Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 39 Researches
7.9
USERS' SCORE
Good
Based on 10 Reviews
8.2
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
8
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
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8
Magnesium protects against bone erosion
We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
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We set out to explore the potential benefits of vitamin D supplementation for people suffering from end-stage knee osteoarthritis (OA). Our research took the form of a double-blinded, randomized controlled trial involving 56 patients with vitamin D insufficiency. This careful design allowed us to compare the effects of vitamin D against a placebo, ensuring that neither the patients nor the assessors knew who received what treatment.
Over six months, participants in the vitamin D group took capsules containing 4,000 IU daily, while the others received a placebo. We measured muscle strength, pain levels, physical function, and signs of sarcopenia at several points: at the start, after three months, and again at the six-month mark.
We aimed to see whether this cost-effective and well-tolerated supplement could improve quality of life by boosting muscle strength and reducing pain for knee OA patients. Given the growing number of people waiting for knee replacements in Hong Kong, our findings could have significant implications for patient care.
Our study's findings may help clarify whether vitamin D supplementation is a viable option for alleviating some symptoms associated with knee osteoarthritis. With ongoing interest in non-surgical therapies, understanding the role of vitamin D (particularly in muscle health) is more relevant than ever.
Over six months, participants in the vitamin D group took capsules containing 4,000 IU daily, while the others received a placebo. We measured muscle strength, pain levels, physical function, and signs of sarcopenia at several points: at the start, after three months, and again at the six-month mark.
We aimed to see whether this cost-effective and well-tolerated supplement could improve quality of life by boosting muscle strength and reducing pain for knee OA patients. Given the growing number of people waiting for knee replacements in Hong Kong, our findings could have significant implications for patient care.
Our study's findings may help clarify whether vitamin D supplementation is a viable option for alleviating some symptoms associated with knee osteoarthritis. With ongoing interest in non-surgical therapies, understanding the role of vitamin D (particularly in muscle health) is more relevant than ever.
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Most Useful Reviews
9
Pain relief
2 people found this helpful
These vitamins REALLY WORK FOR ME! I’ve been taking them for about three weeks and can feel a difference in my body already. I suffer from osteoarthritis, particularly in my knees, and after some research, I found magnesium helps with inflammation. Since starting these vitamins, I've had no pain in my knees or feet and can work longer hours without throbbing pain!
Read More
9
Strengthens bones
A very excellent capsule that strengthens your bones and teeth, providing relief from osteoarthritis and arthritis, as well as protecting against rheumatism. I highly recommend purchasing it.
Read More
9
Satisfactory results
This supplement is excellent for arthritis, osteoporosis, and osteochondrosis. We often order it and are satisfied with the purchase.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 39 Researches
7.9
- All Researches
9
We investigated the potential of 2D layered calcium disilicide nanoparticles (CSNs) to treat rheumatoid arthritis (RA) through their unique properties. CSNs are crafted using a straightforward method of aqueous exfoliation, and their hydrolysis generates several beneficial components including hydrogen gas, alkaline calcium hydroxide (Ca(OH)), and silica.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
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9
We explored how vitamin D (VD) affects osteoarthritis (OA), a condition that commonly leads to joint pain and stiffness. Our research focused on the idea that vitamin D might help reduce inflammation and tissue damage driven by the NF-κB pathway, a crucial player in OA development.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
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9
We explored how magnesium (Mg) supplementation impacts rheumatoid arthritis (RA) by analyzing the effects on specific tissues in mice. In our study, we observed that mice with KRN serum-induced arthritis were given either a high magnesium diet or a regular diet for 15 days. After this period, we analyzed the gene activity in their spleens and joint tissues.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
Our findings revealed significant changes in the expression of genes associated with RA and biological processes like oxidative stress and senescence—key factors involved in the disease's progression. Specifically, we noted that high magnesium intake led to higher expression levels of certain genes, while others were suppressed.
This supports the idea that increased magnesium can modify the way our body responds to the stresses associated with arthritis. Overall, our research adds to the evidence that suggests that magnesium supplementation might be a promising approach to managing RA and helps pave the way for new treatment options for autoimmune and inflammatory diseases.
