days, I feel more relaxed than usual. Although I don't generally suffer from anxiety, these pills are remarkable. I’ve noticed a positive shift in my mood without any side effects, and there are no interactions with my medications. I’m very pleased so far.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.4
- All Researches
9
We examined how magnesium, in combination with ibogaine, affects anxiety in veterans with traumatic brain injuries. This was part of a larger study focusing on the wellbeing of Special Operations Forces veterans, who often suffer from mental health issues like anxiety and PTSD after experiencing head trauma.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
Read More
9
We aimed to understand how zinc chloride may help reduce anxiety, particularly when combined with diazepam. In our study, we organized Wistar albino rats into five groups, with each group receiving different combinations of zinc chloride and diazepam. The dosages included two different levels of diazepam (1 and 2 mg/kg) paired with a consistent dose of zinc chloride (10 mg/kg).
To assess the anxiety levels of the rats, we employed four established models: the Elevated Plus Maze, the hole board, the light and dark box, and the mirror chamber. Our observations indicated that when combined, zinc chloride and diazepam produced more potent anxiolytic effects compared to when either treatment was used alone. This suggests a possible synergistic effect that could enhance anxiety relief.
Overall, we found that zinc chloride, especially when combined with diazepam, can significantly improve anxiety outcomes in these animal models. This research opens the door to further studies on zinc's role in anxiety management and its potential as a supplementary treatment option alongside traditional medications.
To assess the anxiety levels of the rats, we employed four established models: the Elevated Plus Maze, the hole board, the light and dark box, and the mirror chamber. Our observations indicated that when combined, zinc chloride and diazepam produced more potent anxiolytic effects compared to when either treatment was used alone. This suggests a possible synergistic effect that could enhance anxiety relief.
Overall, we found that zinc chloride, especially when combined with diazepam, can significantly improve anxiety outcomes in these animal models. This research opens the door to further studies on zinc's role in anxiety management and its potential as a supplementary treatment option alongside traditional medications.
Read More
9
Zinc reduces anxiety in treatment
In a recent study, we investigated how zinc supplementation could impact anxiety levels among patients undergoing methadone maintenance treatment for opioid use disorder. The research involved a randomized controlled trial with 68 participants. We divided them into two groups: one received zinc supplements along with their usual methadone treatment, while the other group only received methadone.
Our findings revealed some encouraging results regarding anxiety reduction. Specifically, we noted a significant decrease in anxiety levels among those who took zinc, with a marked difference when compared to the control group. This was assessed using the Depression, Anxiety, and Stress Scale 21 (DASS-21), where we observed a notable reduction in anxiety scores following the treatment period.
Overall, it appears that zinc supplementation may contribute positively to reducing anxiety in this particular patient demographic. However, since zinc was combined with methadone treatment, it's essential we approach these findings with caution and encourage further research to clarify the role of zinc supplementation alone.
Our findings revealed some encouraging results regarding anxiety reduction. Specifically, we noted a significant decrease in anxiety levels among those who took zinc, with a marked difference when compared to the control group. This was assessed using the Depression, Anxiety, and Stress Scale 21 (DASS-21), where we observed a notable reduction in anxiety scores following the treatment period.
Overall, it appears that zinc supplementation may contribute positively to reducing anxiety in this particular patient demographic. However, since zinc was combined with methadone treatment, it's essential we approach these findings with caution and encourage further research to clarify the role of zinc supplementation alone.
Read More
8
Magnesium's role in anxiety treatment
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
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This study set out to understand how magnesium, combined with lidocaine, influences anxiety levels and postoperative pain in patients undergoing spine fusion surgery. We engaged 120 patients aged 18 to 60 and divided them into different groups, each receiving varying treatments, including a control group that received saline.
Importantly, we observed that the group receiving the combination of lidocaine and magnesium experienced lower anxiety and depression levels following surgery. Not only did this treatment seem to help in managing pain more effectively, but it also enhanced overall patient satisfaction three months after a single infusion.
While the study highlighted the synergistic effects of combining both medications, the specific impact of magnesium alone on anxiety isn't entirely clear. The results suggested that while magnesium played a role within the combination treatment, isolating its effect on anxiety wasn't feasible in this context.
Nonetheless, the findings are promising for those seeking alternatives to standard pain management that could include anxiety relief in the postoperative period. It opens up avenues for further research on magnesium’s individual role in emotional health.
Importantly, we observed that the group receiving the combination of lidocaine and magnesium experienced lower anxiety and depression levels following surgery. Not only did this treatment seem to help in managing pain more effectively, but it also enhanced overall patient satisfaction three months after a single infusion.
While the study highlighted the synergistic effects of combining both medications, the specific impact of magnesium alone on anxiety isn't entirely clear. The results suggested that while magnesium played a role within the combination treatment, isolating its effect on anxiety wasn't feasible in this context.
Nonetheless, the findings are promising for those seeking alternatives to standard pain management that could include anxiety relief in the postoperative period. It opens up avenues for further research on magnesium’s individual role in emotional health.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Curbed anxiety
149 people found this helpful
I bought this as part of my vitamin regimen. I didn’t realise how much it would help. It seems to have curbed my anxiety, for which I am otherwise medicated. I’m sleeping exceptionally well and feeling rested, even when getting up multiple times at night. My acne has also cleared up—it must be related to these vitamins! I definitely have no intention of stopping them soon!
