5/7/2025
Last update
5/7/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.4
Top Medical Research Studies
9
We explored how targeting TMEM16A, a calcium-activated chloride channel, can potentially improve asthma symptoms. In a thoughtfully designed study using guinea pigs with allergic asthma induced by ovalbumin, we treated the animals with a specific blocker, CaCCinh-A01, delivered through inhalation.
The results were promising. We observed a notable reduction in cough reflex sensitivity and airway resistance among the guinea pigs treated with CaCCinh-A01. This suggests that the treatment may help improve overall airway function in asthmatic conditions.
Interestingly, while we found that ciliary beating frequency decreased, the treatment also reduced airway mucus viscosity by lowering the production of a key protein, MUC5AC. Additionally, there was a reduction in inflammatory markers, indicating a decrease in airway inflammation. We also noted diminished signs of airway remodeling, hinting that the treatment could potentially address structural changes in the airways typically seen in asthma.
Although further research is needed to fully assess TMEM16A's viability as a therapeutic target for asthma, our findings indicate that it may play a significant role in alleviating various aspects of the disease, including airway hyperreactivity, inflammation, and remodeling.
The results were promising. We observed a notable reduction in cough reflex sensitivity and airway resistance among the guinea pigs treated with CaCCinh-A01. This suggests that the treatment may help improve overall airway function in asthmatic conditions.
Interestingly, while we found that ciliary beating frequency decreased, the treatment also reduced airway mucus viscosity by lowering the production of a key protein, MUC5AC. Additionally, there was a reduction in inflammatory markers, indicating a decrease in airway inflammation. We also noted diminished signs of airway remodeling, hinting that the treatment could potentially address structural changes in the airways typically seen in asthma.
Although further research is needed to fully assess TMEM16A's viability as a therapeutic target for asthma, our findings indicate that it may play a significant role in alleviating various aspects of the disease, including airway hyperreactivity, inflammation, and remodeling.
Read More
8
We explored how intravenous magnesium sulfate (IVMg) can help children facing severe asthma attacks. The study included 49 pediatric patients who were treated with IVMg after presenting to the emergency department. Some received a placebo, while others were given either 50 or 75 mg/kg of magnesium.
Our analysis showed that higher magnesium levels in the blood were linked to improvements in asthma symptoms, specifically reductions in the Pediatric Respiratory Assessment Measure scores. This suggests that IVMg could be an effective treatment for moderate to severe asthma exacerbations in children.
Interestingly, we noticed that only two out of 31 participants experienced hypotension, showcasing the safety of IVMg, as severe side effects are rare. Moreover, we proposed that a total serum magnesium area under the concentration-time curve greater than 63.1 mg h/L might be a useful target for effective dosing. Further research in larger studies is necessary to confirm these findings, but they indicate that IVMg could serve as a beneficial adjunct treatment for young patients suffering from asthma attacks.
Our analysis showed that higher magnesium levels in the blood were linked to improvements in asthma symptoms, specifically reductions in the Pediatric Respiratory Assessment Measure scores. This suggests that IVMg could be an effective treatment for moderate to severe asthma exacerbations in children.
Interestingly, we noticed that only two out of 31 participants experienced hypotension, showcasing the safety of IVMg, as severe side effects are rare. Moreover, we proposed that a total serum magnesium area under the concentration-time curve greater than 63.1 mg h/L might be a useful target for effective dosing. Further research in larger studies is necessary to confirm these findings, but they indicate that IVMg could serve as a beneficial adjunct treatment for young patients suffering from asthma attacks.
Read More
8
We explored the relationship between dietary zinc intake and asthma in overweight or obese children and adolescents. This research utilized data from the National Health and Nutrition Examination Survey, focusing on those aged 20 and younger who had both asthma and dietary zinc consumption.