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9
We explored how magnesium affects arthritis, particularly osteoarthritis (OA), focusing on its role in both cartilage and bone health. By studying the protective effects of magnesium at the cellular and animal levels, we sought to understand how it interacts with joint tissues to potentially alleviate symptoms of OA.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Our investigation indicated that magnesium has significant benefits, especially when it comes to the interaction between cartilage and bone. We found that these positive effects are primarily influenced by the PI3K/AKT signaling pathway, a crucial mechanism in cell communication and response.
To make this treatment practical, we developed tiny microspheres made from poly(lactic-co-glycolic acid) (PLGA) that are loaded with nano-magnesium oxide, modified to enhance their effectiveness. These innovative microspheres, which can be injected directly into the joints, showed encouraging results in reducing OA symptoms in rat models.
Our findings highlight the potential of magnesium-based therapies, especially with this new delivery system, paving the way for exciting clinical applications in the future.
Read More
9
We delved into the potential of magnesium chloride (MgCl) as a treatment for arthritis, particularly looking at its anti-inflammatory effects. In our study, we used a model of acute arthritis where mice were injected with zymosan to induce inflammation in their knees. To evaluate the impact of magnesium, we administered it both orally and directly into the joint, comparing its effects to a control group that received a saline solution.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
The results were promising! We observed that magnesium chloride treatment lowered inflammation, reduced pain levels, and decreased the presence of certain inflammatory cells and cytokines, specifically interleukin-1. Both systemic and local administrations of MgCl significantly improved the conditions in the mice compared to the saline group.
Importantly, one of the mechanisms behind these benefits seems to involve the suppression of a key inflammatory pathway known as NFκB. This study marks a significant step forward, as it is the first to show how magnesium chloride can effectively reduce signs of arthritis in a live model, leading to decreased inflammation and relief from pain.
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User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pain relief
2 people found this helpful
These vitamins REALLY WORK FOR ME! I’ve been taking them for about three weeks and can feel a difference in my body already. I suffer from osteoarthritis, particularly in my knees, and after some research, I found magnesium helps with inflammation. Since starting these vitamins, I've had no pain in my knees or feet and can work longer hours without throbbing pain!
Read More
9
Strengthens bones
A very excellent capsule that strengthens your bones and teeth, providing relief from osteoarthritis and arthritis, as well as protecting against rheumatism. I highly recommend purchasing it.
Read More
9
Satisfactory results
This supplement is excellent for arthritis, osteoporosis, and osteochondrosis. We often order it and are satisfied with the purchase.
Read More
9
Disease remission
Wonderful complex at a bargain price. I was diagnosed with polyarthritis. My doctor advised strengthening my bones, as deformation is a frequent issue with arthritis. I take this drug in courses twice a year. The composition includes D3, magnesium, and zinc. After taking it, my disease has gone into remission.
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7.5
Knees improved
Great! My mother's favourite complex, as she mentions that her knees have stopped creaking and her arthritis has become easier.
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Frequently Asked Questions
9
Pain relief
2 people found this helpful
These vitamins REALLY WORK FOR ME! I’ve been taking them for about three weeks and can feel a difference in my body already. I suffer from osteoarthritis, particularly in my knees, and after some research, I found magnesium helps with inflammation. Since starting these vitamins, I've had no pain in my knees or feet and can work longer hours without throbbing pain!
7.5
Knees improved
Great! My mother's favourite complex, as she mentions that her knees have stopped creaking and her arthritis has become easier.
9
Disease remission
Wonderful complex at a bargain price. I was diagnosed with polyarthritis. My doctor advised strengthening my bones, as deformation is a frequent issue with arthritis. I take this drug in courses twice a year. The composition includes D3, magnesium, and zinc. After taking it, my disease has gone into remission.
7.5
Natural supplement
This 4 in 1 calcium, magnesium, zinc, and D3 supplement is excellent for those with arthritis. Due to fragile bones from braces, my doctor prescribed calcium, and I drink it for osteoporosis. This natural quality supplement works better than pharmacy versions. It noticeably improves bone health, making it a great addition for anyone suffering from arthritis.
7.5
Ideal complex
An ideal complex for strengthening bones and treating arthritis, with good dosages and excellent quality.
