Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8
USERS' SCORE
Good
Based on 14 Reviews
8
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
Read More
Most Useful Reviews
9
Allergy improvement noted
100 people found this helpful
I tried this vitamin for a month, and it really helped me. I lost some weight, my allergy issues improved, and I felt more energetic than ever. It was definitely worth the money.
Read More
9
No allergies experienced
I recommend these excellent vitamins; they do not cause allergies.
Read More
9
Helpful for allergies
I love these vitamins! This is my third order (I take them and my husband does too). Since starting, his leg cramps have stopped. I also ordered them for my mother, as recommended by her doctor for her bones. Given my chronic allergy, monitoring mineral and vitamin D levels is crucial. They are also affordably priced.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8
- All Researches
9
We explored the effects of vitamin D in combination with fluticasone propionate on allergy-related symptoms in children with bronchial asthma. In this study, we grouped participants into two treatment plans: one group received only fluticasone, while the other group received both fluticasone and vitamin D. By comparing their progress, we noted various health improvements related to asthma control.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
Read More
9
Vitamin D metabolites aid pulmonary health
We explored the impact of vitamin D metabolites on respiratory health, particularly in the context of hypersensitivity pneumonitis (HP). Our study focused on C57BL/6J mice that were placed on a diet severely lacking in vitamin D to induce deficiency. These mice were then exposed to an antigen linked to HP while inhaling either 25(OH)-vitamin D3 or 1,25(OH)2-vitamin D3.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
Read More
9
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
9
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Allergy improvement noted
100 people found this helpful
I tried this vitamin for a month, and it really helped me. I lost some weight, my allergy issues improved, and I felt more energetic than ever. It was definitely worth the money.
Read More
9
No allergies experienced
I recommend these excellent vitamins; they do not cause allergies.
Read More
9
Helpful for allergies
I love these vitamins! This is my third order (I take them and my husband does too). Since starting, his leg cramps have stopped. I also ordered them for my mother, as recommended by her doctor for her bones. Given my chronic allergy, monitoring mineral and vitamin D levels is crucial. They are also affordably priced.
Read More
9
No allergies noted
GREAT PRODUCT! I ordered it for my adult children. It contains everything needed for health; I will order again, as they experienced no allergies.
Read More
7.5
Convenient immune support
101 people found this helpful
A wonderful combination of zinc, magnesium, potassium, and vitamin D3. As someone with allergies, this vitamin complex is perfect and very convenient. I’ve taken it for several years in winter to help maintain my immunity. I feel great, and the small pills are easy to swallow. I'm very satisfied with the quality and price!
Read More
Frequently Asked Questions
9
Allergy improvement noted
100 people found this helpful
I tried this vitamin for a month, and it really helped me. I lost some weight, my allergy issues improved, and I felt more energetic than ever. It was definitely worth the money.
8.5
Allergy reduction benefits
1 people found this helpful
Excellent! These vitamins are great for strong bones, healthy skin, hair, and nails, and preventing allergies. Calcium strengthens teeth and may help with inflammation. Magnesium aids the nervous system. Zinc promotes skin and hair health, boosts immunity, and alleviates stress. I recommend taking three tablets a day for effective results.
2
Still allergic
6 people found this helpful
My child accepted this supplement initially, but allergies developed. Although it seems beneficial as a vitamin complex, it's hard to pinpoint which ingredient is causing the allergic reaction.
0
Allergies persisted
2 people found this helpful
I took one tablet daily and developed allergies after consuming around one-third of the jar. After a ten-day break, the same allergic reactions resumed upon resuming. I experienced no other effects aside from the allergies.
9
Helpful for allergies
I love these vitamins! This is my third order (I take them and my husband does too). Since starting, his leg cramps have stopped. I also ordered them for my mother, as recommended by her doctor for her bones. Given my chronic allergy, monitoring mineral and vitamin D levels is crucial. They are also affordably priced.
7.5
Convenient immune support
101 people found this helpful
A wonderful combination of zinc, magnesium, potassium, and vitamin D3. As someone with allergies, this vitamin complex is perfect and very convenient. I’ve taken it for several years in winter to help maintain my immunity. I feel great, and the small pills are easy to swallow. I'm very satisfied with the quality and price!