Our findings indicate that there is an inverse association between zinc intake and the occurrence of asthma. In simpler terms, higher dietary zinc appears to be linked with lower asthma rates in these children. This suggests that zinc could play an important role in respiratory health, especially for kids struggling with their weight.
While our study sheds light on this potential protective effect of zinc, we recognize that the results in existing literature have been mixed. Some research indicates benefits, while other studies don’t show significant effects. Therefore, while we have uncovered a correlation worth noting, further research is required to fully understand zinc’s role in asthma management.
Our findings indicate that there is an inverse association between zinc intake and the occurrence of asthma. In simpler terms, higher dietary zinc appears to be linked with lower asthma rates in these children. This suggests that zinc could play an important role in respiratory health, especially for kids struggling with their weight.
While our study sheds light on this potential protective effect of zinc, we recognize that the results in existing literature have been mixed. Some research indicates benefits, while other studies don’t show significant effects. Therefore, while we have uncovered a correlation worth noting, further research is required to fully understand zinc’s role in asthma management.
Read More
Most Useful Reviews
7.5
Relaxed bronchials
1 people found this helpful
Great supplement to help relax bronchials and muscles. I take this supplement once daily for my asthma to ease my bronchials and muscles. The zinc and vitamin D contribute significantly to boosting my immune system.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.3
- All Researches
9
We explored how targeting TMEM16A, a calcium-activated chloride channel, can potentially improve asthma symptoms. In a thoughtfully designed study using guinea pigs with allergic asthma induced by ovalbumin, we treated the animals with a specific blocker, CaCCinh-A01, delivered through inhalation.
The results were promising. We observed a notable reduction in cough reflex sensitivity and airway resistance among the guinea pigs treated with CaCCinh-A01. This suggests that the treatment may help improve overall airway function in asthmatic conditions.
Interestingly, while we found that ciliary beating frequency decreased, the treatment also reduced airway mucus viscosity by lowering the production of a key protein, MUC5AC. Additionally, there was a reduction in inflammatory markers, indicating a decrease in airway inflammation. We also noted diminished signs of airway remodeling, hinting that the treatment could potentially address structural changes in the airways typically seen in asthma.
Although further research is needed to fully assess TMEM16A's viability as a therapeutic target for asthma, our findings indicate that it may play a significant role in alleviating various aspects of the disease, including airway hyperreactivity, inflammation, and remodeling.
The results were promising. We observed a notable reduction in cough reflex sensitivity and airway resistance among the guinea pigs treated with CaCCinh-A01. This suggests that the treatment may help improve overall airway function in asthmatic conditions.
Interestingly, while we found that ciliary beating frequency decreased, the treatment also reduced airway mucus viscosity by lowering the production of a key protein, MUC5AC. Additionally, there was a reduction in inflammatory markers, indicating a decrease in airway inflammation. We also noted diminished signs of airway remodeling, hinting that the treatment could potentially address structural changes in the airways typically seen in asthma.
Although further research is needed to fully assess TMEM16A's viability as a therapeutic target for asthma, our findings indicate that it may play a significant role in alleviating various aspects of the disease, including airway hyperreactivity, inflammation, and remodeling.
Read More
8
We explored the effectiveness and safety of magnesium sulfate as a treatment for acute severe asthma in adults through a thorough analysis of randomized controlled trials. The studies compared the outcomes of patients receiving conventional asthma treatments with those given additional intravenous magnesium sulfate.
Our findings indicated that magnesium sulfate significantly enhances the total response rate and improves lung function, specifically measured by peak expiratory flow and forced expiratory volume. Importantly, we observed no increase in adverse reactions among those treated with magnesium sulfate.
However, we must emphasize that the overall number and quality of studies included in our analysis were limited. This suggests a need for further high-quality research to confirm these benefits in the future.
Our findings indicated that magnesium sulfate significantly enhances the total response rate and improves lung function, specifically measured by peak expiratory flow and forced expiratory volume. Importantly, we observed no increase in adverse reactions among those treated with magnesium sulfate.