8
We investigated how vitamin D affects arthritis, specifically focusing on knee osteoarthritis (OA) using a rat model. In our study, male Wistar rats were divided into five groups to evaluate the effects of curcumin, vitamin D, and their combination over 12 weeks.
Both vitamin D and curcumin independently reduced pain in the rats. However, when combined, they provided enhanced pain relief. We observed that vitamin D, alongside curcumin, showed promising results by reducing inflammation and improving joint health. The treatment groups exhibited lower levels of pro-inflammatory cytokines and higher levels of the anti-inflammatory cytokine interleukin-10 (IL-10).
Importantly, the supplements also helped restore some antioxidative markers and led to a significant reduction in the oxidative stress marker known as Cartilage Oligomeric Matrix Protein (COMP). Histological examinations revealed that those treated with vitamin D and curcumin maintained better cartilage integrity and had reduced inflammation in the synovium.
Overall, our findings suggest that vitamin D, particularly in combination with curcumin, could play a vital role in managing knee OA by addressing both pain and the underlying inflammation, making it a potential option for arthritis treatment in clinical settings.
Both vitamin D and curcumin independently reduced pain in the rats. However, when combined, they provided enhanced pain relief. We observed that vitamin D, alongside curcumin, showed promising results by reducing inflammation and improving joint health. The treatment groups exhibited lower levels of pro-inflammatory cytokines and higher levels of the anti-inflammatory cytokine interleukin-10 (IL-10).
Importantly, the supplements also helped restore some antioxidative markers and led to a significant reduction in the oxidative stress marker known as Cartilage Oligomeric Matrix Protein (COMP). Histological examinations revealed that those treated with vitamin D and curcumin maintained better cartilage integrity and had reduced inflammation in the synovium.
Overall, our findings suggest that vitamin D, particularly in combination with curcumin, could play a vital role in managing knee OA by addressing both pain and the underlying inflammation, making it a potential option for arthritis treatment in clinical settings.
8
We aimed to understand how vitamin D deficiency impacts elderly people suffering from osteoarthritis (OA) in their hips and knees. Our study involved 105 OA patients and 152 healthy individuals to compare their vitamin D levels and functional abilities, using criteria like the WOMAC questionnaire to assess pain and functional impairment.
Our findings revealed that patients with low vitamin D levels experienced more severe OA symptoms. They reported higher pain levels and greater difficulties in daily activities compared to those with normal vitamin D levels. Furthermore, their vitamin D deficiency was associated with increased levels of inflammatory markers, TNF-α and IL-6, suggesting a link between inflammation and vitamin D status.
Ultimately, the evidence indicates that maintaining adequate vitamin D levels may be crucial in managing the symptoms of hip and knee osteoarthritis. While further research is necessary to fully understand these relationships, our results hint at the potential benefits of vitamin D supplementation to help alleviate OA symptoms and slow disease progression.
Our findings revealed that patients with low vitamin D levels experienced more severe OA symptoms. They reported higher pain levels and greater difficulties in daily activities compared to those with normal vitamin D levels. Furthermore, their vitamin D deficiency was associated with increased levels of inflammatory markers, TNF-α and IL-6, suggesting a link between inflammation and vitamin D status.
Ultimately, the evidence indicates that maintaining adequate vitamin D levels may be crucial in managing the symptoms of hip and knee osteoarthritis. While further research is necessary to fully understand these relationships, our results hint at the potential benefits of vitamin D supplementation to help alleviate OA symptoms and slow disease progression.
8
We conducted a detailed examination of how dietary magnesium affects people suffering from knee osteoarthritis (OA). In this study, we analyzed data from a two-year trial that involved 392 participants dealing with this common joint issue. Our focus was on dietary macroelements, particularly magnesium, and their relationships with various aspects of OA, including symptoms, quality of life, and related health conditions.
The results were compelling. Higher magnesium intake was associated with fewer OA symptoms, improved quality of life, and less severe comorbid conditions, such as depressive symptoms and lower limb muscle weakness. We observed that people who consumed more magnesium reported feeling better overall, suggesting that this dietary change could support knee OA management.