5
We examined the role of vitamin D supplementation in managing allergic rhinitis through a systematic review and meta-analysis. By reviewing randomized controlled trials focused on patients with allergic rhinitis, we aimed to determine the effectiveness of vitamin D in alleviating symptoms.
Our findings indicate that vitamin D may help reduce allergic rhinitis symptoms compared to placebos; however, the improvement was not statistically significant. We also discovered considerable variation among the studies we analyzed, pointing toward the complexities of measuring vitamin D's effects.
Interestingly, factors like the proportion of female participants and the use of corticosteroids impacted how patients responded to vitamin D. Specifically, vitamin D supplementation that was not paired with corticosteroids showed a more substantial impact on relieving symptoms.
While vitamin D appears to offer some benefits for allergic rhinitis, the overall effect may depend on individual circumstances, including gender and medication use. Thus, it's essential to consider these aspects when evaluating treatment options for allergies.
Our findings indicate that vitamin D may help reduce allergic rhinitis symptoms compared to placebos; however, the improvement was not statistically significant. We also discovered considerable variation among the studies we analyzed, pointing toward the complexities of measuring vitamin D's effects.
Interestingly, factors like the proportion of female participants and the use of corticosteroids impacted how patients responded to vitamin D. Specifically, vitamin D supplementation that was not paired with corticosteroids showed a more substantial impact on relieving symptoms.
While vitamin D appears to offer some benefits for allergic rhinitis, the overall effect may depend on individual circumstances, including gender and medication use. Thus, it's essential to consider these aspects when evaluating treatment options for allergies.
7
Vitamin D's role in allergies explored
We set out to examine the relationship between vitamin D levels and atopic dermatitis (AD), a common chronic inflammatory condition in children that involves skin sensitivity and allergies. In our study, we evaluated blood samples from 51 children with AD and compared their vitamin D levels and other immune markers to those of 20 healthy kids.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
9
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
9
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
9
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
References
- Kawada K, Sato C, Ishida T, Nagao Y, Yamamoto T, et al. Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis. Medicina (Kaunas). 2025;61. doi:10.3390/medicina61020355
- Molatefi R, Fouladi N, Asghariazar V, Samemaleki S, Golizadeh M, et al. The evaluation of the serum levels of vitamin D and interleukin-33 in children with atopic dermatitis and its association with diseases severity. Arch Dermatol Res. 2025;317:182. doi:10.1007/s00403-024-03709-3
- Akbulut O, Köksal BT, Aydın B, Oznacar T, Haberal A, et al. Does vitamin D deficiency predispose to allergic proctocolitis?. Nutrition. 2025;131:112659. doi:10.1016/j.nut.2024.112659
- Nielsen AY, Høj S, Thomsen SF, Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. doi:10.3390/nu16234128
- Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
- Lemieszek MK, Chojnacki M, Paśnik I, Gawryś W, Wilczyńska A, et al. Beneficial Impact of Inhaled 25(OH)-Vitamin D3 and 1,25(OH)2-Vitamin D3 on Pulmonary Response in the Murine Model of Hypersensitivity Pneumonitis. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910289
- Stichova J, Slanina P, Chovancova Z, Baros J, Litzman M, et al. Low CD46 expression on activated CD4 T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donors. Front Allergy. 2024;5:1462579. doi:10.3389/falgy.2024.1462579
- Xu H, Hao C, Wang X, Du J, Zhang T, et al. Effect of Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial. Drug Des Devel Ther. 2024;18:919. doi:10.2147/DDDT.S444896
- Antonelli M, Mazzoleni E, Donelli D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients. 2025;17. doi:10.3390/nu17040712
- Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408
- Otsuka T, Sato K, Kamiya T, Tanaka H, Hara H. Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells. Eur J Pharmacol. 2025;994:177391. doi:10.1016/j.ejphar.2025.177391
- Wang S, Ilves M, Mäenpää K, Zhao L, El-Nezami H, et al. ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice. ACS Nano. 2024;18:29479. doi:10.1021/acsnano.4c04270
- Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. doi:10.1159/000540376
- Maywald M, Rink L. Zinc Deficiency and Zinc Supplementation in Allergic Diseases. Biomolecules. 2024;14. doi:10.3390/biom14070863
- Wei Y, Zhu X, Lin S, Yang W, Wang T, et al. Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. Biomed Pharmacother. 2024;177:117129. doi:10.1016/j.biopha.2024.117129