However, we must emphasize that the overall number and quality of studies included in our analysis were limited. This suggests a need for further high-quality research to confirm these benefits in the future.
Read More
8
We explored how intravenous magnesium sulfate (IVMg) can help children facing severe asthma attacks. The study included 49 pediatric patients who were treated with IVMg after presenting to the emergency department. Some received a placebo, while others were given either 50 or 75 mg/kg of magnesium.
Our analysis showed that higher magnesium levels in the blood were linked to improvements in asthma symptoms, specifically reductions in the Pediatric Respiratory Assessment Measure scores. This suggests that IVMg could be an effective treatment for moderate to severe asthma exacerbations in children.
Interestingly, we noticed that only two out of 31 participants experienced hypotension, showcasing the safety of IVMg, as severe side effects are rare. Moreover, we proposed that a total serum magnesium area under the concentration-time curve greater than 63.1 mg h/L might be a useful target for effective dosing. Further research in larger studies is necessary to confirm these findings, but they indicate that IVMg could serve as a beneficial adjunct treatment for young patients suffering from asthma attacks.
Our analysis showed that higher magnesium levels in the blood were linked to improvements in asthma symptoms, specifically reductions in the Pediatric Respiratory Assessment Measure scores. This suggests that IVMg could be an effective treatment for moderate to severe asthma exacerbations in children.
Interestingly, we noticed that only two out of 31 participants experienced hypotension, showcasing the safety of IVMg, as severe side effects are rare. Moreover, we proposed that a total serum magnesium area under the concentration-time curve greater than 63.1 mg h/L might be a useful target for effective dosing. Further research in larger studies is necessary to confirm these findings, but they indicate that IVMg could serve as a beneficial adjunct treatment for young patients suffering from asthma attacks.
Read More
8
We explored the possible link between zinc levels in the body and the risk of developing allergic asthma. In a comprehensive analysis, we looked at various micronutrients and their potential impact on allergic diseases, particularly focusing on zinc.
Our findings suggest that higher serum zinc concentrations might actually reduce the risk of allergic asthma. This means that adequate levels of zinc could play a significant role in preventing this common respiratory condition. However, it's essential to approach these results with careful consideration and see them as part of a broader dietary picture.
While zinc showed a promising association, the study also revealed complexities in how different micronutrients interact with allergic conditions. As we delve deeper into the relationship between nutrition and health, the role of zinc stands out as an area worth further exploration.
Overall, this study provides valuable insight into how dietary choices, specifically related to zinc intake, could influence asthma outcomes. Our findings underline the importance of understanding micronutrients not just as supplements, but as key players in our overall health.
Our findings suggest that higher serum zinc concentrations might actually reduce the risk of allergic asthma. This means that adequate levels of zinc could play a significant role in preventing this common respiratory condition. However, it's essential to approach these results with careful consideration and see them as part of a broader dietary picture.
While zinc showed a promising association, the study also revealed complexities in how different micronutrients interact with allergic conditions. As we delve deeper into the relationship between nutrition and health, the role of zinc stands out as an area worth further exploration.
Overall, this study provides valuable insight into how dietary choices, specifically related to zinc intake, could influence asthma outcomes. Our findings underline the importance of understanding micronutrients not just as supplements, but as key players in our overall health.
Read More
8
We explored the relationship between dietary zinc intake and asthma in overweight or obese children and adolescents. This research utilized data from the National Health and Nutrition Examination Survey, focusing on those aged 20 and younger who had both asthma and dietary zinc consumption.
Our findings indicate that there is an inverse association between zinc intake and the occurrence of asthma. In simpler terms, higher dietary zinc appears to be linked with lower asthma rates in these children. This suggests that zinc could play an important role in respiratory health, especially for kids struggling with their weight.