This connection is crucial as osteoarthritis currently has no cure, making effective management strategies like dietary adjustments especially valuable. By emphasizing magnesium's potential benefits, we hope to pave the way for new avenues in managing knee OA that can enhance comfort and quality of life for those affected.
The results were compelling. Higher magnesium intake was associated with fewer OA symptoms, improved quality of life, and less severe comorbid conditions, such as depressive symptoms and lower limb muscle weakness. We observed that people who consumed more magnesium reported feeling better overall, suggesting that this dietary change could support knee OA management.
This connection is crucial as osteoarthritis currently has no cure, making effective management strategies like dietary adjustments especially valuable. By emphasizing magnesium's potential benefits, we hope to pave the way for new avenues in managing knee OA that can enhance comfort and quality of life for those affected.
9
Magnesium reduces arthritis severity
We investigated how a high magnesium diet affects arthritis, focusing on its impact on inflammation and T cell development in two mouse models of rheumatoid arthritis. Our findings revealed that the mice receiving a diet rich in magnesium experienced less severe arthritis and reduced joint damage.
In this study, the magnesium-rich diet not only lowered the levels of inflammatory markers but also increased the numbers of beneficial immune cells known as Foxp3+ regulatory T cells. Moreover, we noticed that these immune cells produced more interleukin-10, a cytokine that plays a crucial role in controlling inflammation.
Interestingly, when we tested this in mice lacking interleukin-10, the protective effects of magnesium disappeared. This led us to further explore the role of the intestinal microbiome. By performing fecal material transplantation from mice on a high magnesium diet, we could replicate the beneficial immune responses observed in the original magnesium diet group.
The microbiome analyses revealed significant changes, including a decrease in specific bacteria linked to rheumatoid arthritis and an increase in those that promote health. These results suggest that magnesium might provide a novel approach to modifying the gut microbiome to help treat arthritis and potentially other autoimmune diseases.
In this study, the magnesium-rich diet not only lowered the levels of inflammatory markers but also increased the numbers of beneficial immune cells known as Foxp3+ regulatory T cells. Moreover, we noticed that these immune cells produced more interleukin-10, a cytokine that plays a crucial role in controlling inflammation.
Interestingly, when we tested this in mice lacking interleukin-10, the protective effects of magnesium disappeared. This led us to further explore the role of the intestinal microbiome. By performing fecal material transplantation from mice on a high magnesium diet, we could replicate the beneficial immune responses observed in the original magnesium diet group.
The microbiome analyses revealed significant changes, including a decrease in specific bacteria linked to rheumatoid arthritis and an increase in those that promote health. These results suggest that magnesium might provide a novel approach to modifying the gut microbiome to help treat arthritis and potentially other autoimmune diseases.
References
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- Ranjbar M, Rahimlou M, Fallah M, Djafarian K, Mohammadi H. Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis. Heliyon. 2025;11:e42463. 10.1016/j.heliyon.2025.e42463
- Montemor CN, Fernandes MTP, Marquez AS, Bignardi PR, Poli RC, et al. Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis. Nutrients. 2025;17. 10.3390/nu17030447
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. 10.3390/nu17020349
- Arellano Pérez Vertti RD, Arellano Ramírez DO, González Galarza FF, Prieto Hinojosa AI, Méndez Hernández A, et al. "Association of vitamin D blood deficiency and the rs731236 polymorphism vitamin D receptor with primary knee osteoarthritis in subjects from Mexico". Clin Rheumatol. 2025;44:1329. 10.1007/s10067-025-07332-z
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. 10.1016/j.transproceed.2024.12.020
