Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8.1
Supplement Facts
Serving Size:  3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium  (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium  (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%

Top Medical Research Studies

8
Magnesium improves chest pain outcomes
We examined how oral magnesium might enhance quality of life and reduce exercise-induced chest pain for those with coronary artery disease (CAD). In an impressive multicenter trial, 187 patients were randomly assigned to receive either magnesium supplements or a placebo for six months.

Our findings show that magnesium therapy improved exercise duration and decreased chest pain during exertion. Participants receiving magnesium reported both enhanced exercise tolerance and better quality of life compared to those on a placebo. This suggests that magnesium supplementation could play an important role in managing CAD symptoms.
Read More
8
Magnesium shows promise for angina
We aimed to understand how a 24-hour infusion of magnesium sulphate affects patients with unstable angina. In a double-blind, placebo-controlled study, 62 patients were monitored for signs of myocardial ischaemia after receiving either magnesium or a placebo.

While both groups showed some ECG changes, the magnesium group had fewer overall ischaemic episodes and lower levels of heart enzyme release. Additionally, magnesium seemed to reduce stress hormone levels. Our findings suggest that magnesium can be a valuable treatment option for unstable angina, but more research is needed to confirm its effectiveness.
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9
Zinc treatment for angina pectoris
We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.
Read More

Most Useful Reviews

9
Reduced chest pain
1 people found this helpful
This calcium supplement is economical yet effective. It's better absorbed than other brands, and after a year of use, my friend's elderly mother saw significant improvement, with no more complaints of pain.
Read More
9
Improved chest pain
1 people found this helpful
This perfectly balanced combination helps with vitamin D deficiency, harmful effects on bones, and alleviates joint pain, getting me back to a healthier state.
Read More
9
Improved chest pain
5 people found this helpful
I understand the benefits of combining this with biotin. My hair and nails have improved, and the persistent lower extremity bone pain reduced after starting this supplement. It's a good complex, though the pills are rather large.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.5
  • All Researches
We looked at the case of a 69-year-old woman experiencing intermittent shortness of breath and chest pain. Interestingly, she also described a peculiar symptom—a phantom odor sensation that preceded her episodes. During an exercise stress echocardiography, she demonstrated abnormal smell perception alongside transient changes in her heart's electrical activity, which indicated possible cardiac issues.

After conducting invasive coronary angiography, no significant blockages were found in her coronary arteries. This led to a diagnosis of vasospastic angina, a condition that can cause chest pain due to spasms in the coronary arteries rather than physical blockages. To alleviate her symptoms, she was started on calcium channel blocker therapy. Thankfully, this treatment helped in resolving her discomfort.

While the study highlights the role of calcium treatment in managing her symptoms effectively, it's essential to note that this isn't a guaranteed solution for everyone with chest pain. Phantom odors as an indicative symptom of cardiovascular issues are quite rare, suggesting a need for healthcare providers to remain vigilant when patients present with atypical symptoms.
Read More
9.5
Calcium channels alleviate chest pain
We explored the unusual case of a 50-year-old premenopausal woman suffering from vasospastic angina (VSA), a form of chest pain resulting from coronary artery spasms. Our patient's daily chest pain, triggered by light exertion, led to testing that revealed mild-to-moderate isolated coronary ostial stenosis (ICOS) along with multi-vessel spasms.

Interestingly, despite the severity often associated with ICOS, she experienced considerable relief after starting treatment with calcium channel blockers (CCBs). This finding is significant as it shows how CCB therapy can effectively manage VSA symptoms, leading to alleviation of chest pain without the need for surgical intervention for ICOS—even over a stretch of 24 years.

Notably, follow-up imaging after this duration indicated that ICOS had resolved, suggesting a remarkable possibility of improvement. However, we should remember that while the use of CCBs proved beneficial in this instance, the results highlight the ongoing need for research into the efficacy of different treatments for chest pain.
Read More
9.5
Magnesium's unclear role in chest pain
We examined the role of magnesium in treating chest pain, particularly in a case involving a young female with Gitelman syndrome. This patient experienced recurrent chest pain alongside symptoms like tingling and numbness, prompting a thorough investigation into her condition.

Our exploration revealed that magnesium was indeed part of the treatment plan, but it was combined with potassium and amiloride. This combination makes it challenging to determine how much magnesium alone contributed to alleviating the patient's chest pain.