While our study sheds light on this potential protective effect of zinc, we recognize that the results in existing literature have been mixed. Some research indicates benefits, while other studies don’t show significant effects. Therefore, while we have uncovered a correlation worth noting, further research is required to fully understand zinc’s role in asthma management.
Our findings indicate that there is an inverse association between zinc intake and the occurrence of asthma. In simpler terms, higher dietary zinc appears to be linked with lower asthma rates in these children. This suggests that zinc could play an important role in respiratory health, especially for kids struggling with their weight.
While our study sheds light on this potential protective effect of zinc, we recognize that the results in existing literature have been mixed. Some research indicates benefits, while other studies don’t show significant effects. Therefore, while we have uncovered a correlation worth noting, further research is required to fully understand zinc’s role in asthma management.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Relaxed bronchials
1 people found this helpful
Great supplement to help relax bronchials and muscles. I take this supplement once daily for my asthma to ease my bronchials and muscles. The zinc and vitamin D contribute significantly to boosting my immune system.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Brooks R, Babushkin V, Rekhtman D, Cohen-Cymberknoh M, Shoseyov D, et al. Can Intravenous Caffeine Citrate Be Used for Severe Asthma Exacerbation in Children? A Retrospective Comparative Study. J Paediatr Child Health. 2025. 10.1111/jpc.16799
- Salie M, Salie S. A Retrospective Review of Children Admitted With Acute Severe Asthma to the Paediatric Intensive Care Unit, Red Cross War Memorial Children's Hospital Between 2009 and 2019. J Paediatr Child Health. 2025. 10.1111/jpc.16776
- Zhong Z, Wang Z, Qi S, Li C, Yang X. [Efficacy and safety of magnesium sulfate in the treatment of adult patients with acute severe asthma: a Meta-analysis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2024;36:1256. 10.3760/cma.j.cn121430-20240617-00514
- Rower JE, Johnson MD, Zorc JJ, Shihabuddin B, Dai M, et al. Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations. J Clin Pharmacol. 2025. 10.1002/jcph.6179
- Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. 10.1159/000540376
- Cheng C, Lin J, Zhang Z, Zhang L. Association between dietary zinc intake and asthma in overweight or obese children and adolescents: A cross-sectional analysis of NHANES. World Allergy Organ J. 2024;17:100900. 10.1016/j.waojou.2024.100900
- Atef Abdelsattar Ibrahim H, Mohsen M, Salep Aziz Hanna B, Mahmoud D, Mohamed Abdelhamid El-Khashab K. Childhood asthma biomarkers including zinc: An exploratory cross-sectional study. World J Clin Pediatr. 2024;13:87866. 10.5409/wjcp.v13.i1.87866
- Srivastava S, Tiwari V, Singh S, Karoli R, Bhattacharya P, et al. Low Serum Levels of Zinc, Selenium, and Vitamin D3 Are Biomarkers of Airway Inflammation and Poor Asthma Control: A Two-Centre Study. Cureus. 2023;15:e41082. 10.7759/cureus.41082
- Xue M, Wang Q, Pang B, Zhang X, Zhang Y, et al. Association Between Circulating Zinc and Risk for Childhood Asthma and Wheezing: A Meta-analysis on 21 Articles and 2205 Children. Biol Trace Elem Res. 2024;202:442. 10.1007/s12011-023-03690-4
- Ghosh S, Alkawadri T, McGarvey LP, Hollywood MA, Thornbury KD, et al. Role of voltage-gated Ca channels and Ano1 Ca-activated Cl channels in M2 muscarinic receptor-dependent contractions of murine airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2025;328:L301. 10.1152/ajplung.00188.2024
- Mažerik J, Gondáš E, Dohál M, Smieško L, Jošková M, et al. Targeting TMEM16A ion channels suppresses airway hyperreactivity, inflammation, and remodeling in an experimental Guinea pig asthma model. J Pharmacol Sci. 2024;156:239. 10.1016/j.jphs.2024.10.004