- Liu P, Zhou J, Cui H, Xu J, Ruan G, et al. 1,25(OH)D induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway. Clin Rheumatol. 2025;44:811. 10.1007/s10067-024-07281-z
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- Wielińska J, Górna K, Świerkot J, Bugaj B, Kolossa K, et al. Polymorphic Variants in the Vitamin D Receptor and Clinical Parameters of Rheumatoid Arthritis Patients Undergoing Anti-TNF Treatment. Arch Immunol Ther Exp (Warsz). 2024;72. 10.2478/aite-2024-0023
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- Luo H, Zhang Y, Meng C, Li C, Jia D, et al. The effect of copper and vitamin D on osteoarthritis outcomes: A Mendelian randomization study. Medicine (Baltimore). 2024;103:e39828. 10.1097/MD.0000000000039828
- Zang K, Bhatia R, Xue E, Bennett KJ, Luo KH, et al. Vitamin D as a Modifiable Risk Factor for Juvenile Idiopathic Arthritis: A Systematic Review and Meta-analysis of Observational Studies Comparing Baseline Vitamin D in Children with JIA to Individuals Without. Nutr Rev. 2024. 10.1093/nutrit/nuae148
- Kirikovich SS, Levites EV, Proskurina AS, Ritter GS, Dolgova EV, et al. Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats. Curr Issues Mol Biol. 2024;46:10934. 10.3390/cimb46100650
- Feng Y, Zhu P, Yan D, Wang X, Chen C, et al. Implications of vitamin D levels or status for mortality in rheumatoid arthritis: analysis of 2001-2018 data from the National Health and Nutrition Examination Survey. Front Immunol. 2024;15:1425119. 10.3389/fimmu.2024.1425119
- Wang QW, Ong MT, Man GC, Yeung YM, He X, et al. The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial. PLoS One. 2024;19:e0309610. 10.1371/journal.pone.0309610
- He J, Wu J, Zheng J, Xu Y, Li K, et al. Injectable Chondroitin Sulfate Microspheres with Gallic Acid-Magnesium MOF for Anti-Inflammatory and Cartilage Degeneration Alleviation in Osteoarthritis Treatment. ACS Appl Mater Interfaces. 2025;17:11898. 10.1021/acsami.4c22415
- Chathoth BM, Helmholz H, Angrisani N, Wiese B, Reifenrath J, et al. Investigating the Potential of Magnesium Microparticles on Cartilage and Bone Regeneration Utilizing an In Vitro Osteoarthritis Model. J Biomed Mater Res A. 2025;113:e37862. 10.1002/jbm.a.37862
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. 10.3390/nu16234247
- Li Y, Wang Y, Xu L, Liu C, Cui J, et al. Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study. Front Endocrinol (Lausanne). 2024;15:1375871. 10.3389/fendo.2024.1375871
- Mei S, Jiang F, Liu N, Feng Z, Zheng Y, et al. Sol-gel synthesis of magnesium oxide nanoparticles and their evaluation as a therapeutic agent for the treatment of osteoarthritis. Nanomedicine (Lond). 2024;19:1867. 10.1080/17435889.2024.2382421
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. 10.1186/s41043-024-00597-1
- Zheng L, Zhao S, Li Y, Xu J, Yan W, et al. Engineered MgO nanoparticles for cartilage-bone synergistic therapy. Sci Adv. 2024;10:eadk6084. 10.1126/sciadv.adk6084
- Pinto ACMD, de Melo Nunes R, de Freitas Carvalho WV, Girão VCC, Rocha FAC. Systemic and local antiinflammatory effect of magnesium chloride in experimental arthritis. Adv Rheumatol. 2024;64:6. 10.1186/s42358-023-00346-8
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. 10.1002/advs.202307094
- Yilmaz E, Ünver S. Investigation of the relationship between magnesium level and vitamin D, bone mineral density, and chronic diseases in patients with knee osteoarthritis. Magnes Res. 2023;36:40. 10.1684/mrh.2023.0515
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. 10.1186/s12889-023-16906-y
- Zheng Z, Luo H, Xu W, Shi L, Wang F, et al. Association between Elevated Magnesium Intake and Reduced Risk of Recurrent Falls and Frailty in Osteoarthritis: Data from the Osteoarthritis Initiative. J Nutr Health Aging. 2023;27:775. 10.1007/s12603-023-1979-9
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. 10.1016/j.ebiom.2023.104603
- Zhang Y, Chen T, Luo P, Li S, Zhu J, et al. Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis. Nutrients. 2022;14. 10.3390/nu14173576
- Chen R, Li X, Sun Z, Yin J, Hu X, et al. Intra-bone marrow injection of magnesium isoglyrrhizinate inhibits inflammation and delays osteoarthritis progression through the NF-κB pathway. J Orthop Surg Res. 2022;17:400. 10.1186/s13018-022-03294-z
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