While magnesium is commonly recognized for its various health benefits, in this specific case, we did not see a clear, isolated benefit from it. Instead, the overall treatment approach seemed to require multiple interventions to achieve improvements in symptoms and biochemical markers.
Read More
9
Calcium treatment aids chest pain
We explored how calcium channel blockers (CCBs) can help patients with chest pain, particularly in those who also have heart failure with reduced ejection fraction (HFrEF) and myocardial infarction with non-obstructive coronary arteries (MINOCA).

An 83-year-old woman was admitted with significant shortness of breath and a notable decline in her heart's pumping ability, also accompanied by intermittent chest pain. Although initial tests showed no major blockages in her coronary arteries, a more precise method revealed that she was experiencing severe coronary spasms.

After starting her on dihydropyridine CCBs, we observed a remarkable improvement. Her chest pain gradually went away, and her heart function improved dramatically, as indicated by her higher ejection fraction and lower levels of heart stress markers.

This suggests that CCBs, although not commonly prescribed for HFrEF, can have a useful role in managing chest pain and improving heart function in specific cases. Therefore, we found that tailored treatments and comprehensive diagnostic approaches can lead to better outcomes for patients with similar conditions.
Read More
We investigated the effectiveness of vitamin D in relieving chest pain associated with a complex case of adult-onset hypophosphatemic osteomalacia (HO) in a 47-year-old woman suffering from Sjogren’s syndrome. In this case, the patient experienced progressively worsening pain in the chest, back, and legs, along with muscle weakness, raising questions about the underlying causes and appropriate treatment options.

After examining lab results, radiographic findings, and pathology, the diagnosis of adult-onset HO was confirmed. The treatment regimen included not only vitamin D but also alkalinization, steroids, neutral phosphate, and calcium supplements. Although the combination of treatments resulted in improved outcomes—such as pain relief and increased serum phosphorus levels—it’s difficult to isolate the effect of vitamin D specifically on chest pain, as it was one part of a broader therapeutic approach.

This case highlights the challenges of diagnosing and treating complex conditions like hypophosphatemic osteomalacia, particularly when associated with autoimmune disorders like Sjogren's syndrome. It underscores the importance of considering various factors and the potential interplay of treatments in managing such cases.
Read More

User Reviews

USERS' SCORE
Good
Based on 8 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduced chest pain
1 people found this helpful
This calcium supplement is economical yet effective. It's better absorbed than other brands, and after a year of use, my friend's elderly mother saw significant improvement, with no more complaints of pain.
Read More
9
Improved chest pain
1 people found this helpful
This perfectly balanced combination helps with vitamin D deficiency, harmful effects on bones, and alleviates joint pain, getting me back to a healthier state.
Read More
9
Improved chest pain
5 people found this helpful
I understand the benefits of combining this with biotin. My hair and nails have improved, and the persistent lower extremity bone pain reduced after starting this supplement. It's a good complex, though the pills are rather large.
Read More
7.5
Improved chest pain
3 people found this helpful
I had knee pain after exercising and sought calcium supplementation for relief. Initially, I experienced abdominal pain, but switching to morning doses helped. The knee pain gradually improved, likely due to the calcium.
Read More
9
Stopped chest pain
4 people found this helpful
Since I began taking this, I've noticed remarkable improvement. The pain in my knee has disappeared. I feel grateful for this change.
Read More

Frequently Asked Questions

0
Resolved chest pain
1 people found this helpful
I had chest pain but found that after a week of using this product, the issue vanished completely.
9
Reduced chest pain
1 people found this helpful
This calcium supplement is economical yet effective. It's better absorbed than other brands, and after a year of use, my friend's elderly mother saw significant improvement, with no more complaints of pain.
9
Stopped chest pain
4 people found this helpful
Since I began taking this, I've noticed remarkable improvement. The pain in my knee has disappeared. I feel grateful for this change.
7.5
Relieved chest pain
4 people found this helpful
This combination is ideal for me. Vitamin D deficiency is common, leading to pain and fatigue. This formula with vitamin D has greatly improved my wellness, alleviating joint pain.
7.5
Less chest pain
4 people found this helpful
I'm really pleased with this! The blend is effective, especially magnesium for bone growth. It reduced joint pain and even helped with restless legs syndrome, improving my sleep quality.
We explored the relationship between calcium channel blockers (CCBs) and chest pain in the context of a case involving paroxysmal atrial fibrillation (AF) caused by coronary artery spasm. The patient, a male with a smoking history but no significant risk factors, initially presented with palpitations diagnosed as AF.