Read More
2
Mixed effects
50 people found this helpful
I specifically got this to help with my anxiety, as I read that these vitamins are meant to ease it. Initially, I felt a positive effect, but soon it led to adverse effects that worsened my anxiety. However, this isn’t due to the brand itself. The shipping was quick, packaging was excellent, and I had no stomach issues, which often happen with vitamins.
Read More
7.5
Relaxed mindset
2 people found this helpful
So far so good! After a few days, I feel more relaxed than usual. Although I don't generally suffer from anxiety, these pills are remarkable. I’ve noticed a positive shift in my mood without any side effects, and there are no interactions with my medications. I’m very pleased so far.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. 10.1038/s41598-024-71093-z
- Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, et al. Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria. Microorganisms. 2024;12. 10.3390/microorganisms12071429
- Rawji A, Peltier MR, Mourtzanakis K, Awan S, Rana J, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16:e59317. 10.7759/cureus.59317
- Wang S, Zhang J, Zhu T, Xie X, Xia X, et al. Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study. Alpha Psychiatry. 2024;25:243. 10.5152/alphapsychiatry.2024.231342
- Abdel Rady MM, Osman AM, Abo Elfadl GM, Ahmed HM, Sayed S, et al. Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study. Minerva Anestesiol. 2024;90:397. 10.23736/S0375-9393.24.17868-6
- Cetin A, Ozdemir E, Golgeli A, Taskiran AS, Karabulut S, et al. The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms. Neurol Res. 2024;46:752. 10.1080/01616412.2024.2352234
- Mititelu-Tartau L, Bogdan M, Pavel LL, Rezus C, Foia CI, et al. Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats. Life (Basel). 2024;14. 10.3390/life14030306
- Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, et al. Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med. 2024;30:373. 10.1038/s41591-023-02705-w
- Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
- Hajri L, Othman H, Ghodbane S, Sakly M, Abdelmelek H, et al. Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat. Biomarkers. 2023;28:538. 10.1080/1354750X.2023.2246104
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
- Proskurnina EV, Liaukovich KM, Bychkovskaya LS, Mikheev IV, Alshanskaia EI, et al. Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder. Metabolites. 2023;13. 10.3390/metabo13010073
- Ajibare AJ, Akintoye OO, Oriowo OA, Asuku AO, Oriyomi IA, et al. Zinc Ameliorates Acrylamide-Induced Cognitive Impairment in Male Wistar Rats: Modulation of Oxidative Stress, Neuro-inflammation, and Neurotrophic Pathways. Biol Trace Elem Res. 2024. 10.1007/s12011-024-04490-0
- Apryatin S, Lopachev A, Zhukov I, Efimova E, Apryatina V. BEHAVIORAL AND NEUROCHEMICAL CHANGES DURING INTRANASAL ADMINISTRATION OF ALPHA-GLUTAMYL-TRYPTOPHAN AND CHELATE COMPLEX OF ZINC ARGINYL-GLYCINATE ON MONOAMINE SYSTEMS DYSFUNCTIONS KNOCK-OUT MODELS. Georgian Med News. 2024.
- Naik VV, Desai VH, Noronha S. Synergistic anxiolytic efficacy exploring the combined effects of diazepam and zinc chloride in wistar albino rats. Drug Res (Stuttg). 2024;74:220. 10.1055/a-2308-9192
- Tomas-Sanchez C, Blanco-Alvarez VM, Gonzalez-Barrios JA, Martinez-Fong D, Soto-Rodriguez G, et al. Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack. Heliyon. 2024;10:e30017. 10.1016/j.heliyon.2024.e30017
- Sameei P, Fatehfar S, Abdollahzadeh N, Chodari L, Saboory E, et al. The effects of forced exercise and zinc supplementation during pregnancy on prenatally stress-induced behavioral and neurobiological consequences in adolescent female rat offspring. Dev Psychobiol. 2023;65:e22411. 10.1002/dev.22411
- Azargoonjahromi A. A systematic review of the association between zinc and anxiety. Nutr Rev. 2024;82:612. 10.1093/nutrit/nuad076
- Hamdi E, Muñiz-Gonzalez AB, Hidouri S, Bermejo AM, Sakly M, et al. Prevention of neurotoxicity and cognitive impairment induced by zinc nanoparticles by oral administration of saffron extract. J Anim Physiol Anim Nutr (Berl). 2023;107:1473. 10.1111/jpn.13848
- Amini Z, HeidariFarsani E. Investigating the effect of zinc supplementation on probability of relapse and mental health in patients with opioid use disorder undergoing methadone maintenance treatment. Subst Abuse Treat Prev Policy. 2023;18:1. 10.1186/s13011-023-00514-5
- Nunes EJ, Kimble V, Rajadhyaksha AM, Addy NA. L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats. Neuroscience. 2025;568:314. 10.1016/j.neuroscience.2025.01.003