Over the course of a year, he experienced recurring episodes of chest pain that coincided with his AF. Upon conducting a coronary angiography, doctors found normal coronary anatomy, but a provocation test confirmed the presence of coronary spasm leading to arrhythmia.

Following this diagnosis, the use of CCBs like nifedipine, alongside isosorbide mononitrate, effectively prevented the recurring episodes of chest pain and AF. This suggests that calcium treatment can play a beneficial role in managing chest pain associated with coronary spasms, especially when used in combination with other medications.
9
Calcium treatment aids chest pain
We explored how calcium channel blockers (CCBs) can help patients with chest pain, particularly in those who also have heart failure with reduced ejection fraction (HFrEF) and myocardial infarction with non-obstructive coronary arteries (MINOCA).

An 83-year-old woman was admitted with significant shortness of breath and a notable decline in her heart's pumping ability, also accompanied by intermittent chest pain. Although initial tests showed no major blockages in her coronary arteries, a more precise method revealed that she was experiencing severe coronary spasms.

After starting her on dihydropyridine CCBs, we observed a remarkable improvement. Her chest pain gradually went away, and her heart function improved dramatically, as indicated by her higher ejection fraction and lower levels of heart stress markers.

This suggests that CCBs, although not commonly prescribed for HFrEF, can have a useful role in managing chest pain and improving heart function in specific cases. Therefore, we found that tailored treatments and comprehensive diagnostic approaches can lead to better outcomes for patients with similar conditions.
We looked at the case of a 69-year-old woman experiencing intermittent shortness of breath and chest pain. Interestingly, she also described a peculiar symptom—a phantom odor sensation that preceded her episodes. During an exercise stress echocardiography, she demonstrated abnormal smell perception alongside transient changes in her heart's electrical activity, which indicated possible cardiac issues.

After conducting invasive coronary angiography, no significant blockages were found in her coronary arteries. This led to a diagnosis of vasospastic angina, a condition that can cause chest pain due to spasms in the coronary arteries rather than physical blockages. To alleviate her symptoms, she was started on calcium channel blocker therapy. Thankfully, this treatment helped in resolving her discomfort.

While the study highlights the role of calcium treatment in managing her symptoms effectively, it's essential to note that this isn't a guaranteed solution for everyone with chest pain. Phantom odors as an indicative symptom of cardiovascular issues are quite rare, suggesting a need for healthcare providers to remain vigilant when patients present with atypical symptoms.
9.5
Calcium channels alleviate chest pain
We explored the unusual case of a 50-year-old premenopausal woman suffering from vasospastic angina (VSA), a form of chest pain resulting from coronary artery spasms. Our patient's daily chest pain, triggered by light exertion, led to testing that revealed mild-to-moderate isolated coronary ostial stenosis (ICOS) along with multi-vessel spasms.

Interestingly, despite the severity often associated with ICOS, she experienced considerable relief after starting treatment with calcium channel blockers (CCBs). This finding is significant as it shows how CCB therapy can effectively manage VSA symptoms, leading to alleviation of chest pain without the need for surgical intervention for ICOS—even over a stretch of 24 years.

Notably, follow-up imaging after this duration indicated that ICOS had resolved, suggesting a remarkable possibility of improvement. However, we should remember that while the use of CCBs proved beneficial in this instance, the results highlight the ongoing need for research into the efficacy of different treatments for chest pain.
We investigated how vitamin D influences chest pain in individuals experiencing vaccine-related myocarditis after receiving the BNT162b2 COVID-19 vaccine. Our study involved analyzing vitamin D levels, immune profiles, and genetic factors in 60 patients who suffered from this condition.

A significant finding was that a high percentage of these patients, about 73.3%, were found to have low vitamin D levels. Particularly concerning was the observation that those patients who presented with chest pain were more likely to be vitamin D deficient. We also found that lower vitamin D levels were linked to higher peak levels of cardiac troponin T, a marker indicating heart stress.

Additionally, we explored genetic factors and found that certain genetic variations could either increase or increase the potential risk related to vitamin D status. These findings suggest that hypovitaminosis D may exacerbate inflammation and activate specific immune cells, leading to symptoms like chest pain.

Overall, our research supports the idea that improving vitamin D status could be crucial in reducing vaccine-related myocarditis and associated chest pain, revealing a path for potential preventive measures and treatment strategies.
8
Vitamin D deficiency affects symptoms
We aimed to understand how vitamin D deficiency (VDD) might influence symptoms like chest pain, anxiety, and fatigue in people living with coronary artery disease (CAD). In our investigation, we collected data from 90 CAD patients, focusing on their vitamin D levels and experiences with these symptoms.

The findings were quite revealing. A significant 80% of the participants were found to have low vitamin D levels. Interestingly, we discovered that lower vitamin D levels were linked to increased chest pain and heightened anxiety and fatigue. Specifically, there were strong negative relationships noted: as vitamin D levels dropped, chest pain, anxiety, and fatigue scores rose.

This suggests that addressing vitamin D deficiency might be an important step for managing cardiac-related symptoms in patients with CAD. As this connection unfolds, it seems valuable for healthcare providers to monitor vitamin D levels in CAD patients and consider interventions to correct deficiencies.

References

  1. El Sady BD, Shaker AM, Abdulsaboor A, Ahmed A, Salama ABM. Paroxysmal Atrial Fibrillation as the First Presentation of Coronary Artery Spasm. Cureus. 2024;16:e71186. 10.7759/cureus.71186
  2. Ikebe S, Yamamoto M, Ishii M, Yamamoto E, Tsujita K. Managing heart failure with reduced ejection fraction merged with myocardial infarction with non-obstructive coronary arteries: a case report. Eur Heart J Case Rep. 2024;8:ytae540. 10.1093/ehjcr/ytae540
  3. Zubair H, Suma V, Masood F, Jan MF, Bajwa T, et al. Case Report: Vasospastic angina presenting as phantom odor perception. Front Cardiovasc Med. 2024;11:1416149. 10.3389/fcvm.2024.1416149
  4. Takahashi K, Kodama A, Uemura S, Okura T. Bilateral isolated coronary ostial stenosis in a middle-aged premenopausal woman with vasospastic angina: a case report. Eur Heart J Case Rep. 2024;8:ytae249. 10.1093/ehjcr/ytae249
  5. Tsang HW, Chua GT, Tung KTS, Wong RSM, Tsao SSL, et al. The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis. Front Immunol. 2025;16:1501609. 10.3389/fimmu.2025.1501609
  6. Khater WA, Alfarkh MA, Allnoubani A. The Association Between Vitamin D Level and Chest Pain, Anxiety, and Fatigue in Patients With Coronary Artery Disease. Clin Nurs Res. 2023;32:639. 10.1177/10547738221126325
  7. Alkhatatbeh MJ, Abdul-Razzak KK, Amara NA, Al-Jarrah M. Non-cardiac Chest Pain and Anxiety: A Possible Link to Vitamin D and Calcium. J Clin Psychol Med Settings. 2019;26:194. 10.1007/s10880-018-9579-2
  8. Tsuchiya M, Takaki R, Kobayashi F, Nagasaka T, Shindo K, et al. [Multiple pseudofractures due to Fanconi's syndrome associated with Wilson's disease]. Rinsho Shinkeigaku. 2017;57:527. 10.5692/clinicalneurol.cn-000953
  9. Shen G, Zhang Y, Hu S, Liu B, Kuang A. Adult-onset hypophosphatemic osteomalacia associated with Sjogren syndrome: Clinical case report. Medicine (Baltimore). 2017;96:e6493. 10.1097/MD.0000000000006493
  10. Lee J, Fields KB. Sternal stress fracture in a middle-aged woman. BMJ Case Rep. 2017;2017. 10.1136/bcr-2016-218203
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  15. Pokan R, Hofmann P, von Duvillard SP, Smekal G, Wonisch M, et al. Oral magnesium therapy, exercise heart rate, exercise tolerance, and myocardial function in coronary artery disease patients. Br J Sports Med. 2006;40:773.
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  23. Redwood SR, Bashir Y, Huang J, Leatham EW, Kaski JC, et al. Effect of magnesium sulphate in patients with unstable angina. A double blind, randomized, placebo-controlled study. Eur Heart J. 1997;18:1269.
  24. Satake K, Lee JD, Shimizu H, Ueda T, Nakamura T. Relation between severity of magnesium deficiency and frequency of anginal attacks in men with variant angina. J Am Coll Cardiol. 1996;28:897.
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  28. Feldstedt M, Boesgaard S, Bouchelouche P, Svenningsen A, Brooks L, et al. Magnesium substitution in acute ischaemic heart syndromes. Eur Heart J. 1991;12:1215.
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